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Volumn 8, Issue 3, 2008, Pages 280-285

siRNA and the lung: research tool or therapeutic drug?

Author keywords

[No Author keywords available]

Indexed keywords

ALN RSV 01; ANGIOPOIETIN 2; ANTISENSE OLIGONUCLEOTIDE; CAVEOLIN 1; CELL PENETRATING PEPTIDE; CHITOSAN; FAS ANTIGEN; HEME OXYGENASE 1; LIPOPLEX; LIPOSOME; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; POLYETHYLENEIMINE; SMALL INTERFERING RNA;

EID: 44649091252     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2008.04.005     Document Type: Review
Times cited : (46)

References (31)
  • 1
    • 34248682403 scopus 로고    scopus 로고
    • RNAi therapeutics: principles, prospects and challenges
    • Aagaard L., and Rossi J.J. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev 59 (2007) 75-86
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 75-86
    • Aagaard, L.1    Rossi, J.J.2
  • 2
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: a potential new class of pharmaceutical drugs
    • Bumcrot D., Manoharan M., Koteliansky V., and Sah D.W. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2 (2006) 711-719
    • (2006) Nat Chem Biol , vol.2 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3    Sah, D.W.4
  • 7
    • 39549117983 scopus 로고    scopus 로고
    • Delivery vehicles for small interfering RNA in vivo
    • de Fougerolles A. Delivery vehicles for small interfering RNA in vivo. Hum Gene Ther 19 (2008) 125-132
    • (2008) Hum Gene Ther , vol.19 , pp. 125-132
    • de Fougerolles, A.1
  • 8
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • More than three orders of magnitude viral load reduction by intranasally administered saline-formulated siRNA in doses as low as 70 g per animal.
    • Bitko V., Musiyenko A., Shulyayeva O., and Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 11 (2005) 50-55. More than three orders of magnitude viral load reduction by intranasally administered saline-formulated siRNA in doses as low as 70 g per animal.
    • (2005) Nat Med , vol.11 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 9
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
    • Antiviral activity of direct intranasal instillation of saline-formulated siRNA in the lung of nonhuman primates is demonstrated in this study.
    • Li B.J., Tang Q., Cheng D., Qin C., Xie F.Y., Wei Q., Xu J., Liu Y., Zheng B.J., Woodle M.C., et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med 11 (2005) 944-951. Antiviral activity of direct intranasal instillation of saline-formulated siRNA in the lung of nonhuman primates is demonstrated in this study.
    • (2005) Nat Med , vol.11 , pp. 944-951
    • Li, B.J.1    Tang, Q.2    Cheng, D.3    Qin, C.4    Xie, F.Y.5    Wei, Q.6    Xu, J.7    Liu, Y.8    Zheng, B.J.9    Woodle, M.C.10
  • 10
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • Ge Q., Filip L., Bai A., Nguyen T., Eisen H.N., and Chen J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A 101 (2004) 8676-8681
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8676-8681
    • Ge, Q.1    Filip, L.2    Bai, A.3    Nguyen, T.4    Eisen, H.N.5    Chen, J.6
  • 11
    • 17644418754 scopus 로고    scopus 로고
    • Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
    • Thomas M., Lu J.J., Ge Q., Zhang C., Chen J., and Klibanov A.M. Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A 102 (2005) 5679-5684
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5679-5684
    • Thomas, M.1    Lu, J.J.2    Ge, Q.3    Zhang, C.4    Chen, J.5    Klibanov, A.M.6
  • 12
    • 2942620143 scopus 로고    scopus 로고
    • Protection against lethal influenza virus challenge by RNA interference in vivo
    • Tompkins S.M., Lo C.Y., Tumpey T.M., and Epstein S.L. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A 101 (2004) 8682-8686
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8682-8686
    • Tompkins, S.M.1    Lo, C.Y.2    Tumpey, T.M.3    Epstein, S.L.4
  • 15
    • 1642291631 scopus 로고    scopus 로고
    • Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
    • Report demonstrating endogenous target silencing in the lung through intranasal delivery of saline-formulated HO-1 siRNA.
    • Zhang X., Shan P., Jiang D., Noble P.W., Abraham N.G., Kappas A., and Lee P.J. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J Biol Chem 279 (2004) 10677-10684. Report demonstrating endogenous target silencing in the lung through intranasal delivery of saline-formulated HO-1 siRNA.
    • (2004) J Biol Chem , vol.279 , pp. 10677-10684
