Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16256-16263

  Grandy, David ^a   Shan, Jufang ^a,b   Zhang, Xinxin ^a   Rao, Sujata ^c   Akunuru, Shailaja ^c   Li, Hongyan ^d   Zhang, Yanhui ^b   Alpatov, Ivan ^b   Zhang, Xin A ^b   Lang, Richard A ^c   Shi, De Li ^d   Zheng, Jie J ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^d Université René Descartes   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; BIOLOGICAL EFFECTS; DOWNSTREAM COMPONENTS; MEMBRANE RECEPTORS; NMR SPECTROSCOPY; PDZ DOMAINS; PROSTATE CANCERS; SMALL MOLECULE INHIBITOR; SMALL MOLECULES; STRUCTURE-BASED; TESTING SYSTEMS; WNT SIGNALING; WNT SIGNALING PATHWAYS; XENOPUS;

CELL DEATH; CELL MEMBRANES; DRUG INTERACTIONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

SIGNALING;

BETA CATENIN; DISHEVELLED PROTEIN; PROTEIN INHIBITOR; SMALL MOLECULE INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL MEMBRANE PERMEABILITY; CHEMICAL ANALYSIS; CHEMICAL BINDING; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; BENZOATES; CELL DIVISION; CELL LINE, TUMOR; CELL MEMBRANE; CRYSTALLOGRAPHY; FEMALE; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OOCYTES; PDZ DOMAINS; PHOSPHOPROTEINS; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS LAEVIS;

EID: 67650266967     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.009647     Document Type: Article

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