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Volumn 108, Issue 11, 2011, Pages 1392-1412

Calcific aortic valve stenosis: Methods, models, and mechanisms

Author keywords

animal models; calcification; echocardiography; fibrosis; phenotyping

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANTILIPEMIC AGENT; APOLIPOPROTEIN E; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; CATHEPSIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; GELATINASE B; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; NITRIC OXIDE; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; STROMELYSIN; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

EID: 79958147911     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.234138     Document Type: Article
Times cited : (260)

References (239)
  • 1
    • 33748453667 scopus 로고    scopus 로고
    • Burden of valvular heart diseases: A population-based study
    • DOI 10.1016/S0140-6736(06)69208-8, PII S0140673606692088
    • Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368:1005-1011. (Pubitemid 44353666)
    • (2006) Lancet , vol.368 , Issue.9540 , pp. 1005-1011
    • Nkomo, V.T.1    Gardin, J.M.2    Skelton, T.N.3    Gottdiener, J.S.4    Scott, C.G.5    Enriquez-Sarano, M.6
  • 2
    • 55249125191 scopus 로고    scopus 로고
    • Focused update incorporated into the acc/aha 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology
    • Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the acc/aha 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease): endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008;118:e523-e661.
    • (2008) Circulation , vol.118
    • Bonow, R.O.1    Carabello, B.A.2    Chatterjee, K.3    De Leon Jr., A.C.4    Faxon, D.P.5    Freed, M.D.6    Gaasch, W.H.7    Lytle, B.W.8    Nishimura, R.A.9    O'Gara, P.T.10    O'Rourke, R.A.11    Otto, C.M.12    Shah, P.M.13    Shanewise, J.S.14
  • 5
    • 21044437380 scopus 로고    scopus 로고
    • Spectrum of calcific aortic valve disease: Pathogenesis, disease progression, and treatment strategies
    • DOI 10.1161/CIRCULATIONAHA.104.486738
    • Freeman RV, Otto CM. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation. 2005; 111:3316-3326. (Pubitemid 40875006)
    • (2005) Circulation , vol.111 , Issue.24 , pp. 3316-3326
    • Freeman, R.V.1    Otto, C.M.2
  • 6
    • 77956049813 scopus 로고    scopus 로고
    • Relationship between aortic valve calcification and the severity of coronary atherosclerotic disease
    • Qian J, Chen Z, Ge J, Ma J, Chang S, Fan B, Liu X, Ge L. Relationship between aortic valve calcification and the severity of coronary atherosclerotic disease. J Heart Valve Dis. 2010;19:466-470.
    • (2010) J Heart Valve Dis , vol.19 , pp. 466-470
    • Qian, J.1    Chen, Z.2    Ge, J.3    Ma, J.4    Chang, S.5    Fan, B.6    Liu, X.7    Ge, L.8
  • 7
    • 38449109007 scopus 로고    scopus 로고
    • Aortic valve stenosis and coronary artery disease: Pathophysiological and clinical links
    • DOI 10.2459/JCM.0b013e32802e6c3d, PII 0124466520071200000001
    • Mazzone A, Venneri L, Berti S. Aortic valve stenosis and coronary artery disease: pathophysiological and clinical links. J Cardiovasc Med (Hagerstown). 2007;8:983-989. (Pubitemid 351339554)
    • (2007) Journal of Cardiovascular Medicine , vol.8 , Issue.12 , pp. 983-989
    • Mazzone, A.1    Venneri, L.2    Berti, S.3
  • 8
    • 33646678173 scopus 로고    scopus 로고
    • Oxidative stress and vascular disease: 2005 Duff lecture
    • DOI 10.1161/01.ATV.0000203525.62147.28, PII 0004360520060400000004
    • Heistad DD. Oxidative stress and vascular disease: 2005 Duff lecture. Arterioscler Thromb Vasc Biol. 2006;26:689-695. (Pubitemid 43732139)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.4 , pp. 689-695
    • Heistad, D.D.1
  • 9
    • 77149122729 scopus 로고    scopus 로고
    • Inflammation and the osteogenic regulation of vascular calcification: A review and perspective
    • Shao JS, Cheng SL, Sadhu J, Towler DA. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension. 2010;55:579-592.
