Inhibition of Wnt-1 signaling induces apoptosis in β -catenin-deficient mesothelioma cells

Cancer Research

Volumn 64, Issue 10, 2004, Pages 3474-3478

  You, Liang ^a   He, Biao ^a   Uematsu, Kazutsugu ^a   Xu, Zhidong ^a   Mazieres, Julien ^a   Lee, Amie ^a   McCormick, Frank ^a   Jablons, David M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DISHEVELLED SMALL INTERFERING RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WNT1 PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL KILLING; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

APOPTOSIS; BETA CATENIN; CARCINOMA, NON-SMALL-CELL LUNG; CYTOSKELETAL PROTEINS; HUMANS; LUNG NEOPLASMS; MESOTHELIOMA; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFECTION; WNT PROTEINS; WNT1 PROTEIN;

EID: 2442694379     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0115     Document Type: Article

References (33)

1. Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature (Lond.) 2001;412:86-90.
2. Hsieh JC, Rattner A, Smallwood PM, Nathans J. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc Natl Acad Sci USA 1999;96:3546-51.
3. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998;14:59-88.
4. Uthoff SM, Eichenberger MR, McAuliffe TL, Hamilton CJ, Galandiuk S. Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer. Mol Carcinog 2001;31:56-62.
5. He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science (Wash. DC) 1998;281:1509-12.
6. Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (Lond.) 1999;398:422-6.
7. Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003;5:367-77.
8. Nusse R, Varmus HE. Wnt genes. Cell 1992;69:1073-87.
9. Satoh S, Daigo Y, Furukawa Y, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000;24:245-50.
10. Chen S, Guttridge DC, You Z, et al. Wnt-1 signaling inhibits apoptosis by activating β-catenin/T-cell factor-mediated transcription. J Cell Biol 2001;152:87-96.
11. Ioannidis V, Beermann F, Clevers H, Held W. The β-catenin-TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nat Immunol 2001;2:691-7.
12. You Z, Saims D, Chen S, et al. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol 2002;157:429-40.
13. Nusse R. Developmental biology. Making head or tail of Dickkopf. Nature (Lond.) 2001;411:255-6.
14. Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 2002;21:878-89.
15. Uematsu K, Kanazawa S, You L, et al. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of β-catenin. Cancer Res 2003;63:4547-51.
16. Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. Activation of the Wnt pathway in non-small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003;22:7218-21.
17. He B, You L, Uematsu K, et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004;6:7-14.
18. Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 2002;277:5977-81.
19. Shigemitsu K, Sekido Y, Usami N, et al. Genetic alteration of the β-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion. Oncogene 2001;20:4249-57.
20. Hsu SM, Hsu PL, Zhao X, Kao-Shan CS, Whang-Peng J. Establishment of human mesothelioma cell lines (MS-1, -2) and production of a monoclonal antibody (anti-MS) with diagnostic and therapeutic potential. Cancer Res 1988;48:5228-36.
21. Boutros M, Paricio N, Strutt DI, Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998;94:109-18.
22. Wong HC, Bourdelas A, Krauss A, et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003;12:1251-60.
23. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J Cell Biol 2003;162:899-908.
24. Westfall TA, Brimeyer R, Twedt J, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity. J Cell Biol 2003;162:889-98.
25. Zhang Y, Neo SY, Wang X, Han J, Lin SC. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J Biol Chem 1999;274:35247-54.
26. Neo SY, Zhang Y, Yaw LP, Li P, Lin SC. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate β-catenin levels. Biochem Biophys Res Commun 2000;272:144-50.
27. Zeng W, Wharton KA Jr, Mack JA, et al. Naked cuticle encodes an inducible antagonist of Wnt signalling. Nature (Lond.) 2000;403:789-95.
28. Yan D, Wallingford JB, Sun TQ, et al. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci USA 2001;98:3802-7.
29. Sun TQ, Lu B, Feng JJ, et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol 2001;3:628-36.
30. Bennett BL, Sasaki DT, Murray BW, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001;98:13681-6.
31. Krilleke D, Ucur E, Pulte D, Schulze-Osthoff K, Debatin KM, Herr I. Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis. Int J Cancer 2003;107:520-7.
32. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-52.
33. Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNF-α-induced apoptosis. Cell 2003;115:61-70.