Epigenetic silencing of WIF-1 in hepatocellular carcinomas

Journal of Cancer Research and Clinical Oncology

Volumn 136, Issue 8, 2010, Pages 1161-1167

  Deng, Yun ^a   Yu, Bin ^a,b   Cheng, Qin ^a   Jin, Jie ^c   You, Haiyan ^a   Ke, Ronghu ^a   Tang, Ning ^a   Shen, Qiujin ^a   Shu, Huiqun ^a   Yao, Genfu ^a   Zhang, Zhigang ^a   Qin, Wenxin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANTONG UNIVERSITY   (China)

^c JIANGSU UNIVERSITY   (China)

Author keywords

HCC; Methylation; Wnt inhibitory factor 1; Wnt Catenin signaling

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; GENOMIC DNA; GLYCOPROTEIN; LUCIFERASE; MESSENGER RNA; PROTEIN WIF 1; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT PROTEIN; DNA; PRIMER DNA; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WIF1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DNA SEQUENCE; EPIGENETICS; GENE EXPRESSION PROFILING; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL CARCINOMA; LIVER PARENCHYMA; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL DIVISION; CELL STRAIN HEPG2; CHEMISTRY; DNA METHYLATION; GENETICS; LIVER; LIVER TUMOR; METHODOLOGY; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; REFERENCE VALUE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; GENE SILENCING; GENES, REPORTER; HEP G2 CELLS; HUMANS; LIVER; LIVER NEOPLASMS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; REFERENCE VALUES; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77954599313     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0763-5     Document Type: Article

References (24)

1. Batra S, Shi Y, Kuchenbecker KM et al. (2006) Wnt inhibitory factor- 1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun 342:1228-1232
2. Bengochea A, de Souza MM, Lefrançois L et al. (2008) Common dysregulation of Wnt/frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 99:143-150
3. Bruix J, Boix L, Sala M et al. (2004) Focus on hepatocellular carcinoma. Cancer Cell 5:215-219
4. Cebrat M, Strzadala L, Kisielow P (2004) Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cancer Lett 206:107-113
5. Civenni G, Holbro T, Hynes NE (2003) Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells. EMBO Rep 4:166-171
6. Clevers H (2004) Wnt breakers in colon cancer. Cancer Cell 5:5-6
7. Farazi PA, DePinho RA (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6:674-687
8. He B, Reguart N, You L et al. (2005a) Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 24:3054-3058
9. He B, Lee AY, Dadfarmay S et al. (2005b) Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deWcient human mesothelioma cells. Cancer Res 65:743-748
10. Hsieh JC, Kodjabachian L, Rebbert ML et al. (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398:431-436
11. Huang H, He X (2008) Wnt/catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 20:119-125
12. Kensler TW, Qian GS, Chen JG et al. (2003) Translational strategies for cancer prevention in liver. Nat Rev Cancer 3:321-329
13. Kim M, Lee HC, Tsedensodnom O et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48:780-791
14. Kirikoshi H, Sekihara H, Katoh M (2001) Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFN gamma and up-regulation of WNT14B by-estradiol. Int J Oncol 19:1221-1225
15. Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8:387-398
16. Lee HC, Kim M, Wands JR (2006) Wnt/frizzled signaling in hepatocellular carcinoma. Front Biosci 11:1901-1915
17. Lin YC, You L, Xu Z et al. (2007) Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther 18:379-386 (Pubitemid 46709349)
18. Mazieres J, He B, You L et al. (2004) Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res 64:4717-4720 (Pubitemid 38924512)
19. Saitoh T, Mine T, Katoh M (2002) Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med 9:515-519
20. Smith K, Bui TD, Poulsom R et al. (1999) Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. Br J Cancer 81:496-502
21. Staal FJ, Luis TC, Tiemessen MM (2008) WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 8:581-593
22. Urakami S, Shiina H, Enokida H et al. (2006) Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/-catenin signaling pathway. Clin Cancer Res 12:383-391
23. Wissmann C, Wild PJ, Kaiser S et al. (2003) WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J Pathol 201:204-212
24. Xie L, Qin WX, Li JJ et al. (2007) BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells. Oncol Rep 17:605-610