    • (2010) Hypertension , vol.55 , pp. 579-592
    • Shao, J.S.1    Cheng, S.L.2    Sadhu, J.3    Towler, D.A.4
  • 10
    • 77956058459 scopus 로고    scopus 로고
    • Regulatory mechanisms in vascular calcification
    • Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010;7:528-536.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 528-536
    • Sage, A.P.1    Tintut, Y.2    Demer, L.L.3
  • 14
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • DOI 10.1161/CIRCULATIONAHA.106.634139, PII 0000301720061107000013
    • Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation. 2006;114: 2065-2069. (Pubitemid 44706883)
    • (2006) Circulation , vol.114 , Issue.19 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3    Young, S.G.4    Heistad, D.D.5
  • 18
    • 3442899990 scopus 로고    scopus 로고
    • Evaluation of aortic stenosis by cardiovascular magnetic resonance imaging: Comparison with established routine clinical techniques
    • DOI 10.1136/hrt.2003.022376
    • Kupfahl C, Honold M, Meinhardt G, Vogelsberg H, Wagner A, Mahrholdt H, Sechtem U. Evaluation of aortic stenosis by cardiovascular magnetic resonance imaging: comparison with established routine clinical techniques. Heart. 2004;90:893-901. (Pubitemid 39005936)
    • (2004) Heart , vol.90 , Issue.8 , pp. 893-901
    • Kupfahl, C.1    Honold, M.2    Meinhardt, G.3    Vogelsberg, H.4    Wagner, A.5    Mahrholdt, H.6    Sechtem, U.7
  • 19
    • 33846429618 scopus 로고    scopus 로고
    • Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    • DOI 10.1161/CIRCULATIONAHA.106.654913, PII 0000301720070123000016
    • Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007;115:377-386. (Pubitemid 46148512)
    • (2007) Circulation , vol.115 , Issue.3 , pp. 377-386
    • Aikawa, E.1    Nahrendorf, M.2    Sosnovik, D.3    Lok, V.M.4    Jaffer, F.A.5    Aikawa, M.6    Weissleder, R.7
  • 24
    • 0025820657 scopus 로고
    • Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice
    • Mehrabian M, Demer LL, Lusis AJ. Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice. Arterioscler Thromb. 1991;11:947-957.
    • (1991) Arterioscler Thromb , vol.11 , pp. 947-957
    • Mehrabian, M.1    Demer, L.L.2    Lusis, A.J.3
  • 27
    • 0028607266 scopus 로고
    • Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light
    • Whittaker P, Kloner RA, Boughner DR, Pickering JG. Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol. 1994;89:397-410.
    • (1994) Basic Res Cardiol , vol.89 , pp. 397-410
    • Whittaker, P.1    Kloner, R.A.2    Boughner, D.R.3    Pickering, J.G.4
  • 28
    • 34248562606 scopus 로고    scopus 로고
    • Fetuin-a, valve calcification, and diabetes: What do we understand?
    • Burke AP, Kolodgie FD, Virmani R. Fetuin-a, valve calcification, and diabetes: what do we understand? Circulation. 2007;115:2464-2467.
    • (2007) Circulation , vol.115 , pp. 2464-2467
    • Burke, A.P.1    Kolodgie, F.D.2    Virmani, R.3
  • 29
    • 77149165705 scopus 로고    scopus 로고
    • Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice
    • Matsumoto Y, Adams V, Jacob S, Mangner N, Schuler G, Linke A. Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice. Circulation. 2010;121:759-767.
    • (2010) Circulation , vol.121 , pp. 759-767
    • Matsumoto, Y.1    Adams, V.2    Jacob, S.3    Mangner, N.4    Schuler, G.5    Linke, A.6
  • 30
    • 77957298092 scopus 로고    scopus 로고
    • Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves
    • Chakraborty S, Wirrig EE, Hinton RB, Merrill WH, Spicer DB, Yutzey KE. Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol. 2010;347:167-179.
    • (2010) Dev Biol , vol.347 , pp. 167-179
    • Chakraborty, S.1    Wirrig, E.E.2    Hinton, R.B.3    Merrill, W.H.4    Spicer, D.B.5    Yutzey, K.E.6
  • 31
    • 75049083319 scopus 로고    scopus 로고
    • Wnt signaling in heart valve development and osteogenic gene induction
    • Alfieri CM, Cheek J, Chakraborty S, Yutzey KE. Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol. 2010;338: 127-135.
