메뉴 건너뛰기




Volumn 11, Issue 6, 2011, Pages 549-559

Points of therapeutic intervention along the wnt signaling pathway in hepatocellular carcinoma

Author keywords

Frizzled; Hepatocellular carcinoma; Molecular target; Targeted therapy; WNT; catenin

Indexed keywords

BETA CATENIN; CASEIN KINASE I; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DIETHYLNITROSAMINE; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MONOCLONAL ANTIBODY; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; T CELL FACTOR PROTEIN; WNT PROTEIN; WNT1 PROTEIN;

EID: 79959287290     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152011796011019     Document Type: Review
Times cited : (18)

References (140)
  • 1
  • 3
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet, J.M.; Bruix, J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology, 2008, 48(4), 1312-1327.
    • (2008) Hepatology , vol.48 , Issue.4 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 4
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker, S.; Marais, R.; Zhu, A.X. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene, 2010, 29(36), 4989-5005.
    • (2010) Oncogene , vol.29 , Issue.36 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 5
    • 33845373278 scopus 로고    scopus 로고
    • Colorectal cancer and genetic alterations in the Wnt pathway
    • Segditsas, S.; Tomlinson, I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene, 2006, 25(57), 7531-7537.
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7531-7537
    • Segditsas, S.1    Tomlinson, I.2
  • 6
    • 47149097853 scopus 로고    scopus 로고
    • Epigenetic gene silencing in the Wnt pathway in breast cancer
    • Klarmann, G.J.; Decker, A.; Farrar, W.L. Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics, 2008, 3(2), 59-63.
    • (2008) Epigenetics , vol.3 , Issue.2 , pp. 59-63
    • Klarmann, G.J.1    Decker, A.2    Farrar, W.L.3
  • 7
    • 32944460267 scopus 로고    scopus 로고
    • The WNT/Beta-catenin pathway in melanoma
    • Larue, L.; Delmas, V. The WNT/Beta-catenin pathway in melanoma. Front. Biosci., 2006, 11, 733-742.
    • (2006) Front. Biosci. , vol.11 , pp. 733-742
    • Larue, L.1    Delmas, V.2
  • 8
    • 33645997016 scopus 로고    scopus 로고
    • Developmental signalling pathways in lung cancer
    • Daniel, V.C.; Peacock, C.D.; Watkins, D.N. Developmental signalling pathways in lung cancer. Respirology, 2006, 11(3), 234-240.
    • (2006) Respirology , vol.11 , Issue.3 , pp. 234-240
    • Daniel, V.C.1    Peacock, C.D.2    Watkins, D.N.3
  • 9
    • 0030265570 scopus 로고    scopus 로고
    • A frizzled homolog functions in a vertebrate Wnt signaling pathway
    • Yang-Snyder, J.; Miller, J.R.; Brown, J.D.; Lai, C.J.; Moon, R.T. A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol., 1996, 6(10), 1302-1306.
    • (1996) Curr. Biol. , vol.6 , Issue.10 , pp. 1302-1306
    • Yang-Snyder, J.1    Miller, J.R.2    Brown, J.D.3    Lai, C.J.4    Moon, R.T.5
  • 10
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • Mao, J.; Wang, J.; Liu, B.; Pan, W.; Farr, G.H., 3rd; Flynn, C.; Yuan, H.; Takada, S.; Kimelman, D.; Li, L.; Wu, D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell, 2001, 7(4), 801-809.
    • (2001) Mol. Cell. , vol.7 , Issue.4 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr 3rd, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.10    Wu, D.11
  • 12
    • 12144289950 scopus 로고    scopus 로고
    • Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
    • Xu, Q.; Wang, Y.; Dabdoub, A.; Smallwood, P.M.; Williams, J.; Woods, C.; Kelley, M.W.; Jiang, L.; Tasman, W.; Zhang, K.; Nathans, J. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 2004, 116(6), 883-895.
    • (2004) Cell , vol.116 , Issue.6 , pp. 883-895
    • Xu, Q.1    Wang, Y.2    Dabdoub, A.3    Smallwood, P.M.4    Williams, J.5    Woods, C.6    Kelley, M.W.7    Jiang, L.8    Tasman, W.9    Zhang, K.10    Nathans, J.11
  • 15
    • 5344273899 scopus 로고    scopus 로고
    • Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    • Lu, W.; Yamamoto, V.; Ortega, B.; Baltimore, D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell, 2004, 119(1), 97-108.
    • (2004) Cell , vol.119 , Issue.1 , pp. 97-108
    • Lu, W.1    Yamamoto, V.2    Ortega, B.3    Baltimore, D.4
  • 16
    • 33744976112 scopus 로고    scopus 로고
    • The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum
    • Keeble, T.R.; Halford, M.M.; Seaman, C.; Kee, N.; Macheda, M.; Anderson, R.B.; Stacker, S.A.; Cooper, H.M. The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J. Neurosci., 2006, 26(21), 5840-5848.
    • (2006) J. Neurosci. , vol.26 , Issue.21 , pp. 5840-5848
    • Keeble, T.R.1    Halford, M.M.2    Seaman, C.3    Kee, N.4    Macheda, M.5    Anderson, R.B.6    Stacker, S.A.7    Cooper, H.M.8
  • 19
    • 0029775569 scopus 로고    scopus 로고
    • Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
    • Bouwmeester, T.; Kim, S.; Sasai, Y.; Lu, B.; De Robertis, E.M. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature, 1996, 382(6592), 595-601.
