A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy

Molecular Therapy

Volumn 11, Issue 6, 2005, Pages 990-995

  Moghimi, S Moein ^a   Symonds, Peter ^b   Murray, J Clifford ^b   Hunter, A Christy ^a   Debska, Grazyna ^c   Szewczyk, Adam ^c  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Apoptosis; Gene transfer systems; Mitochondria; Necrosis; Phosphatidylserine; Poly(ethylenimine); Polycations

Indexed keywords

CASPASE 3; CYTOCHROME C; GENE PRODUCT; LACTATE DEHYDROGENASE; PHOSPHATIDYLSERINE; POLYCATION; POLYETHYLENEIMINE; POLYMER;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; CHANNEL GATING; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME RELEASE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; LIVER CELL CULTURE; MACROMOLECULE; MEMBRANE DAMAGE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PROTEIN LOCALIZATION; UMBILICAL VEIN; VIRAL GENE DELIVERY SYSTEM;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CELL MEMBRANE; CYTOCHROMES C; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; L-LACTATE DEHYDROGENASE; MITOCHONDRIA; POLYETHYLENEIMINE; PROTEIN TRANSPORT;

EID: 19444372923     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.02.010     Document Type: Article

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