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Volumn 67, Issue 2, 2007, Pages 573-579

An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; DISHEVELLED PROTEIN; FJ 9; FRIZZLED PROTEIN; PDZ PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 33846673934     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2726     Document Type: Article
Times cited : (202)

References (50)
  • 1
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 2
    • 4344584730 scopus 로고    scopus 로고
    • WNT and β-catenin signalling: Diseases and therapies
    • Moon RT, Kohn AD, De Ferrari GV, et al. WNT and β-catenin signalling: diseases and therapies. Nat Rev Genet 2004;5:691-701.
    • (2004) Nat Rev Genet , vol.5 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    De Ferrari, G.V.3
  • 3
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 4
    • 24044490922 scopus 로고    scopus 로고
    • Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    • Mazieres J, You L, He B, et al. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene 2005;24:5396-400.
    • (2005) Oncogene , vol.24 , pp. 5396-5400
    • Mazieres, J.1    You, L.2    He, B.3
  • 5
    • 33745763860 scopus 로고    scopus 로고
    • The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line
    • Casagrande G, te Kronnie G, Basso G. The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. Haematologica 2006;91:765-71.
    • (2006) Haematologica , vol.91 , pp. 765-771
    • Casagrande, G.1    te Kronnie, G.2    Basso, G.3
  • 6
    • 0033731796 scopus 로고    scopus 로고
    • Altered HOX and WNT7A expression in human lung cancer
    • Calvo R, West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 2000;97:12776-81.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12776-12781
    • Calvo, R.1    West, J.2    Franklin, W.3
  • 8
    • 21244440303 scopus 로고    scopus 로고
    • Restoration of Wnt7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
    • Winn RA, Marek L, Han SY, et al. Restoration of Wnt7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. J Biol Chem 2005;280:19625-34.
    • (2005) J Biol Chem , vol.280 , pp. 19625-19634
    • Winn, R.A.1    Marek, L.2    Han, S.Y.3
  • 9
    • 0037093230 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    • Bremnes RM, Veve R, Gabrielson E, et al. High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 2002;20:2417-28.
    • (2002) J Clin Oncol , vol.20 , pp. 2417-2428
    • Bremnes, R.M.1    Veve, R.2    Gabrielson, E.3
  • 10
    • 0036469157 scopus 로고    scopus 로고
    • Increased expression of β-catenin predicts better prognosis in nonsmall cell lung carcinomas
    • Hommura F, Furuuchi K, Yamazaki K, et al. Increased expression of β-catenin predicts better prognosis in nonsmall cell lung carcinomas. Cancer 2002;94:752-8.
    • (2002) Cancer , vol.94 , pp. 752-758
    • Hommura, F.1    Furuuchi, K.2    Yamazaki, K.3
  • 11
    • 0032431279 scopus 로고    scopus 로고
    • The expression of β-catenin in non-small-cell lung cancer: A clinicopathological study
    • Retera JM, Leers MP, Sulzer MA, et al. The expression of β-catenin in non-small-cell lung cancer: a clinicopathological study. J Clin Pathol 1998;51:891-4.
    • (1998) J Clin Pathol , vol.51 , pp. 891-894
    • Retera, J.M.1    Leers, M.P.2    Sulzer, M.A.3
  • 12
    • 14244249744 scopus 로고    scopus 로고
    • Loss of expression of E-cadherin and β-catenin is associated with progression of pulmonary adenocarcinoma
    • Awaya H, Takeshima Y, Amatya VJ, et al. Loss of expression of E-cadherin and β-catenin is associated with progression of pulmonary adenocarcinoma. Pathol Int 2005;55:14-8.
    • (2005) Pathol Int , vol.55 , pp. 14-18
    • Awaya, H.1    Takeshima, Y.2    Amatya, V.J.3
  • 13
    • 2442694379 scopus 로고    scopus 로고
    • Inhibition of Wnt-1 signaling induces apoptosis in β-catenin-deficient mesothelioma cells
    • You L, He B, Uematsu K, et al. Inhibition of Wnt-1 signaling induces apoptosis in β-catenin-deficient mesothelioma cells. Cancer Res 2004;64:3474-8.
    • (2004) Cancer Res , vol.64 , pp. 3474-3478
    • You, L.1    He, B.2    Uematsu, K.3
  • 14
    • 0035368394 scopus 로고    scopus 로고
    • G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway
    • Liu T, DeCostanzo AJ, Liu X, et al. G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science 2001;292:1718-22.
    • (2001) Science , vol.292 , pp. 1718-1722
    • Liu, T.1    DeCostanzo, A.J.2    Liu, X.3
  • 15
    • 0141484619 scopus 로고    scopus 로고
    • Functional characterization of WNT7A signaling in PC12 cells: Interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins
    • Caricasole A, Ferraro T, Iacovelli L, et al. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J Biol Chem 2003;278:37024-31.
    • (2003) J Biol Chem , vol.278 , pp. 37024-37031
    • Caricasole, A.1    Ferraro, T.2    Iacovelli, L.3
  • 16
    • 26244447326 scopus 로고    scopus 로고
    • Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma
    • Merle P, Kim M, Herrmann M, et al. Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma. J Hepatol 2005;43:854-62.
