Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3

Cancer Research

Volumn 58, Issue 12, 1998, Pages 2524-2527

  Miyoshi, Yasuo ^a   Iwao, Kyoko ^a   Nagasawa, Yutaka ^a   Aihara, Tomohiko ^a   Sasaki, Yo ^b   Imaoka, Shingi ^b   Murata, Masaru ^c   Shimano, Takashi ^c   Nakamura, Yusuke ^a,d  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c Ikeda Municipal Hospital   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; BETA CATENIN; DNA; GLYCINE; NUCLEOTIDE; RNA; SERINE; THREONINE;

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; EXON; GENE; GENE ACTIVATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION;

BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CYTOSKELETAL PROTEINS; EXONS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; NEOPLASM PROTEINS; PHOSPHORYLATION; POINT MUTATION; POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS;

EID: 0032525836     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Simonetti, R. G., Camma, C., Fiorello, F., Politi, F., D'amico, G., and Pagliaro, L. Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig. Dis. Sci., 36: 962-972, 1991.
2. Peng, S. Y., Lai, P. L., and Hsu, M. C. Activation of the c-myc gene in human hepatocellular carcinoma: biologic significance. J. Formos. Med. Assoc., 92: 866-870, 1993.
3. Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., Ikenaga, M., and Ishizaki, K. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 54: 3107-3110, 1994.
4. Lin, Y., Shi, C. Y., Li, B., Soo, B. H., Mohammed, A. S., Wee, A., Oon, C. J., Mack, P. O., and Chan, S. H. Tumour suppressor p53 and Rb genes in human hepatocellular carcinoma. Ann. Acad. Med. Singapore, 25: 22-30, 1996.
5. Kanai, Y., Ushijima, S., Hui, A-M., Ochiai, A., Tsuda, H., Sakamoto, M, and Hirohashi, S. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int. J. Cancer, 71: 355-359, 1997.
6. Slagle, B. L., Zhou, Y. Z., Birchmeier, W., and Scorsone, K. A. Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology, 18: 757-762, 1993.
7. Ihara, A., Koizumi, H., Hashizume, R., and Uchikoshi, T. Expression of epithelial cadherin and α-and β-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology, 23: 1441-1447, 1996.
8. Stamatoglou, S. C., and Hughes, R. C. Cell adhesion molecules in liver function and pattern formation. FASEB J., 8: 420-427, 1994.
9. Gumbiner, B. M. Signal transduction by β-catenin. Curr. Opin. Cell Biol., 7: 634-640, 1995.
10. Korinek, V., Barker, N., Morin, P. J., Wichen, D., Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC -/-colon carcinoma. Science (Washington DC), 275: 1784-1787, 1997.
11. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Washington DC), 275: 1787-1790, 1997.
12. Rubinfeld, B., Robbins, P., El-Gamil, M., Albert, I., Porfiri, E., and Polakis, P. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science (Washington DC), 275: 1790-1792, 1997.
13. Kitaeva, M. N., Grogan, L., Williams, J. P., Dimond, E., Nakahara, K., Hausner, P., DeNobile, J. W., Soballe, P. W., and Kirsch, I. R. Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res., 57: 4478-4481, 1997.
14. Iwao, K., Nakamori, S., Kameyama, M., Imaoka, S., Kinoshita, M., Fukui, T., Ishiguro, S., Nakamura, Y., and Miyoshi, Y. Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res., 58: 1021-1026, 1998.
15. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
16. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., and Polakis, P. Binding of GSK-3β to the APC-β-catenin complex and regulation of complex assembly. Science (Washington DC), 272: 1023-1026, 1996.
17. Cleves, H. C., and Grosschedl, R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunol. Today, 17: 336-343, 1996.
18. Molenaar, M., Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Goldsave, S., Korinek, V., Roose, J., Destree, O., and Clevers, H. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell, 86: 391-399, 1996.
19. Behrens, J., Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. Functional interaction of β-catenin with the transcription factor LEF-1. Nature (Lond.), 382: 638-642, 1996.
20. Takahashi, M., Fukuda, K., Sugimura, T., and Wakabayashi, K. β-Catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res., 58: 42-46, 1998.
21. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J., 16: 3797-3804, 1997.