-
1
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
-
(2010)
CA Cancer J Clin.
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
2
-
-
64849092309
-
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
-
Jones S, Hruban RH, Kamiyama M, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009;324(5924):217.
-
(2009)
Science
, vol.324
, Issue.5924
, pp. 217
-
-
Jones, S.1
Hruban, R.H.2
Kamiyama, M.3
-
3
-
-
47949103491
-
Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma
-
Omura N, Li CP, Li A, et al. Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma. Cancer Biol Ther. 2008;7(7):1146-1156.
-
(2008)
Cancer Biol Ther.
, vol.7
, Issue.7
, pp. 1146-1156
-
-
Omura, N.1
Li, C.P.2
Li, A.3
-
4
-
-
0035577825
-
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma
-
Ueki T, Toyota M, Skinner H, et al. Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. Cancer Res. 2001;61 (23):8540-8546. (Pubitemid 33131137)
-
(2001)
Cancer Research
, vol.61
, Issue.23
, pp. 8540-8546
-
-
Ueki, T.1
Toyota, M.2
Skinner, H.3
Walter, K.M.4
Yeo, C.J.5
Issa, J.-P.J.6
Hruban, R.H.7
Goggins, M.8
-
5
-
-
0037742210
-
Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays
-
Sato N, Fukushima N, Maitra A, et al. Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res. 2003;63(131:3735-3742.
-
(2003)
Cancer Res.
, vol.63
, Issue.131
, pp. 3735-3742
-
-
Sato, N.1
Fukushima, N.2
Maitra, A.3
-
6
-
-
1542636969
-
Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling
-
DOI 10.1038/sj.onc.1207269
-
Sato N, Fukushima N, Matsubayashi H, Goggins M. Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene. 2004;23(8):1531-1538. (Pubitemid 38406515)
-
(2004)
Oncogene
, vol.23
, Issue.8
, pp. 1531-1538
-
-
Sato, N.1
Fukushima, N.2
Matsubayashi, H.3
Goggins, M.4
-
7
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008; 321(5897):1801-1806.
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
8
-
-
0027733796
-
K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
-
Hruban RH, van Mansfeld AD, Offerhaus GJ, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993;143(2):545-554.
-
(1993)
Am J Pathol.
, vol.143
, Issue.2
, pp. 545-554
-
-
Hruban, R.H.1
Van Mansfeld, A.D.2
Offerhaus, G.J.3
-
10
-
-
0030050945
-
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
-
DOI 10.1053/gast.1996.v110.pm8536861
-
Tada M, Ohashi M, Shiratori Y, et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology. 1996;110(1):227-231. (Pubitemid 26021622)
-
(1996)
Gastroenterology
, vol.110
, Issue.1
, pp. 227-231
-
-
Tada, M.1
Ohashi, M.2
Shiratori, Y.3
Okudaira, T.4
Komatsu, Y.5
Kawabe, T.6
Yoshida, H.7
Machinami, R.8
Kishi, K.9
Omata, M.10
-
11
-
-
0030988302
-
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
-
Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997; 57(11):2140-2143. (Pubitemid 27247028)
-
(1997)
Cancer Research
, vol.57
, Issue.11
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
12
-
-
0141425732
-
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: Potential therapeutic targets
-
Calhoun ES, Jones JB, Ashfaq R, et al. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol. 2003;163(4):1255-1260. (Pubitemid 37175075)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.4
, pp. 1255-1260
-
-
Calhoun, E.S.1
Jones, J.B.2
Ashfaq, R.3
Adsay, V.4
Baker, S.J.5
Valentine, V.6
Hempen, P.M.7
Hilgers, W.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
13
-
-
0031936947
-
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
-
DOI 10.1002/(SICI)1098-2744(199802)21:2<81::AID-MC1>3.0.CO;2-R
-
Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog. 1998;21(2):81-86. (Pubitemid 28122842)
-
(1998)
Molecular Carcinogenesis
, vol.21
, Issue.2
, pp. 81-86
-
-
Ruggeri, B.A.1
Huang, L.2
Wood, M.3
Cheng, J.Q.4
Testa, J.R.5
-
14
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
DOI 10.1073/pnas.93.8.3636
-
Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA. 1996;93(8):3636-3641. (Pubitemid 26127592)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.8
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
15
-
-
54349103007
-
Lacobuzio-Donahue CA. Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma
-
Fu B, Luo M, Lakkur S, Lucito R, lacobuzio-Donahue CA. Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma. Cancer Biol Ther. 2008;7(10):1593-1601.
-
(2008)
Cancer Biol Ther.
, vol.7
, Issue.10
, pp. 1593-1601
-
-
Fu, B.1
Luo, M.2
Lakkur, S.3
Lucito, R.4
-
16
-
-
44949129758
-
Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer
-
doi:10.1371/journal.pgen.1000081
-
Kwei KA, Bashyam MD, KaoJ, et al. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genet. 2008;4(5):e1000081.doi:10.1371/journal.pgen.1000081.
-
(2008)
PLoS Genet.
, vol.4
, Issue.5
-
-
Kwei, K.A.1
Bashyam, M.D.2
Kao, J.3
-
17
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
DOI 10.1038/ng0994-27
-
Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTSD gene in pancreatic adenocarcinoma. Nat Genet. 1994;8(1):27-32. (Pubitemid 24274057)
-
(1994)
Nature Genetics
, vol.8
, Issue.1
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
Weinstein, C.L.7
Hruban, R.H.8
Yeo, C.J.9
Kern, S.E.10
-
18
-
-
0036369438
-
Epigenetics by DNA methylation for development of normal and cloned animals
-
DOI 10.1046/j.1432-0436.2002.690406.x
-
Shiota K, Yanagimachi R. Epigenetics by DNA methylation for development of normal and cloned animals. Differentiation. 2002;69(4-5):162-166. (Pubitemid 41701536)
-
(2002)
Differentiation
, vol.69
, Issue.4-5
, pp. 162-166
-
-
Shiota, K.1
Yanagimachi, R.2
-
19
-
-
0028308492
-
p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
-
Redston MS, Caldas C, Seymour AB, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res. 1994;54(11):3025-3033. (Pubitemid 24187791)
-
(1994)
Cancer Research
, vol.54
, Issue.11
, pp. 3025-3033
-
-
Redston, M.S.1
Caldas, C.2
Seymour, A.B.3
Hruban, R.H.4
Da, C.L.5
Yeo, C.J.6
Kern, S.E.7
-
20
-
-
0033891752
-
Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
-
Wilentz RE, Su GH, Dai JL, et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol. 2000;156(1):37-43. (Pubitemid 30644436)
-
(2000)
American Journal of Pathology
, vol.156
, Issue.1
, pp. 37-43
-
-
Wilentz, R.E.1
Su, G.H.2
Le, D.J.3
Sparks, A.B.4
Argani, P.5
Sohn, T.A.6
Yeo, C.J.7
Kern, S.E.8
Hruban, R.H.9
-
21
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
Schutte M, Hruban RH, Geradts J, et al. Abrogation of the Rb/p16 tumorsuppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997; 57(15):3126-3130. (Pubitemid 27351723)
-
(1997)
Cancer Research
, vol.57
, Issue.15
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
Maynard, R.4
Hilgers, W.5
Rabindran, S.K.6
Moskaluk, C.A.7
Hahn, S.A.8
Schwarte-Waldhoff, I.9
Schmiegel, W.10
Baylin, S.B.11
Kern, S.E.12
Herman, J.G.13
-
22
-
-
0034075153
-
Hypermethylation of multiple genes in pancreatic adenocarcinoma
-
Ueki T, Toyota M, Sohn T, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res. 2000;60(7):1835-1839. (Pubitemid 30207640)
-
(2000)
Cancer Research
, vol.60
, Issue.7
, pp. 1835-1839
-
-
Ueki, T.1
Toyota, M.2
Sohn, T.3
Yeo, C.J.4
Issa, J.-P.J.5
Hruban, R.H.6
Goggins, M.7
-
24
-
-
0035207991
-
Genetic profile of 22 pancreatic carcinoma cell lines: Analysis of K-ras, p53, p16 and DPC4/Smad4
-
Moore PS, Sipos B, Orlandini S, et al. Genetic profile of 22 pancreatic carcinoma cell lines: analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 2001;439(6):798-802. (Pubitemid 33141325)
-
(2001)
Virchows Archiv
, vol.439
, Issue.6
, pp. 798-802
-
-
Moore, P.S.1
Sipos, B.2
Orlandini, S.3
Sorio, C.4
Real, F.X.5
Lemoine, N.R.6
Gress, T.7
Bassi, C.8
Kloppel, G.9
Kalthoff, H.10
Ungefroren, H.11
Lohr, M.12
Scarpa, A.13
-
25
-
-
0027743438
-
Pancreatic adenocarcinomas frequently show p53 gene mutations
-
Scarpa A, Capelli P, Mukai K, et al. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol. 1993;142(5):1534-1543. (Pubitemid 24058140)
-
(1993)
American Journal of Pathology
, vol.142
, Issue.5
, pp. 1534-1543
-
-
Scarpa, A.1
Capelli, P.2
Mukai, K.3
Zamboni, G.4
Oda, T.5
Iacono, C.6
Hirohashi, S.7
-
26
-
-
4043181214
-
Cancer genes and the pathways they control
-
DOI 10.1038/nm1087
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004;10(8):789-799. (Pubitemid 39070849)
-
(2004)
Nature Medicine
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
27
-
-
1842481404
-
Missense mutations of MADH4: Characterization of the mutational hot spot and functional consequences in human tumors
-
lacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, Kern SE. Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res. 2004,10(5): 1597-1604.