    • (1996) Nature , vol.382 , Issue.6592 , pp. 595-601
    • Bouwmeester, T.1    Kim, S.2    Sasai, Y.3    Lu, B.4    de Robertis, E.M.5
  • 20
    • 0033602241 scopus 로고    scopus 로고
    • The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
    • Piccolo, S.; Agius, E.; Leyns, L.; Bhattacharyya, S.; Grunz, H.; Bouwmeester, T.; De Robertis, E.M. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature, 1999, 397(6721), 707-710.
    • (1999) Nature , vol.397 , Issue.6721 , pp. 707-710
    • Piccolo, S.1    Agius, E.2    Leyns, L.3    Bhattacharyya, S.4    Grunz, H.5    Bouwmeester, T.6    de Robertis, E.M.7
  • 22
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka, A.; Wu, W.; Delius, H.; Monaghan, A.P.; Blumenstock, C.; Niehrs, C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature, 1998, 391(6665), 357-362.
    • (1998) Nature , vol.391 , Issue.6665 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 23
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semenov, M.V.; Tamai, K.; Brott, B.K.; Kuhl, M.; Sokol, S.; He, X. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol., 2001, 11(12), 951-961.
    • (2001) Curr. Biol. , vol.11 , Issue.12 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5    He, X.6
  • 25
    • 0344413477 scopus 로고    scopus 로고
    • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the Cterminal region of Frizzled
    • Wong, H.C.; Bourdelas, A.; Krauss, A.; Lee, H.J.; Shao, Y.; Wu, D.; Mlodzik, M.; Shi, D.L.; Zheng, J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the Cterminal region of Frizzled. Mol. Cell, 2003, 12(5), 1251-1260.
    • (2003) Mol. Cell. , vol.12 , Issue.5 , pp. 1251-1260
    • Wong, H.C.1    Bourdelas, A.2    Krauss, A.3    Lee, H.J.4    Shao, Y.5    Wu, D.6    Mlodzik, M.7    Shi, D.L.8    Zheng, J.9
  • 26
    • 0034665045 scopus 로고    scopus 로고
    • The C-terminal cytoplasmic Lys-thr- X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling
    • Umbhauer, M.; Djiane, A.; Goisset, C.; Penzo-Mendez, A.; Riou, J.F.; Boucaut, J.C.; Shi, D.L. The C-terminal cytoplasmic Lys-thr- X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J., 2000, 19(18), 4944-4954.
    • (2000) EMBO J , vol.19 , Issue.18 , pp. 4944-4954
    • Umbhauer, M.1    Djiane, A.2    Goisset, C.3    Penzo-Mendez, A.4    Riou, J.F.5    Boucaut, J.C.6    Shi, D.L.7
  • 27
    • 0032529161 scopus 로고    scopus 로고
    • Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    • Axelrod, J.D.; Miller, J.R.; Shulman, J.M.; Moon, R.T.; Perrimon, N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev., 1998, 12(16), 2610-2622.
    • (1998) Genes Dev , vol.12 , Issue.16 , pp. 2610-2622
    • Axelrod, J.D.1    Miller, J.R.2    Shulman, J.M.3    Moon, R.T.4    Perrimon, N.5
  • 28
    • 0030973456 scopus 로고    scopus 로고
    • Casein kinase 2 associates with and phosphorylates dishevelled
    • Willert, K.; Brink, M.; Wodarz, A.; Varmus, H.; Nusse, R. Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J., 1997, 16(11), 3089-3096.
    • (1997) EMBO J , vol.16 , Issue.11 , pp. 3089-3096
    • Willert, K.1    Brink, M.2    Wodarz, A.3    Varmus, H.4    Nusse, R.5
  • 29
    • 0026727910 scopus 로고
    • The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis
    • DeMarais, A.A.; Moon, R.T. The armadillo homologs beta-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis. Dev. Biol., 1992, 153(2), 337-346.
    • (1992) Dev. Biol. , vol.153 , Issue.2 , pp. 337-346
    • Demarais, A.A.1    Moon, R.T.2
  • 30
    • 0025877228 scopus 로고
    • Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure
    • McCrea, P.D.; Gumbiner, B.M. Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure. J. Biol. Chem., 1991, 266(7), 4514-4520
    • (1991) J. Biol. Chem. , vol.266 , Issue.7 , pp. 4514-4520
    • McCrea, P.D.1    Gumbiner, B.M.2
  • 31
    • 0036571011 scopus 로고    scopus 로고
    • Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: A molecular switch for the Wnt pathway
    • Amit, S.; Hatzubai, A.; Birman, Y.; Andersen, J.S.; Ben-Shushan, E.; Mann, M.; Ben-Neriah, Y.; Alkalay, I. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev., 2002, 16(9), 1066-1076.
    • (2002) Genes Dev , vol.16 , Issue.9 , pp. 1066-1076
    • Amit, S.1    Hatzubai, A.2    Birman, Y.3    Andersen, J.S.4    Ben-Shushan, E.5    Mann, M.6    Ben-Neriah, Y.7    Alkalay, I.8
  • 32
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost, C.; Torres, M.; Miller, J.R.; Huang, E.; Kimelman, D.; Moon, R.T. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev., 1996, 10(12), 1443-1454.
    • (1996) Genes Dev , vol.10 , Issue.12 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.R.3    Huang, E.4    Kimelman, D.5    Moon, R.T.6
  • 33
    • 0030978351 scopus 로고    scopus 로고
    • Betacatenin is a target for the ubiquitin-proteasome pathway
    • Aberle, H.; Bauer, A.; Stappert, J.; Kispert, A.; Kemler, R. betacatenin is a target for the ubiquitin-proteasome pathway. EMBO J., 1997, 16(13), 3797-3804.
