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Volumn 13, Issue 1, 2003, Pages 6-13

Ras redux: Rethinking how and where Ras acts

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RAS PROTEIN;

EID: 0037310529     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00017-5     Document Type: Review
Times cited : (74)

References (58)
  • 1
    • 0008903932 scopus 로고
    • Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses
    • Der C.J., Krontiris T.G., Cooper G.M. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc. Natl. Acad. Sci. U.S.A. 79:1982;3637-3640.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 3637-3640
    • Der, C.J.1    Krontiris, T.G.2    Cooper, G.M.3
  • 2
    • 0020328955 scopus 로고
    • Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
    • Parada L.F., Tabin C.J., Shih C., Weinberg R.A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 297:1982;474-478.
    • (1982) Nature , vol.297 , pp. 474-478
    • Parada, L.F.1    Tabin, C.J.2    Shih, C.3    Weinberg, R.A.4
  • 3
    • 0019973408 scopus 로고
    • T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
    • Santos E., Tronick S.R., Aaronson S.A., Pulciani S., Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 298:1982;343-347.
    • (1982) Nature , vol.298 , pp. 343-347
    • Santos, E.1    Tronick, S.R.2    Aaronson, S.A.3    Pulciani, S.4    Barbacid, M.5
  • 4
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • Bos J.L. The ras gene family and human carcinogenesis. Mutat. Res. 195:1988;255-271.
    • (1988) Mutat. Res. , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 5
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 6
    • 0036091925 scopus 로고    scopus 로고
    • Ras signalling on the endoplasmic reticulum and the Golgi
    • Through the use of a fluorescence-tagged Ras-binding domain reporter, the authors demonstrate that Ras can engage and activate effector signaling pathways from endomembrane compartments to induce biological outcomes. These findings subvert previous dogma restricting Ras activity to the PM. Together with other studies demonstrating distinct subcellular compartmentalization of Ras isoforms, these data may also explain how Ras proteins induce isoform-specific cellular responses
    • Chiu V.K., Bivona T., Hach A., Sajous J.B., Silletti J., Wiener H., Johnson R.L. II, Cox A.D., Philips M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4:2002;343-350 Through the use of a fluorescence-tagged Ras-binding domain reporter, the authors demonstrate that Ras can engage and activate effector signaling pathways from endomembrane compartments to induce biological outcomes. These findings subvert previous dogma restricting Ras activity to the PM. Together with other studies demonstrating distinct subcellular compartmentalization of Ras isoforms, these data may also explain how Ras proteins induce isoform-specific cellular responses.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 343-350
    • Chiu, V.K.1    Bivona, T.2    Hach, A.3    Sajous, J.B.4    Silletti, J.5    Wiener, H.6    Johnson R.L. II7    Cox, A.D.8    Philips, M.R.9
  • 7
    • 18644382594 scopus 로고    scopus 로고
    • CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
    • On the basis of evidence for a new link between ras overexpression and down-regulation of CDK4 protein levels, the authors present a unique model for transforming human keratinocytes requiring ectopic coexpression of ras and CDK4 only. Ras/CDK4 co-transduced keratinocytes form invasive tumors resembling SCC in xenograft models. Curiously, however, such cells are neither immortal nor transformed by standard tissue culture criteria. This model may prove useful not only for exploring the minimal requirements to make human tumor cells but also to investigate the dynamic reciprocal interactions between tumor cells and tissue microenvironment and the efficacy of potential targeted therapies against Ras and CDKs
    • Lazarov M., Kubo Y., Cai T., Dajee M., Tarutani M., Lin Q., Fang M., Tao S., Green C.L., Khavari P.A. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat. Med. 8:2002;1105-1114 On the basis of evidence for a new link between ras overexpression and down-regulation of CDK4 protein levels, the authors present a unique model for transforming human keratinocytes requiring ectopic coexpression of ras and CDK4 only. Ras/CDK4 co-transduced keratinocytes form invasive tumors resembling SCC in xenograft models. Curiously, however, such cells are neither immortal nor transformed by standard tissue culture criteria. This model may prove useful not only for exploring the minimal requirements to make human tumor cells but also to investigate the dynamic reciprocal interactions between tumor cells and tissue microenvironment and the efficacy of potential targeted therapies against Ras and CDKs.
