Polymers in small-interfering RNA delivery

Nucleic Acid Therapeutics

Volumn 21, Issue 3, 2011, Pages 133-147

  Singha, Kaushik ^a   Namgung, Ran ^a   Kim, Won Jong ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON NANOTUBE; CHITOSAN; CYCLODEXTRIN; DENDRIMER; GOLD NANOPARTICLE; NANOPARTICLE; POLYETHYLENEIMINE; POLYGLACTIN; POLYMER; POLYPEPTIDE; SILICON DIOXIDE; SMALL INTERFERING RNA;

DRUG DELIVERY SYSTEM; HUMAN; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW;

CELLULOSE; CHITOSAN; CYCLODEXTRINS; DENDRIMERS; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LACTIC ACID; NANOPARTICLES; NANOTUBES, CARBON; PEPTIDES; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; POLYMERS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 80052140404     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2011.0293     Document Type: Review

References (132)

1. AL-JAMAL, K.T., TOMA, F.M., YILMAZER, A., ALI-BOU-CETTA, H., NUNES, A., HERRERO, M.A., TIAN, B., ED-DAOUDI, A., AL-JAMAL, W.T., BIANCO, A., PRATO, M., and KOSTARELO, K. (2010). Enhanced cellular internaliza-tion and gene silencing with a series of cationic dendron-multiwalled carbon nanotube:siRNA complexes. FASEB J. 24, 4354-4365.
2. ALSHAMSAN, A., HADDADI, A., HAMDY, S., SAMUEL, J., EL-KADI, A.O., ULUDAG, H., and LAVASANIFAR, A. (2010). STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response. Mol. Pharm. 7, 1643-1654.
3. ALSHAMSAN, A., HADDADI, A., INCANI, V., SAMUEL, J., LAVASANIFAR, A., and ULUDAG, H. (2009). Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine. Mol. Pharm. 6, 121-133.
4. ALSHAMSAN, A., HAMDY, S., SAMUEL, J., EL-KADI, A.O., LAVASANIFAR, A., and ULUDAG?, H. (2010). The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine. Biomater-ials 31, 1420-1428.
5. AMERES, S.L., MARTINEZ, J., and SCHROEDER, R. (2007). Molecular basis for target RNA recognition and cleavage by human RISC. Cell 130, 101-112. (Pubitemid 47031315)
6. ANDERSEN, M.Ø., LICHAWSKA, A., ARPANAEI, A., RASK JENSEN, S.M., KAUR, H., OUPICKY, D., BESENBACHER, F., KINGSHOTT, P., KJEMS, J., and HOWARD, K.A. (2010). Surface functionalisation of PLGA nanoparticles for gene silencing. Biomaterials 31, 5671-5677.
7. BARTLETT, D.W., and DAVIS, M.E. (2007). Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug. Chem. 18, 456-468. (Pubitemid 46493517)
8. BERNSTEIN, E., CAUDY, A.A., HAMMOND, S.M., and HAN-NON, G.J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366. (Pubitemid 32151243)
9. BISWAL, B.K., DEBATA, N.B., and VERMA, R.S. (2010) Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate. Mol. Biol. Rep. 37, 2919-2926.
10. BLACKBURN, W.H., DICKERSON, E.B., SMITH, M.H., MCDONALD, J.F., and LYON, L.A. (2009). Peptide-functio-nalized nanogels for targeted siRNA delivery. Bioconjug. Chem. 20, 960-968.
11. BØE, S.L., LONGVA, A.S., and HOVIG, E. (2010). Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing. Oligonucleotides 20, 175-182.
12. BOLCATO-BELLEMIN, A.L., BONNET, M.E., CREUSAT, G., ERBACHER, P., and BEHR, J.P. (2007). Sticky overhangs enhance siRNA-mediated gene silencing. Proc. Natl. Acad. Sci. U.S.A. 104, 16050-16055. (Pubitemid 350099361)
13. BOUSSIF, O., LEZOUALC'H, F., ZANTA, M.A., MERGNY, M.D., SCHERMAN, D., DEMENEIX, B., and BEHR, J.P. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92, 7297-7301.
14. BREUNIG, M., HOZSA, C., LUNGWITZ, U., WATANABE, K., UMEDA, I., KATO, H., and GOEPFERICH, A. (2008). Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo. J. Control. Release 130, 57-63.