    • (2005) J Hepatol , vol.43 , pp. 854-862
    • Merle, P.1    Kim, M.2    Herrmann, M.3
  • 17
    • 23844461568 scopus 로고    scopus 로고
    • Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth
    • Vincan E, Darcy PK, Smyth MJ, et al. Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. Differentiation 2005;73:142-53.
    • (2005) Differentiation , vol.73 , pp. 142-153
    • Vincan, E.1    Darcy, P.K.2    Smyth, M.J.3
  • 18
    • 0032501156 scopus 로고    scopus 로고
    • Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7
    • Sagara N, Toda G, Hirai M, et al. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Biochem Biophys Res Commun 1998;252:117-22.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 117-122
    • Sagara, N.1    Toda, G.2    Hirai, M.3
  • 19
    • 0032544039 scopus 로고    scopus 로고
    • A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals
    • Tanaka S, Akiyoshi T, Mori M, et al. A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals. Proc Natl Acad Sci U S A 1998;95:10164-9.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10164-10169
    • Tanaka, S.1    Akiyoshi, T.2    Mori, M.3
  • 20
    • 0344413477 scopus 로고    scopus 로고
    • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
    • Wong HC, Bourdelas A, Krauss A, et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003;12:1251-60.
    • (2003) Mol Cell , vol.12 , pp. 1251-1260
    • Wong, H.C.1    Bourdelas, A.2    Krauss, A.3
  • 21
    • 0031581105 scopus 로고    scopus 로고
    • cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas
    • Bui TD, Beier DR, Jonssen M, et al. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. Biochem Biophys Res Commun 1997;239:510-6.
    • (1997) Biochem Biophys Res Commun , vol.239 , pp. 510-516
    • Bui, T.D.1    Beier, D.R.2    Jonssen, M.3
  • 22
    • 0043092191 scopus 로고    scopus 로고
    • Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of β-catenin
    • Uematsu K, Kanazawa S, You L, et al. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of β-catenin. Cancer Res 2003;63:4547-51.
    • (2003) Cancer Res , vol.63 , pp. 4547-4551
    • Uematsu, K.1    Kanazawa, S.2    You, L.3
  • 23
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • Uematsu K, He B, You L, et al. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003;22:7218-21.
    • (2003) Oncogene , vol.22 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3
  • 24
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the Dishevelled PDZ domain
    • Shan J, Shi DL, Wang J, et al. Identification of a specific inhibitor of the Dishevelled PDZ domain. Biochemistry 2005;44:15495-503.
    • (2005) Biochemistry , vol.44 , pp. 15495-15503
    • Shan, J.1    Shi, D.L.2    Wang, J.3
  • 25
    • 0034916230 scopus 로고    scopus 로고
    • PDZ domains and the organization of supramolecular complexes
    • Sheng M, Sala C. PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 2001;24:1-29.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 1-29
    • Sheng, M.1    Sala, C.2
  • 26
    • 0034740693 scopus 로고    scopus 로고
    • Mechanism and role of PDZ domains in signaling complex assembly
    • Harris BZ, Lim WA. Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci 2001;114:3219-31.
    • (2001) J Cell Sci , vol.114 , pp. 3219-3231
    • Harris, B.Z.1    Lim, W.A.2
  • 27
    • 0037174635 scopus 로고    scopus 로고
    • Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions
    • Aarts M, Liu Y, Liu L, et al. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 2002;298:846-50.
    • (2002) Science , vol.298 , pp. 846-850
    • Aarts, M.1    Liu, Y.2    Liu, L.3
  • 28
    • 10444276589 scopus 로고    scopus 로고
    • Making protein interactions druggable: Targeting PDZ domains
    • Dev KK. Making protein interactions druggable: targeting PDZ domains. Nat Rev Drug Discov 2004;3:1047-56.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1047-1056
    • Dev, K.K.1
  • 29
    • 0141958040 scopus 로고    scopus 로고
    • A selective irreversible inhibitor targeting a PDZ protein interaction domain
    • Fujii N, Haresco JJ, Novak KA, et al. A selective irreversible inhibitor targeting a PDZ protein interaction domain. J Am Chem Soc 2003;125:12074-5.
    • (2003) J Am Chem Soc , vol.125 , pp. 12074-12075
    • Fujii, N.1    Haresco, J.J.2    Novak, K.A.3
  • 30
    • 0033979731 scopus 로고    scopus 로고
    • Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
    • Dickson MA, Hahn WC, Ino Y, et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000;20:1436-47.
    • (2000) Mol Cell Biol , vol.20 , pp. 1436-1447
    • Dickson, M.A.1    Hahn, W.C.2    Ino, Y.3
  • 31
    • 0032588317 scopus 로고    scopus 로고
    • NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
    • Wang CY, Guttridge DC, Mayo MW, et al. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999;19:5923-9.
    • (1999) Mol Cell Biol , vol.19 , pp. 5923-5929
    • Wang, C.Y.1    Guttridge, D.C.2    Mayo, M.W.3
  • 32
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    • He B, You L, Uematsu K, et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004;6:7-14.
