High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterization

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 1, 2011, Pages 26-35

  Cun, Dongmei ^a   Jensen, Ditte Krohn ^a   Maltesen, Morten Jonas ^a,d   Bunker, Matthew ^b   Whiteside, Paul ^b   Scurr, David ^c   Foged, Camilla ^a   Nielsen, Hanne Mørck ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Molecular Profiles Ltd   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d NOVO NORDISK A S   (Denmark)

Author keywords

Drug delivery; Nanomedicine; Nanoparticles; Poly(dl lactide co glycolide acid); siRNA; Sustained release

Indexed keywords

BOVINE SERUM ALBUMIN; NANOPARTICLE; OIL; POLYGLACTIN; SMALL INTERFERING RNA; WATER;

ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; EMULSION; EVAPORATION; FACTORIAL DESIGN; HUMAN; HUMAN CELL; NANOENCAPSULATION; PARTICLE SIZE; SUSTAINED DRUG RELEASE; ULTRASOUND; VISCOSITY;

ACETYLATION; CELL LINE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; EXCIPIENTS; GENE SILENCING; HUMANS; LACTIC ACID; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POLYGLYCOLIC ACID; RNA, SMALL INTERFERING; SERUM ALBUMIN, BOVINE; SOLUBILITY; SURFACE PROPERTIES; VISCOSITY;

EID: 78650697312     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.11.008     Document Type: Article

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