-
(2004)
Clin Cancer Res.
, vol.10
, Issue.5
, pp. 1597-1604
-
-
Lacobuzio-Donahue, C.A.1
Song, J.2
Parmiagiani, G.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
28
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271 (5247):350-353.
-
(1996)
Science
, vol.271
, Issue.5247
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
-
29
-
-
0033759142
-
Dpc4 protein in mucinous cystic neoplasms of the pancreas: Frequent loss of expression in invasive carcinomas suggests a role in genetic progression
-
lacobuzio-Donahue CA, Wilentz RE, Argani P, et al. Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am J Surg Pathol. 2000,24(11):1544-1548.
-
(2000)
Am J Surg Pathol.
, vol.24
, Issue.11
, pp. 1544-1548
-
-
Lacobuzio-Donahue, C.A.1
Wilentz, R.E.2
Argani, P.3
-
30
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
-
Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer. 2003;3(11):807-821.
-
(2003)
Nat Rev Cancer.
, vol.3
, Issue.11
, pp. 807-821
-
-
Siegel, P.M.1
Massague, J.2
-
31
-
-
0034032009
-
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
-
Wilentz RE, lacobuzio-Donahue CA, Argani P, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60(7):2002-2006.
-
(2000)
Cancer Res.
, vol.60
, Issue.7
, pp. 2002-2006
-
-
Wilentz, R.E.1
Lacobuzio-Donahue, C.A.2
Argani, P.3
-
32
-
-
0035671396
-
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
-
Tascilar M, Skinner HG, Rosty C, et al. The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2001;7(12):4115-4121. (Pubitemid 34044636)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.12
, pp. 4115-4121
-
-
Tascilar, M.1
Skinner, H.G.2
Rosty, C.3
Sohn, T.4
Wilentz, R.E.5
Offerhaus, G.J.A.6
Adsay, V.7
Abrams, R.A.8
Cameron, J.L.9
Kern, S.E.10
Yeo, C.J.11
Hruban, R.H.12
Goggins, M.13
-
33
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009; 15(14):4674-4679.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.14
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
-
34
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res. 1996;56(111:2527-2530.
-
(1996)
Cancer Res.
, vol.56
, Issue.11
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
-
35
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
lacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27(111:1806-1813.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.11
, pp. 1806-1813
-
-
Lacobuzio-Donahue, C.A.1
Fu, B.2
Yachida, S.3
-
36
-
-
0032984141
-
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
-
Su GH, Hruban RH, Bansal RK, et al. Germline and somatic mutations of the STKI1/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol. 1999;154(6):1835-1840. (Pubitemid 29262866)
-
(1999)
American Journal of Pathology
, vol.154
, Issue.6
, pp. 1835-1840
-
-
Su, G.H.1
Hruban, R.H.2
Bansal, R.K.3
Bova, G.S.4
Tang, D.J.5
Shekher, M.C.6
Westerman, A.M.7
Entius, M.M.8
Goggins, M.9
Yeo, C.J.10
Kern, S.E.11
-
37
-
-
0035184065
-
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
-
Sato N, Rosty C, Jansen M, et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol. 2001;159(6):2017-2022. (Pubitemid 33104257)
-
(2001)
American Journal of Pathology
, vol.159
, Issue.6
, pp. 2017-2022
-
-
Sato, N.1
Rosty, C.2
Jansen, M.3
Fukushima, N.4
Ueki, T.5
Yeo, C.J.6
Cameron, J.L.7
Iacobuzio-Donahue, C.A.8
Hruban, R.H.9
Goggins, M.10
-
38
-
-
0032404111
-
Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
-
Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res. 1998;58(23):5329-5332. (Pubitemid 28551110)
-
(1998)
Cancer Research
, vol.58
, Issue.23
, pp. 5329-5332
-
-
Goggins, M.1
Shekher, M.2
Turnacioglu, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
39
-
-
0032100617
-
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
-
Su GH, Hilgers W, Shekher MC, et al. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res. 1998,58(111:2339-2342.
-
(1998)
Cancer Res.
, vol.58
, Issue.11
, pp. 2339-2342
-
-
Su, G.H.1
Hilgers, W.2
Shekher, M.C.3
-
40
-
-
0030757691
-
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor
-
Teng DH, Perry WL III, Hogan JK, et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res. 1997;57(19):4177-4182. (Pubitemid 27413418)
-
(1997)
Cancer Research
, vol.57
, Issue.19
, pp. 4177-4182
-
-
Teng, D.H.-F.1
Perry III, W.L.2
Hogan, J.K.3
Baumgard, M.4
Bell, R.5
Berry, S.6
Davis, T.7
Frank, D.8
Frye, C.9
Hattier, T.10
Hu, R.11
Jammulapati, S.12
Janecki, T.13
Leavitt, A.14
Mitchell, J.T.15
Pero, R.16
Sexton, D.17
Schroeder, M.18
Su, P.-H.19
Swedlund, B.20
Kyriakis, J.M.21
Avruch, J.22
Bartel, P.23
Wong, A.K.C.24
Oliphant, A.25
Thomas, A.26
Skolnick, M.H.27
Tavtigian, S.V.28
more..
-
41
-
-
0035853078
-
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
-
DOI 10.1073/pnas.051484398
-
Su GH, Bansal R, Murphy KM, et al. ACVRIB (ALK4, activin receptor type 1 B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci USA. 2001; 98(6):3254-3257. (Pubitemid 32220832)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3254-3257
-
-
Su, G.H.1
Bansal, R.2
Murphy, K.M.3
Montgomery, E.4
Yeo, C.J.5
Hruban, R.H.6
Kern, S.E.7
-
42
-
-
33751207530
-
Tumors of the pancreas. washington, DC: Armed forces institute of pathology
-
4th series
-
Hruban RH, Pitman MB, Klimstra DS. Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology; 2007. Atlas of Tumor Pathology, 4th series.
-
(2007)
Atlas of Tumor Pathology
-
-
Hruban, R.H.1
Pitman, M.B.2
Klimstra, D.S.3
-
43
-
-
0035020633
-
Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions
-
Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001;25(5):579-586.
-
(2001)
Am J Surg Pathol.
, vol.25
, Issue.5
, pp. 579-586
-
-
Hruban, R.H.1
Adsay, N.V.2
Albores-Saavedra, J.3
-
44
-
-
3042581455
-
The genetics of FANCC and FANCG in familial pancreatic cancer
-
Rogers CD, van der Heijden MS, Brune K, et al. The genetics of FANCC and FANCG in familial pancreatic cancer. Cancer Biol Ther. 2004;3(2):167-169. (Pubitemid 41350898)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.2
, pp. 167-169
-
-
Rogers, C.D.1
Van Der, H.M.S.2
Brune, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
Goggins, M.7
-
45
-
-
17144364694
-
Precursors to invasive pancreatic cancer
-
DOI 10.1097/01.pap.0000155055.14238.25
-
Maitra A, Fukushima N, Takaori K, Hruban RH. Precursors to invasive pancreatic cancer. Adv Anat Pathol. 2005;12(2):81-91. (Pubitemid 40515796)
-
(2005)
Advances in Anatomic Pathology
, vol.12
, Issue.2
, pp. 81-91
-
-
Maitra, A.1
Fukushima, N.2
Takaori, K.3
Hruban, R.H.4
-
46
-
-
0036841802
-
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
-
van Heek NT, Meeker AK, Kern SE, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol. 2002;161 (5):1541-1547.