    • (2010) Dev Biol , vol.338 , pp. 127-135
    • Alfieri, C.M.1    Cheek, J.2    Chakraborty, S.3    Yutzey, K.E.4
  • 35
    • 79955026350 scopus 로고    scopus 로고
    • Design-based stereology: Introduction to basic concepts and practical approaches for estimation of cell number
    • Boyce R, Dorph-Petersen KA, Lyck L, Gundersen H. Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number. Toxicol Pathol. 2010;38:1011-1025.
    • (2010) Toxicol Pathol , vol.38 , pp. 1011-1025
    • Boyce, R.1    Dorph-Petersen, K.A.2    Lyck, L.3    Gundersen, H.4
  • 36
    • 18444365600 scopus 로고    scopus 로고
    • Stereological measures of trabecular bone structure: Comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies
    • DOI 10.1111/j.1365-2818.2005.01469.x
    • Thomsen JS, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W. Stereological measures of trabecular bone structure: comparison of 3d micro computed tomography with 2d histological sections in human proximal tibial bone biopsies. J Microsc. 2005;218:171-179. (Pubitemid 40646647)
    • (2005) Journal of Microscopy , vol.218 , Issue.2 , pp. 171-179
    • Thomsen, J.S.1    Laib, A.2    Koller, B.3    Prohaska, S.4    Mosekilde, Li.5    Gowin, W.6
  • 37
    • 34848906042 scopus 로고    scopus 로고
    • Improved correction of axial geometrical distortion in index-mismatched fluorescent confocal microscopic images using high-aperture objective lenses
    • DOI 10.1111/j.1365-2818.2007.01822.x
    • van Elburg HJ, Kuypers LC, Decraemer WF, Dirckx JJ. Improved correction of axial geometrical distortion in index-mismatched fluorescent confocal microscopic images using high-aperture objective lenses. J Microsc. 2007;228:45-54. (Pubitemid 47512255)
    • (2007) Journal of Microscopy , vol.228 , Issue.1 , pp. 45-54
    • Van Elburg, H.J.1    Kuypers, L.C.2    Decraemer, W.F.3    Dirckx, J.J.J.4
  • 38
    • 17144402183 scopus 로고    scopus 로고
    • A procedure to determine the correct thickness of an object with confocal microscopy in case of refractive index mismatch
    • DOI 10.1111/j.1365-2818.2005.01457.x
    • Kuypers LC, Decraemer WF, Dirckx JJ, Timmermans JP. A procedure to determine the correct thickness of an object with confocal microscopy in case of refractive index mismatch. J Microsc. 2005;218:68-78. (Pubitemid 40524170)
    • (2005) Journal of Microscopy , vol.218 , Issue.1 , pp. 68-78
    • Kuypers, L.C.1    Decraemer, W.F.2    Dirckx, J.J.J.3    Timmermans, J.-P.4
  • 41
    • 78149444571 scopus 로고    scopus 로고
    • In vivo mapping of vascular inflammation using multimodal imaging
    • Jarrett BR, Correa C, Ma KL, Louie AY. In vivo mapping of vascular inflammation using multimodal imaging. PLoS One. 2010;5:e13254.
    • (2010) PLoS One , vol.5
    • Jarrett, B.R.1    Correa, C.2    Ma, K.L.3    Louie, A.Y.4
  • 43
    • 79551611520 scopus 로고    scopus 로고
    • Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves
    • Wirrig EE, Hinton RB, Yutzey KE. Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol. 2011;50:561-569.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 561-569
    • Wirrig, E.E.1    Hinton, R.B.2    Yutzey, K.E.3
  • 44
    • 59449104824 scopus 로고    scopus 로고
    • Altered shear stress stimulates upregulation of endothelial vcam-1 and icam-1 in a bmp-4-and tgf-beta1-dependent pathway
    • Sucosky P, Balachandran K, Elhammali A, Jo H, Yoganathan AP. Altered shear stress stimulates upregulation of endothelial vcam-1 and icam-1 in a bmp-4-and tgf-beta1-dependent pathway. Arterioscler Thromb Vasc Biol. 2009;29:254-260.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 254-260
    • Sucosky, P.1    Balachandran, K.2    Elhammali, A.3    Jo, H.4    Yoganathan, A.P.5
  • 45
    • 77957935751 scopus 로고    scopus 로고
    • Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow
    • Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son DJ, Visvader JE, Jo H. Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood. 2010;116: e66-e73.