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 34
    • 0030779038 scopus 로고    scopus 로고
    • Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
    • Orford, K.; Crockett, C.; Jensen, J.P.; Weissman, A.M.; Byers, S.W. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem., 1997, 272(40), 24735-24738.
    • (1997) J. Biol. Chem. , vol.272 , Issue.40 , pp. 24735-24738
    • Orford, K.1    Crockett, C.2    Jensen, J.P.3    Weissman, A.M.4    Byers, S.W.5
  • 35
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    • Ikeda, S.; Kishida, S.; Yamamoto, H.; Murai, H.; Koyama, S.; Kikuchi, A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J., 1998, 17(5), 1371-1384.
    • (1998) EMBO J , vol.17 , Issue.5 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 37
    • 0035312290 scopus 로고    scopus 로고
    • All Tcf HMG box transcription factors interact with Groucho-related corepressors
    • Brantjes, H.; Roose, J.; van De Wetering, M.; Clevers, H. All Tcf HMG box transcription factors interact with Groucho-related corepressors. Nucleic Acids Res., 2001, 29(7), 1410-1419.
    • (2001) Nucleic Acids Res , vol.29 , Issue.7 , pp. 1410-1419
    • Brantjes, H.1    Roose, J.2    van de Wetering, M.3    Clevers, H.4
  • 38
    • 0033817339 scopus 로고    scopus 로고
    • Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
    • Billin, A.N.; Thirlwell, H.; Ayer, D.E. Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator. Mol. Cell. Biol., 2000, 20(18), 6882-6890.
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.18 , pp. 6882-6890
    • Billin, A.N.1    Thirlwell, H.2    Ayer, D.E.3
  • 39
    • 0037134467 scopus 로고    scopus 로고
    • Functional diversity of Xenopus lymphoid enhancer factor/T-cell factor transcription factors relies on combinations of activating and repressing elements
    • Gradl, D.; Konig, A.; Wedlich, D. Functional diversity of Xenopus lymphoid enhancer factor/T-cell factor transcription factors relies on combinations of activating and repressing elements. J. Biol. Chem., 2002, 277(16), 14159-14171.
    • (2002) J. Biol. Chem. , vol.277 , Issue.16 , pp. 14159-14171
    • Gradl, D.1    Konig, A.2    Wedlich, D.3
  • 40
    • 0030067337 scopus 로고    scopus 로고
    • Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
    • Van de Wetering, M.; Castrop, J.; Korinek, V.; Clevers, H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell. Biol., 1996, 16(3), 745-752.
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.3 , pp. 745-752
    • van de Wetering, M.1    Castrop, J.2    Korinek, V.3    Clevers, H.4
  • 42
    • 0033011602 scopus 로고    scopus 로고
    • Dix domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
    • Kishida, S.; Yamamoto, H.; Hino, S.; Ikeda, S.; Kishida, M.; Kikuchi, A. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol. Cell. Biol., 1999, 19(6), 4414-4422.
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.6 , pp. 4414-4422
    • Kishida, S.1    Yamamoto, H.2    Hino, S.3    Ikeda, S.4    Kishida, M.5    Kikuchi, A.6
  • 44
    • 36048967529 scopus 로고    scopus 로고
    • Sirnamediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival
    • Zeng, G.; Apte, U.; Cieply, B.; Singh, S.; Monga, S.P. siRNAmediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia, 2007, 9(11), 951-959.
    • (2007) Neoplasia , vol.9 , Issue.11 , pp. 951-959
    • Zeng, G.1    Apte, U.2    Cieply, B.3    Singh, S.4    Monga, S.P.5
  • 46
    • 0034678357 scopus 로고    scopus 로고
    • The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
    • Takemaru, K.I.; Moon, R.T. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J. Cell. Biol., 2000, 149(2), 249-254.
    • (2000) J. Cell. Biol. , vol.149 , Issue.2 , pp. 249-254
    • Takemaru, K.I.1    Moon, R.T.2
  • 47
    • 0037023584 scopus 로고    scopus 로고
    • Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
    • Kramps, T.; Peter, O.; Brunner, E.; Nellen, D.; Froesch, B.; Chatterjee, S.; Murone, M.; Zullig, S.; Basler, K. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell, 2002, 109(1), 47-60.
    • (2002) Cell , vol.109 , Issue.1 , pp. 47-60
    • Kramps, T.1    Peter, O.2    Brunner, E.3    Nellen, D.4    Froesch, B.5    Chatterjee, S.6    Murone, M.7    Zullig, S.8    Basler, K.9
  • 48
    • 3242706980 scopus 로고    scopus 로고
    • Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function
    • Townsley, F.M.; Cliffe, A.; Bienz, M. Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function. Nat. Cell Biol., 2004, 6(7), 626-633.
    • (2004) Nat. Cell Biol. , vol.6 , Issue.7 , pp. 626-633
    • Townsley, F.M.1    Cliffe, A.2    Bienz, M.3
  • 49
    • 70249121438 scopus 로고    scopus 로고
    • The transcriptional activity of Pygopus is enhanced by its interaction with cAMPresponse- element-binding protein (CREB)-binding protein
    • Andrews, P.G.; He, Z.; Popadiuk, C.; Kao, K.R. The transcriptional activity of Pygopus is enhanced by its interaction with cAMPresponse- element-binding protein (CREB)-binding protein. Biochem. J., 2009, 422(3), 493-501.
    • (2009) Biochem. J. , vol.422 , Issue.3 , pp. 493-501
    • Andrews, P.G.1    He, Z.2    Popadiuk, C.3    Kao, K.R.4
  • 50
    • 0035801499 scopus 로고    scopus 로고
    • The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
    • Barker, N.; Hurlstone, A.; Musisi, H.; Miles, A.; Bienz, M.; Clevers, H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J., 2001, 20(17), 4935-4943.