    • (2002) Nat. Med. , vol.8 , pp. 1105-1114
    • Lazarov, M.1    Kubo, Y.2    Cai, T.3    Dajee, M.4    Tarutani, M.5    Lin, Q.6    Fang, M.7    Tao, S.8    Green, C.L.9    Khavari, P.A.10
  • 8
    • 0037102561 scopus 로고    scopus 로고
    • Distinct requirements for Ras oncogenesis in human versus mouse cells
    • The authors express effector-specific ras mutants in different human cell types immortalized with hTERT and SV40 large T and small t antigens to determine which pathway(s) is predominant in causing transformation. Surprisingly, and in contrast to a large body of evidence in rodent systems, activation of the RalGEF pathway alone is sufficient to cause these permissive human cells to grow in soft agar. Neither PI3K-specific nor MAPK-specific mutants, either alone or in combination, could do so. Notably, however, activation of all three pathways was necessary for these cells to form tumors in nude mice. Nevertheless, these data require reassessment of the view that the MAPK pathway predominates in promoting proliferation and transformation, at least in human cells
    • Hamad N.M., Elconin J.H., Karnoub A.E., Bai W., Rich J.N., Abraham R.T., Der C.J., Counter C.M. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 16:2002;2045-2057 The authors express effector-specific ras mutants in different human cell types immortalized with hTERT and SV40 large T and small t antigens to determine which pathway(s) is predominant in causing transformation. Surprisingly, and in contrast to a large body of evidence in rodent systems, activation of the RalGEF pathway alone is sufficient to cause these permissive human cells to grow in soft agar. Neither PI3K-specific nor MAPK-specific mutants, either alone or in combination, could do so. Notably, however, activation of all three pathways was necessary for these cells to form tumors in nude mice. Nevertheless, these data require reassessment of the view that the MAPK pathway predominates in promoting proliferation and transformation, at least in human cells.
    • (2002) Genes Dev. , vol.16 , pp. 2045-2057
    • Hamad, N.M.1    Elconin, J.H.2    Karnoub, A.E.3    Bai, W.4    Rich, J.N.5    Abraham, R.T.6    Der, C.J.7    Counter, C.M.8
  • 9
    • 0035337097 scopus 로고    scopus 로고
    • Ras effectors: Buying shares in Ras plc
    • Cullen P.J. Ras effectors: buying shares in Ras plc. Curr. Biol. 11:2001;R342-R344.
    • (2001) Curr. Biol. , vol.11
    • Cullen, P.J.1
  • 11
    • 0032401757 scopus 로고    scopus 로고
    • All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
    • Bos J.L. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J. 17:1998;6776-6782.
    • (1998) EMBO J. , vol.17 , pp. 6776-6782
    • Bos, J.L.1
  • 13
    • 0035131187 scopus 로고    scopus 로고
    • A Ras by any other name
    • Bar-Sagi D. A Ras by any other name. Mol. Cell Biol. 21:2001;1441-1443.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1441-1443
    • Bar-Sagi, D.1
  • 15
    • 0031043776 scopus 로고    scopus 로고
    • Signal transduction from multiple Ras effectors
    • Katz M.E., McCormick F. Signal transduction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7:1997;75-79.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 75-79
    • Katz, M.E.1    McCormick, F.2
  • 16
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351:2000;289-305.
    • (2000) Biochem. J. , vol.351 , pp. 289-305
    • Kolch, W.1
  • 17
    • 0025010979 scopus 로고
    • The GTPase superfamily: A conserved switch for diverse cell functions
    • Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 348:1990;125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 18
    • 0035936783 scopus 로고    scopus 로고
    • NF1 tumor suppressor gene function: Narrowing the GAP
    • Cichowski K., Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell. 104:2001;593-604.
    • (2001) Cell , vol.104 , pp. 593-604
    • Cichowski, K.1    Jacks, T.2
  • 19
    • 0028170814 scopus 로고
    • Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes
    • Glomset J.A., Farnsworth C.C. Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes. Annu. Rev. Cell Biol. 10:1994;181-205.
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 181-205
    • Glomset, J.A.1    Farnsworth, C.C.2
  • 20
    • 0033538474 scopus 로고    scopus 로고
    • New insights into the interaction of Ras with the plasma membrane
    • Magee T., Marshall C. New insights into the interaction of Ras with the plasma membrane. Cell. 98:1999;9-12.