    • (2010) Blood , vol.116
    • Ni, C.W.1    Qiu, H.2    Rezvan, A.3    Kwon, K.4    Nam, D.5    Son, D.J.6    Visvader, J.E.7    Jo, H.8
  • 46
    • 52449102202 scopus 로고    scopus 로고
    • Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    • Csiszar A, Labinskyy N, Jo H, Ballabh P, Ungvari Z. Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2008;295:H569-H577.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Csiszar, A.1    Labinskyy, N.2    Jo, H.3    Ballabh, P.4    Ungvari, Z.5
  • 49
    • 24644510707 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway
    • DOI 10.1161/01.CIRCULATIONAHA.104.524306
    • Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the lrp5 receptor pathway. Circulation. 2005;112: I229-I234. (Pubitemid 41266679)
    • (2005) Circulation , vol.112 , Issue.SUPPL.
    • Rajamannan, N.M.1    Subramaniam, M.2    Caira, F.3    Stock, S.R.4    Spelsberg, T.C.5
  • 50
    • 59649120970 scopus 로고    scopus 로고
    • Substrate properties influence calcification in valvular interstitial cell culture
    • Benton JA, Kern HB, Anseth KS. Substrate properties influence calcification in valvular interstitial cell culture. J Heart Valve Dis. 2008;17: 689-699.
    • (2008) J Heart Valve Dis , vol.17 , pp. 689-699
    • Benton, J.A.1    Kern, H.B.2    Anseth, K.S.3
  • 51
    • 57349116705 scopus 로고    scopus 로고
    • Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors
    • Kennedy JA, Hua X, Mishra K, Murphy GA, Rosenkranz AC, Horowitz JD. Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors. Eur J Pharmacol. 2009;602:28-35.
    • (2009) Eur J Pharmacol , vol.602 , pp. 28-35
    • Kennedy, J.A.1    Hua, X.2    Mishra, K.3    Murphy, G.A.4    Rosenkranz, A.C.5    Horowitz, J.D.6
  • 53
    • 28944438309 scopus 로고    scopus 로고
    • Activation of valvular interstitial cells is mediated by transforming growth factor-β1 interactions with matrix molecules
    • DOI 10.1016/j.matbio.2005.06.007, PII S0945053X05000879
    • Cushing MC, Liao JT, Anseth KS. Activation of valvular interstitial cells is mediated by transforming growth factor-beta1 interactions with matrix molecules. Matrix Biol. 2005;24:428-437. (Pubitemid 41781640)
    • (2005) Matrix Biology , vol.24 , Issue.6 , pp. 428-437
    • Cushing, M.C.1    Liao, J.-T.2    Anseth, K.S.3
  • 54
    • 4043127381 scopus 로고    scopus 로고
    • Valvular myofibroblast activation by transforming growth factor-β: Implications for pathological extracellular matrix remodeling in heart valve disease
    • DOI 10.1161/01.RES.0000136520.07995.aa
    • Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res. 2004;95:253-260. (Pubitemid 39056285)
    • (2004) Circulation Research , vol.95 , Issue.3 , pp. 253-260
    • Walker, G.A.1    Masters, K.S.2    Shah, D.N.3    Anseth, K.S.4    Leinwand, L.A.5
  • 55
    • 0037314647 scopus 로고    scopus 로고
    • Progression of aortic valve stenosis: TGF-β1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    • DOI 10.1016/S0003-4975(02)04312-6, PII S0003497502043126
    • Jian B, Narula N, Li QY, Mohler ER III, Levy RJ. Progression of aortic valve stenosis: Tgf-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg. 2003;75:457-465. (Pubitemid 36184488)
    • (2003) Annals of Thoracic Surgery , vol.75 , Issue.2 , pp. 457-465
    • Jian, B.1    Narula, N.2    Li, Q.-Y.3    Mohler III, E.R.4    Levy, R.J.5
  • 57
    • 79952134815 scopus 로고    scopus 로고
    • {beta}-catenin mediates mechanically regulated, transforming growth factor-{beta}1-induced myofibroblast differentiation of aortic valve interstitial cells
    • Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA. {beta}-catenin mediates mechanically regulated, transforming growth factor-{beta}1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol. 2011;31:590-597.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 590-597
    • Chen, J.H.1    Chen, W.L.2    Sider, K.L.3    Yip, C.Y.4    Simmons, C.A.5
  • 58
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix
    • Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol. 2009;29:936-942.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 936-942
    • Yip, C.Y.1    Chen, J.H.2    Zhao, R.3    Simmons, C.A.4
  • 60
    • 59449092756 scopus 로고    scopus 로고
    • Calcific aortic stenosis: Lessons learned from experimental and clinical studies
    • Rajamannan NM. Calcific aortic stenosis: lessons learned from experimental and clinical studies. Arterioscler Thromb Vasc Biol. 2009;29: 162-168.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 162-168
    • Rajamannan, N.M.1
  • 62
    • 0034800126 scopus 로고    scopus 로고
    • Aortic valve endothelial cells undergo transforming growth factor-β-mediated and non-transforming growth factor-β-mediated transdifferentiation in Vitro
    • Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J. Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro. Am J Pathol. 2001; 159:1335-1343. (Pubitemid 32947963)
    • (2001) American Journal of Pathology , vol.159 , Issue.4 , pp. 1335-1343
    • Paranya, G.1    Vineberg, S.2    Dvorin, E.3    Kaushal, S.4    Roth, S.J.5    Rabkin, E.6    Schoen, F.J.7    Bischoff, J.8
  • 68
    • 59449096216 scopus 로고    scopus 로고
    • Novel aspects of oxidative stress in cardiovascular diseases
    • Heistad DD, Wakisaka Y, Miller J, Chu Y, Pena-Silva R. Novel aspects of oxidative stress in cardiovascular diseases. Circ J. 2009;73:201-207.
