Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles

Bioconjugate Chemistry

Volumn 18, Issue 2, 2007, Pages 456-468

  Bartlett, Derek W ^a   Davis, Mark E ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; CYCLODEXTRINS; LANTHANUM COMPOUNDS; LIGANDS; LIGHT SCATTERING; NANOPARTICLES; POLYETHYLENE GLYCOLS;

ADAMANTANES; BIOLOGICAL CHARACTERIZATION; DELIVERY VEHICLE; NUCLEIC ACID CONTAINING NANOPARTICLES; PHYSICO-CHEMICAL CHARACTERIZATION; PLASMID DNA; POLYCATIONS; SMALL INTERFERING RNA; SYSTEMIC DELIVERIES; TARGETING LIGANDS;

NUCLEIC ACIDS;

ADAMANTANE; BALANCED SALT SOLUTION; CYCLODEXTRIN; LIGAND; MACROGOL; NANOPARTICLE; NUCLEASE; NUCLEIC ACID; PLASMID DNA; POLYCATION; SMALL INTERFERING RNA; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CONFOCAL MICROSCOPY; DRUG TARGETING; ENZYMATIC DEGRADATION; ERYTHROCYTE AGGREGATION; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; LIGHT SCATTERING; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; STEREOCHEMISTRY; ZETA POTENTIAL;

EID: 33947696667     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0603539     Document Type: Article

References (27)

1. Morrissey, D. V., Blanchard, K., Shaw, L., Jensen, K., Lockridge, J. A., Dickinson, B., McSwiggen, J. A., Vargeese, C., Bowman, K., Shaffer, C. S., Polisky, B. A., and Zinnen, S. (2005) Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology 41, 1349-1356.
2. Layzer, J. M., McCaffrey, A. P., Tanner, A. K., Huang, Z., Kay, M. A., and Sullenger, B. A. (2004) In vivo activity of nuclease-resistant siRNAs. RNA 10, 766-771.
3. Schatzlein, A. G. (2003) Targeting of synthetic gene delivery systems. J. Biomed. Biotechnol. 2, 149-158.
4. Soutschek, J., Akinc, A., Bramiage, B., Charisse, K., Constien, R., Donoghue, M., Elbashir, S., Geick, A., Hadwiger, P., Harborth, J., John, M., Kesavan, V., Lavine, G., Pandey, R. K., Racie, T., Rajeev, K. G., Rohl, I., Toudjarska, I., Wang, G., Wuschko, S., Bumcrot, D., Koteliansky, V., Limmer, S., Manoharan, M., and Vornlocher, H.-P. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (London) 432, 173-178.
5. Dykxhoorn, D. M., Palliser, D., and Lieberman, J. (2006) The silent treatment: siRNAs as small molecule drugs. Gene Ther. 13, 541-552.
6. Song, E., Zhu, P., Lee, S.-K., Chowdhury, D., Kussman, S., Dykxhoorn, D. M., Feng, Y., Palliser, D., Weiner, D. B., Shankar, P., Marasco, W. A., and Lieberman, J. (2005) Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23, 709-717.
7. Hu-Lieskovan, S., Heidel, J. D., Bartlett, D. W., Davis, M. E., and Triche, T. J. (2005) Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of Ewing's sarcoma. Cancer Res. 65, 8984-8992.
8. Ogris, M., Brunner, S., Schuller, S., Kircheis, R., and Wagner, E. (1999) PEGylated DNA/transferrin-PE1 complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595-605.
9. Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K., Jensen, K., Breen, W., Hartsough, K., Machemer, L., Radka, S., Jadhav, V., Vaish, N., Zinnen, S., Vargeese, C., Bowman, K., Shaffer, C. S., Jeffs, L. B., Judge, A., MacLachlan, I., and Polisky, B. (2005) Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23, 1002-1007.
10. Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., Judge, A. D., Lam, K., McClintock, K., Nechev, L. V., Palmer, L. R., Racie, T., Rohl, I., Seiffert, S., Shanmugam, S., Sood, V., Soutschek, J., Toudjarska, I., Wheat, A. J., Yaworski, E., Zedalis, W., Koteliansky, V., Manoharan, M., Vornlocher, H.-P., and MacLachlan, I. (2006) RNAi-mediated gene silencing in non-human primates. Nature (London) 441, 111-114.
11. Plank, C., Mechtler, K., Szoka, F. C. J., and Wagner, E. (1996) Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7, 1437-1446.
12. Chonn, A., Cullis, P. R., and Devine, D. V. (1991) The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J. Immunol. 146, 4234-4241.
13. Venturoli, D., and Rippe, B. (2005) Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability. Am. J. Physiol. Renal Physiol. 288, F605-613.
14. Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., and Chilkoti, A. (2006) Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl. Cancer Inst. 98, 335-344.
15. Rensen, P., Sliedregt, L., Ferns, M., Kieviet, E., van Rossenberg, S., van Leeuwen, S., van Berkel, T., and Biessen, E. (2001) Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo. J. Biol. Chem. 276, 37577-37584.
16. Mishra, S., Webster, P., and Davis, M. E. (2004) PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 83, 97-111.
17. Davis, M. E., Pun, S. H., Bellocq, N. C., Reineke, T. M., Popielarski, S. R., Mishra, S., and Heidel, J. D. (2004) Self-assembling nucleic acid delivery vehicles via linear, water-soluble cyclodextrin-containing polymers. Curr. Med. Chem. 11, 1241-1253.
18. Mishra, S., Heidel, J. D., Webster, P., and Davis, M. E. (2006) Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes. J. Controlled Release 116, 179-191.
19. Bellocq, N. C., Pun, S. H., Jensen, G. S., and Davis, M. E. (2003) Transferrin-containing polymer-based particles for tumor-targeted gene delivery. Bioconjugate Chem. 14, 1122-1132.
20. Pun, S. H., Bellocq, N. C., Cheng, J., Grubbs, B. H., Jensen, G. S., Davis, M. E., Tack, F., Brewster, M., Janicot, M., Janssens, B., Floren, W., and Bakker, A. (2004) Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol. Ther. 3, 31-40.
21. Blandamer, M. J., Cullis, P. M. and Engberts, J. B. F. N. (1998) Titration microcalorimetry. J. Chem. Soc., Faraday Trans. 94, 2261-2267.
22. Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Scanlon, M. J., Chalmers, D., and Charman, W. N. (2006) The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins. J. Pharm. Sci. 95, 146-158.
23. Hansen, P. L., Cohen, J. A., Podgornik, R., and Parsegian, V. A. (2003) Osmotic properties of poly(ethylene glycols): quantitative features of brush and bulk scaling laws. Biophys. J. 84, 350-355.
24. Pun, S. H., and Davis, M. E. (2002) Development of a nonviral gene delivery vehicle for systemic application. Bioconjugate Chem. 13, 630-639.
25. Adams, G. P., Tai, M.-S., McCartney, J. E., Marks, J. D., Stafford, W. F., III, Houston, L. L., Huston, J. S., and Weiner, L. M. (2006) Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers. Clin. Cancer Res. 12, 1599-1605.
26. Phillips, J., Rutledge, L., and Winters, W. (1986) Transferrin binding to two human colon carcinoma cell lines: characterization and effect of 60 Hz electromagnetic fields. Cancer Res. 46, 239-244.
27. Shir, A., Ogris, M., Wagner, E., and Levitzki, A. (2006) EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Med. 3, e6.