15. CHEN, A.M., TARATULA, O., WEI, D., YEN, H.I., THOMAS, T., THOMAS, T.J., MINKO, T., and HE, H. (2010). Labile catalytic packaging of DNA/siRNA: control of gold nano-particles "out" of DNA/siRNA complexes. ACS Nano 4, 3679-3688.
16. CHEUNG, W., PONTORIERO, F., TARATULA, O., CHEN, A.M., and HE, H. (2010). DNA and carbon nanotubes as medicine. Adv. Drug Deliv. Rev. 62, 633-649.
17. CUN, D., FOGED, C., YANG, M., FRØKJAER, S., and NIELSEN, H.M. (2010). Preparation and characterization of poly(dl-lactide-co-glycolide) nanoparticles for siRNA delivery. Int. J. Pharm. 390, 70-75.
18. CUN, D., JENSEN, D.K., MALTESEN, M.J., BUNKER, M., WHITESIDE, P., SCURR, D., FOGED, C., and NIELSEN, H.M. (2011). High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles-Quality by design optimization and characterization. Eur. J. Pharm. Biopharm. 77, 26-35.
19. DE FOUGEROLLES, A., and NOVOBRANTSEVA, T. (2008). siRNA and the lung: research tool or therapeutic drug? Curr. Opin. Pharmacol. 8, 280-285.
20. DE LAS HERAS ALARCON, C., PENNADAM, S., and ALEXANDER, C. (2005). Stimuli responsive polymers for biomedi-cal applications. Chem. Soc. Rev. 34, 276-285. (Pubitemid 40444408)
21. DE SMEDT, S.C., DEMEESTER, J., and HENNINK, W.E. (2000). Cationic polymer based gene delivery systems. Pharm. Res. 17, 113-126. (Pubitemid 30158358)
22. DIFIGLIA, M., SENA-ESTEVES, M., CHASE, K., SAPP, E., PFISTER, E., SASS, M., YODER, J., REEVES, P., PANDEY, R.K., RAJEEV, K.G., MANOHARAN, M., SAH, D.W., ZA-MORE, P.D., and ARONIN, N. (2007). Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proc. Natl. Acad. Sci. U.S.A. 104, 17204-17209. (Pubitemid 350211015)
23. ELBAKRY, A., ZAKY, A., LIEBL, R., RACHEL, R., GOEPFER-ICH, A., and BREUNIG, M. (2009). Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery. Nano Lett. 9, 2059-2064.
24. ELBASHIR, S.M., HARBORTH, J., LENDECKEL, W., YALCIN, A., WEBER, K., and TUSCHL, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498. (Pubitemid 32494397)
25. FIRE, A., XU, S., MONTGOMERY, M.K., KOSTAS, S.A., DRIVER, S.E., and MELLO, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811. (Pubitemid 28099681)
26. FRANK-KAMENETSKY, M., GREFHORST, A., ANDERSON, N.N., RACIE, T.S., BRAMLAGE, B., AKINC, A., BUTLER, D., CHARISSE, K., DORKIN, R., FAN, Y., GAMBA-VITALO, C., HADWIGER, P., JAYARAMAN, M., JOHN, M., JAYAPRAKASH, K.N., MAIER, M., NECHEV, L., RAJEEV, K.G., READ, T., ROHL, I., SOUTSCHEK, J., TAN, P., WONG, J., WANG, G., ZIMMERMANN, T., DE FOUGEROLLES, A., VORNLOCHER, H.P., LANGER, R., ANDERSON, D.G., MANOHARAN, M., KOTELIANSKY, V., HORTON, J.D., and FITZGERALD, K. (2008). Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 105, 11915-11920.
27. GARRIPELLI, V.K., KIM, J.K., NAMGUNG, R., KIM, W.J., RE-PKA, M.A., and JO, S. (2010). A novel thermosensitive polymer with pH-dependent degradation for drug delivery. Acta Biomater. 6, 477-485.
28. GARY, D.J., PURI, N., and WON, Y.Y. (2007). Polymer-based siRNA delivery: perspectives on the fundamental and phe-nomenological distinctions from polymer-based DNA delivery. J. Control. Release 121, 64-73. (Pubitemid 47126065)
29. GHOSH, P., HAN, G., DE, M., KIM, C.K., and ROTELLO, V.M. (2008). Gold nanoparticles in delivery applications. Adv. Drug Deliv. Rev. 60, 1307-1315.
