Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen

Carcinogenesis

Volumn 32, Issue 1, 2011, Pages 52-57

  Rignall, Benjamin ^a   Braeuning, Albert ^a   Buchmann, Albrecht ^a   Schwarz, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BETA CATENIN; CYTOCHROME P450 2E1; DIETHYLNITROSAMINE; GLUCOSE 6 PHOSPHATASE; GLUTAMATE AMMONIA LIGASE; PHENOBARBITAL; CARCINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GENE MUTATION; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; LIPID STORAGE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER TUMOR; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CHEMICALLY INDUCED DISORDER; GENETICS; IMMUNOHISTOCHEMISTRY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ANIMALS; BETA CATENIN; CARCINOGENS; DIETHYLNITROSAMINE; DNA MUTATIONAL ANALYSIS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; PHENOBARBITAL; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 79952118383     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq226     Document Type: Article

References (29)

1. Aydinlik,H. et al. (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene, 20, 7812-7816.
2. Strathmann,J. et al. (2006) PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol. Sci., 93, 34-40.
3. Lustig,B. et al. (2003) The Wnt signaling pathway and its role in tumor development. J. Cancer Res. Clin. Oncol., 129, 199-221.
4. Behrens,J. et al. (2004) The Wnt connection to tumorigenesis. Int. J. Dev. Biol., 48, 477-487.
5. Behrens,J. et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science, 280, 596-599.
6. Willert,K. et al. (1998) Beta-catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev., 8, 95-102.
7. Behrens,J. et al. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1. Nature, 382, 638-642.
8. Loeppen,S. et al. (2002) Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res., 62, 5685-5688.
9. Huelsken,J. et al. (2001) Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell, 105, 533-545.
10. Braeuning,A. et al. (2009) Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab. Dispos., 37, 1138-1145.
11. Sorg,U.R. et al. (2007) O6-methylguanine-DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: studies addressing safety issues. DNA Repair (Amst.), 6, 1197-1209.
12. Wachstein,M. et al. (1957) Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. Am. J. Clin. Pathol., 27, 13-23.
13. Chayen,J. et al. (1973) Practical Histochemistry. JohnWiley Sons, London, UK.
14. Buchmann,A. et al. (2008) Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis. Mutat. Res., 638, 66-74.
15. Kang,J.S. et al. (2007) Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res., 67, 11141-11146.
16. Pegg,A.E. (1977) Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents. Adv. Cancer Res., 25, 195-269.
17. Gebhardt,R. et al. (1983) Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J., 2, 567-570.
18. Braeuning,A. (2009) Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling. Curr. Drug Metab., 10, 138-158.
19. Sekine,S. et al. (2006) Liver-specific loss of ß-catenin blocks glutamine synthetis pathway activity and cytochrome P450 expression in mice. Hepatology, 43, 817-825.
20. Zhang,X.F. et al. (2010) Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology, 52, 954-965.
21. Braeuning,A. et al. (2010) Phenotype and growth behavior of residual b-catenin-positive hepatocytes in livers of b-catenin-deficient mice. Histochem. Cell Biol., 134, 469-481.
22. Blikkendaal-Lieftinck,L.F. et al. (1977) Cell kinetics in the liver of rats under normal and abnormal dietary conditions. An autoradiographic study by means of [3H]thymidine. Exp. Mol. Pathol., 26, 184-192.
23. Moennikes,O. et al. (2000) Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. Cancer Res., 60, 5087-5091.
24. Yamamoto,Y. et al. (2004) The orphan nuclear receptor constitutive active/ androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res., 64, 7197-7200.
25. Sekine,S. et al. (2009) Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology, 136, 2304-2315e1-e4.
26. Giera,S. et al. (2010) Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver. Toxicol. Sci., 115, 22-33.
27. Hayes,J.D. et al. (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res., 31, 273-300.
28. Diez-Fernandez,C. et al. (1998) The effect of non-genotoxic carcinogens, phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis. Carcinogenesis, 19, 1715-1722.
29. Scholz,W. et al. (1990) Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules. Cancer Res., 50, 7015-7022.