    • (2001) EMBO J , vol.20 , Issue.17 , pp. 4935-4943
    • Barker, N.1    Hurlstone, A.2    Musisi, H.3    Miles, A.4    Bienz, M.5    Clevers, H.6
  • 53
    • 0035893568 scopus 로고    scopus 로고
    • Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer
    • Zhang, T.; Otevrel, T.; Gao, Z.; Gao, Z.; Ehrlich, S.M.; Fields, J.Z.; Boman, B.M. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res., 2001, 61(24), 8664-8667.
    • (2001) Cancer Res , vol.61 , Issue.24 , pp. 8664-8667
    • Zhang, T.1    Otevrel, T.2    Gao, Z.3    Gao, Z.4    Ehrlich, S.M.5    Fields, J.Z.6    Boman, B.M.7
  • 54
    • 0032884884 scopus 로고    scopus 로고
    • Betacatenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • Brabletz, T.; Jung, A.; Dag, S.; Hlubek, F.; Kirchner, T. betacatenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am. J. Pathol., 1999, 155(4), 1033-1038.
    • (1999) Am. J. Pathol. , vol.155 , Issue.4 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Hlubek, F.4    Kirchner, T.5
  • 57
    • 35348998631 scopus 로고    scopus 로고
    • Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells
    • Qin, X.; Zhang, H.; Zhou, X.; Wang, C.; Zhang, H.; Zhang, X.; Ye, L. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl. Res., 2007, 150(5), 281-294.
    • (2007) Transl. Res. , vol.150 , Issue.5 , pp. 281-294
    • Qin, X.1    Zhang, H.2    Zhou, X.3    Wang, C.4    Zhang, H.5    Zhang, X.6    Ye, L.7
  • 60
    • 0032885751 scopus 로고    scopus 로고
    • Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
    • Nhieu, J.T.; Renard, C.A.; Wei, Y.; Cherqui, D.; Zafrani, E.S.; Buendia, M.A. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am. J. Pathol., 1999, 155(3), 703-710.
    • (1999) Am. J. Pathol. , vol.155 , Issue.3 , pp. 703-710
    • Nhieu, J.T.1    Renard, C.A.2    Wei, Y.3    Cherqui, D.4    Zafrani, E.S.5    Buendia, M.A.6
  • 61
    • 0033387207 scopus 로고    scopus 로고
    • Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma
    • Kondo, Y.; Kanai, Y.; Sakamoto, M.; Genda, T.; Mizokami, M.; Ueda, R.; Hirohashi, S. Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma. Jpn J. Cancer Res., 1999, 90(12), 1301-1309.
    • (1999) Jpn J. Cancer Res. , vol.90 , Issue.12 , pp. 1301-1309
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Genda, T.4    Mizokami, M.5    Ueda, R.6    Hirohashi, S.7
  • 62
    • 0032525836 scopus 로고    scopus 로고
    • Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
    • Miyoshi, Y.; Iwao, K.; Nagasawa, Y.; Aihara, T.; Sasaki, Y.; Imaoka, S.; Murata, M.; Shimano, T.; Nakamura, Y. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res., 1998, 58(12), 2524-2527.
    • (1998) Cancer Res , vol.58 , Issue.12 , pp. 2524-2527
    • Miyoshi, Y.1    Iwao, K.2    Nagasawa, Y.3    Aihara, T.4    Sasaki, Y.5    Imaoka, S.6    Murata, M.7    Shimano, T.8    Nakamura, Y.9
  • 63
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang, H.; Fujii, H.; Sankila, A.; Mahler-Araujo, B.M.; Matsuda, M.; Cathomas, G.; Ohgaki, H. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am. J. Pathol., 1999, 155(6), 1795-1801.
    • (1999) Am. J. Pathol. , vol.155 , Issue.6 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3    Mahler-Araujo, B.M.4    Matsuda, M.5    Cathomas, G.6    Ohgaki, H.7
  • 67
    • 14544270262 scopus 로고    scopus 로고
    • Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis
    • Park, J.Y.; Park, W.S.; Nam, S.W.; Kim, S.Y.; Lee, S.H.; Yoo, N.J.; Lee, J.Y.; Park, C.K. Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis. Liver Int., 2005, 25(1), 70-76.
    • (2005) Liver Int , vol.25 , Issue.1 , pp. 70-76
    • Park, J.Y.1    Park, W.S.2    Nam, S.W.3    Kim, S.Y.4    Lee, S.H.5    Yoo, N.J.6    Lee, J.Y.7    Park, C.K.8
  • 69
    • 0037367866 scopus 로고    scopus 로고
    • Wnt signaling in hepatocellular carcinoma: Analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes
    • Cui, J.; Zhou, X.; Liu, Y.; Tang, Z.; Romeih, M. Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. J. Gastroenterol. Hepatol., 2003, 18(3), 280-287.
    • (2003) J. Gastroenterol. Hepatol. , vol.18 , Issue.3 , pp. 280-287
    • Cui, J.1    Zhou, X.2    Liu, Y.3    Tang, Z.4    Romeih, M.5
  • 71
    • 34547770885 scopus 로고    scopus 로고
    • Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
    • Huang, J.; Zhang, Y.L.; Teng, X.M.; Lin, Y.; Zheng, D.L.; Yang, P.Y.; Han, Z.G. Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma. BMC Cancer, 2007, 7, 126.