30. GHOSN, B., KASTURI, S.P., and ROY, K. (2008). Enhancing polysaccharide-mediated delivery of nucleic acids through functionalization with secondary and tertiary Amines. Curr. Top Med. Chem. 8, 331-340. (Pubitemid 351791027)
31. GHOSN, B., SINGH, A., LI, M., VLASSOV, A.V., BURNETT, C., PURI, N., and ROY, K. (2010). Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA. Oligonucleotide 20, 163-172.
32. GILJOHANN, D.A., SEFEROS, D.S., PRIGODICH, A.E., PATEL, P.C., and MIRKIN, C.A. (2009). Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates. J. Am. Chem. Soc. 131, 2072-2073.
33. GODBEY, W.T., WU, K.K., and MIKOS, A.G. (1999). Size matters: molecular weight affects the efficiency of poly (ethylenimine) as a gene delivery vehicle. J. Biomed. Mater. Res. 45, 268-275. (Pubitemid 29165943)
34. GONZALEZ, H., HWANG, S.J., and DAVIS, M.E. (1999). New class of polymers for the delivery of macromolecular therapeutics. Bioconjug. Chem. 10, 1068-1074.
35. GRAYSON, A.C., DOODY, A.M., and PUTNAM, D. (2006). Biophysical and structural characterization of poly-ethylenimine-mediated siRNA delivery in vitro. Pharm. Res. 23, 1868-1876. (Pubitemid 44200551)
36. HALDER, J., KAMAT, A.A., LANDEN, C.N., Jr., HAN, L.Y., LUTGENDORF, S.K., LIN, Y.G., MERRITT, W.M., JENNINGS, N.B., CHAVEZ-REYES, A., COLEMAN, R.L., GERSHENSON, D.M., SCHMANDT, R., COLE, S.W., LOPEZ-BERESTEIN, G., and SOOD, A.K. (2006). Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res. 12, 4916-4924. (Pubitemid 44338579)
37. HAN, H.D., MANGALA, L.S., LEE, J.W., SHAHZAD, M.M., KIM, H.S., SHEN, D., NAM, E.J., MORA, E.M., STONE, R.L., LU, C., LEE, S.J., ROH, J.W., NICK, A.M., LOPEZ-BERESTEIN, G., and SOOD, A.K. (2010). Targeted gene silencing using RGD labeled chitosan nanoparticles, Clin. Cancer Res. 16, 3910-3922.
38. HART, S.L. (2010). Multifunctional nanocomplexes for gene transfer and gene therapy. Cell Biol. Toxicol. 26, 69-81.
39. HASSANI, Z., LEMKINE, G.F., ERBACHER, P., PALMIER, K., ALFAMA, G., GIOVANNANGELI, C., BEHR, J.P., and DE-MENEIX, B.A. (2005). Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J. Gene Med. 7, 198-207. (Pubitemid 40348024)
40. HERRERO, M.A., TOMA, F.M., AL-JAMAL, K.T., KOSTAR-ELOS, K., BIANCO, A., DA ROS, T., BANO, F., CASALIS, L., SCOLES, G., and PRATO, M. (2009). Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery. J. Am. Chem. Soc. 131, 9843-9848.
41. HOM, C., LU, J., and TAMANOI, F. (2009). Silica nanoparticles as a delivery system for nucleic acid-based reagents. J. Mater. Chem. 19, 6308-6316.
42. HOMBACH, J., and BERNKOP-SCHNURCH, A. (2009). Chit-osan solutions and particles: evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model. Int. J. Pharm. 376, 104-109.
43. HOWARD, K.A., RAHBEK, U.L., LIU, X., DAMGAARD, C.K., GLUD, S.Z., ANDERSEN, M.O., HOVGAARD, M.B., SCHMITZ, A., NYENGAARD, J.R., BESENBACHER, F., and KJEMS, J. (2006). RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol. Ther. 14, 476-484. (Pubitemid 44296092)
44. HU-LIESKOVAN, S., HEIDEL, J.D., BARTLETT, D.W., DAVIS, M.E., and TRICHE, T.J. (2005). Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 65, 8984-8992. (Pubitemid 41377390)
45. HUNTER, A.C., and MOGHIMI, S.M. (2002). Therapeutic synthetic polymers: a game of Russian roulette? Drug Discov. Today 7, 998-1001. (Pubitemid 35304569)
46. JOHANSSON, H.J., ANDALOUSSI, S.E., and LANGEL, U. (2011). Mimicry of protein function with cell-penetrating peptides. Methods Mol. Biol. 683, 233-47.
