Preparation of polyethyleneimine incorporated poly(d,l-lactide-co-glycolide) nanoparticles by spontaneous emulsion diffusion method for small interfering RNA delivery

International Journal of Pharmaceutics

Volumn 369, Issue 1-2, 2009, Pages 144-154

  Katas, Haliza ^a,b   Cevher, Erdal ^a,c   Alpar, H Oya ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^c ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Gene silencing; Nanoparticles; Poly(d,l lactide co glycolide); Polyethyleneimine; siRNA

Indexed keywords

NANOPARTICLE; POLYETHYLENEIMINE DERIVATIVE; POLYGLACTIN; POLYMER; SMALL INTERFERING RNA; SURFACTANT;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; EMBRYO; EMULSION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; EMULSIONS; EXCIPIENTS; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LACTIC ACID; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; POLYVINYL ALCOHOL; RNA STABILITY; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS; TRANSFECTION;

EID: 61349137559     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.10.012     Document Type: Article

References (43)

1. Ahn C.H., Chae S.Y., Bae Y.H., and Kim S.W. Biodegradable poly(ethylenimine) for plasmid DNA delivery. J. Control. Release 80 (2002) 273-282
2. Akhtar S. Antisense technology: selection and delivery of optimally acting antisense oligonucleotides. J. Drug Target. 5 (1998) 225-234
3. Behr J. The proton sponge: a trick to enter cells the viruses did not exploit. Chimia 51 (1997) 34-36
4. Bivas-Benita M., Romeijn S., Junginger H.E., and Borchard G. PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium. Eur. J. Pharm. Biopharm. 58 (2004) 1-6
5. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., and Berh J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 7297-7301
6. Brownlie A., Uchegbu I.F., and Schatzlein A.G. PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. Int. J. Pharm. 274 (2004) 41-52
7. Cegnar M., Kos J., and Kristl J. Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity. Eur. J. Pharm. Sci. 22 (2004) 357-364
8. Chen X.G., Liu C.S., Liu C.G., Meng X.H., Lee C.M., and Park H.J. Preparation and biocompatibility of chitosan microcarriers as biomaterial. Biochem. Eng. J. 272 (2006) 269-274
9. Chirila T.V., Rakoczy P.E., Garrett K.L., Lou X., and Constable I.J. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 23 (2002) 321-342
10. Dailey L.A., Kleemann E., Merdan T., Petersen H., Schmehl T., Gessler T., Hanze J., Seeger W., and Kissel T. Modified polyethylenimines as non viral gene delivery systems for aerosol therapy: effects of nebulization on cellular uptake and transfection efficiency. J. Control. Release 100 (2004) 425-436
11. De Rosa G., Bochot A., Quaglia F., Besnard M., and Fattal E. A new delivery system for antisense therapy: PLGA microspheres encapsulating oligonucleotide/polyethyleneimine solid complexes. Int. J. Pharm. 254 (2003) 89-93
12. Dunn S.E., Coombes A.G.A., Garnett M.C., Davis S.S., Davies M.C., and Illum L. In vitro cell interaction and in vivo biodistribution of poly(lactide-co-glycolide) nanospheres surface modified by poloxamer and poloxamine copolymers. J. Control. Release 44 (1997) 65-76
13. Finsinger D., Remy J.S., Erbacher P., Koch C., and Plank C. Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Ther. 7 (2000) 1183-1192
14. Garcia del Barrio G., Novo F.J., and Irache J.M. Loading of plasmid DNA into PLGA microparticles using TROMS (Total Recirculation One-Machine System): evaluation of its integrity and controlled release properties. J. Control. Release 86 (2003) 123-130
15. Godbey W.T., and Mikos A.G. Recent progress in gene delivery using non-viral transfer complexes. J. Control. Release 72 (2001) 115-125
16. Godbey W.T., Wu K.K., and Mikos A.G. Poly(ethylenimine) and its role in gene delivery. J. Control. Release 60 (1999) 149-160
17. Hsu Y.Y., Hao T., and Hedley M.L. Comparison of process parameters for microencapsulation of plasmid DNA in poly(d,l-lactic-co-glycolic) acid microspheres. J. Drug Target. 7 (1999) 313-323
18. Kakizawa Y., Furukawa S., Ishii A., and Kataoka K. Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer. J. Control. Release 111 (2006) 368-370
19. Kasturi S.P., Sachaphibulkij K., and Roy K. Covalent conjugation of polyethyleneimine on biodegradable microparticles for delivery of plasmid DNA vaccines. Biomaterials 26 (2005) 6375-6385
