Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery

Journal of Controlled Release

Volumn 140, Issue 3, 2009, Pages 284-293

  Taratula, Oleh ^a,b   Garbuzenko, Olga B ^a   Kirkpatrick, Paul ^b   Pandya, Ipsit ^b   Savla, Ronak ^a,b   Pozharov, Vitaly P ^a   He, Huixin ^b   Minko, Tamara ^a  

^a RUTGERS UNIVERSITY   (United States)

^b University Heights   (United States)

Author keywords

Cytotoxicity; In vivo imaging; LHRH peptide; Poly(propyleneimine) dendrimer; siRNA targeted to BCL2 mRNA; Tumor targeting

Indexed keywords

BCL-2MRNA; IN-VIVO IMAGING; LHRH PEPTIDE; POLY(PROPYLENE IMINE); POLY(PROPYLENEIMINE) DENDRIMER; TUMOR TARGETING;

AMINES; BIOCHEMISTRY; BLOOD; CELL MEMBRANES; CYTOTOXICITY; DENDRIMERS; DRUG THERAPY; ETHYLENE; ETHYLENE GLYCOL; GENETIC ENGINEERING; NANOPARTICLES; NUCLEIC ACIDS; PEPTIDES; PLASMA STABILITY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SEMICONDUCTOR QUANTUM DOTS; SYSTEM STABILITY; TUMORS;

RNA;

DENDRIMER; GONADORELIN DERIVATIVE; MACROGOL; NANOCARRIER; POLY(PROPYLENEININE); SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG TARGETING; DRUG UPTAKE; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR STABILITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; SURFACE PROPERTY;

ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; DENDRIMERS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION; GENES, BCL-2; GONADOTROPIN-RELEASING HORMONE; HUMANS; INDICATORS AND REAGENTS; LUNG NEOPLASMS; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASM TRANSPLANTATION; POLYPROPYLENES; RNA, MESSENGER; RNA, SMALL INTERFERING; SURFACE PROPERTIES; TISSUE DISTRIBUTION; TOLUENE;

EID: 70449700090     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.06.019     Document Type: Article

References (40)