47. KABANOV, A.V., and VINOGRADOV, S.V. (2009). Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew. Chem. Int. Ed. Engl. 48, 5418-5429.
48. KAM, N.W., LIU, Z., and DAI, H. (2005). Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J. Am. Chem. Soc. 127, 12492-12493. (Pubitemid 41292159)
49. KANG, J.H., TACHIBANA, Y., KAMATA, W., MAHARA, A., HARADA-SHIBA, M., and YAMAOKA, T. (2010). Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier. Bioorg. Med. Chem. 18, 3946-39.
50. KATAS, H., CEVHER, E., and ALPAR, H.O. (2009). Preparation of polyethylenimine incorporated poly(d,l-lactide-co-glycolide) nanoparticles by spontaneous emulsion diffusion method for small interfering RNA delivery. Int. J. Pharm. 369, 144-154.
51. KIM, H.J., ISHII, A., MIYATA, K., LEE, Y., WU, S., OBA, M., NISHIYAMA, N., and KATAOKA, K. (2010c). Introduction of stearoyl moieties into a biocompatible cationic poly-aspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145, 141-148.
52. KIM, S.K., PARK, K.M., SINGHA, K., KIM, J., AHN, Y., KIM, K., and KIM, W.J. (2010b). Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery. Chem. Com-mun. 46, 692-694.
53. KIM, T.I., LEE, M., and KIM, S.W. (2010a). A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems. Biomaterials 31, 1798-1804.
54. KIM, W.J, CHRISTENSEN, L.V., JO, S., YOCKMAN, J.W., JEONG, J.H., KIM, Y.H., and KIM, S.W. (2006b). Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarci-noma. Mol. Ther. 14, 343-350. (Pubitemid 44184964)
55. KIM, W.J., and KIM, S.W. (2009). Efficient siRNA delivery with non-viral polymeric vehicles. Pharm. Res. 26, 657-666.
56. KIM, W.J., CHANG, C.W., LEE, M., and KIM, S.W. (2007). Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy. J. Control. Release 118, 357-363. (Pubitemid 46441547)
57. KIM, W.J., YOCKMAN, J.W., JEONG, J.H., CHRISTENSEN, L.V., LEE, M., KIM, Y.H., and KIM, S.W. (2006a). Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice. J. Control. Release 114, 381-388. (Pubitemid 44310812)
58. KIM, W.J., YOCKMAN, J.W., LEE, M., JEONG, J.H., KIM, Y.H., and KIM, S.W. (2005). Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. J. Control. Release 106, 224-234. (Pubitemid 41140097)
59. KIM, S.H., JEONG, J.H., LEE, S.H., KIM, S.W., and PARK, T.G. (2008). Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 129, 107-116.
60. KOPING-HOGGARD, M., TUBULEKAS, I., GUAN, H., EDWARDS, K., NILSSON, M., VARUM, K.M., and ARTURS-SON, P. (2001). Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther. 8, 1108-1121. (Pubitemid 32962708)
61. KULKARNI, R.P., MISHRA, S., FRASER, S.E., and DAVIS, M.E. (2005). Single cell kinetics of intracellular, nonviral, nucleic acid delivery vehicle acidification and trafficking. Bioconjug. Chem. 16, 986-994. (Pubitemid 41026184)
62. KWON, J.S., PARK, I.K., CHO, A.S., SHIN, S.M., HONG, M.H., JEONG, S.Y., KIM, Y.S., MIN, J.J., JEONG, M.H., KIM, W.J., JO, S., PUN, S.H., CHO, J.G., PARK, J.C., KANG, J.C., and AHN, Y. (2009). Enhanced angiogenesis mediated by VEGF plasmid-loaded thermo-responsive amphiphilic hydrogel in rat myocardial infarction model. J. Control. Release 138, 168-176.
63. LACERDA, L., BIANCO, A., PRATO, M., and KOSTARELOS, K. (2006). Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv. Drug Deliv. Rev. 58, 1460-1470. (Pubitemid 44822607)
64. LANGLET-BERTIN, B., LEBORGNE, C., SCHERMAN, D., BE-CHINGER, B., MASON, A.J., and KICHLER, A. (2010). Design and evaluation of histidine rich amphipathic peptides for siRNA delivery. Pharm. Res. 27, 1426-1436.