20. Kircheis R., Schuller S., Brunner S., Ogris M., Heider K.H., Zauner W., and Wagner E. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J. Gene Med. 1 (1999) 111-120
21. Kircheis R., and Wagner E. Polycation/DNA complexes for in vivo gene delivery. Gene Ther. Reg. 1 (2000) 95-114
22. Kircheis R., Wightman L., and Wagner E. Design and gene delivery activity of modified polyethylenimines. Adv. Drug Deliv. Rev. 53 (2001) 341-358
23. Kleemann E., Neu M., Jekel N., Fink L., Schmehl T., Gessler T., Seeger W., and Kissel T. Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J. Control. Release 109 (2005) 299-316
24. Kwon H.Y., Lee J.Y., Choi S.W., Jang Y., and Kim J.H. Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method. Colloids Surf. A: Physicochem. Eng. Aspects 182 (2001) 123-130
25. Litzinger D.C. Limitations of cationic liposomes for antisense oligonucleotide delivery in vivo. J. Liposome Res. 7 (1997) 51-61
26. Medberry P., Dennis S., Van Hecke T., and DeLong R.K. pDNA bioparticles: comparative heterogeneity, surface, binding, and activity analyses. Biochem. Biophys. Res. Commun. 319 (2004) 426-432
27. Merdan T., Kopecek J., and Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliv. Rev. 54 (2002) 715-758
28. Messai I., Munier S., Ataman-Onal Y., Verrier B., and Delair T. Elaboration of poly(ethyleneimine) coated poly(d,l-lactic acid) particles. Effect of ionic strength on the surface properties and DNA binding capabilities. Colloids Surf. B. Biointerfaces 32 (2003) 293-305
29. Murakami H., Kawashima Y., Niwa T., Hino T., Takeuchi H., and Kobayashi M. Influence of the degrees of hydrolyzation and polymerization of poly(vinylalcohol) on the preparation and properties of poly(d,l-lactide-co-glycolide) nanoparticle. Int. J. Pharm. 149 (1997) 43-49
30. Muratovska A., and Eccles M.R. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. 558 (2004) 63-68
31. Ogris M., Brunner S., Schuller S., Kircheis R., and Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6 (1999) 595-605
32. Panyam J., and Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55 (2003) 329-347
33. Rehmet R., and Killmann E. Adsorption of cationic poly(diallyl-dimethyl-ammoniumchloride), poly(diallyl-dimethyl-ammoniumchloride-co-N-methyl-N-vinyl acetamide) and poly(N-methyl-N-vinyl-acetamide) on polystyrene latex. Colloids Surf. A: Physicochem. Eng. Aspects 149 (1999) 323-328
34. Remy J.S., Abdallah B., Zanta M.A., Boussif O., Behr J.P., and Demeneix B. Gene transfer with lipospermines and polyethylenimines. Adv. Drug Del. Rev. 30 (1998) 85-95
35. Rozema D.B., and Lewis D.L. siRNA delivery technologies for mammalian systems. Targets 2 (2003) 253-260
36. Rudolph C., Schillinger U., Plank C., Gessner A., Nicklaus P., Muller R.H., and Rosenecker J. Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine. Biochim. Biophys. Acta-Gen. Subj. 1573 (2002) 75-83
37. Schiffelers R.M., Mixson A.J., Ansari A.M., Fens M.H.A.M., Tang Q., Zhou Q., Xu J., Molema G., Lu P.Y., Scaria P.V., Storm G., and Woodle M.C. Transporting silence: design of carriers for siRNA to angiogenic endothelium. J. Control. Release 109 (2005) 5-14
38. Schiffelers R.M., Woodle M.C., and Scaria P. Pharmaceutical prospects for RNA interference. Pharm. Res. 21 (2004) 1-7
39. Trimaille T., Pichot C., and Delair T. Surface functionalization of poly(l-lactic acid) nanoparticles with poly(ethylenimine) and plasmid DNA by the layer-by-layer approach. Colloids Surf. A: Physicochem. Eng. Aspects 221 (2003) 39-48
40. Woodle M.C., Scaria P., Ganesh S., Subramanian K., Titmas R., Cheng C., Yang J., Pan Y., Weng K., and Gu C. Sterically stabilized polyplex: ligand-mediated activity. J. Control. Release 74 (2001) 309-311
41. Yamauchi M., Kusano H., Saito E., Iwata T., Nakakura M., Kato Y., and Aoki N. Development of wrapped liposomes: novel liposomes comprised of polyanion drug and cationic lipid complexes wrapped with neutral lipids. Biochim. Biophys. Acta-Biomembr. 1758 (2006) 90-97
42. Zhang C., Tang N., Liu X., Liang W., Xu W., and Torchilin V.P. siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene. J. Control. Release 112 (2006) 229-239
43. Zou S.M., Erbacher P., Remy J.S., and Behr J.P. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J. Gene Med. 2 (2000) 128-134