-
(2002)
Am J Pathol.
, vol.161
, Issue.5
, pp. 1541-1547
-
-
Van Heek, N.T.1
Meeker, A.K.2
Kern, S.E.3
-
47
-
-
0033887693
-
Progression model for pancreatic cancer
-
Hruban RH, Goggins M, Parsons J, Kern SE. Progression model for pancreatic cancer. Clin Cancer Res. 2000;6(8):2969-2972. (Pubitemid 30637716)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.8
, pp. 2969-2972
-
-
Hruban, R.H.1
Goggins, M.2
Parsons, J.3
Kern, S.E.4
-
49
-
-
43349105069
-
PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/ carcinoma (IPMN/C) of the pancreas
-
Schonleben F, Qiu W, Remotti HE, Hohenberger W, Su GH. PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/ carcinoma (IPMN/C) of the pancreas. Langenbecks Arch Surg. 2008;393(3): 289-296.
-
(2008)
Langenbecks Arch Surg.
, vol.393
, Issue.3
, pp. 289-296
-
-
Schonleben, F.1
Qiu, W.2
Remotti, H.E.3
Hohenberger, W.4
Su, G.H.5
-
50
-
-
0028597442
-
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: An investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients
-
Sessa F, Solcia E, Capella C, et al. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch. 1994;425(4):357-367.
-
(1994)
Virchows Arch.
, vol.425
, Issue.4
, pp. 357-367
-
-
Sessa, F.1
Solcia, E.2
Capella, C.3
-
51
-
-
0031459206
-
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas
-
[discussion in: Ann Surg. 1997;226(4):498-500]
-
Z'graggen K, Rivera JA, Compton CC, et al. Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas [discussion in: Ann Surg. 1997;226(4):498-500]. Ann Surg. 1997;226(4):491-498.
-
(1997)
Ann Surg.
, vol.226
, Issue.4
, pp. 491-498
-
-
Z'Graggen, K.1
Rivera, J.A.2
Compton, C.C.3
-
52
-
-
35948976564
-
Genome-wide allelotypes of familial pancreatic adenocarcinomas and familial and sporadic intraductal papillary mucinous neoplasms
-
DOI 10.1158/1078-0432.CCR-07-0471
-
Abe T, Fukushima N, Brune K, et al. Genome-wide allelotypes of familial pancreatic adenocarcinomas and familial and sporadic intraductal papillary mucinous neoplasms. Clin Cancer Res. 2007;13(20):6019-6025. (Pubitemid 350075057)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.20
, pp. 6019-6025
-
-
Abe, T.1
Fukushima, N.2
Brune, K.3
Boehm, C.4
Sato, N.5
Matsubayashi, H.6
Canto, M.7
Petersen, G.M.8
Hruban, R.H.9
Goggins, M.10
-
53
-
-
0034495006
-
Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: Comparison with conventional ductal adenocarcinomas
-
lacobuzio-Donahue CA, Klimstra DS, Adsay NV, et al. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157(3):755-761.
-
(2000)
Am J Pathol.
, vol.157
, Issue.3
, pp. 755-761
-
-
Lacobuzio-Donahue, C.A.1
Klimstra, D.S.2
Adsay, N.V.3
-
54
-
-
0033497531
-
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy
-
discussion in: J. Ann Surg. 1999;230(4):501-509
-
Jimenez RE, Warshaw AL, Z'graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy [discussion in: Ann Surg. 1999;230(4):509-511J. Ann Surg. 1999;230(4):501-509.
-
(1999)
Ann Surg.
, vol.230
, Issue.4
, pp. 509-511
-
-
Jimenez, R.E.1
Warshaw, A.L.2
Z'graggen, K.3
-
55
-
-
0032955877
-
Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: A clinicopathologic study of 130 cases
-
DOI 10.1097/00000478-199901000-00001
-
Thompson LD, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999;23(1):1-16. (Pubitemid 29025236)
-
(1999)
American Journal of Surgical Pathology
, vol.23
, Issue.1
, pp. 1-16
-
-
Thompson, L.D.R.1
Becker, R.C.2
Przygodzki, R.M.3
Adair, C.F.4
Heffess, C.S.5
-
56
-
-
0242522859
-
Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
-
DOI 10.1097/01.MP.0000094088.37888.A6
-
Kim SG, Wu TT, Lee JH, et al. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod Pathol. 2003;16(11):1086-1094. (Pubitemid 37414202)
-
(2003)
Modern Pathology
, vol.16
, Issue.11
, pp. 1086-1094
-
-
Kim, S.G.1
Wu, T.-T.2
Lee, J.H.3
Yun, Y.K.4
Issa, J.-P.5
Hamilton, S.R.6
Rashid, A.7
-
57
-
-
0035192708
-
Colloid (mucinous noncystic) carcinoma of the pancreas
-
Adsay NV, Pierson C, Sarkar F, et al. Colloid (mucinous noncystic) carcinoma of the pancreas. Am J Surg Pathol. 2001 ;25(11:26-42.
-
(2001)
Am J Surg Pathol.
, vol.25
, Issue.11
, pp. 26-42
-
-
Adsay, N.V.1
Pierson, C.2
Sarkar, F.3
-
58
-
-
67349211022
-
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma
-
Brody JR, Costantino CL, Potoczek M, et al. Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. Mod Pathol. 2009;22(5):651-659.
-
(2009)
Mod Pathol.
, vol.22
, Issue.5
, pp. 651-659
-
-
Brody, J.R.1
Costantino, C.L.2
Potoczek, M.3
-
59
-
-
17644430199
-
+
-
Goggins M, Offerhaus GJ, Hilgers W, et al. Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology: poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol. 1998;152(6):1501-1507. (Pubitemid 28275008)
-
(1998)
American Journal of Pathology
, vol.152
, Issue.6
, pp. 1501-1507
-
-
Goggins, M.1
Offerhaus, G.J.A.2
Hilgers, W.3
Griffin, C.A.4
Shekher, M.5
Tang, D.6
Sohn, T.A.7
Yeo, C.J.8
Kern, S.E.9
Hruban, R.H.10
-
60
-
-
64049089987
-
Molecular classification of neoplasms of the pancreas
-
Hruban RH, Adsay NV. Molecular classification of neoplasms of the pancreas. Hum Patho J. 2009;40(5):612-623.
-
(2009)
Hum Patho J.
, vol.40
, Issue.5
, pp. 612-623
-
-
Hruban, R.H.1
Adsay, N.V.2
-
61
-
-
0033847858
-
Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity
-
Wilentz RE, Goggins M, Redston M, et al. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol. 2000;156(5):1641-1651. (Pubitemid 30646702)
-
(2000)
American Journal of Pathology
, vol.156
, Issue.5
, pp. 1641-1651
-
-
Wilentz, R.E.1
Goggins, M.2
Redston, M.3
Marcus, V.A.4
Volkan, A.N.5
Sohn, T.A.6
Kadkol, S.S.7
Yeo, C.J.8
Choti, M.9
Zahurak, M.10
Johnson, K.11
Tascilar, M.12
Offerhaus, G.J.A.13
Hruban, R.H.14
Kern, S.E.15
-
62
-
-
1542787474
-
Negative hMSH2 protein expression in pancreatic carcinoma may predict a better prognosis of patients
-
Nakata B, Wang YQ, Yashiro M, et al. Negative hMSH2 protein expression in pancreatic carcinoma may predict a better prognosis of patients. Oncol Rep. 2003; 10(4):997-1000.
-
(2003)
Oncol Rep.
, vol.10
, Issue.4
, pp. 997-1000
-
-
Nakata, B.1
Wang, Y.Q.2
Yashiro, M.3
-
63
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
-
DOI 10.1056/NEJMoa022289
-
Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349(3):247-257. (Pubitemid 36859476)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.3
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
Thibodeau, S.N.4
French, A.J.5
Goldberg, R.M.6
Hamilton, S.R.7
Laurent-Puig, P.8
Gryfe, R.9
Shepherd, L.E.10
Tu, D.11
Redston, M.12
Gallinger, S.13
-
64
-
-
3042801238
-
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: Delineation of an " intestinal" pathway of carcinogenesis in the pancreas
-
DOI 10.1097/00000478-200407000-00001
-
Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28(7):839-848. (Pubitemid 38856838)
-
(2004)
American Journal of Surgical Pathology
, vol.28
, Issue.7
, pp. 839-848
-
-
Adsay, N.V.1
Merati, K.2
Basturk, O.3
Iacobuzio-Donahue, C.4
Levi, E.5
Cheng, J.D.6
Sarkar, F.H.7
Hruban, R.H.8
Klimstra, D.S.9
-
65
-
-
0037407686
-
Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas
-
Adsay NV, Merati K, Nassar H, et al. Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Am J Surg Pathol. 2003;27(5):571-578.