    • (2004) Neoplasia , vol.6 , pp. 7-14
    • He, B.1    You, L.2    Uematsu, K.3
  • 33
    • 1542493294 scopus 로고    scopus 로고
    • A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology
    • Wilson J, Rossi CP, Carboni S, et al. A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology. J Biomol Screen 2003;8:522-32.
    • (2003) J Biomol Screen , vol.8 , pp. 522-532
    • Wilson, J.1    Rossi, C.P.2    Carboni, S.3
  • 34
    • 4143140829 scopus 로고    scopus 로고
    • Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain
    • London TB, Lee HJ, Shao Y, et al. Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain. Biochem Biophys Res Commun 2004;322:326-32.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 326-332
    • London, T.B.1    Lee, H.J.2    Shao, Y.3
  • 35
    • 0037229938 scopus 로고    scopus 로고
    • Wharton KA, Jr. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 2003;253:1-17.
    • Wharton KA, Jr. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 2003;253:1-17.
  • 36
    • 0020624204 scopus 로고
    • Regulation of the cytoskeleton in mesothelial cells: Reversible loss of keratin and increase in vimentin during rapid growth in culture
    • Connell ND, Rheinwald JG. Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell 1983;34:245-53.
    • (1983) Cell , vol.34 , pp. 245-253
    • Connell, N.D.1    Rheinwald, J.G.2
  • 38
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 39
    • 0033119801 scopus 로고    scopus 로고
    • β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 40
    • 0038498213 scopus 로고    scopus 로고
    • Survivin and molecular pathogenesis of colorectal cancer
    • Kim PJ, Plescia J, Clevers H, et al. Survivin and molecular pathogenesis of colorectal cancer. Lancet 2003;362:205-9.
    • (2003) Lancet , vol.362 , pp. 205-209
    • Kim, P.J.1    Plescia, J.2    Clevers, H.3
  • 41
    • 0035907390 scopus 로고    scopus 로고
    • Akt participation in the Wnt signaling pathway through Dishevelled
    • Fukumoto S, Hsieh CM, Maemura K, et al. Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem 2001;276:17479-83.
    • (2001) J Biol Chem , vol.276 , pp. 17479-17483
    • Fukumoto, S.1    Hsieh, C.M.2    Maemura, K.3
  • 42
    • 0032898364 scopus 로고    scopus 로고
    • Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
    • Li L, Yuan H, Xie W, et al. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem 1999;274:129-34.
    • (1999) J Biol Chem , vol.274 , pp. 129-134
    • Li, L.1    Yuan, H.2    Xie, W.3
  • 43
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation in apoptosis: A double-edged sword
    • Liu J, Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res 2005;15:36-42.
    • (2005) Cell Res , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 44
    • 0344255675 scopus 로고    scopus 로고
    • β-Catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion
    • Usami N, Sekido Y, Maeda O, et al. β-Catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion. Oncogene 2003;22:7923-30.
    • (2003) Oncogene , vol.22 , pp. 7923-7930
    • Usami, N.1    Sekido, Y.2    Maeda, O.3
  • 45
    • 4644302254 scopus 로고    scopus 로고
    • Dickkopf-1 antagonizes Wnt signaling independent of β-catenin in human mesothelioma
    • Lee AY, He B, You L, et al. Dickkopf-1 antagonizes Wnt signaling independent of β-catenin in human mesothelioma, Biochem Biophys Res Commun 2004;323:1246-50.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 1246-1250
    • Lee, A.Y.1    He, B.2    You, L.3
  • 46
    • 13444267284 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in β-catenin-deficient human mesothelioma cells
    • He B, Lee AY, Dadfarmay S, et al. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in β-catenin-deficient human mesothelioma cells. Cancer Res 2005;65:743-8.
    • (2005) Cancer Res , vol.65 , pp. 743-748
    • He, B.1    Lee, A.Y.2    Dadfarmay, S.3
  • 47
    • 4444262013 scopus 로고    scopus 로고
    • MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap
    • Yao R, Natsume Y, Noda T. MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 2004;23:6023-30.
    • (2004) Oncogene , vol.23 , pp. 6023-6030
    • Yao, R.1    Natsume, Y.2    Noda, T.3
  • 48
    • 32444449180 scopus 로고    scopus 로고
    • Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
    • Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A 2006;103:1888-93.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1888-1893
    • Tovar, C.1    Rosinski, J.2    Filipovic, Z.3
  • 49
    • 4544285754 scopus 로고    scopus 로고
    • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    • Romer JT, Kimura H, Magdaleno S, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 2004;6:229-40.
    • (2004) Cancer Cell , vol.6 , pp. 229-240
    • Romer, J.T.1    Kimura, H.2    Magdaleno, S.3
  • 50
    • 0035692448 scopus 로고    scopus 로고
    • Drug resistance in melanoma: Mechanisms, apoptosis, and new potential therapeutic targets
    • Grossman D, Altieri DC. Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets. Cancer Metastasis Rev 2001;20:3-11.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 3-11
    • Grossman, D.1    Altieri, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.