    • (1999) Cell , vol.98 , pp. 9-12
    • Magee, T.1    Marshall, C.2
  • 22
    • 0034062812 scopus 로고    scopus 로고
    • H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
    • Apolloni A., Prior I.A., Lindsay M., Parton R.G., Hancock J.F. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol. Cell Biol. 20:2000;2475-2487.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2475-2487
    • Apolloni, A.1    Prior, I.A.2    Lindsay, M.3    Parton, R.G.4    Hancock, J.F.5
  • 23
    • 0030727170 scopus 로고    scopus 로고
    • Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking
    • Thissen J.A., Gross J.M., Subramanian K., Meyer T., Casey P.J. Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. J. Biol. Chem. 272:1997;30362-30370.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30362-30370
    • Thissen, J.A.1    Gross, J.M.2    Subramanian, K.3    Meyer, T.4    Casey, P.J.5
  • 24
    • 0034731405 scopus 로고    scopus 로고
    • The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
    • Chen Z., Otto J.C., Bergo M.O., Young S.G., Casey P.J. The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. J. Biol. Chem. 275:2000;41251-41257.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41251-41257
    • Chen, Z.1    Otto, J.C.2    Bergo, M.O.3    Young, S.G.4    Casey, P.J.5
  • 26
    • 0035067187 scopus 로고    scopus 로고
    • GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
    • Together with their earlier study on the effects of disrupting calveolae [25], the authors demonstrate that H-ras and K-ras4B segregate to discrete domains within the inner leaflet of the PM and, in the case of H-ras, that this specific sublocalization is necessary for biological activity. In addition, for maximal efficacy, H-ras must be able to shift laterally in a GTP-dependent manner from lipid rafts into the disordered PM. The authors also establish a new function for the linker sequence of the hypervariable region, as its deletion prevents this release of H-ras from rafts. The existence of specialized islands of H-ras activity amidst a disordered lipid sea scattered with K-ras may contribute to the abilities of these isoforms to engender unique cellular responses
    • Prior I.A., Harding A., Yan J., Sluimer J., Parton R.G., Hancock J.F. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3:2001;368-375 Together with their earlier study on the effects of disrupting calveolae [25], the authors demonstrate that H-ras and K-ras4B segregate to discrete domains within the inner leaflet of the PM and, in the case of H-ras, that this specific sublocalization is necessary for biological activity. In addition, for maximal efficacy, H-ras must be able to shift laterally in a GTP-dependent manner from lipid rafts into the disordered PM. The authors also establish a new function for the linker sequence of the hypervariable region, as its deletion prevents this release of H-ras from rafts. The existence of specialized islands of H-ras activity amidst a disordered lipid sea scattered with K-ras may contribute to the abilities of these isoforms to engender unique cellular responses.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 368-375
    • Prior, I.A.1    Harding, A.2    Yan, J.3    Sluimer, J.4    Parton, R.G.5    Hancock, J.F.6
  • 27
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 28
    • 0031692336 scopus 로고    scopus 로고
    • The caveolae membrane system
    • Anderson R.G. The caveolae membrane system. Annu. Rev. Biochem. 67:1998;199-225.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 199-225
    • Anderson, R.G.1
  • 30
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 31
    • 0008573656 scopus 로고    scopus 로고
    • Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: Implications in prevention of apoptosis
    • Rebollo A., Perez-Sala D., Martinez A.C. Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis. Oncogene. 18:1999;4930-4939.
    • (1999) Oncogene , vol.18 , pp. 4930-4939
    • Rebollo, A.1    Perez-Sala, D.2    Martinez, A.C.3
  • 32
    • 0021063848 scopus 로고
    • Cellular oncogenes and multistep carcinogenesis
    • Land H., Parada L.F., Weinberg R.A. Cellular oncogenes and multistep carcinogenesis. Science. 222:1983;771-778.
    • (1983) Science , vol.222 , pp. 771-778
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 33
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:1997;593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 35
    • 0028981277 scopus 로고
    • P53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest
    • Ewen M.E., Oliver C.J., Sluss H.K., Miller S.J., Peeper D.S. p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest. Genes Dev. 9:1995;204-217.
