K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: Genetic evidence to support origin from the duct epithelium

American Journal of Surgical Pathology

Volumn 22, Issue 10, 1998, Pages 1247-1254

  Westra, William H ^a   Sturm, Patrick ^b   Drillenburg, Paul ^b   Choti, Michael A ^a   Klimstra, David S ^c   Albores Saavedra, Jorge ^d   Montag, Anthony ^e   Offerhaus, G Johan A ^b   Hruban, Ralph H ^a,f  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Giant cell tumor; K ras; Oncogenes; Osteoclast; Osteoclast like; Pancreas; Pancreatic neoplasms

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM TUMOR; GIANT CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; MACROPHAGE; MONONUCLEAR CELL; ONCOGENE K RAS; OSTEOCLAST; PANCREAS TUMOR; PHAGOCYTOSIS;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BILE DUCTS; DNA PRIMERS; DNA, NEOPLASM; EPITHELIAL CELLS; GENES, RAS; GIANT CELL TUMORS; GIANT CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MACROPHAGES; MUTATION; OSTEOCLASTS; PANCREATIC DUCTS; PANCREATIC NEOPLASMS;

EID: 0031683984     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199810000-00010     Document Type: Article

References (33)

1. Andreola S, Lombardi L, Scurelli A, Bersiga A. Osteoclastoma-like giant-cell tumor of the liver. Case report. Tumori 1985;71: 615-20.
2. Berendt R, Shnitka T, Wiens E, Manickavel V, Jewell L. The osteoclast-type giant cell tumor of the pancreas. Arch Pathol Lab Med 1987;111:43-8.
3. Bergman S, Medeiros L, Radr T, Mangham D, Lewandrowski K. Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. Int J Pancreatol 1995;18: 71-5.
4. Brat D, Lillemoe K, Yeo C, Warfield P, Hruban R. Progression of pancreatic intraductal neoplasia to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol 1998;22:163-9.
5. Caldas C, Hahn S, Hruban R, Redston M, Yeo C, Kern S. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 1994;54:3568-73.
6. Cubilla A, Fitzgerald P. Malignant neoplasms. In: Cubilla A, Fitzgerald P, eds. Tumors of the Exocrine Pancreas, 2nd series ed. Washington, DC: Armed Forces Institute of Pathology; 1984:111-233.
7. Dahir G, Vnencak-Jones C, Schwartz H, Butler M. Dosage and allelic restriction fragment studies and per analysis of the H-ras locus in giant cell tumor of bone. Cancer Genet Cytogenet 1994; 74:95-8.
8. DiGiuseppe J, Hruban R, Offerhaus G, Clement M, van den Berg F, Cameron J, van Mansfeld A. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma. Am J Pathol 1994;144:889-95.
9. Dizon M, Multhaupt H, Paskin D, Warhol M. Osteoclastic giant cell tumor of the pancreas. Arch Pathol Lab Med 1996;120:306-9.
10. Doussis I, Gatter K, Mason D. CD68 reactivity of non-macrophage derived tumours in cytological specimens. J Clin Pathol 1993;46: 334-6.
11. Gloghini A, Rizzo A, Zanette I, Canal B, Rupolo G, Bassi P. KP1/CD68 expression in malignant neoplasms including lymphomas, sarcomas, and carcinomas. Am J Clin Pathol 1995;103:425-31.
12. Gocke C, Dabbs D, Benko F, Silverman J. KRAS oncogen mutations suggest a common histogenetic origin for pleomorphic giant cell tumor of the pancreas, osteoclastoma of the pancreas, and pancreatic duct adenocarcinoma. Hum Pathol 1997;28:80-3.
13. Goldberg R, Michelassi F, Montag A. Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone. Hum Pathol 1991;22:618-22.
14. Hahn S, Kern S. Molecular genetics of exocrine pancreatic neoplasms. Surg Clin North Am 1995;75:857-69.
15. Hood D, Bauer T, Leibel S, McMahon J. Hepatic giant cell carcinoma. Am J Clin Pathol 1990;93:111-6.
16. Horie Y, Hirayama C, Hashimoto K, Yumoto C, Tanikawa K. Osteoclast-like giant cell tumor of the liver. Acta Pathol Jpn 1987; 37:1327-35.
17. Hruban R, van Mansfeld A, Offerhaus G, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993;143:545-54.
18. Jalloh S. Giant cell tumour (osteoclastoma) of the pancreas - an epithelial tumour probably of pancreatic acinar origin. J Clin Pathol 1983;36:1171-5.
19. Janatpour K, Teplitz R, Min B, et al. Pancreatic tumors with osteoclastic and pleomorphic giant cells. Mod Pathol 1995;8:129. Abstract.
20. Jeffrey I, Crow J, Ellis B. Osteoclast-type giant cell tumour of the pancreas. J Clin Pathol 1983;36:1165-70.
21. Klimstra D, Rosai J. Critical commentary on "Osteoclastical giant cell tumor of the pancreas." Pathol Res Pract 1993;189:232-3.
22. Lewandrowski K, Weston L, Dickersin G, Rattner D, Compton C. Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: evidence for a histogenetic relationship and mesenchymal differentiation. Hum Pathol 1990;21:1184-7.
23. Mentes A, Yuce G. Osteoclast-type giant cell tumor of the pancreas associated with mucinous cystadenoma. Eur J Surg Oncol 1993;19:84-6.
24. Molberg K, Heffess C, Delgado R, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer 1998;82:1288-95.
25. Moskaluk C, Hruban R, Kern S. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997;57:2140-3.
26. Munoz P, Rao M, Reddy J. Osteoclastoma-like giant cell tumor of the liver. Cancer 1980;46:771-9.
27. Pompetti F, Rizzo P, Simon R, et al. Oncogene alterations in primary, recurrent, and metastatic bone tumors. J Cell Biochem 1996;63:37-50.
28. Rosai J. Carcinoma of pancreas simulating giant cell tumor of bone: electron-microscopic evidence of its acinar cell origin. Cancer 1968;22:333-44.
29. Rosai J. Liver cell carcinoma with osteoclast-like giant cells: non-epitheliogenic giant cells in diverse malignancies. Hepatology 1990;12:782-3.
30. Slebos RJC, Boerrigter L, Evers SG, Wisman P, Mooi WJ, Rodenhuis S. A rapid and simple procedure for the routine detection of ras point mutations in formalin-fixed paraffin-embedded tissues. Diagn Mol Pathol 1992;1:136-41.
31. Solcia E, Capella C, Kloppel G. Tumors of the exocrine pancreas. In: Rosai J, Sobin L, eds. Tumors of the Pancreas, 3rd series, fascicle 20. Washington, DC: Armed Forces Institute of Pathology: 1997:31-144.
32. Trepeta R, Mathur B, Lagin S, LiVolsi V. Giant cell tumor ("osteoclastoma") of the pancreas: a tumor of epithelial origin. Cancer 1981;48:2022-8.
33. Wright D, Manos M. Sample Preparation from Paraffin-Embedded Tissues. PCR Protocols. San Diego: Academic Press; 1990.