Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas

Annals of Surgery

Volumn 226, Issue 4, 1997, Pages 491-500

  Z'graggen, Kaspar ^a   Rivera, Jaime A ^a   Compton, Carolyn C ^a   Pins, Michael ^a   Werner, Jens ^a   Fernández del Castillo, Carlos ^a   Rattner, David W ^a   Lewandrowski, Kent B ^a   Rustgi, Anil K ^a   Warshaw, Andrew L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; CARCINOGENESIS; CARCINOMA IN SITU; CONTROLLED STUDY; DNA SEQUENCE; DYSPLASIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; ONCOGENE K RAS; PANCREAS CANCER; PANCREAS CARCINOMA; PANCREAS DUCT; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

CARCINOMA, DUCTAL, BREAST; CYSTADENOMA, MUCINOUS; DNA PRIMERS; DNA, NEOPLASM; GENES, RAS; HUMANS; PANCREATIC NEOPLASMS; POINT MUTATION; POLYMERASE CHAIN REACTION; PREVALENCE;

EID: 0031459206     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199710000-00010     Document Type: Article

References (44)

1. Azar C, Van de Stadt J, Rickaert F, et al. Intraductal papillary mucinous tumours of the pancreas. Clinical and therapeutic issues in 32 patients. Gut 1996; 39:457-464.
2. Loftus EV, Jr, Olivares-Pakzad BA, Batts KP, et al. Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Members of the Pancreas Clinic, and Pancreatic Surgeons of Mayo Clinic. Gastroenterology 1996; 110:1909-1918.
3. Rivera JA, Fernandez-del Castillo C, Pins M, et al. Pancreatic mucinous ductal ectasia and intraductal papillary neoplasms: a single malignant clinicopalhological entity. Ann Surg 1997; 225:637-646.
4. Shyr YM, Su CH, Tsay SH, Lui WY. Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms. Ann Surg 1996; 223:141-146.
5. Warshaw AL, Compton CC, Lewandrowski KB, et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990; 212:452-445.
6. Warshaw AL, Fernandez-del Castillo C. Pancreatic carcinoma. N Engl J Med 1992; 326:455-465.
7. Kloeppel G, Solcia E, Longnecker DF, et al. Histological typing of tumors of the exocrine pancreas. 2nd ed. New York: Springer Verlag; 1996.
8. Kawarada Y, Yano T, Yamamoto T, et al. Imraductal mucin-producing tumors of the pancreas. Am J Gastroenterol 1992; 87:634-638.
9. Fiemann JF, Kohler B. Intraductal mucin-hypersecreting neoplasms of the pancreas. Gastroenterology 1992; 102:1092-1093.
10. Rickaert F, Cremer M, Deviere J, et al. Imraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology 1991; 101:512-519.
11. Payan MJ, Xerri L, Moncada K, et al. Villous adenoma of the main pancreatic duct: a potentially malignant tumor? Am J Gastroenterol 1990; 85:459-463.
12. Obara T, Maguchi H, Saitoh Y, et al. Mucin-producing tumor of the pancreas: natural history and serial pancreatogram changes. Am J Gastroenierol 1993; 88:564-569.
13. Yaniada M, Kozuka S, Yamao K, et al. Mucin producing tumor of the pancreas. Cancer 1991; 68:159-168.
14. Yamaguchi K, Ogawa Y, Chijiiwa K, Tanaka M. Mucin-hypersecreting tumors of the pancreas: assessing the grade of malignancy preoperatively. Am J Surg 1996; 171:427-431.
15. Obara T, Maguchi H, Saitoh Y, et al. Mucin-producing tumor of the pancreas: a unique clinical entity. Am J Gastroenterol 1991; 86:1619-1625.
16. Obara T, Saitoh Y, Maguchi H, et al. Papillary adenoma of the pancreas with excessive mucin secretion. Pancreas 1992; 7:114-117.
17. Yamaguchi K, Tanaka M. Mucin-hypersecreting tumor of the pancreas with mucin extrusion through an enlarged papilla. Am J Gastroenterol 1991; 86:835-839.
18. Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989; 49:4682-4689.
19. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53:549-554.
20. Friess H, Berberat P, Schilling M, et al. Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J Mol Med 1996; 74:35-42.
21. Smit VTHB, Boot AJM, Smits AMM, et al. K-ras codon 12 mutations occur very frequently in pancreatic adenocarcinoma. Nucleic Acids Res 1988; 16:7773-7782.
22. Barbacid M. ras Genes. Ann Rev Biochem 1987; 56:779-827.
23. Santos E, Nebreda AR. Structural and functional properties of ras proteins. FASEB J 1989; 3:2151-2163.
24. Shibata D, Capella G, Perucho M. Mutational activation of the c-K-ras gene in human pancreatic carcinoma. Baillieres Clin Gastroenterol 1990; 4:151-169.
25. Neuman WL, Wasylyshyn ML, Jacoby R, et al. Evidence for common molecular pathogenesis in colorectal, gastric, and pancreatic cancer. Genes Chromosomes Cancer 1991; 3:468-473.
26. Nagata Y, Abe M, Motoshima K, et al. Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese. Jpn J Cancer Res 1990; 81:135-140.
27. Motojima M, Tsunoda T, Kanematsu T, et al. Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene. Ann Surg 1991; 214:657-662.
28. Mariyania M, Kishi K, Nakamura K, et al. Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients. Jpn J Cancer Res 1989; 80:622-626.
29. Lemoine NR, Jain S, Hyghes CM, et al. Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992; 102:230-236.
30. Gruenwald K, Lyons J, Froehlich A, et al. High frequency of Kiras codon 12 mutations in pancreatic adenocarcinomas. Int J Cancer 1989; 43:1037-1041.
31. Gonzalez-Cadavid NF, Zhou D, Battiforu H, et al. Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas. Oncogene 1989; 4:1137-1140.
32. Hruban RH, van Mansfeld ADM, Offerhaus GJA, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. Am J Pathol 1993; 143:545-554.
33. Burmer GC, Rabinovitch PS, Loeb LA. Frequency and spectrum of c-Ki-ras mutations in human sporadic carcinoma, carcinomas arising in ulcerative colitis and pancreatic adenocarcinoma. Environ Health Perspect 1991; 93:27-31.
34. Capella G, Cronauer-Mitra S, Pienado MA, Perucho M. Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 1991; 93:125-131.
35. Satoh K, Shimosegawa T, Moriizumi S, et al. K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas 1996; 12:362-368.
36. Satoh K, Sawai T, Shimosegawa T, et al. The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas. Int J Pancrcatol 1993; 14:135-143.
37. Sessa F, Solcia E, Capella C, et al. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and cerbB-2 abnormalities in 26 patients. Virchows Arch 1994; 425:357-367.
38. Tada M, Omata M, Ohto M. Ras gene mutations in intraduclal papillary neoplasms of the pancreas. Analysis in five cases. Cancer 1991; 67:634-637.
39. Yanagisawa A, Kato Y, Ohtake K, et al. c-Ki-ras point mutation in ductectatic-type mucinous cystic neoplasm of the pancreas. Jpn J Cancer Res 1991; 82:1057-1060.
40. Rail CJ, Van YX, Graeme-Cook F, et al. Ki-ras and P53 mutations in pancreatic ductal adenocarcinoma. Pancreas 1996; 12:10-17.
41. Light R, Margolin BH. Analysis of variance for categorical data. J Am Stat Assoc 1971; 66:534-544.
42. Rivera JA, Rail CJN, Graeme-Cook F, et al. Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia. Surgery 1997; 121:42-49.
43. Terada T, Ohta T, Nakanuma Y. Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. Histopathology 1996; 29:355-361.
44. Hoshi T, Imai M, Ogawa K. Frequent K-ras mutations and absence of p53 mutations in mucin producing tumors of the pancreas. J Surg Oncol 1994; 55:84-91.