The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein

Biochemical Journal

Volumn 422, Issue 3, 2009, Pages 493-501

  Andrews, Phillip G P ^a   He, Zhijian ^a   Popadiuk, Cathy ^a   Kao, Kenneth R ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

cAMP responsive element binding protein (CREB) binding protein (CBP); Colorectal cancer; Histone acetylation; Pygopus; Transcription; Wnt signalling

Indexed keywords

CAMP-RESPONSIVE-ELEMENT-BINDING PROTEIN (CREB)-BINDING PROTEIN (CBP); COLORECTAL CANCER; HISTONE ACETYLATION; PYGOPUS; WNT SIGNALLING;

ACETYLATION; CELL MEMBRANES; CHLORINATION; COMPRESSED AIR MOTORS; CONTEXT SENSITIVE GRAMMARS; FETAL MONITORING; GENES; NUCLEIC ACIDS; TRANSCRIPTION;

PROTEINS;

BETA CATENIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; LYMPHOID ENHANCER FACTOR 1; PYGOPUS; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HISTONE; PYGO2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ACETYLATION; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; PROTEIN BINDING;

PYGOPUS;

ACETYLATION; CELL LINE; CREB-BINDING PROTEIN; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HISTONES; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING;

EID: 70249121438     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090134     Document Type: Article

References (39)