65. LANNER, J.T., BRUTON, J.D., ASSEFAW-REDDA, Y., ANDRONACHE, Z., ZHANG, S.J., SEVERA, D., ZHANG, Z.-B., MELZER, W., ZHANG, S.-L., KATZ, A., and WESTER-BLAD, H. (2009). Knockdown of TRPC3 with siRNA coupled to carbon nanotubes results in decreased insulin-mediated glucose uptake in adult skeletal muscle cells. FASEB J. 23, 1728-1738.
66. LEE, J.S., GREEN, J.J., LOVE, K.T., SUNSHINE, J., LANGER, R., and ANDERSON, D.G. (2009). Gold, poly(b-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 9, 2402-2406.
67. LEE, K., BAE, K.H., LEE, Y., LEE, S.H., AHN, C.H., and PARK, T.G. (2010). Pluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals for magnetically triggered delivery of siRNA. Macromol. Biosci. 10, 239-245.
68. LEE, Y., MIYATA, K., OBA, M., ISHII, T., FUKUSHIMA, S., HAN, M., KOYAMA, H., NISHIYAMA, N., and KATAOKA, K. (2008). Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery. Angew. Chem., Int. Ed. Engl. 47, 5163-5166.
69. LENG, Q., SCARIA, P., ZHU, J., AMBULOS, N., CAMPBELL, P., and MIXSON, A.J. (2005). Highly branched HK peptides are effective carriers of siRNA. J. Gene. Med. 7, 977-986. (Pubitemid 41015546)
70. LIU, X.X., ROCCHI, P., QU, F.Q., ZHENG, S.Q., LIANG, Z.C., GLEAVE, M., IOVANNA, J., and PENG, L. (2009). PAMAM dendrimers mediate sirna delivery to target hsp27 and produce potent antiproliferative effects on prostate cancer cells. ChemMedChem. 4, 1302-1310.
71. LIU, Z., WINTERS, M., HOLODNIY, M., and DAI, H. (2007). siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew. Chem. Int. Ed. Engl. 46, 2023-2027. (Pubitemid 46973660)
72. MAO, S., NEU, M., GERMERSHAUS, O., MERKEL, O., SITTERBERG, J., BAKOWSKY, U., and KISSEL, T. (2006). Influence of polyethylene glycol chain length on the physico-chemical and biological properties of poly(ethylene imine)-graft- poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjug. Chem. 17, 1209-1218. (Pubitemid 44455329)
73. MAO, S., SUN, W., and KISSEL, T. (2010). Chitosan-based formulations for delivery of DNA and siRNA. Adv. Drug Deliv. Rev. 62, 12-27.
74. MATRANGA, C., TOMARI, Y., SHIN, C., BARTEL, D.P. and ZAMORE, P.D. (2005). Passenger-strand cleavage facilitates assembly of siRNA into ago2-containing RNAi enzyme complexes. Cell 123, 607-620. (Pubitemid 41608464)
75. MEHVAR, R. (2003). Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: Pharmacokinetic and pharmacodynamic perspectives. Curr. Pharm. Biotechnol. 4, 283-302. (Pubitemid 37220861)
76. MENG, H., LIONG, M., XIA, T., LI, Z., JI, Z., ZINK, J.I., and NEL, A.E. (2010). Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and p-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 4, 4539-4550.
77. MIDOUX, P., and MONSIGNY, M. (1999). Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjug. Chem. 10, 406-411. (Pubitemid 29243322)
78. MIYATA, K., OBA, M., NAKANISHI, M., FUKUSHIMA, S., YAMASAKI, Y., KOYAMA, H., NISHIYAMA, N., and KATAOKA, K. (2008). Polyplexes from poly(aspartamide) bearing 1, 2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified trans-fection and negligible cytotoxicity. J. Am. Chem. Soc. 130, 16287-16294.
79. MOGHIMI, S.M., SYMONDS, P., MURRAY, J.C., HUNTER, A.C., DEBSKA, G., and SZEWCZYK, A. (2005). A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol. Ther. 11, 990-995. (Pubitemid 40724119)
80. MORRISSEY, D.V., LOCKRIDGE, J.A., SHAW, L., BLAN-CHARD, K., JENSEN, K., BREEN, W., HARTSOUGH, K., MACHEMER, L., RADKA, S., JADHAV, V., VAISH, N., ZINNEN, S., VARGEESE, C., BOWMAN, K., SHAFFER, C.S., JEFFS, L.B., JUDGE, A., MACLACHLAN, I., and POLISKY, B. (2005). Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotech. 23, 1002-1007. (Pubitemid 41114035)
81. NAKAMURA, Y., KOGURE, K., FUTAKI, S., and HARA-SHIMA, H. (2007). Octaarginine-modified multifunctional envelope-type nano device for siRNA. J. Control. Release 119, 360-367. (Pubitemid 46770881)
82. NAMGUNG, R., KIM, J., SINGHA, K., KIM, C.H., and KIM, W.J. (2009a). Synergistic effect of low cytotoxic linear poly-ethylenimine and multiarm polyethylene glycol: study of physicochemical properties and in vitro gene transfection. Mol. Pharm. 6, 1826-1835.
