Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia

American Journal of Pathology

Volumn 161, Issue 5, 2002, Pages 1541-1547

  Van Heek, N Tjarda ^a,b   Meeker, Alan K ^a   Kern, Scott E ^a   Yeo, Charles J ^a   Lillemoe, Keith D ^a   Cameron, John L ^a   Offerhaus, G Johan A ^b   Hicks, Jessica L ^a   Wilentz, Robb E ^a   Goggins, Michael G ^a   De Marzo, Angelo M ^a   Hruban, Ralph H ^a   Maitra, Anirban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); KI 67 ANTIGEN;

ACINAR CELL; ARTICLE; CANCER GRADING; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOME BREAKAGE; CHROMOSOME STRUCTURE; CHRONIC PANCREATITIS; CONTROLLED STUDY; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN TISSUE; PANCREAS ADENOCARCINOMA; PANCREAS ISLET; PANCREAS TUMOR; PRIORITY JOURNAL; TELOMERE;

EID: 0036841802     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64432-X     Document Type: Article

References (36)

1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M: Cancer statistics, 2001 CA Cancer J Clin 2001, 51:15-36
2. Hruban RH, Canto MI, Yeo CJ: Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. Dig Dis 2001, 19:76-84
3. Fearon ER, Vogeistein B: A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767
4. Hruban RH, Wilentz RE, Kern SE: Genetic progression in the pancreatic ducts. Am J Pathol 2000, 156:1821-1825
5. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, Kern SE, Klimstra DS, Kloppel G, Longnecker DS, Luttges J, Offerhaus GJ: Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001, 25:579-586
6. Hulst SPL: Zur kenntnis der genese des adenokarzinoms und karzinoms des pankreas. Virchows Arch 1905, 180:288-316
7. Goggins M, Hruban RH, Kern SE: BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: Evidence and implications. Am J Pathol 2000, 156:1767-1771
8. Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, Yeo CJ, Kern SE, Hruban RH: Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression. Cancer Res 1998, 58:4740-4744
9. Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, Kern SE, Hruban RH: Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 2000, 60:2002-2006
10. Harley CB, Villeponteau B: Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 1995, 5:249-255
11. O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, DePinho R: Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002, 2:149-155
12. Rudolph KL, Millard M, Bosenberg MW, DePinho RA: Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001, 28:155-159
13. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA: Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406:641-645
14. Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA: p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999, 97:527-538
15. Gisselsson D, Jonson T, Petersen A, Strombeck B, Dal Cin P, Hoglund M, Mitelman F, Mertens F, Mandahl N: Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA 2001, 98:12683-12688
16. Hackett JA, Greider CW: Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 2002, 21:619-626
17. McClintock B: The stability of broken ends of chromosomes in Zea mays. Genetics 1941, 26:234-282
18. Griffin CA, Hruban RH, Morsberger LA, Ellingham T, Long PP, Jaffee EM, Hauda KM, Bohlander SK, Yeo CJ: Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 1995, 55:2394-2399
19. Brat DJ, Hahn SA, Griffin CA, Yeo CJ, Kern SE, Hruban RH: The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma. Am J Pathol 1997, 150:383-391
20. Johansson B, Bardi G, Heim S, Mandahl N, Mertens F, Bak-Jensen E, Andren-Sandberg A, Mitelman F: Nonrandom chromosomal rearrangements in pancreatic carcinomas. Cancer 1992, 69:1674-1681
21. Meeker AK, Gage WR, Hicks JL, Simon I, Coffman JR, Platz EA, March GE, De Marzo AM: Telomere length assessment in human archival tissues: Combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol 2002, 160:1259-1268
22. Manley S, Mucci NR, De Marzo AM, Rubin MA: Relational database structure to manage high-density tissue microarray data and images for pathology studies focusing on clinical outcome: The prostate specialized program of research excellence model. Am J Pathol 2001, 159:837-843
23. Brummendorf TH, Rufer N, Holyoake TL, Maciejewski J, Barnett MJ, Eaves CJ, Eaves AC, Young N, Lansdorp PM: Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Ann NY Acad Sci 2001, 938:293-303
24. Shay JW: Molecular pathogenesis of aging and cancer: Are telomeres and telomerase the connection? J Clin Pathol 1997, 50:799-800
25. Lengauer C: How do tumors make ends meet? Proc Natl Acad Sci USA 2001, 98:12331-12333
26. Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B: Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 2001, 61:818-822
27. Meeker AK, Hicks JE, Platz EA, March GE, Bennett CJ, DeMarzo AM: Teiomere shortening is an early somatic DNA alteration in human prostate tumorigenesis Cancer Res 2002, in press
28. Luttges J, Kloppel G: Update on the pathology and genetics of exocrine pancreatic tumors with ductal phenotype: Precursor lesions and new tumor entities. Dig Dis 2001, 19:15-23
29. Hruban RH, Wilentz RE, Goggins M, Offerhaus GJ, Yeo CJ, Kern SE: Pathology of incipient pancreatic cancer. Ann Oncol 1999, 10:9-11
30. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB: Telomere end-replication problem and cell aging. J Mol Biol 1992, 225:951-960
31. Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE: Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): Additional evidence for a recently proposed model of progression. Mod Pathol 2002, 15:441-447
32. von Zglinicki T, Pilger R, Sitte N: Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med 2000, 28:64-74
33. Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T: Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 2000, 20:1659-1668
34. Ancelin K, Brunori M, Bauwens S, Koering CE, Brun C, Ricoul M, Pommier JP, Sabatier L, Gilson E: Targeting assay to study the cis functions of human telomeric proteins: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol 2002, 22:3474-3487
35. Baumann P, Cech TR: Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 2001, 292:1171-1175
36. Luttges J, Galehdari H, Brocker V, Schwarte-Waldhoff I, Henne-Bruns D, Kloppel G, Schmiegel W, Hahn SA: Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 2001, 158:1677-1683