ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 10, 2008, Pages 3974-3979

  Okumura, Atsushi ^a   Pitha, Paula M ^b   Harty, Ronald N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Ebola virus; Innate immunity; Interferon; Ubiquitin

Indexed keywords

PROTEIN; PROTEIN ISG15; PROTEIN VP40; UBIQUITIN PROTEIN LIGASE NEDD4; CORE PROTEIN; CYTOKINE; G1P2 PROTEIN, HUMAN; NEDD4 UBIQUITIN PROTEIN LIGASES; NUCLEOPROTEIN; NUCLEOPROTEIN VP40, EBOLA VIRUS; SMALL INTERFERING RNA; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EBOLA VIRUS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; VIRUS LIKE AGENT; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; VIRION;

BACTERIA (MICROORGANISMS); EBOLA VIRUS; MAMMALIA;

CELL LINE; CYTOKINES; HUMANS; MUTATION; NUCLEOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UBIQUITINS; VIRAL CORE PROTEINS; VIRION;

EID: 41649084195     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0710629105     Document Type: Article

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