1. Jessen, S., Gu, B. and Dai, X. (2008) Pygopus and the Wnt signaling pathway: a diverse set of connections. Bioessays 30, 448-456
2. Huang, H. and He, X. (2008) Wnt/β-catenin signaling: new (and old) players and new insights. Curr. Opin. Cell Biol. 20, 119-125
3. Xu, W. and Kimelman, D. (2007) Mechanistic insights from structural studies of β-catenin and its binding partners. J. Cell Sci. 120, 3337-3344
4. Stadeli, R., Hoffmans, R. and Basler, K. (2006) Transcription under the control of nuclear Arm/β-catenin. Curr. Biol. 16, R378-R385
5. Clevers, H. (2006) Wnt/β-catenin signaling in development and disease. Cell 127, 469-480
6. Thompson, B., Townsley, F., Rosin-Arbesfeld, R., Musisi, H. and Bienz, M. (2002) A new nuclear component of the Wnt signalling pathway. Nat. Cell Biol. 4, 367-373
7. Kramps, T., Peter, O., Brunner, E., Nellen, D., Froesch, B., Chatterjee, S., Murone, M., Zullig, S. and Basler, K. (2002) Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex. Cell 109, 47-60
8. Carrera, I., Janody, F., Leeds, N., Duveau, F. and Treisman, J. E. (2008) Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc. Natl. Acad. Sci. U.S.A. 105, 6644-6649
9. Stadeli, R. and Basler, K. (2005) Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mech. Dev. 122, 1171-1182
10. Hoffmans, R., Stadeli, R. and Basler, K. (2005) Pygopus and legless provide essential transcriptional coactivator functions to armadillo/ β-catenin. Curr. Biol. 15, 1207-1211
11. Thompson, B. J. (2004) A complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate wingless target genes. Curr. Biol. 14, 458-466
12. Townsley, F. M., Thompson, B. and Bienz, M. (2004) Pygopus residues required for its binding to Legless are critical for transcription and development. J. Biol. Chem. 279, 5177-5183
13. Lake, B. B. and Kao, K. R. (2003) Pygopus is required for embryonic brain patterning in Xenopus. Dev. Biol. 261, 132-148
14. Wright, K. J. and Tjian, R. (2009) Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo. Proc. Natl. Acad. Sci. U.S.A. 106, 55-60
15. Sierra, J., Yoshida, T., Joazeiro, C. A. and Jones, K. A. (2006) The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 20, 586-600
16. Shahbazian, M. D. and Grunstein, M. (2007) Functions of site-specific histone acetylation and deacetylation. Annu. Rev. Biochem. 76, 75-100
17. Fiedler, M., Sanchez-Barrena, M. J., Nekrasov, M., Mieszczanek, J., Rybin, V., Muller, J., Evans, P. and Bienz, M. (2008) Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol. Cell 30, 507-518
18. Feng, Y., Lee, N. and Fearon, E. R. (2003) TIP49 regulates β-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. Cancer Res. 63, 8726-8734
19. Parker, D. S., Ni, Y. Y., Chang, J. L., Li, J. and Cadigan, K. M. (2008) Wingless signaling induces widespread chromatin remodeling of target loci. Mol. Cell Biol. 28, 1815-1828
20. Sustmann, C., Flach, H., Ebert, H., Eastman, Q. and Grosschedl, R. (2008) Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with β-catenin. Mol. Cell Biol. 28, 3526-3537
21. Barker, N., Hurlstone, A., Musisi, H., Miles, A., Bienz, M. and Clevers, H. (2001) The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation. EMBO J. 20, 4935-4943
22. Takemaru, K. I. and Moon, R. T. (2000) The transcriptional coactivator CBP interacts with β-catenin to activate gene expression. J. Cell Biol. 149, 249-254
23. Hecht, A., Vleminckx, K., Stemmler, M. P., van Roy, F. and Kemler, R. (2000) The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates. EMBO J. 19, 1839-1850
24. Nair, M., Nagamori, I., Sun, P., Mishra, D. P., Rheaume, C., Li, B., Sassone-Corsi, P. and Dai, X. (2008) Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev. Biol. 15, 446-455
25. Andrews, P. G., Kennedy, M. W., Popadiuk, C. M. and Kao, K. R. (2008) Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1. Mol. Cancer Res. 6, 259-266
26. Popadiuk, C. M., Xiong, J., Wells, M. G., Andrews, P. G., Dankwa, K., Hirasawa, K., Lake, B. B. and Kao, K. R. (2006) Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer. Clin. Cancer Res. 12, 2216-2223
27. Chrivia, J. C., Kwok, R. P., Lamb, N., Hagiwara, M., Montminy, M. R. and Goodman, R. H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859
28. Blackmore, T. M., Mercer, C. F., Paterno, G. D. and Gillespie, L. L. (2008) The transcriptional cofactor MIER1-β negatively regulates histone acetyltransferase activity of the CREB-binding protein. BMC. Res. Notes 1, 68
29. Korzus, E., Torchia, J., Rose, D. W., Xu, L., Kurokawa, R., McInerney, E. M., Mullen, T. M., Glass, C. K. and Rosenfeld, M. G. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279, 703-707
30. Andrews, P. G., Lake, B. B., Popadiuk, C. and Kao, K. R. (2007) Requirement of Pygopus 2 in breast cancer. Int. J. Oncol. 30, 357-363
31. Ding, Z., Gillespie, L. L., Mercer, F. C. and Paterno, G. D. (2004) The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter. J. Biol. Chem. 279, 28009-28016
32. Ait-Si-Ali, S., Ramirez, S., Barre, F. X., Dkhissi, F., Magnaghi-Jaulin, L., Girault, J. A., Robin, P., Knibiehler, M., Pritchard, L. L., Ducommun, B. et al. (1998) Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396, 184-186
33. Shih, I. M., Yu, J., He, T. C., Vogelstein, B. and Kinzler, K. W. (2000) The β-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 60, 1671-1676
34. Arany, Z., Sellers, W. R., Livingston, D. M. and Eckner, R. (1994) E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77, 799-800
35. Neish, A. S., Anderson, S. F., Schlegel, B. P., Wei, W. and Parvin, J. D. (1998) Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res. 26, 847-853
36. Tutter, A. V., Fryer, C. J. and Jones, K. A. (2001) Chromatin-specific regulation of LEF-1-β-catenin transcription activation and inhibition in vitro. Genes Dev. 15, 3342-3354
37. Townsley, F. M., Cliffe, A. and Bienz, M. (2004) Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function. Nat. Cell Biol. 6, 626-633
38. Mosimann, C., Hausmann, G. and Basler, K. (2006) Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with β-catenin/Armadillo. Cell 125, 327-341
39. Kim, S., Xu, X., Hecht, A. and Boyer, T. G. (2006) Mediator is a transducer of Wnt/β-catenin signaling. J. Biol. Chem. 281, 14066-14075