    • (2007) BMC Cancer , vol.7 , pp. 126
    • Huang, J.1    Zhang, Y.L.2    Teng, X.M.3    Lin, Y.4    Zheng, D.L.5    Yang, P.Y.6    Han, Z.G.7
  • 73
    • 40949086754 scopus 로고    scopus 로고
    • Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells
    • Kim, M.; Lee, H.C.; Tsedensodnom, O.; Hartley, R.; Lim, Y.S.; Yu, E.; Merle, P.; Wands, J.R. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J. Hepatol., 2008, 48(5), 780-791.
    • (2008) J. Hepatol. , vol.48 , Issue.5 , pp. 780-791
    • Kim, M.1    Lee, H.C.2    Tsedensodnom, O.3    Hartley, R.4    Lim, Y.S.5    Yu, E.6    Merle, P.7    Wands, J.R.8
  • 74
    • 67651174546 scopus 로고    scopus 로고
    • Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma
    • Ding, Z.; Qian, Y.B.; Zhu, L.X.; Xiong, Q.R. Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma. World J. Gastroenterol., 2009, 15(21), 2595-2601.
    • (2009) World J. Gastroenterol. , vol.15 , Issue.21 , pp. 2595-2601
    • Ding, Z.1    Qian, Y.B.2    Zhu, L.X.3    Xiong, Q.R.4
  • 75
    • 2942588392 scopus 로고    scopus 로고
    • PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma
    • Pang, R.; Yuen, J.; Yuen, M.F.; Lai, C.L.; Lee, T.K.; Man, K.; Poon, R.T.; Fan, S.T.; Wong, C.M.; Ng, I.O.; Kwong, Y.L.; Tse, E. PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene, 2004, 23(23), 4182-4186.
    • (2004) Oncogene , vol.23 , Issue.23 , pp. 4182-4186
    • Pang, R.1    Yuen, J.2    Yuen, M.F.3    Lai, C.L.4    Lee, T.K.5    Man, K.6    Poon, R.T.7    Fan, S.T.8    Wong, C.M.9    Ng, I.O.10    Kwong, Y.L.11    Tse, E.12
  • 76
    • 0038121958 scopus 로고    scopus 로고
    • EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
    • Shibata, T.; Chuma, M.; Kokubu, A.; Sakamoto, M.; Hirohashi, S. EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma. Hepatology, 2003, 38(1), 178-186.
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 178-186
    • Shibata, T.1    Chuma, M.2    Kokubu, A.3    Sakamoto, M.4    Hirohashi, S.5
  • 77
    • 33749501476 scopus 로고    scopus 로고
    • Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer
    • Chan, D.W.; Chan, C.Y.; Yam, J.W.; Ching, Y.P.; Ng, I.O. Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology, 2006, 131(4), 1218-1227.
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1218-1227
    • Chan, D.W.1    Chan, C.Y.2    Yam, J.W.3    Ching, Y.P.4    Ng, I.O.5
  • 78
    • 33746296615 scopus 로고    scopus 로고
    • Promoter methylation of the secreted frizzledrelated protein 1 gene SFRP1 is frequent in hepatocellular carcinoma
    • Shih, Y.L.; Shyu, R.Y.; Hsieh, C.B.; Lai, H.C.; Liu, K.Y.; Chu, T.Y.; Lin, Y.W. Promoter methylation of the secreted frizzledrelated protein 1 gene SFRP1 is frequent in hepatocellular carcinoma. Cancer, 2006, 107(3), 579-590.
    • (2006) Cancer , vol.107 , Issue.3 , pp. 579-590
    • Shih, Y.L.1    Shyu, R.Y.2    Hsieh, C.B.3    Lai, H.C.4    Liu, K.Y.5    Chu, T.Y.6    Lin, Y.W.7
  • 79
    • 78449244507 scopus 로고    scopus 로고
    • SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma
    • Jia, Y.; Yang, Y.; Liu, S.; Herman, J.G.; Lu, F.; Guo, M. SOX17 antagonizes WNT/beta-catenin signaling pathway in hepatocellular carcinoma. Epigenetics, 2010, 5(8), 1-7.
    • (2010) Epigenetics , vol.5 , Issue.8 , pp. 1-7
    • Jia, Y.1    Yang, Y.2    Liu, S.3    Herman, J.G.4    Lu, F.5    Guo, M.6
  • 81
    • 79952443282 scopus 로고    scopus 로고
    • Identification of T-Cell Factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells
    • Tsedensodnom, O.; Koga, H.; Rosenberg, S.; Nambotin, S.B.; Carroll, J.; Wands, J.; Kim, M. Identification of T-Cell Factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells. Exp. Cell Res., 2011, 317(7), 920-931.
    • (2011) Exp. Cell Res. , vol.317 , Issue.7 , pp. 920-931
    • Tsedensodnom, O.1    Koga, H.2    Rosenberg, S.3    Nambotin, S.B.4    Carroll, J.5    Wands, J.6    Kim, M.7
  • 82
    • 36348991571 scopus 로고    scopus 로고
    • Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma
    • Yamashita, T.; Budhu, A.; Forgues, M.; Wang, X.W. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res., 2007, 67(22), 10831-10839.
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10831-10839
    • Yamashita, T.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 89
    • 68949091982 scopus 로고    scopus 로고
    • Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver
    • Longato, L.; de la Monte, S.; Kuzushita, N.; Horimoto, M.; Rogers, A.B.; Slagle, B.L.; Wands, J.R. Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology, 2009, 49(6), 1935-1943.
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1935-1943
    • Longato, L.1    de la Monte, S.2    Kuzushita, N.3    Horimoto, M.4    Rogers, A.B.5    Slagle, B.L.6    Wands, J.R.7
  • 90
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • Rhee, C.S.; Sen, M.; Lu, D.; Wu, C.; Leoni, L.; Rubin, J.; Corr, M.; Carson, D.A. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene, 2002, 21(43), 6598-6605.