-
(2003)
Am J Surg Pathol.
, vol.27
, Issue.5
, pp. 571-578
-
-
Adsay, N.V.1
Merati, K.2
Nassar, H.3
-
66
-
-
0031782102
-
Undifferentiated carcinoma of the pancreas: Analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin
-
DOI 10.1002/(SICI)1096-9896(199805)185:1<53::AID-PATH45>3.0.CO;2-F
-
Hoorens A, Prenzel K, Lemoine NR, Kloppel G. Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol. 1998;185(1):53-60. (Pubitemid 28266717)
-
(1998)
Journal of Pathology
, vol.185
, Issue.1
, pp. 53-60
-
-
Hoorens, A.1
Prenzel, K.2
Lemoine, N.R.3
Kloppel, G.4
-
67
-
-
38949178861
-
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
-
DOI 10.1158/1078-0432.CCR-07-0487
-
Winter JM, Ting AH, Vilardell F, et al. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res. 2008;14(2):412-418. (Pubitemid 351226108)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.2
, pp. 412-418
-
-
Winter, J.M.1
Ting, A.H.2
Vilardell, F.3
Gallmeier, E.4
Baylin, S.B.5
Hruban, R.H.6
Kern, S.E.7
Iacobuzio-Donahue, C.A.8
-
68
-
-
77949639777
-
Expression of LICAM, COX2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: Putative therapeutic targets?
-
Bergmann F, Moldenhauer G, Herpel E, et al. Expression of LICAM, COX2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets? Histopathology. 2010;56(4):440-448.
-
(2010)
Histopathology
, vol.56
, Issue.4
, pp. 440-448
-
-
Bergmann, F.1
Moldenhauer, G.2
Herpel, E.3
-
69
-
-
58749103181
-
Undifferentiated carcinoma with osteoclastic giant cells (UCOCGC) of the pancreas associated with the familial atypical multiple mole melanoma syndrome (FAMMM)
-
Koorstra JB, Maitra A, Morsink FH, et al. Undifferentiated carcinoma with osteoclastic giant cells (UCOCGC) of the pancreas associated with the familial atypical multiple mole melanoma syndrome (FAMMM). Am J Surg Pathol. 2008; 32(12):1905-1909.
-
(2008)
Am J Surg Pathol.
, vol.32
, Issue.12
, pp. 1905-1909
-
-
Koorstra, J.B.1
Maitra, A.2
Morsink, F.H.3
-
70
-
-
0030724379
-
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer
-
Kopreski MS, Benko FA, Kwee C, et al. Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. Br J Cancer. 1997;76(10): 1293-1299. (Pubitemid 27474970)
-
(1997)
British Journal of Cancer
, vol.76
, Issue.10
, pp. 1293-1299
-
-
Kopreski, M.S.1
Benko, F.A.2
Kwee, C.3
Leitzel, K.E.4
Eskander, E.5
Lipton, A.6
Gocke, C.D.7
-
71
-
-
0032055165
-
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region
-
DOI 10.1002/(SICI)1097-0142(19980401)82:7<1279::AID-CNCR10>3.0. CO;2-3
-
Molberg KH, Heffess C, Delgado R, Albores-Saavedra J. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer. 1998;82(7):1279-1287. (Pubitemid 28155389)
-
(1998)
Cancer
, vol.82
, Issue.7
, pp. 1279-1287
-
-
Molberg, K.H.1
Heffess, C.2
Delgado, R.3
Albores-Saavedra, J.4
-
72
-
-
0033753999
-
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas
-
Sakai Y, Kupelioglu AA, Yanagisawa A, et al. Origin of giant cells in osteoclast-like giant cell tumors of the pancreas. Hum Pathol. 2000;31(10):1223-1229.
-
(2000)
Hum Pathol.
, vol.31
, Issue.10
, pp. 1223-1229
-
-
Sakai, Y.1
Kupelioglu, A.A.2
Yanagisawa, A.3
-
73
-
-
0031683984
-
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: Genetic evidence to support origin from the duct epithelium
-
DOI 10.1097/00000478-199810000-00010
-
Westra WH, Sturm P, Drillenburg P, et al. K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium. Am J Surg Pathol. 1998;22(10):1247- 1254. (Pubitemid 28462773)
-
(1998)
American Journal of Surgical Pathology
, vol.22
, Issue.10
, pp. 1247-1254
-
-
Westra, W.H.1
Sturm, P.2
Drillenburg, P.3
Choti, M.A.4
Klimstra, D.S.5
Albores-Saavedra, J.6
Montag, A.7
Offerhaus, G.J.A.8
Hruban, R.H.9
-
75
-
-
13444268381
-
Cancer as a complex phenotype: Pattern of cancer distribution within and beyond the nuclear family
-
doi:10.1371/journal.pmed.0010065
-
Amundadottir LT, Thorvaldsson S, Gudbjartsson DF, et al. Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family. PLoS Med. 2004;1(3):e65. doi:10.1371/journal.pmed.0010065.
-
(2004)
PLoS Med.
, vol.1
, Issue.3
-
-
Amundadottir, L.T.1
Thorvaldsson, S.2
Gudbjartsson, D.F.3
-
76
-
-
11144353646
-
Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
-
DOI 10.1158/0008-5472.CAN-03-3823
-
Klein AP, Brune KA, Petersen GM, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004;64(7):2634-2638. (Pubitemid 38523922)
-
(2004)
Cancer Research
, vol.64
, Issue.7
, pp. 2634-2638
-
-
Klein, A.P.1
Brune, K.A.2
Petersen, G.M.3
Goggins, M.4
Tersmette, A.C.5
Offerhaus, G.J.A.6
Griffin, C.7
Cameron, J.L.8
Yeo, C.J.9
Kern, S.10
Hruban, R.H.11
-
77
-
-
0032777035
-
Pathology of incipient pancreatic cancer
-
Hruban RH, Wilentz RE, Goggins M, Offerhaus GJ, Yeo CJ, Kern SE. Pathology of incipient pancreatic cancer. Ann Oncol. 1999;10(suppl 4):9-11.
-
(1999)
Ann Oncol.