1. Betigeri S., Pakunlu R.I., Wang Y., Khandare J.J., and Minko T. JNK1 as a molecular target to limit cellular mortality under hypoxia. Mol. Pharmacol. 3 4 (2006) 424-430
2. de Fougerolles A., Vornlocher H.-P., Maraganore J., and Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat. Rev. Drug Discovery 6 (2007) 443-453
3. Garbuzenko O.B., Saad M., Betigeri S., Zhang M., Vetcher A.A., Soldatenkov V.A., Reimer D.C., Pozharov V.P., and Minko T. Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug. Pharm. Res. 26 2 (2009) 382-394
4. Patil M.L., Zhang M., Betigeri S., Taratula O., He H., and Minko T. Surface-modified and internally cationic polyamidoamine dendrimers for efficient siRNA delivery. Bioconjug. Chem. 19 7 (2008) 1396-1403
5. Saad M., Garbuzenko O.B., and Minko T. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. Nanomed 3 6 (2008) 761-776
6. Chiu Y.-L., Ali A., Chu C.Y., Cao H., and Rana T.M. Visualizing a correction between siRNA localization, cellular uptake, and RNAi in living cells. Chem. Biol. 11 (2004) 1165-1175
7. Bessis N., GarciaCozar F.J., and Boissier M.C. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms. Gene Ther. 11 (2004) S10-17
8. Kim W.J., and Kim S.W. Efficient siRNA delivery with non-viral polymeric vehicles. Pharm. Res. 26 3 (2009) 657-666
9. Pack D.W., Hoffman A.S., Pun S., and Stayton P.S. Design and development of polymers for gene delivery. Nat. Rev. Drug Discovery 4 (2005) 581-593
10. Shim M.S., and Kwon Y.J. Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine. J. Control. Release 133 3 (2009) 206-213
11. Blessing T., Remy J.S., and Behr J.P. Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1427-1431
12. Oupicky D., Carlisle R.C., and Seymour L.W. Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo. Gene Ther. 8 9 (2001) 713-724
13. Dharap S.S., Wang Y., Chandna P., Khandare J.J., Qiu B., Gunaseelan S., Sinko P.J., Stein S., Farmanfarmaian A., and Minko T. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc. Natl. Acad. Sci. U.S.A. 102 36 (2005) 12962-12967
14. Ooya T., Lee J., and Park K. Hydrotropic dendrimers of generations 4 and 5: synthesis, characterization, and hydrotropic solubilization of paclitaxel. Bioconjug. Chem. 15 6 (2004) 1221-1229
15. Trubetskoy V.S., Loomis A., Slattum P.M., Hagstrom J.E., Budker V.G., and Wolff J.A. Caged DNA does not aggregate in high ionic strength solutions. Bioconjug. Chem. 10 4 (1999) 624-628
16. Miyata K., Kakizawa Y., Nishiyama N., Harada A., Yamasaki Y., Koyama H., and Kataoka K. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 8 (2004) 2355-2361
17. Spagnou S., Miller A.D., and Keller M. Lipidic carriers of siRNA: differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry 43 42 (2004) 13348-13356
18. Hagerman P.J. Investigation of the flexibility of DNA using transient electric birefringence. Biopolymers 20 7 (1981) 1503-1535
19. Shah S.A., and Brunger A.T. The 1.8 A crystal structure of a statically disordered 17 base-pair RNA duplex: principles of RNA crystal packing and its effect on nucleic acid structure. J. Mol. Biol. 285 4 (1999) 1577-1588
20. Snyder S.L., and Sobocinski P.Z. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines. Anal. Biochem. 64 1 (1975) 284-288
21. Pakunlu R.I., Wang Y., Tsao W., Pozharov V., Cook T.J., and Minko T. Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system. Cancer Res. 64 17 (2004) 6214-6224
22. Jayant S., Khandare J.J., Wang Y., Singh A.P., Vorsa N., and Minko T. Targeted sialic acid-doxorubicin prodrugs for intracellular delivery and cancer treatment. Pharm. Res. 24 11 (2007) 2120-2130
23. Khandare J.J., Chandna P., Wang Y., Pozharov V.P., and Minko T. Novel polymeric prodrug with multivalent components for cancer therapy. J. Pharmacol. Exp. Ther. 317 3 (2006) 929-937
24. Saad M., Garbuzenko O.B., Ber E., Chandna P., Khandare J.J., Pozharov V.P., and Minko T. Receptor targeted polymers, dendrimers, liposomes: which nanocarrier is the most efficient for tumor-specific treatment and imaging?. J. Control. Release 130 2 (2008) 107-114
25. Chen A.M., Santhakumaran L.M., Nair S.K., Amenta P.S., Thomas T., He H., and Thomas T.J. Oligonucleotide nanostructure formation in the presence of polypropyleneimine dendrimers and their uptake in breast cancer cells. Nanotechnology 17 (2006) 5449-5460
26. Oh J.K., Tang C., Gao H., Tsarevsky N.V., and Matyjaszewski K. Inverse miniemulsion ATRP: a new method for synthesis and functionalization of well-defined water-soluble/cross-linked polymeric particles. J. Am. Chem. Soc. 128 16 (2006) 5578-5584
27. Dash P.R., Read M.L., Barrett L.B., Wolfert M.A., and Seymour L.W. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther. 6 4 (1999) 643-650
28. Soutschek J., Akinc A., Bramlage B., Charisse K., Constien R., Donoghue M., Elbashir S., Geick A., Hadwiger P., Harborth J., John M., Kesavan V., Lavine G., Pandey R.K., Racie T., Rajeev K.G., Rohl I., Toudjarska I., Wang G., Wuschko S., Bumcrot D., Koteliansky V., Limmer S., Manoharan M., and Vornlocher H.P. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 7014 (2004) 173-178
29. van Steenis J.H., van Maarseveen E.M., Verbaan F.J., Verrijk R., Crommelin D.J., Storm G., and Hennink W.E. Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. J. Control. Release 87 1-3 (2003) 167-176
30. Gosselin M.A., Guo W., and Lee R.J. Incorporation of reversibly cross-linked polyplexes into LPDII vectors for gene delivery. Bioconjug. Chem. 13 5 (2002) 1044-1053
31. Kleemann E., Neu M., Jekel N., Fink L., Schmehl T., Gessler T., Seeger W., and Kissel T. Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J. Control. Release 109 1-3 (2005) 299-316
32. Kim T.I., Baek J.U., Zhe Bai C., and Park J.S. Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier. Biomaterials 28 11 (2007) 2061-2067
33. Kim S.H., Jeong J.H., Lee S.H., Kim S.W., and Park T.G. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. J. Control. Release 116 2 (2006) 123-129
34. Katas H., and Alpar H.O. Development and characterisation of chitosan nanoparticles for siRNA delivery. J. Control. Release 115 2 (2006) 216-225
35. Chandna P., Saad M., Wang Y., Ber E., Khandare J., Vetcher A.A., Soldatenkov V.A., and Minko T. Targeted proapoptotic anticancer drug delivery system. Mol. Pharmacol. 4 5 (2007) 668-678
36. Dharap S.S., and Minko T. Targeted proapoptotic LHRH-BH3 peptide. Pharm. Res. 20 6 (2003) 889-896
37. Dharap S.S., Qiu B., Williams G.C., Sinko P., Stein S., and Minko T. Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides. J. Control. Release 91 1-2 (2003) 61-73
38. Kam N.W., Liu Z., and Dai H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J. Am. Chem. Soc. 127 36 (2005) 12492-12493
39. Chiu Y.L., Ali A., Chu C.Y., Cao H., and Rana T.M. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem. Biol. 11 8 (2004) 1165-1175
40. Patil M.L., Zhang M., Taratula O., Garbuzenko O.B., He H., and Minko T. Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting. Biomacromolecules 10 2 (2009) 258-266