83. NAMGUNG, R., NAM, S., KIM, S.K., SON, S., SINGHA, K., KWON, J.S., AHN, Y., JEONG, M.H., PARK, I.K., GARRI-PELLI, V.K., JO, S., and KIM, W.J. (2009b). An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells. Biomaterials 30, 5225-5233.
84. NAMGUNG, R., SINGHA, K., YU, M.K., JON, S., KIM, Y.S., AHN, Y., PARK, I.K., and KIM, W.J. (2010). Hybrid super-paramagnetic iron oxide nanoparticle-branched poly-ethylenimine magnetoplexes for gene transfection of vascular endothelial cells. Biomaterials 31, 4204-4213.
85. NIELSEN, E.J., NIELSEN, J.M., BECKER, D., KARLAS, A., PRAKASH, H., GLUD, S.Z., MERRISON, J., BESENBACHER, F., MEYER, T.F., KJEMS, J., and HOWARD, K.A. (2010). Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles. Pharm. Res. 27, 2520-2527.
86. NIU, X.Y., PENG, Z.L., DUAN, W.Q., WANG, H., and WANG, P. (2006). Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo. Int. J. Gynecol. Cancer 16, 743-751.
87. NOH, S.M., HAN, S.E., SHIM, G., LEE, K.E., KIM, C.W., HAN, S.S., CHOI, Y., KIM, Y.K., KIM, W.K., and OH, Y.K. (2011). Tocopheryl oligochitosan-based self assembling oligomer-somes for siRNA delivery. Biomaterials 32, 849-857.
88. OH, J.K., LEE, D.I., and PARK, J.M. (2009). Biopolymer-based microgels/nanogels for drug delivery applications. Prog. Polym. Sci. 34, 1261-1282.
89. OKUMURA, A., PITHA, P.M., and HARTY, R.N. (2008). ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4ligase activity. Proc. Natl. Acad. Sci. U.S.A. 105, 3974-3979. (Pubitemid 351723509)
90. OPANASOPIT, P., TECHAARPORNKUL, S., ROJANARATA, T., NGAWHIRUNPAT, T., and RUKTANONCHAI, U. (2010). Nucleic acid delivery with chitosan hydroxybenzotriazole. Oligonucleotides 20, 127-136.
91. OSKUEE, R.K., PHILIPP, A., DEHSHAHRI, A., WAGNER, E., and RAMEZANI, M. (2010). The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery. J. Gene. Med. 12, 729-738.
92. PARK, I.K., IHM, J.E., PARK, Y.H., CHOI, Y.J., KIM, S.I., KIM, W.J., AKAIKE, T., and CHO, C.S. (2003). Galactosylated chit-osan (GC)-graft-poly(vinyl pyrrolidone) (PVP) as hepatocyte-targeting DNA carrier: preparation and physicochemical characterization of GC-graft-PVP/DNA complex (1). J. Control. Release 86, 349-359. (Pubitemid 36084278)
93. PARK, I.K., SINGHA, K., AROTE, R.B., CHOI, Y.-J., KIM, W.J, and CHO, C.S. (2010). pH-Responsive polymers as gene carriers. Macromol. Rapid Commun. 31, 1122-1133.
94. PATIL, M.L., ZHANG, M., BETIGERI, S., TARATULA, O., HE, H., and MINKO, T. (2008). Surface-modified and internally cationic polyamidoamine dendrimers for efficient siRNA delivery. Bioconjug. Chem. 19, 1396-1403. (Pubitemid 352032339)
95. PATIL, M.L., ZHANG, M., TARATULA, O., GARBUZENKO, O.B., HE, H., and MINKO, T. (2009). Internally cationic polyamidoamine pamam-oh dendrimers for sirna delivery: effect of the degree of quaternization and cancer targeting. Biomacromolecules 10, 258-266.