, vol.10
, Issue.SUPPL. 4
, pp. 9-11
-
-
Hruban, R.H.1
Wilentz, R.E.2
Goggins, M.3
Offerhaus, G.J.4
Yeo, C.J.5
Kern, S.E.6
-
78
-
-
0037420026
-
BRCA2 germline mutations in familial pancreatic carcinoma
-
Hahn SA, Greenhalf B, Ellis I, et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst. 2003;95(3):214-221. (Pubitemid 36240634)
-
(2003)
Journal of the National Cancer Institute
, vol.95
, Issue.3
, pp. 214-221
-
-
Hahn, S.A.1
Greenhalf, B.2
Ellis, I.3
Sina-Frey, M.4
Rieder, H.5
Korte, B.6
Gerdes, B.7
Kress, R.8
Ziegler, A.9
Raeburn, J.A.10
Campra, D.11
Grutzmann, R.12
Rehder, H.13
Rothmund, M.14
Schmiegel, W.15
Neoptolemos, J.P.16
Bartsch, D.K.17
-
79
-
-
24944434401
-
Cancer risks in BRCA2 families: Estimates for sites other than breast and ovary
-
DOI 10.1136/jmg.2004.028829
-
van Asperen CJ, Brohet RM, Meijers-Heijboer EJ, et al. Cancer risks in BRCA2 families: estimates for sites other than breast and ovary. J Med Genet. 2005;42(9):711-719. (Pubitemid 41306062)
-
(2005)
Journal of Medical Genetics
, vol.42
, Issue.9
, pp. 711-719
-
-
Van Asperen, C.J.1
Brohet, R.M.2
Meijers-Heijboer, E.J.3
Hoogerbrugqe, N.4
Verhoef, S.5
Vasen, H.F.A.6
Ausems, M.G.E.M.7
Menko, F.H.8
Gomez, G.E.B.9
Klijn, J.G.M.10
Hogervorst, F.B.L.11
Van Houwelingen, J.C.12
Van't, V.L.J.13
Rookus, M.A.14
Van Leeuwen, F.E.15
-
80
-
-
33846333535
-
Targeting fanconi anemia/BRCA2 pathway defects in cancer: The significance of preclinical pharmacogenomic models
-
DOI 10.1158/1078-0432.CCR-06-1637
-
Gallmeier E, Kern SE. Targeting Fanconi anemia/BRCA2 pathway defects in cancer: the significance of preclinical pharmacogenomic models. Clin Cancer Res. 2007;13(1):4-10. (Pubitemid 46121846)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.1
, pp. 4-10
-
-
Gallmeier, E.1
Kern, S.E.2
-
81
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
DOI 10.1038/nature03443
-
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005; 434(7035):913-917. (Pubitemid 40559005)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
82
-
-
27744568392
-
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-Ribose) polymerase: An issue of potency
-
McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. BRCA2deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADPRibose) polymerase: an issue of potency. Cancer Biol Ther. 2005;4(9):934-936. (Pubitemid 41598586)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.9
, pp. 934-936
-
-
McCabe, N.1
Lord, C.J.2
Tutt, A.N.J.3
Martin, N.M.B.4
Smith, G.C.M.5
Ashworth, A.6
-
83
-
-
27144532118
-
In vivo therapeutic responses contingent on fanconi anemia/BRCA2 status of the tumor
-
DOI 10.1158/1078-0432.CCR-05-1048
-
van der Heijden MS, Brody JR, Dezentje DA, et al. In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res. 2005;11(20):7508-7515. (Pubitemid 41507712)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.20
, pp. 7508-7515
-
-
Van Der, H.M.S.1
Brody, J.R.2
Dezentje, D.A.3
Gallmeier, E.4
Cunningham, S.C.5
Swartz, M.J.6
DeMarzo, A.M.7
Offerhaus, G.J.A.8
Isacoff, W.H.9
Hruban, R.H.10
Kern, S.E.11
-
85
-
-
0034464147
-
Very high risk of cancer in familial Peutz-Jeghers syndrome
-
Giardiello FM, Brensinger JD, Tersmette AC, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000;119(6):1447-1453. (Pubitemid 32198669)
-
(2000)
Gastroenterology
, vol.119
, Issue.6
, pp. 1447-1453
-
-
Giardiello, F.M.1
Brensinger, J.D.2
Tersmette, A.C.3
Goodman, S.N.4
Petersen, G.M.5
Booker, S.V.6
Cruz-Correa, M.7
Offerhaus, J.A.8
-
86
-
-
0029038538
-
CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families
-
Gruis NA, Sandkuijl LA, van der Velden PA, Bergman W, Frants RR. CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families. Melanoma Res. 1995; 5(31:169-177.
-
(1995)
Melanoma Res.
, vol.5
, Issue.31
, pp. 169-177
-
-
Gruis, N.A.1
Sandkuijl, L.A.2
Van Der Velden, P.A.3
Bergman, W.4
Frants, R.R.5
-
87
-
-
0025963801
-
Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome
-
Lynch HT, Fusaro RM. Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome. Pancreas. 1991;6(2):127-131.
-
(1991)
Pancreas
, vol.6
, Issue.2
, pp. 127-131
-
-
Lynch, H.T.1
Fusaro, R.M.2
-
88
-
-
58149229703
-
Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families
-
de Snoo FA, Bishop DT, Bergman W, et al. Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families. Clin Cancer Res. 2008;14(21):7151-7157.
-
(2008)
Clin Cancer Res.
, vol.14
, Issue.21
, pp. 7151-7157
-
-
De Snoo, F.A.1
Bishop, D.T.2
Bergman, W.3
-
89
-
-
68149173367
-
Hereditary pancreatitis: Clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSSI) in six Spanish families
-
de las Heras-Castano G, Castro-Senosiain B, Fontalba A, Lopez-Hoyos M, Sanchez-Juan P. Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSSI) in six Spanish families. JOP. 2009;10(3):249-255.
-
(2009)
JOP
, vol.10
, Issue.3
, pp. 249-255
-
-
De Las Heras-Castano, G.1
Castro-Senosiain, B.2
Fontalba, A.3
Lopez-Hoyos, M.4
Sanchez-Juan, P.5
-
90
-
-
0030975440
-
Hereditary pancreatitis and the risk of pancreatic cancer
-
Lowenfels AB, Maisonneuve P, DiMagno EP, et al. Hereditary pancreatitis and the risk of pancreatic cancer: International Hereditary Pancreatitis Study Group. J Natl Cancer Inst. 1997;89(6):442-446. (Pubitemid 27136736)
-
(1997)
Journal of the National Cancer Institute
, vol.89
, Issue.6
, pp. 442-446
-
-
Lowenfels, A.B.1
Maisonneuve, P.2
DiMagno, E.P.3
Elitsur, Y.4
Gates Jr., L.K.5
Perrault, J.6
Whitcomb, D.C.7
-
91
-
-
0036789204
-
SPINK1/PSTI mutations are associated with tropical pancreatitis and type Il diabetes mellitus in Bangladesh
-
Schneider A, Suman A, Rossi L, et al. SPINK1/PSTI mutations are associated with tropical pancreatitis and type Il diabetes mellitus in Bangladesh. Gastroenterology. 2002;123(4):1026-1030.
-
(2002)
Gastroenterology
, vol.123
, Issue.4
, pp. 1026-1030
-
-
Schneider, A.1
Suman, A.2
Rossi, L.3
-
92
-
-
10144246566
-
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
-
DOI 10.1038/ng1096-141
-
Whitcomb DC, Gorry MC, Preston RA, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996; 14(2): 141-145. (Pubitemid 26338792)
-
(1996)
Nature Genetics
, vol.14
, Issue.2
, pp. 141-145
-
-
Whitcomb, D.C.1
Gorry, M.C.2
Preston, R.A.3
Furey, W.4
Sossenheimer, M.J.5
Ulrich, C.D.6
Martin, S.P.7
Gates Jr., L.K.8
Amann, S.T.9
Toskes, P.P.10
Liddle, R.11
McGrath, K.12
Uomo, G.13
Post, J.C.14
Ehrlich, G.D.15
-
93
-
-
35348992639
-
The genetics of hereditary colon cancer
-
DOI 10.1101/gad.1593107
-
Rustgi AK. The genetics of hereditary colon cancer. Genes Dev. 2007; 21(20):2525-2538. (Pubitemid 47607664)
-
(2007)
Genes and Development
, vol.21
, Issue.20
, pp. 2525-2538
-
-
Rustgi, A.K.1
-
94
-
-
0025938038
-
Identification and characterization of the familial adenomatous polyposis coli gene
-
Groden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 1991;66(3):589-600.
-
(1991)
Cell
, vol.66
, Issue.3
, pp. 589-600
-
-
Groden, J.1
Thliveris, A.2
Samowitz, W.3
-
95
-
-
0025817880
-
Identification of FAP locus genes from chromosome 5q21
-
Kinzler KW, Nilbert MC, Su LK, et al. Identification of FAP locus genes from chromosome 5q21. Science. 1991;253(5020):661-665. (Pubitemid 21917199)
-
(1991)
Science
, vol.253
, Issue.5020
, pp. 661-665
-
-
Kinzler, K.W.1
Nilbert, M.C.2
Su, L.-K.3
Vogelstein, B.4
Bryan, T.M.5
Levy, D.B.6
Smith, K.J.7
Preisinger, A.C.8
Hedge, P.9
Mckechnie, D.10
Finniear, R.11
Markham, A.12
Groffen, J.13
Boguski, M.S.14
Altschul, S.F.15
Horii, A.16
Ando, H.17
Miyoshi, Y.18
Miki, Y.19
Nishisho, I.20
Nakamura, Y.21
more..
-
96
-
-
0027429364
-
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis
-
Giardiello FM, Offerhaus GJ, Lee DH, et al. Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut. 1993;34(10): 1394-1396. (Pubitemid 23293626)
-
(1993)
Gut
, vol.34
, Issue.10
, pp. 1394-1396
-
-
Giardiello, F.M.1
Offerhaus, G.J.A.2
Lee, D.H.3
Krush, A.J.4
Tersmette, A.C.5
Booker, S.V.6
Kelley, N.C.7
Hamilton, S.R.8
-
97
-
-
33847065486
-
The epigenomics of cancer
-
DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128(4):683-692. (Pubitemid 46273572)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
98
-
-
0023701018
-
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells: The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
-
Bestor T, Laudano A, Mattaliano R, Ingram V. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells: the carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988;203(4):971-983.