    • (2002) Oncogene , vol.21 , Issue.43 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3    Wu, C.4    Leoni, L.5    Rubin, J.6    Corr, M.7    Carson, D.A.8
  • 92
    • 9644265250 scopus 로고    scopus 로고
    • Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm
    • Lin, S.M.; Lin, C.J.; Lin, C.C.; Hsu, C.W.; Chen, Y.C. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm. Gastroenterology, 2004, 127(6), 1714-1723.
    • (2004) Gastroenterology , vol.127 , Issue.6 , pp. 1714-1723
    • Lin, S.M.1    Lin, C.J.2    Lin, C.C.3    Hsu, C.W.4    Chen, Y.C.5
  • 93
    • 70449366626 scopus 로고    scopus 로고
    • Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
    • Wei, W.; Chua, M.S.; Grepper, S.; So, S.K. Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol. Cancer, 2009, 8, 76.
    • (2009) Mol. Cancer. , vol.8 , pp. 76
    • Wei, W.1    Chua, M.S.2    Grepper, S.3    So, S.K.4
  • 95
    • 2442694379 scopus 로고    scopus 로고
    • Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells
    • You, L.; He, B.; Uematsu, K.; Xu, Z.; Mazieres, J.; Lee, A.; McCormick, F.; Jablons, D.M. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Res., 2004, 64(10), 3474-3478.
    • (2004) Cancer Res , vol.64 , Issue.10 , pp. 3474-3478
    • You, L.1    He, B.2    Uematsu, K.3    Xu, Z.4    Mazieres, J.5    Lee, A.6    McCormick, F.7    Jablons, D.M.8
  • 96
    • 0043092191 scopus 로고    scopus 로고
    • Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of beta-catenin
    • Uematsu, K.; Kanazawa, S.; You, L.; He, B.; Xu, Z.; Li, K.; Peterlin, B.M.; McCormick, F.; Jablons, D.M. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res., 2003, 63(15), 4547-4551.
    • (2003) Cancer Res , vol.63 , Issue.15 , pp. 4547-4551
    • Uematsu, K.1    Kanazawa, S.2    You, L.3    He, B.4    Xu, Z.5    Li, K.6    Peterlin, B.M.7    McCormick, F.8    Jablons, D.M.9
  • 97
    • 0037155199 scopus 로고    scopus 로고
    • PDZ domains: Structural modules for protein complex assembly
    • Hung, A.Y.; Sheng, M. PDZ domains: structural modules for protein complex assembly. J. Biol. Chem., 2002, 277(8), 5699-5702.
    • (2002) J. Biol. Chem. , vol.277 , Issue.8 , pp. 5699-5702
    • Hung, A.Y.1    Sheng, M.2
  • 99
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the dishevelled PDZ domain
    • Shan, J.; Shi, D.L.; Wang, J.; Zheng, J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry, 2005, 44(47), 15495-15503.
    • (2005) Biochemistry , vol.44 , Issue.47 , pp. 15495-15503
    • Shan, J.1    Shi, D.L.2    Wang, J.3    Zheng, J.4
  • 100
    • 58049192960 scopus 로고    scopus 로고
    • Optimizing Dvl PDZ domain inhibitor by exploring chemical space
    • Shan, J.; Zheng, J.J. Optimizing Dvl PDZ domain inhibitor by exploring chemical space. J. Comput. Aided Mol. Des., 2009, 23(1), 37-47.
    • (2009) J. Comput. Aided Mol. Des. , vol.23 , Issue.1 , pp. 37-47
    • Shan, J.1    Zheng, J.J.2
  • 104
    • 34547093863 scopus 로고    scopus 로고
    • SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway
    • Shih, Y.L.; Hsieh, C.B.; Lai, H.C.; Yan, M.D.; Hsieh, T.Y.; Chao, Y.C.; Lin, Y.W. SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway. Int. J. Cancer, 2007, 121(5), 1028-1035.
    • (2007) Int. J. Cancer. , vol.121 , Issue.5 , pp. 1028-1035
    • Shih, Y.L.1    Hsieh, C.B.2    Lai, H.C.3    Yan, M.D.4    Hsieh, T.Y.5    Chao, Y.C.6    Lin, Y.W.7
  • 105
    • 70149095242 scopus 로고    scopus 로고
    • Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma
    • Hu, J.; Dong, A.; Fernandez-Ruiz, V.; Shan, J.; Kawa, M.; Martinez-Anso, E.; Prieto, J.; Qian, C. Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res., 2009, 69(17), 6951-6959.
    • (2009) Cancer Res , vol.69 , Issue.17 , pp. 6951-6959
    • Hu, J.1    Dong, A.2    Fernandez-Ruiz, V.3    Shan, J.4    Kawa, M.5    Martinez-Anso, E.6    Prieto, J.7    Qian, C.8
  • 106
    • 79952945559 scopus 로고    scopus 로고
    • Oncolytic adenoviruses for the treatment of human cancer: Focus on translational and clinical data
    • Pesonen, S.; Kangasniemi, L.; Hemminki, A. Oncolytic adenoviruses for the treatment of human cancer: focus on translational and clinical data. Mol. Pharm., 2010, 8(1), 12-28.
    • (2010) Mol. Pharm. , vol.8 , Issue.1 , pp. 12-28
    • Pesonen, S.1    Kangasniemi, L.2    Hemminki, A.3
  • 108
    • 0035120593 scopus 로고    scopus 로고
    • Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway
    • Brunori, M.; Malerba, M.; Kashiwazaki, H.; Iggo, R. Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. J. Virol., 2001, 75(6), 2857-2865.