96. PERRIMAN, A.W., WILLIAMS, D.S., JACKSON, A.J., GRILLO, I., KOOMULLIL, J.M., GHASPARIAN, A., ROBINSON, J.A., and MANN, S. (2010). Synthetic viruslike particles and hybrid constructs based on lipopeptide self-assembly. Small 6, 1185-1190.
97. PHILIPP, A., ZHAO, X., TARCHA, P., WAGNER, E., and ZINTCHENKO, A. (2009). Hydrophobically modified oli-goethylenimines as highly efficient transfection agents for siRNA delivery. Bioconjug. Chem. 20, 2055-2061.
98. PTASZNIK, A., NAKATA, Y., KALOTA, A., EMERSON, S.G., and GEWIRTZ, A.M. (2004). Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drugresistant, BCR-ABL1\+ leukemia cells. Nat. Med. 10, 1187-1189. (Pubitemid 39540433)
99. RAEMDONCK, K., NAEYE, B., BUYENS, K., VANDEN-BROUCKE, R.E., HØGSET, A., DEMEESTER, J., and SMEDT, S.C.D. (2009). Biodegradable dextran nanogels for RNA interference: focusing on endosomal escape and intracellular siRNA delivery. Adv. Funct. Mater. 19, 1406-1415.
100. RAEMDONCK, K., NAEYE, B., HØGSET, A., DEMEESTER, J., and SMEDT, S.C.D. (2010). Prolonged gene silencing by combining siRNA nanogels and photochemical internaliza-tion. J. Control. Release 145, 281-288.
101. RAND, T.A., GINALSKI, K., GRISHIN, N.V., and WANG, X. (2004). Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl Acad. Sci. U.S.A. 101, 14385-14389. (Pubitemid 39346758)
102. ROJANARATA, T., OPANASOPIT, P., TECHAARPORNKUL, S., NGAWHIRUNPAT, T., and RUKTANONCHAI, U. (2008). Chitosan-thiamine pyrophosphate as a novel carrier for siR-NA delivery. Pharm. Res. 25, 2807-2814.
103. SALLAS, F., and DARCY, R. (2008). Amphiphilic cyclodextrins-advances in synthesis and supramolecular chemistry. Eur. J. Org. Chem. 2008, 957-969.
104. SATO, Y., HATAKEYAMA, H., and HARASHIMA, H. (2010). Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells. Biol. Pharm. Bull. 33, 1246-1249.
105. SATO, Y., MURASE, K., KATO, J., KOBUNE, M., SATO, T., KAWANO, Y., TAKIMOTO, R., TAKADA, K., MIYANISHI, K., MATSUNAGA, T., TAKAYAMA, T., and NIITSU, Y. (2008). Resolution of liver cirrhosis usingvitamin A-coupled liposomes to deliver siRNA against a collagen-specific chap-erone. Nat. Biotech. 26, 431-442. (Pubitemid 351501817)
106. SCHIFFELERS, R.M., ANSARI, A., XU, J., ZHOU, Q., TANG, Q., STORM, G., MOLEMA, G., LU, P.Y., SCARIA, P.V., and WOODLE, M.C. (2004). Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized na-noparticle. Nucleic Acids Res. 32, e149.
107. SINGH, B., DAHIYA, M., SAHARAN, P., and AHUJA, N. (2005b). Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects, Crit. Rev. Ther. Drug Carrier Syst. 22, 215-293. (Pubitemid 41568171)
108. SINGH, B., KUMAR, R., and AHUJA, N. (2005a). Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects. Crit. Rev. Ther. Drug Carrier Syst. 22, 27-105.
109. SON, S., and KIM, W.J. (2010). Biodegradable nanoparticles modified by branched polyethylenimine for plasmid DNA delivery. Biomaterials 31, 133-143.
110. SON, S., HWANG, D.W., SINGHA, K., JEONG, J.H., PARK, T.G., LEE, D.S., and KIM, W.J. (2010b). RVG peptide tethered bioreducible polyethylenimine for gene delivery to brain. J. Control. Release. doi:10.1016/j.jconrel.2010. 08.011.
111. SON, S., SINGHA, K., and KIM, W.J. (2010a). Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier. Biomaterials 31, 6344-6354.
112. SONG, E., LEE, S.K., WANG, J., INCE, N., OUYANG, N., MIN, J., CHEN, J., SHANKAR, P., and LIEBERMAN, J. (2003). RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9, 347-351. (Pubitemid 36362792)
113. SONG, W.J., DU, J.Z., SUN, T.M., ZHANG, P.Z., and WANG, J. (2010). Gold nanoparticles capped with polyethylenimine for enhanced siRNA delivery. Small 6, 239-246.