    • (2009) Circ J , vol.73 , pp. 201-207
    • Heistad, D.D.1    Wakisaka, Y.2    Miller, J.3    Chu, Y.4    Pena-Silva, R.5
  • 69
    • 77952503290 scopus 로고    scopus 로고
    • Nox isoforms in vascular pathophysiology: Insights from transgenic and knockout mouse models
    • Rivera J, Sobey CG, Walduck AK, Drummond GR. Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep. 2010;15:50-63.
    • (2010) Redox Rep , vol.15 , pp. 50-63
    • Rivera, J.1    Sobey, C.G.2    Walduck, A.K.3    Drummond, G.R.4
  • 71
    • 78650882643 scopus 로고    scopus 로고
    • Reactive oxygen species and vascular biology: Implications in human hypertension
    • Touyz RM, Briones AM. Reactive oxygen species and vascular biology: implications in human hypertension. Hypertens Res. 2011;34:5-14.
    • (2011) Hypertens Res , vol.34 , pp. 5-14
    • Touyz, R.M.1    Briones, A.M.2
  • 73
    • 77950896739 scopus 로고    scopus 로고
    • Nadph oxidases: Functions and pathologies in the vasculature
    • Lassegue B, Griendling KK. Nadph oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol. 2010;30:653-661.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 653-661
    • Lassegue, B.1    Griendling, K.K.2
  • 74
    • 70449520200 scopus 로고    scopus 로고
    • Oxidative risk for atherothrombotic cardiovascular disease
    • Leopold JA, Loscalzo J. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med. 2009;47:1673-1706.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1673-1706
    • Leopold, J.A.1    Loscalzo, J.2
  • 75
    • 64549119138 scopus 로고    scopus 로고
    • Redox control of platelet function
    • Essex DW. Redox control of platelet function. Antioxid Redox Signal. 2009;11:1191-1225.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1191-1225
    • Essex, D.W.1
  • 76
    • 44449162751 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies
    • DOI 10.1038/ncpcardio1211, PII NCPCARDIO1211
    • Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med. 2008;5:338-349. (Pubitemid 351761708)
    • (2008) Nature Clinical Practice Cardiovascular Medicine , vol.5 , Issue.6 , pp. 338-349
    • Forstermann, U.1
  • 77
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482-2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 78
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller JD, Chu Y, Brooks RM, Richenbacher WE, Pena-Silva R, Heistad DD. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol. 2008;52:843-850.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3    Richenbacher, W.E.4    Pena-Silva, R.5    Heistad, D.D.6
  • 80
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-β1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • DOI 10.1161/01.RES.0000187457.24338.3D
    • Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D. Nad(p)h oxidase 4 mediates transforming growth factorbeta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res. 2005;97:900-907. (Pubitemid 41552675)
    • (2005) Circulation Research , vol.97 , Issue.9 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3    Phelan, P.J.4    Ariyan, S.5    Dikalov, S.6    Sorescu, D.7
  • 81
    • 47249157776 scopus 로고    scopus 로고
    • Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor runx2 by akt signaling
    • Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor runx2 by akt signaling. J Biol Chem. 2008;283:15319-15327.