-
(1988)
J Mol Biol.
, vol.203
, Issue.4
, pp. 971-983
-
-
Bestor, T.1
Laudano, A.2
Mattaliano, R.3
Ingram, V.4
-
99
-
-
0031860739
-
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
-
Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet. 1998,-19(31:219-220.
-
(1998)
Nat Genet.
, vol.19
, Issue.31
, pp. 219-220
-
-
Okano, M.1
Xie, S.2
Li, E.3
-
100
-
-
0026575884
-
Isolation and characterization of the cDNA encoding human DNA methyltransferase
-
Yen RW, Vertino PM, Nelkin BD, et al. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res. 1992; 20(9):2287-2291.
-
(1992)
Nucleic Acids Res.
, vol.20
, Issue.9
, pp. 2287-2291
-
-
Yen, R.W.1
Vertino, P.M.2
Nelkin, B.D.3
-
101
-
-
77953571951
-
Pancreatic cancer DNMTI expression and sensitivity to DNMTI inhibitors
-
Li A, Omura N, Hong SM, Goggins M. Pancreatic cancer DNMTI expression and sensitivity to DNMTI inhibitors. Cancer Biol Ther. 2010;9(4).
-
(2010)
Cancer Biol Ther.
, vol.9
, Issue.4
-
-
Li, A.1
Omura, N.2
Hong, S.M.3
Goggins, M.4
-
102
-
-
0022540321
-
CpG-rich islands and the function of DNA methylation
-
Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986;321(6067):209-213. (Pubitemid 16016411)
-
(1986)
Nature
, vol.321
, Issue.6067
, pp. 209-213
-
-
Bird, A.P.1
-
104
-
-
35948981875
-
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
-
Shen L, Kondo Y, Guo Y, et al. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007;3(10):2023-2036.
-
(2007)
PLoS Genet.
, vol.3
, Issue.10
, pp. 2023-2036
-
-
Shen, L.1
Kondo, Y.2
Guo, Y.3
-
105
-
-
0037389979
-
Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues
-
Matsubayashi H, Sato N, Fukushima N, et al. Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. Clin Cancer Res. 2003;9(4):1446-1452. (Pubitemid 36418400)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.4
, pp. 1446-1452
-
-
Matsubayashi, H.1
Sato, N.2
Fukushima, N.3
Yeo, C.J.4
Walter, K.M.5
Brune, K.6
Sahin, F.7
Hruban, R.H.8
Goggins, M.9
-
106
-
-
12244255359
-
Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice
-
Matsubayashi H, Sato N, Brune K, et al. Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice. Clin Cancer Res. 2005,11(2, pt 1):573-583. (Pubitemid 40116882)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.2
, pp. 573-583
-
-
Matsubayashi, H.1
Sato, N.2
Brune, K.3
Blackford, A.L.4
Hruban, R.H.5
Canto, M.6
Yeo, C.J.7
Goggins, M.8
-
107
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3(6):415-428. (Pubitemid 34587077)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.6
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
108
-
-
0036023411
-
Prognostic value of microsatellite instability in resectable pancreatic cancer
-
Nakata B, Wang YQ, Yashiro M, et al. Prognostic value of microsatellite instability in resectable pancreatic cancer. Clin Cancer Res. 2002;8(8):2536-2540. (Pubitemid 34856337)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.8
, pp. 2536-2540
-
-
Nakata, B.1
Wang, Y.Q.2
Yashiro, M.3
Nishioka, N.4
Tanaka, H.5
Ohira, M.6
Ishikawa, T.7
Nishino, H.8
Hirakawa, K.9
-
109
-
-
0035300547
-
Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability
-
Yamamoto H, ltoh F, Nakamura H, et al. Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res. 2001 ;61 (71:3139-3144.
-
(2001)
Cancer Res.
, vol.61
, Issue.71
, pp. 3139-3144
-
-
Yamamoto, H.1
Ltoh, F.2
Nakamura, H.3
-
110
-
-
0042284883
-
SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions
-
DOI 10.1038/sj.onc.1206807
-
Sato N, Fukushima N, Maehara N, et al. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene. 2003;22(32):5021-5030. (Pubitemid 37026400)
-
(2003)
Oncogene
, vol.22
, Issue.32
, pp. 5021-5030
-
-
Sato, N.1
Fukushima, N.2
Maehara, N.3
Matsubayashi, H.4
Koopmann, J.5
Su, G.H.6
Hruban, R.H.7
Goggins, M.8
-
111
-
-
33846916208
-
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
-
DOI 10.1200/JCO.2006.07.8824
-
Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol. 2007;25(3):319-325. (Pubitemid 350003021)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.3
, pp. 319-325
-
-
Infante, J.R.1
Matsubayashi, H.2
Sato, N.3
Tonascia, J.4
Klein, A.P.5
Riall, T.A.6
Yeo, C.7
Iacobuzio-Donahue, C.8
Goggins, M.9
-
112
-
-
32044467674
-
Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers
-
Sato N, Fukushima N, Chang R, Matsubayashi H, Goggins M. Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers. Gastroenterology. 2006; 130(21:548-565.
-
(2006)
Gastroenterology
, vol.130
, Issue.21
, pp. 548-565
-
-
Sato, N.1
Fukushima, N.2
Chang, R.3
Matsubayashi, H.4
Goggins, M.5
-
113
-
-
13444291198
-
Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma
-
Sato N, Parker AR, Fukushima N, et al. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene. 2005,-24(51:850-858.
-
(2005)
Oncogene
, vol.24
, Issue.51
, pp. 850-858
-
-
Sato, N.1
Parker, A.R.2
Fukushima, N.3
-
114
-
-
1842432473
-
Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines
-
DOI 10.1038/sj.onc.1207395
-
Wada M, Yazumi S, Takaishi S, et al. Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene. 2004; 23(13):2401-2407. (Pubitemid 38496795)
-
(2004)
Oncogene
, vol.23
, Issue.13
, pp. 2401-2407
-
-
Wada, M.1
Yazumi, S.2
Takaishi, S.3
Hasegawa, K.4
Sawada, M.5
Tanaka, H.6
Ida, H.7
Sakakura, C.8
Ito, K.9
Ito, Y.10
Chiba, T.11
-
115
-
-
0042575343
-
Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
-
DOI 10.1038/sj.bjc.6601039
-
Fukushima N, Sato N, Sahin F, Su GH, Hruban RH, Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer. 2003;89(2):338-343. (Pubitemid 36980626)
-
(2003)
British Journal of Cancer
, vol.89
, Issue.2
, pp. 338-343
-
-
Fukushima, N.1
Sato, N.2
Sahin, F.3
Su, G.H.4
Hruban, R.H.5
Goggins, M.6
-
116
-
-
0041559969
-
Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs
-
Jansen M, Fukushima N, Rosty C, et al. Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. Cancer Biol Ther. 2002;1(3):293-296.
-
(2002)
Cancer Biol Ther.
, vol.1
, Issue.3
, pp. 293-296
-
-
Jansen, M.1
Fukushima, N.2
Rosty, C.3
-
117
-
-
0036097181
-
Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
-
Fukushima N, Sato N, Ueki T, et al. Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol. 2002;160(51:1573-1581.
-
(2002)
Am J Pathol.
, vol.160
, Issue.51
, pp. 1573-1581
-
-
Fukushima, N.1
Sato, N.2
Ueki, T.3
-
118
-
-
33745848467
-
Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma
-
Sato N, Fukushima N, Matsubayashi H, lacobuzio-Donahue CA, Yeo CJ, Goggins M. Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma. Cancer. 2006; 107(21:251-257.
-
(2006)
Cancer
, vol.107
, Issue.21
, pp. 251-257
-
-
Sato, N.1
Fukushima, N.2
Matsubayashi, H.3
Lacobuzio-Donahue, C.A.4
Yeo, C.J.5
Goggins, M.6
-
119
-
-
27644466889
-
Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling
-
Sato N, Matsubayashi H, Abe T, Fukushima N, Goggins M. Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. Clin Cancer Res. 2005,11(131:4681-4688.
-
(2005)
Clin Cancer Res.