114. SPAGNOU, S., MILLER, A.D., and KELLER, M. (2004). Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry 43, 13348-13356. (Pubitemid 39391135)
115. TAHARA, K., SAKAI, T., YAMAMOTO, H., TAKEUCHI, H., and KAWASHIMA, Y. (2008) Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery. Int. J. Pharm. 354, 210-216.
116. TAKESHITA, F., MINAKUCHI, Y., NAGAHARA, S., HONMA, K., SASAKI, H., HIRAI, K, TERATANI, T., NAMATAME, N, YAMAMOTO, Y., HANAI, K., KATO, T., SANO, A., and OCHIYA, T. (2005). Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc. Natl Acad. Sci. U.S.A. 102, 12177-12182. (Pubitemid 41291148)
117. TAMURA, A, OISHI, M, and NAGASAKI, Y. (2009). Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure. Biomacromolecules 10, 1818-1827.
118. TAMURA, A., OISHI, M., and NAGASAKI, Y. (2010). Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core. J. Control. Release 146, 378-387.
119. TARATULA, O., GARBUZENKO, O.B., KIRKPATRICK, P., PANDYA, I., SAVLA, R, POZHAROV, V.P., HE, H, and MINKO, T. (2009). Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. J. Control. Release 140, 284-293.
120. TARATULA, O., SAVLA, R, HE, H, and MINKO, T. (2011). Poly(propyleneimine) dendrimers as potential siRNA delivery nanocarrier: from structure to function. Int. J. Nanotechnol. 8, 36-52.
121. TREWYN, B.G, GIRI, S., SLOWING, I.I., and LIN, V.S.-Y. (2007). Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems. Chem. Commun. 3236-3245. (Pubitemid 47197838)
122. VINOGRADOV, S., BATRAKOVA, E., and KABANOV, A. (1999). Poly(ethylene glycol)-polyethylenimine NanoGel™ particles: novel drug delivery systems for antisense oligonucleotides. Colloids Surfaces B: Biointerfaces 16, 291-304. (Pubitemid 29486816)
123. VINOGRADOV, S.V., BRONICH, T.K., and KABANOV, A.V. (2002). Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv. Drug Deliv. Rev. 54, 135-147. (Pubitemid 34075317)
124. WANG, J., FENG, S.S., WANG, S., and CHEN, ZY. (2010). Evaluation of cationic nanoparticles of biodegradable copol-ymers as siRNA delivery system for hepatitis B treatment. Int. J. Pharm. 400, 194-200.
125. WERTH, S., URBAN-KLEIN, B., DAI, L., HOBEL, S., GRZE-LINSKI, M., BAKOWSKY, U., CZUBAYKO, F., and AIGNER, A. (2006). A low molecular weight fraction of poly-ethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J. Control. Release 112, 257-270.
126. XIA, T., KOVOCHICH, M., LIONG, M., MENG, H., KABEHIE, S., GEORGE, S., ZINK, J.I., and NEL, A.E. (2009). Poly-ethylenimine coating enhances the cellular uptake of meso-porous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 3, 3273-3286.
127. XIA, C.F., ZHANG, Y., ZHANG, Y., BOADO, R., and PAR-DRIDGE, W. (2007). Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology. Pharm. Res. 24, 2309-2316. (Pubitemid 350060723)
128. XING, J., DENG, L., GUO, S., DONG, A., and LIANG, X.J. (2010). Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo. Mini Rev. Med. Chem. 10, 126-137.
129. YAMAOKA, T., TABATA, Y., and IKADA, Y. (1993). Body distribution profile of polysaccharides after intravenous administration. Drug Delivery 1, 75-82.
130. YUAN, X., LI, L., RATHINAVELU, A., HAO, J., HE, M., HEITLAGE, V., TAM, L., VIQAR, S., and SALEHI, M. (2006). SiRNA drug delivery by biodegradable polymeric nano-particles. J. Nanosci. Nanotechnol. 6, 2821-2828. (Pubitemid 44579952)
131. ZHANG, X.Q., INTRA, J., and SALEM, A.K. (2008). Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. J. Microencapsul. 25, 1-12.
132. ZHOU, J., WU, J., HAFDI, N., BEHR, J.P., ERBACHER, P., and PENG, L. (2006). PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chem. Commun. 22, 2362-2364. (Pubitemid 43846378)