    • (2008) J Biol Chem , vol.283 , pp. 15319-15327
    • Byon, C.H.1    Javed, A.2    Dai, Q.3    Kappes, J.C.4    Clemens, T.L.5    Darley-Usmar, V.M.6    McDonald, J.M.7    Chen, Y.8
  • 82
    • 0035882483 scopus 로고    scopus 로고
    • Oxidative stress modulates osteoblastic differentiation of vascular and bone cells
    • DOI 10.1016/S0891-5849(01)00610-4, PII S0891584901006104
    • Mody N, Parhami F, Sarafian TA, Demer LL. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med. 2001;31:509-519. (Pubitemid 32728438)
    • (2001) Free Radical Biology and Medicine , vol.31 , Issue.4 , pp. 509-519
    • Mody, N.1    Parhami, F.2    Sarafian, T.A.3    Demer, L.L.4
  • 83
    • 75149144852 scopus 로고    scopus 로고
    • Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium
    • Guerraty MA, Grant GR, Karanian JW, Chiesa OA, Pritchard WF, Davies PF. Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium. Arterioscler Thromb Vasc Biol. 2010;30:225-231.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 225-231
    • Guerraty, M.A.1    Grant, G.R.2    Karanian, J.W.3    Chiesa, O.A.4    Pritchard, W.F.5    Davies, P.F.6
  • 84
    • 0041386133 scopus 로고    scopus 로고
    • Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis
    • DOI 10.1016/S0046-8177(03)00245-4
    • Soini Y, Salo T, Satta J. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol. 2003;34:756-763. (Pubitemid 37040610)
    • (2003) Human Pathology , vol.34 , Issue.8 , pp. 756-763
    • Soini, Y.1    Salo, T.2    Satta, J.3
  • 85
    • 33750844857 scopus 로고    scopus 로고
    • Distribution of SPARC during neovascularisation of degenerative aortic stenosis
    • DOI 10.1136/hrt.2005.086595
    • Charest A, Pepin A, Shetty R, Cote C, Voisine P, Dagenais F, Pibarot P, Mathieu P. Distribution of sparc during neovascularisation of degenerative aortic stenosis. Heart. 2006;92:1844-1849. (Pubitemid 44851338)
    • (2006) Heart , vol.92 , Issue.12 , pp. 1844-1849
    • Charest, A.1    Pepin, A.2    Shetty, R.3    Cote, C.4    Voisine, P.5    Dagenais, F.6    Pibarot, P.7    Mathieu, P.8
  • 88
    • 33846429653 scopus 로고    scopus 로고
    • Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (ADMA)
    • DOI 10.1016/j.niox.2006.10.003, PII S1089860306004289
    • Ngo DT, Heresztyn T, Mishra K, Marwick TH, Horowitz JD. Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (adma). Nitric Oxide. 2007;16:197-201. (Pubitemid 46149393)
    • (2007) Nitric Oxide - Biology and Chemistry , vol.16 , Issue.2 , pp. 197-201
    • Ngo, D.T.M.1    Heresztyn, T.2    Mishra, K.3    Marwick, T.H.4    Horowitz, J.D.5
  • 93
    • 0344015781 scopus 로고    scopus 로고
    • Evidence that macrophages in atherosclerotic lesions contain angiotensin II
    • Potter DD, Sobey CG, Tompkins PK, Rossen JD, Heistad DD. Evidence that macrophages in atherosclerotic lesions contain angiotensin ii. Circulation. 1998;98:800-807. (Pubitemid 28391846)
    • (1998) Circulation , vol.98 , Issue.8 , pp. 800-807
    • Dean Potter, D.1    Sobey, C.G.2    Tompkins, P.K.3    Rossen, J.D.4    Heistad, D.D.5
  • 94
    • 0027991976 scopus 로고
    • Characterization of the early lesion of 'degenerative' valvular aortic stenosis: Histological and immunohistochemical studies
    • Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 1994;90: 844-853. (Pubitemid 24242754)
    • (1994) Circulation , vol.90 , Issue.2 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3    Gown, A.M.4    O'Brien, K.D.5
  • 96
    • 70349231111 scopus 로고    scopus 로고
    • Endogenous interleukin-10 inhibits angiotensin ii-induced vascular dysfunction
    • Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM. Endogenous interleukin-10 inhibits angiotensin ii-induced vascular dysfunction. Hypertension. 2009;54:619-624.