    • Zhang, X.1    Shan, P.2    Jiang, D.3    Noble, P.W.4    Abraham, N.G.5    Kappas, A.6    Lee, P.J.7
  • 16
    • 33750699301 scopus 로고    scopus 로고
    • Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death
    • Chemically modified siRNA targeting Ang2 and delivered intranasally is shown to effectively reduce lung pathology and mouse morbidity.
    • Bhandari V., Choo-Wing R., Lee C.G., Zhu Z., Nedrelow J.H., Chupp G.L., Zhang X., Matthay M.A., Ware L.B., Homer R.J., et al. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 12 (2006) 1286-1293. Chemically modified siRNA targeting Ang2 and delivered intranasally is shown to effectively reduce lung pathology and mouse morbidity.
    • (2006) Nat Med , vol.12 , pp. 1286-1293
    • Bhandari, V.1    Choo-Wing, R.2    Lee, C.G.3    Zhu, Z.4    Nedrelow, J.H.5    Chupp, G.L.6    Zhang, X.7    Matthay, M.A.8    Ware, L.B.9    Homer, R.J.10
  • 17
    • 20044385081 scopus 로고    scopus 로고
    • In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury
    • Lomas-Neira J.L., Chung C.S., Wesche D.E., Perl M., and Ayala A. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol 77 (2005) 846-853
    • (2005) J Leukoc Biol , vol.77 , pp. 846-853
    • Lomas-Neira, J.L.1    Chung, C.S.2    Wesche, D.E.3    Perl, M.4    Ayala, A.5
  • 18
    • 28244480458 scopus 로고    scopus 로고
    • Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis
    • Perl M., Chung C.S., Lomas-Neira J., Rachel T.M., Biffl W.L., Cioffi W.G., and Ayala A. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 167 (2005) 1545-1559
    • (2005) Am J Pathol , vol.167 , pp. 1545-1559
    • Perl, M.1    Chung, C.S.2    Lomas-Neira, J.3    Rachel, T.M.4    Biffl, W.L.5    Cioffi, W.G.6    Ayala, A.7
  • 19
    • 33748657147 scopus 로고    scopus 로고
    • Airway epithelium directed gene therapy for cystic fibrosis
    • White A.F., and Ponnazhagan S. Airway epithelium directed gene therapy for cystic fibrosis. Med Chem 2 (2006) 499-503
    • (2006) Med Chem , vol.2 , pp. 499-503
    • White, A.F.1    Ponnazhagan, S.2
  • 20
    • 33748539369 scopus 로고    scopus 로고
    • Current prospects for gene therapy of cystic fibrosis
    • Ziady A.G., and Davis P.B. Current prospects for gene therapy of cystic fibrosis. Curr Opin Pharmacol 6 (2006) 515-521
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 515-521
    • Ziady, A.G.1    Davis, P.B.2
  • 21
    • 36649027868 scopus 로고    scopus 로고
    • Pulmonary delivery of nucleic acids
    • Birchall J. Pulmonary delivery of nucleic acids. Expert Opin Drug Deliv 4 (2007) 575-578
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 575-578
    • Birchall, J.1
  • 22
    • 1542425280 scopus 로고    scopus 로고
    • Delivery of DNA to lung airway epithelium
    • Weiss D.J. Delivery of DNA to lung airway epithelium. Methods Mol Biol 246 (2004) 53-68
    • (2004) Methods Mol Biol , vol.246 , pp. 53-68
    • Weiss, D.J.1
  • 24
    • 33748054817 scopus 로고    scopus 로고
    • RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
    • The authors introduce chitosan-based siRNA nanoparticles and demonstrate in vivo RNA interference in bronchiole epithelial cells.
    • Howard K.A., Rahbek U.L., Liu X., Damgaard C.K., Glud S.Z., Andersen M.O., Hovgaard M.B., Schmitz A., Nyengaard J.R., Besenbacher F., et al. RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol Ther 14 (2006) 476-484. The authors introduce chitosan-based siRNA nanoparticles and demonstrate in vivo RNA interference in bronchiole epithelial cells.
    • (2006) Mol Ther , vol.14 , pp. 476-484
    • Howard, K.A.1    Rahbek, U.L.2    Liu, X.3    Damgaard, C.K.4    Glud, S.Z.5    Andersen, M.O.6    Hovgaard, M.B.7    Schmitz, A.8    Nyengaard, J.R.9    Besenbacher, F.10
  • 27
    • 34548154576 scopus 로고    scopus 로고
    • Cell-penetrating-peptide-mediated siRNA lung delivery
    • Moschos S.A., Williams A.E., and Lindsay M.A. Cell-penetrating-peptide-mediated siRNA lung delivery. Biochem Soc Trans 35 (2007) 807-810
    • (2007) Biochem Soc Trans , vol.35 , pp. 807-810
    • Moschos, S.A.1    Williams, A.E.2    Lindsay, M.A.3
  • 28
    • 33645155231 scopus 로고    scopus 로고
    • Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs
    • de Jonge J., Holtrop M., Wilschut J., and Huckriede A. Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs. Gene Ther 13 (2006) 400-411
    • (2006) Gene Ther , vol.13 , pp. 400-411
    • de Jonge, J.1    Holtrop, M.2    Wilschut, J.3    Huckriede, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.