    • (1995) Genes Dev. , vol.9 , pp. 204-217
    • Ewen, M.E.1    Oliver, C.J.2    Sluss, H.K.3    Miller, S.J.4    Peeper, D.S.5
  • 36
    • 0027374766 scopus 로고
    • TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest
    • Ewen M.E., Sluss H.K., Whitehouse L.L., Livingston D.M. TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell. 74:1993;1009-1020.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sluss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 37
    • 0034704916 scopus 로고    scopus 로고
    • Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras
    • Tremain R., Marko M., Kinnimulki V., Ueno H., Bottinger E., Glick A. Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene. 19:2000;1698-1709.
    • (2000) Oncogene , vol.19 , pp. 1698-1709
    • Tremain, R.1    Marko, M.2    Kinnimulki, V.3    Ueno, H.4    Bottinger, E.5    Glick, A.6
  • 38
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • Sherr C.J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 60:2000;3689-3695.
    • (2000) Cancer Res. , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 39
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M., Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer. 1:2001;222-231.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 40
    • 0035803395 scopus 로고    scopus 로고
    • Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors
    • Sotillo R., Dubus P., Martin J., de la Cueva E., Ortega S., Malumbres M., Barbacid M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20:2001;6637-6647.
    • (2001) EMBO J. , vol.20 , pp. 6637-6647
    • Sotillo, R.1    Dubus, P.2    Martin, J.3    De la Cueva, E.4    Ortega, S.5    Malumbres, M.6    Barbacid, M.7
  • 41
    • 0036134935 scopus 로고    scopus 로고
    • Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence
    • Rane S.G., Cosenza S.C., Mettus R.V., Reddy E.P. Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. Mol. Cell Biol. 22:2002;644-656.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 644-656
    • Rane, S.G.1    Cosenza, S.C.2    Mettus, R.V.3    Reddy, E.P.4
  • 42
  • 43
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • -/- MEFs can be fully transformed by transduction with either ras or neu. These findings suggest that a subset of human cancers might be uniquely sensitive to disruption of cyclin D1 function
    • -/- MEFs can be fully transformed by transduction with either ras or neu. These findings suggest that a subset of human cancers might be uniquely sensitive to disruption of cyclin D1 function.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 45
    • 0033546419 scopus 로고    scopus 로고
    • Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
    • Voice J.K., Klemke R.L., Le A., Jackson J.H. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J. Biol. Chem. 274:1999;17164-17170.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17164-17170
    • Voice, J.K.1    Klemke, R.L.2    Le, A.3    Jackson, J.H.4
  • 46
    • 0035844149 scopus 로고    scopus 로고
    • Differential activation of the Rac pathway by Ha-Ras and K-Ras
    • Walsh A.B., Bar-Sagi D. Differential activation of the Rac pathway by Ha-Ras and K-Ras. J. Biol. Chem. 276:2001;15609-15615.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15609-15615
    • Walsh, A.B.1    Bar-Sagi, D.2
  • 47
    • 0032508517 scopus 로고    scopus 로고
    • Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
    • Yan J., Roy S., Apolloni A., Lane A., Hancock J.F. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 273:1998;24052-24056.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24052-24056
    • Yan, J.1    Roy, S.2    Apolloni, A.3    Lane, A.4    Hancock, J.F.5
  • 51
    • 0023791431 scopus 로고
    • Ras oncogenes in hematopoietic malignancies
    • Bos J.L. Ras oncogenes in hematopoietic malignancies. Hematol. Pathol. 2:1988;55-63.
    • (1988) Hematol. Pathol. , vol.2 , pp. 55-63
    • Bos, J.L.1
  • 55
    • 0032803236 scopus 로고    scopus 로고
    • Suppression of Ras-induced apoptosis by the Rac GTPase
    • Joneson T., Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell Biol. 19:1999;5892-5901.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5892-5901
    • Joneson, T.1    Bar-Sagi, D.2
  • 58
    • 0035951882 scopus 로고    scopus 로고
    • A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
    • Lopez I., Mak E.C., Ding J., Hamm H.E., Lomasney J.W. A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J. Biol. Chem. 276:2001;2758-2765.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2758-2765
    • Lopez, I.1    Mak, E.C.2    Ding, J.3    Hamm, H.E.4    Lomasney, J.W.5


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