    • (2009) Hypertension , vol.54 , pp. 619-624
    • Didion, S.P.1    Kinzenbaw, D.A.2    Schrader, L.I.3    Chu, Y.4    Faraci, F.M.5
  • 98
    • 45849086107 scopus 로고    scopus 로고
    • Role of the renin-angiotensin system in vascular inflammation
    • Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008;29: 367-374.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 367-374
    • Marchesi, C.1    Paradis, P.2    Schiffrin, E.L.3
  • 99
    • 33947579076 scopus 로고    scopus 로고
    • Angiotensin Receptor-1 Blocker Inhibits Atherosclerotic Changes and Endothelial Disruption of the Aortic Valve in Hypercholesterolemic Rabbits
    • DOI 10.1016/j.jacc.2006.11.043, PII S0735109707002306
    • Arishiro K, Hoshiga M, Negoro N, Jin D, Takai S, Miyazaki M, Ishihara T, Hanafusa T. Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits. J Am Coll Cardiol. 2007;49:1482-1489. (Pubitemid 46482919)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.13 , pp. 1482-1489
    • Arishiro, K.1    Hoshiga, M.2    Negoro, N.3    Jin, D.4    Takai, S.5    Miyazaki, M.6    Ishihara, T.7    Hanafusa, T.8
  • 103
    • 77649228699 scopus 로고    scopus 로고
    • The osteoprotegerin/rank/rankl system: A bone key to vascular disease
    • D'Amelio P, Isaia G, Isaia GC. The osteoprotegerin/rank/rankl system: a bone key to vascular disease. J Endocrinol Invest. 2009;32:6-9.
    • (2009) J Endocrinol Invest , vol.32 , pp. 6-9
    • D'Amelio, P.1    Isaia, G.2    Isaia, G.C.3
  • 104
    • 34548454049 scopus 로고    scopus 로고
    • Biology of rank, rankl, and osteoprotegerin
    • Boyce BF, Xing L. Biology of rank, rankl, and osteoprotegerin. Arthritis Res Ther. 2007;9(Suppl 1):S1.
    • (2007) Arthritis Res Ther , vol.9 , Issue.SUPPL. 1
    • Boyce, B.F.1    Xing, L.2
  • 105
    • 79957463868 scopus 로고    scopus 로고
    • Runx2-upregulated receptor activator of nuclear factor {kappa}b ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages
    • PMID-21454810
    • Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y. Runx2-upregulated receptor activator of nuclear factor {kappa}b ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol. 2011; PMID-21454810.
    • (2011) Arterioscler Thromb Vasc Biol
    • Byon, C.H.1    Sun, Y.2    Chen, J.3    Yuan, K.4    Mao, X.5    Heath, J.M.6    Anderson, P.G.7    Tintut, Y.8    Demer, L.L.9    Wang, D.10    Chen, Y.11
  • 106
  • 107
    • 22144457305 scopus 로고    scopus 로고
    • A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
    • DOI 10.1182/blood-2004-09-3662
    • Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY. A crucial role for reactive oxygen species in rankl-induced osteoclast differentiation. Blood. 2005;106:852-859. (Pubitemid 41076424)
    • (2005) Blood , vol.106 , Issue.3 , pp. 852-859
    • Lee, N.K.1    Choi, Y.G.2    Baik, J.Y.3    Han, S.Y.4    Jeong, D.-W.5    Bae, Y.S.6    Kim, N.7    Lee, S.Y.8
  • 114
    • 39449102532 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ-mediated effects in the vasculature
    • DOI 10.1161/CIRCRESAHA.107.164384, PII 0000301220080215000007
    • Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res. 2008; 102:283-294. (Pubitemid 351271648)
    • (2008) Circulation Research , vol.102 , Issue.3 , pp. 283-294
    • Duan, S.Z.1    Usher, M.G.2    Mortensen, R.M.3
  • 117
    • 33745839778 scopus 로고    scopus 로고
    • Transient suppression of PPARγ directed ES cells into an osteoblastic lineage
    • DOI 10.1016/j.febslet.2006.06.057, PII S0014579306007745
    • Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R. Transient suppression of ppargamma directed es cells into an osteoblastic lineage. FEBS Lett. 2006;580:4121-4125. (Pubitemid 44037579)
    • (2006) FEBS Letters , vol.580 , Issue.17 , pp. 4121-4125
    • Yamashita, A.1    Takada, T.2    Nemoto, K.-i.3    Yamamoto, G.4    Torii, R.5
  • 118
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • DOI 10.1038/34178
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 1998;391:79-82. (Pubitemid 28079218)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 120
    • 70349256058 scopus 로고    scopus 로고
    • Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix gla protein
    • Yao Y, Watson AD, Ji S, Bostrom KI. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix gla protein. Circ Res. 2009;105:575-584.