    • (2001) J. Virol. , vol.75 , Issue.6 , pp. 2857-2865
    • Brunori, M.1    Malerba, M.2    Kashiwazaki, H.3    Iggo, R.4
  • 109
    • 14944353116 scopus 로고    scopus 로고
    • HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: Involvement of methylation-mediated gene silencing
    • Yau, T.O.; Chan, C.Y.; Chan, K.L.; Lee, M.F.; Wong, C.M.; Fan, S.T.; Ng, I.O. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene, 2005, 24(9), 1607-1614.
    • (2005) Oncogene , vol.24 , Issue.9 , pp. 1607-1614
    • Yau, T.O.1    Chan, C.Y.2    Chan, K.L.3    Lee, M.F.4    Wong, C.M.5    Fan, S.T.6    Ng, I.O.7
  • 110
    • 0035909783 scopus 로고    scopus 로고
    • Beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
    • Chen, W.; Hu, L.A.; Semenov, M.V.; Yanagawa, S.; Kikuchi, A.; Lefkowitz, R.J.; Miller, W.E. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. U S A, 2001, 98(26), 14889-14894.
    • (2001) Proc. Natl. Acad. Sci. U S A , vol.98 , Issue.26 , pp. 14889-14894
    • Chen, W.1    Hu, L.A.2    Semenov, M.V.3    Yanagawa, S.4    Kikuchi, A.5    Lefkowitz, R.J.6    Miller, W.E.7
  • 112
    • 34147165527 scopus 로고    scopus 로고
    • Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation
    • Bryja, V.; Cajanek, L.; Grahn, A.; Schulte, G. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiol. (Oxf), 2007, 190(1), 55-61.
    • (2007) Acta Physiol. (Oxf) , vol.190 , Issue.1 , pp. 55-61
    • Bryja, V.1    Cajanek, L.2    Grahn, A.3    Schulte, G.4
  • 113
    • 37249092938 scopus 로고    scopus 로고
    • Endocytosis: A positive or a negative influence on Wnt signalling?
    • Gagliardi, M.; Piddini, E.; Vincent, J.P. Endocytosis: a positive or a negative influence on Wnt signalling? Traffic, 2008, 9(1), 1-9.
    • (2008) Traffic , vol.9 , Issue.1 , pp. 1-9
    • Gagliardi, M.1    Piddini, E.2    Vincent, J.P.3
  • 115
    • 33751318469 scopus 로고    scopus 로고
    • Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
    • Takada, R.; Satomi, Y.; Kurata, T.; Ueno, N.; Norioka, S.; Kondoh, H.; Takao, T.; Takada, S. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell, 2006, 11(6), 791-801.
    • (2006) Dev. Cell. , vol.11 , Issue.6 , pp. 791-801
    • Takada, R.1    Satomi, Y.2    Kurata, T.3    Ueno, N.4    Norioka, S.5    Kondoh, H.6    Takao, T.7    Takada, S.8
  • 117
    • 77951230705 scopus 로고    scopus 로고
    • Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo
    • Wei, W.; Chua, M.S.; Grepper, S.; So, S. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int. J. Cancer, 2009, 126(10), 2426-2436.
    • (2009) Int. J. Cancer. , vol.126 , Issue.10 , pp. 2426-2436
    • Wei, W.1    Chua, M.S.2    Grepper, S.3    So, S.4
  • 118
    • 0033635606 scopus 로고    scopus 로고
    • Crystal structure of a beta-catenin/Tcf complex
    • Graham, T.A.; Weaver, C.; Mao, F.; Kimelman, D.; Xu, W. Crystal structure of a beta-catenin/Tcf complex. Cell, 2000, 103(6), 885-896.
    • (2000) Cell , vol.103 , Issue.6 , pp. 885-896
    • Graham, T.A.1    Weaver, C.2    Mao, F.3    Kimelman, D.4    Xu, W.5
  • 119
    • 0035805117 scopus 로고    scopus 로고
    • The structure of the beta-catenin/Ecadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    • Huber, A.H.; Weis, W.I. The structure of the beta-catenin/Ecadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell, 2001, 105(3), 391-402.
    • (2001) Cell , vol.105 , Issue.3 , pp. 391-402
    • Huber, A.H.1    Weis, W.I.2
  • 121
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • Goodman, R.H.; Smolik, S. CBP/p300 in cell growth, transformation, and development. Genes Dev., 2000, 14(13), 1553-1577.
    • (2000) Genes Dev , vol.14 , Issue.13 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 124
    • 0033714885 scopus 로고    scopus 로고
    • Control of betacatenin stability: Reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts
    • Salic, A.; Lee, E.; Mayer, L.; Kirschner, M.W. Control of betacatenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol. Cell, 2000, 5(3), 523-532.
    • (2000) Mol. Cell. , vol.5 , Issue.3 , pp. 523-532
    • Salic, A.1    Lee, E.2    Mayer, L.3    Kirschner, M.W.4
  • 125
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    • Lee, E.; Salic, A.; Kruger, R.; Heinrich, R.; Kirschner, M.W. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol., 2003, 1(1), E10.
    • (2003) PLoS Biol , vol.1 , Issue.1
    • Lee, E.1    Salic, A.2    Kruger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 128
    • 73949116718 scopus 로고    scopus 로고
    • Organ patterning in the adult stage: The role of Wnt/beta-catenin signaling in liver zonation and beyond
    • Gebhardt, R.; Hovhannisyan, A. Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond. Dev. Dyn., 2010, 239(1), 45-55.