, vol.11
, Issue.131
, pp. 4681-4688
-
-
Sato, N.1
Matsubayashi, H.2
Abe, T.3
Fukushima, N.4
Goggins, M.5
-
120
-
-
0028988158
-
Cloning of p57KIP2, a cyclindependent kinase inhibitor with unique domain structure and tissue distribution
-
Lee MH, Reynisdottir I, Massague J. Cloning of p57KIP2, a cyclindependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995;9(6):639-649.
-
(1995)
Genes Dev.
, vol.9
, Issue.6
, pp. 639-649
-
-
Lee, M.H.1
Reynisdottir, I.2
Massague, J.3
-
121
-
-
0028988159
-
P57KIP2, a structurally distinct member of the p21C1P1 Cdk inhibitor family, is a candidate tumor suppressor gene
-
Matsuoka S, Edwards MC, Bai C, et al. p57KIP2, a structurally distinct member of the p21C1P1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995;9(6):650-662.
-
(1995)
Genes Dev.
, vol.9
, Issue.6
, pp. 650-662
-
-
Matsuoka, S.1
Edwards, M.C.2
Bai, C.3
-
122
-
-
0036305839
-
Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas
-
Sato N, Ueki T, Fukushima N, et al. Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. Gastroenterology. 2002,-123(1):365-372.
-
(2002)
Gastroenterology
, vol.123
, Issue.1
, pp. 365-372
-
-
Sato, N.1
Ueki, T.2
Fukushima, N.3
-
123
-
-
56649085104
-
Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas
-
Hong SM, Kelly D, Griffith M, et al. Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas. Mod Pathol. 2008; 21(12):1499-1507.
-
(2008)
Mod Pathol.
, vol.21
, Issue.12
, pp. 1499-1507
-
-
Hong, S.M.1
Kelly, D.2
Griffith, M.3
-
124
-
-
39749128967
-
CpG island methylation profile of pancreatic intraepithelial neoplasia
-
DOI 10.1038/modpathol.3800991, PII 3800991
-
Sato N, Fukushima N, Hruban RH, Goggins M. CpG island methylation profile of pancreatic intraepithelial neoplasia. Mod Pathol. 2008;21(3):238-244. (Pubitemid 351304281)
-
(2008)
Modern Pathology
, vol.21
, Issue.3
, pp. 238-244
-
-
Sato, N.1
Fukushima, N.2
Hruban, R.H.3
Goggins, M.4
-
125
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
DOI 10.1038/301089a0
-
Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983;301 (5895):89-92. (Pubitemid 13154475)
-
(1983)
Nature
, vol.301
, Issue.5895
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
126
-
-
0021101229
-
The 5-methylcytosine content of DNA from human tumors
-
Gama-Sosa MA, Slagel VA, Trewyn RW, et al. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 1983;11(19):6883-6894.
-
(1983)
Nucleic Acids Res.
, vol.11
, Issue.19
, pp. 6883-6894
-
-
Gama-Sosa, M.A.1
Slagel, V.A.2
Trewyn, R.W.3
-
127
-
-
0031971515
-
A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
-
DOI 10.1086/301825
-
van der Put NM, Gabreels F, Stevens EM, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998;62(5):1044-1051. (Pubitemid 28199004)
-
(1998)
American Journal of Human Genetics
, vol.62
, Issue.5
, pp. 1044-1051
-
-
Van Der, P.N.M.J.1
Gabreels, F.2
Stevens, E.M.B.3
Smeitink, J.A.M.4
Trijbels, F.J.M.5
Eskes, T.K.A.B.6
Van Den, H.L.P.7
Blom, H.J.8
-
128
-
-
0030979178
-
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
-
Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA. 1997;94(7):3290-3295.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.7
, pp. 3290-3295
-
-
Blount, B.C.1
Mack, M.M.2
Wehr, C.M.3
-
129
-
-
0028925741
-
Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats
-
Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 1995; 55(9):1894-1901.
-
(1995)
Cancer Res.
, vol.55
, Issue.9
, pp. 1894-1901
-
-
Pogribny, I.P.1
Basnakian, A.G.2
Miller, B.J.3
Lopatina, N.G.4
Poirier, L.A.5
James, S.J.6
-
130
-
-
23644457453
-
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes
-
DOI 10.1016/S1542-3565(05)00359-9, PII S1542356505003599
-
Matsubayashi H, Skinner HG, lacobuzio-Donahue C, et al. Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes. Clin Gastroenterol Hepatol. 2005;3(8):752-760. (Pubitemid 41116727)
-
(2005)
Clinical Gastroenterology and Hepatology
, vol.3
, Issue.8
, pp. 752-760
-
-
Matsubayashi, H.1
Skinner, H.G.2
Iacobuzio-Donahue, C.3
Abe, T.4
Sato, N.5
Riall, T.S.6
Yeo, C.J.7
Kern, S.E.8
Goggins, M.9
-
131
-
-
0036141349
-
Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
-
Rosty C, Ueki T, Argani P, et al. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol. 2002; 160(11:45-50.
-
(2002)
Am J Pathol.
, vol.160
, Issue.11
, pp. 45-50
-
-
Rosty, C.1
Ueki, T.2
Argani, P.3
-
132
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
Sato N, Maitra A, Fukushima N, et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 2003;63(14):4158-4166. (Pubitemid 36917941)
-
(2003)
Cancer Research
, vol.63
, Issue.14
, pp. 4158-4166
-
-
Sato, N.1
Maitra, A.2
Fukushima, N.3
Van Heek, N.T.4
Matsubayashi, H.5
Iacobuzio-Donahue, C.A.6
Rosty, C.7
Goggins, M.8
-
133
-
-
33645321647
-
MicroRNAs in cell proliferation, cell death, and tumorigenesis
-
Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer. 2006;94(6):776-780.
-
(2006)
Br J Cancer.
, vol.94
, Issue.6
, pp. 776-780
-
-
Hwang, H.W.1
Mendell, J.T.2
-
134
-
-
33846188098
-
MicroRNAs as oncogenes and tumor suppressors
-
DOI 10.1016/j.ydbio.2006.08.028, PII S0012160606010967
-
Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol. 2007;302(1):1-12. (Pubitemid 46096921)
-
(2007)
Developmental Biology
, vol.302
, Issue.1
, pp. 1-12
-
-
Zhang, B.1
Pan, X.2
Cobb, G.P.3
Anderson, T.A.4
-
135
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature. 2005;438(7068):685-689.
-
(2005)
Nature
, vol.438
, Issue.7068
, pp. 685-689
-
-
Krutzfeldt, J.1
Rajewsky, N.2
Braich, R.3
-
136
-
-
18744396337
-
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
DOI 10.1073/pnas.242606799
-
Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2002;99(24): 15524-15529. (Pubitemid 35403967)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.24
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
Bichi, R.4
Zupo, S.5
Noch, E.6
Aldler, H.7
Rattan, S.8
Keating, M.9
Rai, K.10
Rassenti, L.11
Kipps, T.12
Negrini, M.13
Bullrich, F.14
Croce, C.M.15
-
137
-
-
27544495514
-
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
-
Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 2005;65(211:9628-9632.
-
(2005)
Cancer Res.
, vol.65
, Issue.21
, pp. 9628-9632
-
-
Hayashita, Y.1
Osada, H.2
Tatematsu, Y.3
-
138
-
-
34247869960
-
Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma [2]
-
DOI 10.1080/10428190601059738, PII 770740562
-
Rinaldi A, Poretti G, Kwee I, et al. Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma. Leuk Lymphoma. 2007;48(2):410-412. (Pubitemid 46994894)
-
(2007)
Leukemia and Lymphoma
, vol.48
, Issue.2
, pp. 410-412
-
-
Rinaldi, A.1
Poretti, G.2
Kwee, I.3
Zucca, E.4
Catapano, C.5
Tibiletti, M.G.6
Bertoni, F.7
-
139
-
-
33847748913
-
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
-
DOI 10.1158/0008-5472.CAN-06-4074
-
Brueckner B, Stresemann C, Kuner R, et al. The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res. 2007;67(4):1419-1423. (Pubitemid 46383365)
-
(2007)
Cancer Research
, vol.67
, Issue.4
, pp. 1419-1423
-
-
Brueckner, B.1
Stresemann, C.2
Kuner, R.3
Mund, C.4
Musch, T.5
Meister, M.6
Sultmann, H.7
Lyko, F.8
-
140
-
-
33744805399
-
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
-
DOI 10.1016/j.ccr.2006.04.020, PII S1535610806001437
-
Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006;9(6):435-443. (Pubitemid 43832188)
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
Friedman, J.M.4
Chuang, J.C.5
Coetzee, G.A.6
Jones, P.A.7
-
141
-
-
38949115888
-
DNA methylation regulates microRNA expression
-
Han L, Witmer PD, Casey E, Valle D, Sukumar S. DNA methylation regulates MicroRNA expression. Cancer Biol Ther. 2007;6(8):1284-1288. (Pubitemid 351590384)
-
(2007)
Cancer Biology and Therapy
, vol.6
, Issue.8
, pp. 1284-1288
-
-
Han, L.1
Witmer, P.D.2
Casey, E.3
Valle, D.4
Sukumar, S.5
-
142
-
-
37549008310
-
Widespread microRNA repression by Myc contributes to tumorigenesis
-
Chang TC, Yu D, Lee YS, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 2008;40(1):43-50.
