The genetics of FANCC and FANCG in familial pancreatic cancer

Cancer Biology and Therapy

Volumn 3, Issue 2, 2004, Pages 167-169

  Rogers, Carmelle D ^a   Van Der Heijden, Michiel S ^a   Brune, Kieran ^a   Yeo, Charles J ^a   Hruban, Ralph H ^a   Kern, Scott E ^a   Goggins, Michael ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BRCA2; Familial; Polymorphism

Indexed keywords

ARTICLE; CANCER FAMILY; CANCER GENETICS; CLINICAL ARTICLE; EXON; FAMILIAL CANCER; FANCC GENE; FANCG GENE; FANCONI ANEMIA; GENE MUTATION; GENETIC POLYMORPHISM; GENETICS; HUMAN; INTRON; ONCOGENE; PANCREAS CANCER; PHENOTYPE; SEQUENCE ANALYSIS; SOMATIC MUTATION; FEMALE; GENETIC PREDISPOSITION; MALE; MUTATION; PANCREAS TUMOR; PATHOLOGY; PEDIGREE;

DNA; DNA BINDING PROTEIN; FANCE PROTEIN, HUMAN; FANCG PROTEIN, HUMAN; FANCONI ANEMIA GROUP E PROTEIN; FANCONI ANEMIA GROUP G PROTEIN; NUCLEAR PROTEIN;

DNA, NEOPLASM; DNA-BINDING PROTEINS; FANCONI ANEMIA COMPLEMENTATION GROUP E PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP G PROTEIN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; MALE; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; PEDIGREE;

EID: 3042581455     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.2.609     Document Type: Article

References (22)

1. Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, et al. BRCA1-independent ubiquitination of FANCD2. Mol Cell 2003; 12:247-54.
2. Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C, et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002; 297:606-9.
3. Van der Heijden MS, Yeo CJ, Hruban RH, Kern SE. Fanconi Anemia Gene Mutations in Young-onset Pancreatic Cancer. Cancer Res 2003; 63:2585-8.
4. Grompe M, D'Andrea A. Fanconi anemia and DNA repair. Hum Mol Genet 2001; 10:2253-9.
5. Joenje H, Patel KJ. The emerging genetic and molecular basis of Fanconi anaemia. Nat Rev Genet 2001; 2:446-57.
6. Alter BP, Greene MH, Velazquez I, Rosenberg PS. Cancer in Fanconi anemia. Blood 2003; 101:2072.
7. Auerbach AD. Fanconi anemia diagnosis and the diepoxybutane (DEB) test. Exp Hematol 1993; 21:731-3.
8. Auerbach AD, Rogatko A, Schroeder-Kurth TM. International Fanconi Anemia Registry: Relation of clinical symptoms to diepoxybutane sensitivity. Blood 1989; 73:391-6.
9. Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001; 7:249-62.
10. Goggins M, Schutte M, Lu J, Moskaluk CA, Weinstein CL, Petersen GM, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996; 56:5360-4.
11. Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst 1999; 91:1310-6.
12. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet 1998; 62:676-89.
13. Murphy KM, Brune KA, Griffin C, Sollenberger JE, Petersen GM, Bansal R, et al. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: Deleterious BRCA2 mutations in 17%. Cancer Res 2002; 62:3789-93.
14. Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, Korte B, et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 2003; 95:214-21.
15. Verlander PC, Lin JD, Udono MU, Zhang Q, Gibson RA, Mathew CG, et al. Mutation analysis of the Fanconi anemia gene FACC. Am J Hum Genet 1994; 54:595-601.
16. Tischkowitz MD, Hodgson SV. Fanconi anaemia. J Med Genet 2003; 40:1-10.
17. Bogliolo M, Cabre O, Callen E, Castillo V, Creus A, Marcos R, et al. The Fanconi anaemia genome stability and tumour suppressor network. Mutagenesis 2002; 17:529-38.
18. Petersen GM, Hruban RH. Familial pancreatic cancer: Where are we in 2003? J Natl Cancer Inst 2003; 95:180-1.
19. Eberle MA, Pfutzer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, et al. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet 2002; 70:1044-8.
20. Klein AP, Beaty TH, Bailey-Wilson JE, Brune KA, Hruban RH, Petersen GM. Evidence for a major gene influencing risk of pancreatic cancer. Genet Epidemiol 2002; 23:133-49.
21. Houghtaling S, Timmers C, Noll M, Finegold MJ, Jones SN, Meyn MS, et al. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev 2003; 31:31.
22. Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, et al. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res 2003; 63:4204-10.