    • (2010) Dev. Dyn. , vol.239 , Issue.1 , pp. 45-55
    • Gebhardt, R.1    Hovhannisyan, A.2
  • 129
    • 20144389123 scopus 로고    scopus 로고
    • Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo
    • Barraud, L.; Merle, P.; Soma, E.; Lefrancois, L.; Guerret, S.; Chevallier, M.; Dubernet, C.; Couvreur, P.; Trepo, C.; Vitvitski, L. Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo. J. Hepatol., 2005, 42(5), 736-743.
    • (2005) J. Hepatol. , vol.42 , Issue.5 , pp. 736-743
    • Barraud, L.1    Merle, P.2    Soma, E.3    Lefrancois, L.4    Guerret, S.5    Chevallier, M.6    Dubernet, C.7    Couvreur, P.8    Trepo, C.9    Vitvitski, L.10
  • 130
    • 70349254047 scopus 로고    scopus 로고
    • Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury
    • Apte, U.; Singh, S.; Zeng, G.; Cieply, B.; Virji, M.A.; Wu, T.; Monga, S.P. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am. J. Pathol., 2009, 175(3), 1056-1065.
    • (2009) Am. J. Pathol. , vol.175 , Issue.3 , pp. 1056-1065
    • Apte, U.1    Singh, S.2    Zeng, G.3    Cieply, B.4    Virji, M.A.5    Wu, T.6    Monga, S.P.7
  • 131
    • 77953202987 scopus 로고    scopus 로고
    • The role of the Wnt family of secreted proteins in rat oval stem cell-based liver regeneration: Wnt1 drives differentiation
    • Williams, J.M.; Oh, S.H.; Jorgensen, M.; Steiger, N.; Darwiche, H.; Shupe, T.; Petersen, B.E. The role of the Wnt family of secreted proteins in rat oval stem cell-based liver regeneration: Wnt1 drives differentiation. Am. J. Pathol., 2010, 176(6), 2732-2742.
    • (2010) Am. J. Pathol. , vol.176 , Issue.6 , pp. 2732-2742
    • Williams, J.M.1    Oh, S.H.2    Jorgensen, M.3    Steiger, N.4    Darwiche, H.5    Shupe, T.6    Petersen, B.E.7
  • 132
    • 77957362839 scopus 로고    scopus 로고
    • Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine
    • Thompson, M.D.; Awuah, P.; Singh, S.; Monga, S.P. Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine. Am. J. Pathol., 2010, 177(4), 1812-1822.
    • (2010) Am. J. Pathol. , vol.177 , Issue.4 , pp. 1812-1822
    • Thompson, M.D.1    Awuah, P.2    Singh, S.3    Monga, S.P.4
  • 133
    • 33750726092 scopus 로고    scopus 로고
    • Conditional deletion of beta-catenin reveals its role in liver growth and regeneration
    • Tan, X.; Behari, J.; Cieply, B.; Michalopoulos, G.K.; Monga, S.P. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology, 2006, 131(5), 1561-1572.
    • (2006) Gastroenterology , vol.131 , Issue.5 , pp. 1561-1572
    • Tan, X.1    Behari, J.2    Cieply, B.3    Michalopoulos, G.K.4    Monga, S.P.5
  • 134
    • 77956632050 scopus 로고    scopus 로고
    • Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: Role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling
    • Zhang, X.F.; Tan, X.; Zeng, G.; Misse, A.; Singh, S.; Kim, Y.; Klaunig, J.E.; Monga, S.P. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology, 2010, 52(3), 954-965.
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 954-965
    • Zhang, X.F.1    Tan, X.2    Zeng, G.3    Misse, A.4    Singh, S.5    Kim, Y.6    Klaunig, J.E.7    Monga, S.P.8
  • 135
    • 79952118383 scopus 로고    scopus 로고
    • Tumor formation in liver of conditional beta-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen
    • Rignall, B.; Braeuning, A.; Buchmann, A.; Schwarz, M. Tumor formation in liver of conditional beta-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. Carcinogenesis, 2011, 32(1), 52-57.
    • (2011) Carcinogenesis , vol.32 , Issue.1 , pp. 52-57
    • Rignall, B.1    Braeuning, A.2    Buchmann, A.3    Schwarz, M.4
  • 136
    • 78149448121 scopus 로고    scopus 로고
    • Alkylation of the tumor suppressor PTEN activates Akt and beta-catenin signaling: A mechanism linking inflammation and oxidative stress with cancer
    • Covey, T.M.; Edes, K.; Coombs, G.S.; Virshup, D.M.; Fitzpatrick, F.A. Alkylation of the tumor suppressor PTEN activates Akt and beta-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One, 2010, 5(10), e13545.
    • (2010) PLoS One , vol.5 , Issue.10
    • Covey, T.M.1    Edes, K.2    Coombs, G.S.3    Virshup, D.M.4    Fitzpatrick, F.A.5
  • 137
    • 63349098247 scopus 로고    scopus 로고
    • Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    • Cieply, B.; Zeng, G.; Proverbs-Singh, T.; Geller, D.A.; Monga, S.P. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology, 2009, 49(3), 821-831.
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 821-831
    • Cieply, B.1    Zeng, G.2    Proverbs-Singh, T.3    Geller, D.A.4    Monga, S.P.5
  • 138
    • 67650469849 scopus 로고    scopus 로고
    • Liver cancer stem cells: Implications for a new therapeutic target
    • Lee, T.K.; Castilho, A.; Ma, S.; Ng, I.O. Liver cancer stem cells: implications for a new therapeutic target. Liver Int., 2009, 29(7), 955-965.
    • (2009) Liver Int , vol.29 , Issue.7 , pp. 955-965
    • Lee, T.K.1    Castilho, A.2    Ma, S.3    Ng, I.O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.