-
(2008)
Nat Genet.
, vol.40
, Issue.1
, pp. 43-50
-
-
Chang, T.C.1
Yu, D.2
Lee, Y.S.3
-
143
-
-
20444479428
-
c-Myc-regulated microRNAs modulate E2F1 expression
-
DOI 10.1038/nature03677
-
O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Mycregulated microRNAs modulate E2F1 expression. Nature. 2005;435(7043):839-843. (Pubitemid 40839736)
-
(2005)
Nature
, vol.435
, Issue.7043
, pp. 839-843
-
-
O'Donnell, K.A.1
Wentzel, E.A.2
Zeller, K.I.3
Dang, C.V.4
Mendell, J.T.5
-
144
-
-
34247862190
-
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
-
DOI 10.1001/jama.297.17.1901
-
Bloomston M, Frankel WL, Petrocca F, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 2007;297(17):1901-1908. (Pubitemid 46707844)
-
(2007)
Journal of the American Medical Association
, vol.297
, Issue.17
, pp. 1901-1908
-
-
Bloomston, M.1
Frankel, W.L.2
Petrocca, F.3
Volinia, S.4
Alder, H.5
Hagan, J.P.6
Liu, C.-G.7
Bhatt, D.8
Taccioli, C.9
Croce, C.M.10
-
145
-
-
57049090610
-
MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival
-
Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M. MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. J Castrointest Sunj. 2008;12(12):2171-2176.
-
(2008)
J Castrointest Sunj.
, vol.12
, Issue.12
, pp. 2171-2176
-
-
Dillhoff, M.1
Liu, J.2
Frankel, W.3
Croce, C.4
Bloomston, M.5
-
146
-
-
33846813656
-
Expression profiling identifies microRNA signature in pancreatic cancer
-
DOI 10.1002/ijc.22394
-
Lee EJ, Gusev Y, Jiang J, et al. Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer. 2007; 120(5): 1046-1054. (Pubitemid 46214304)
-
(2007)
International Journal of Cancer
, vol.120
, Issue.5
, pp. 1046-1054
-
-
Eun, J.L.1
Gusev, Y.2
Jiang, J.3
Nuovo, G.J.4
Lerner, M.R.5
Frankel, W.L.6
Morgan, D.L.7
Postier, R.G.8
Brackett, D.J.9
Schmittgen, T.D.10
-
147
-
-
34248200155
-
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
-
DOI 10.1038/sj.onc.1210228, PII 1210228
-
Szafranska AE, Davison TS, John J, et al. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene. 2007;26(30):4442-4452. (Pubitemid 47014466)
-
(2007)
Oncogene
, vol.26
, Issue.30
, pp. 4442-4452
-
-
Szafranska, A.E.1
Davison, T.S.2
John, J.3
Cannon, T.4
Sipos, B.5
Maghnouj, A.6
Labourier, E.7
Hahn, S.A.8
-
148
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
DOI 10.1073/pnas.0510565103
-
Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 2006; 103(7):2257-2261. (Pubitemid 43271657)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.7
, pp. 2257-2261
-
-
Volinia, S.1
Calin, G.A.2
Liu, C.-G.3
Ambs, S.4
Cimmino, A.5
Petrocca, F.6
Visone, R.7
Iorio, M.8
Roldo, C.9
Ferracin, M.10
Prueitt, R.L.11
Yanaihara, N.12
Lanza, G.13
Scarpa, A.14
Vecchione, A.15
Negrini, M.16
Harris, C.C.17
Croce, C.M.18
-
149
-
-
62549109089
-
Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis
-
Zhang Y, Li M, Wang H, et al. Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg. 2009;33(4):698-709.
-
(2009)
World J Surg.
, vol.33
, Issue.4
, pp. 698-709
-
-
Zhang, Y.1
Li, M.2
Wang, H.3
-
150
-
-
34249817549
-
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
-
DOI 10.1016/j.molcel.2007.05.010, PII S1097276507003103
-
Chang TC, Wentzel EA, Kent OA, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007; 26(5):745-752. (Pubitemid 46856245)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 745-752
-
-
Chang, T.-C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, D.E.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
151
-
-
73549106305
-
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells
-
Kent OA, Mullendore M, Wentzel EA, et al. A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells. Cancer Biol Ther. 2009,8(21):2013-2024.
-
(2009)
Cancer Biol Ther.
, vol.8
, Issue.21
, pp. 2013-2024
-
-
Kent, O.A.1
Mullendore, M.2
Wentzel, E.A.3
-
152
-
-
77954354936
-
Pancreatic cancers epigenetically silence SIPI and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels
-
Li A, Omura N, Hong SM, et al. Pancreatic cancers epigenetically silence SIPI and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 2010,70(13): 5226-5237.
-
(2010)
Cancer Res.
, vol.70
, Issue.13
, pp. 5226-5237
-
-
Li, A.1
Omura, N.2
Hong, S.M.3
-
153
-
-
77949564293
-
Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma
-
Ryu JK, Hong SM, Karikari CA, Hruban RH, Goggins MG, Maitra A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology. 2010;10(1):66-73.
-
(2010)
Pancreatology
, vol.10
, Issue.1
, pp. 66-73
-
-
Ryu, J.K.1
Hong, S.M.2
Karikari, C.A.3
Hruban, R.H.4
Goggins, M.G.5
Maitra, A.6
-
154
-
-
62549154091
-
MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
-
Habbe N, Koorstra JB, Mendell JT, et al. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther. 2009;8(4):340-346.
-
(2009)
Cancer Biol Ther.
, vol.8
, Issue.4
, pp. 340-346
-
-
Habbe, N.1
Koorstra, J.B.2
Mendell, J.T.3
-
155
-
-
12644253827
-
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
-
Goggins M, Schutte M, Lu J, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 1996; 56(231:5360-5364.
-
(1996)
Cancer Res.
, vol.56
, Issue.23
, pp. 5360-5364
-
-
Goggins, M.1
Schutte, M.2
Lu, J.3
-
156
-
-
3442888541
-
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
-
Okami J, Simeone DM, Logsdon CD. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 2004;64(151:5338-5346.
-
(2004)
Cancer Res.
, vol.64
, Issue.15
, pp. 5338-5346
-
-
Okami, J.1
Simeone, D.M.2
Logsdon, C.D.3
-
157
-
-
0344827241
-
Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control
-
Fitzgerald M, Oshiro M, Holtan N, et al. Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia. 2003;5(5):427-436. (Pubitemid 37475651)
-
(2003)
Neoplasia
, vol.5
, Issue.5
, pp. 427-436
-
-
Fitzgerald, M.1
Oshiro, M.2
Holtan, N.3
Krager, K.4
Cullen, J.J.5
Futscher, B.W.6
Domann, F.E.7
-
158
-
-
0142123394
-
Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
-
DOI 10.1016/S0304-3835(03)00390-2
-
Ohike N, Maass N, Mundhenke C, et al. Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. Cancer Lett. 2003;199(2):193-200. (Pubitemid 37297712)
-
(2003)
Cancer Letters
, vol.199
, Issue.2
, pp. 193-200
-
-
Ohike, N.1
Maass, N.2
Mundhenke, C.3
Biallek, M.4
Zhang, M.5
Jonat, W.6
Luttges, J.7
Morohoshi, T.8
Kloppel, G.9
Nagasaki, K.10
-
159
-
-
0037379406
-
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
-
lacobuzio-Donahue CA, Maitra A, Olsen M, et al. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol. 2003;162(4):1151-1162.
-
(2003)
Am J Pathol.
, vol.162
, Issue.4
, pp. 1151-1162
-
-
Lacobuzio-Donahue, C.A.1
Maitra, A.2
Olsen, M.3
|