    • (2009) Circ Res , vol.105 , pp. 575-584
    • Yao, Y.1    Watson, A.D.2    Ji, S.3    Bostrom, K.I.4
  • 121
    • 14544283020 scopus 로고    scopus 로고
    • Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD
    • DOI 10.1097/01.ASN.0000141960.01035.28
    • Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in esrd. J Am Soc Nephrol. 2004;15:2857-2867. (Pubitemid 41103395)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.11 , pp. 2857-2867
    • Reynolds, J.L.1    Joannides, A.J.2    Skepper, J.N.3    Mcnair, R.4    Schurgers, L.J.5    Proudfoot, D.6    Jahnen-Dechent, W.7    Weissberg, P.L.8    Shanahan, C.M.9
  • 122
    • 0030947025 scopus 로고    scopus 로고
    • Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protien
    • DOI 10.1038/386078a0
    • Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix gla protein. Nature. 1997;386:78-81. (Pubitemid 27130923)
    • (1997) Nature , vol.386 , Issue.6620 , pp. 78-81
    • Luo, G.1    Ducy, P.2    McKee, M.D.3    Pinero, G.J.4    Loyer, E.5    Behringer, R.R.6    Karsenty, G.7
  • 123
    • 77956225591 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    • Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Bostrom KI. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res. 2010;107:485-494.
    • (2010) Circ Res , vol.107 , pp. 485-494
    • Yao, Y.1    Bennett, B.J.2    Wang, X.3    Rosenfeld, M.E.4    Giachelli, C.5    Lusis, A.J.6    Bostrom, K.I.7
  • 125
    • 70350580660 scopus 로고    scopus 로고
    • Notch1 represses osteogenic pathways in aortic valve cells
    • Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009;47:828-834.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 828-834
    • Nigam, V.1    Srivastava, D.2
  • 128
    • 67650334134 scopus 로고    scopus 로고
    • Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells: Role of msx2 gene induction via notch-rbp-jk signaling
    • Shimizu T, Tanaka T, Iso T, Doi H, Sato H, Kawai-Kowase K, Arai M, Kurabayashi M. Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells: role of msx2 gene induction via notch-rbp-jk signaling. Arterioscler Thromb Vasc Biol. 2009;29:1104-1111.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1104-1111
    • Shimizu, T.1    Tanaka, T.2    Iso, T.3    Doi, H.4    Sato, H.5    Kawai-Kowase, K.6    Arai, M.7    Kurabayashi, M.8
  • 133
    • 0033735304 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression in nonrheumatic aortic stenosis
    • Edep ME, Shirani J, Wolf P, Brown DL. Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol. 2000;9: 281-286.
    • (2000) Cardiovasc Pathol , vol.9 , pp. 281-286
    • Edep, M.E.1    Shirani, J.2    Wolf, P.3    Brown, D.L.4
  • 139
    • 77950889002 scopus 로고    scopus 로고
    • Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in balb/c mice
    • Isoda K, Matsuki T, Kondo H, Iwakura Y, Ohsuzu F. Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in balb/c mice. Arterioscler Thromb Vasc Biol. 2010;30:708-715.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 708-715
    • Isoda, K.1    Matsuki, T.2    Kondo, H.3    Iwakura, Y.4    Ohsuzu, F.5
  • 141
    • 64549087652 scopus 로고    scopus 로고
    • Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: Role of nuclear factor-kappab and inflammatory activation
    • Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan YT, Prabhu SD. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappab and inflammatory activation. Circulation. 2009;119:1386-1397.
    • (2009) Circulation , vol.119 , pp. 1386-1397
    • Hamid, T.1    Gu, Y.2    Ortines, R.V.3    Bhattacharya, C.4    Wang, G.5    Xuan, Y.T.6    Prabhu, S.D.7
  • 142
    • 78449238727 scopus 로고    scopus 로고
    • Arterial calcification is driven by rage in enpp1-/- mice
    • Cecil DL, Terkeltaub RA. Arterial calcification is driven by rage in enpp1-/- mice. J Vasc Res. 2010;48:227-235.
    • (2010) J Vasc Res , vol.48 , pp. 227-235
    • Cecil, D.L.1    Terkeltaub, R.A.2
  • 143
    • 70349235519 scopus 로고    scopus 로고
    • Advanced glycation end-products enhance calcification in vascular smooth muscle cells
    • Ren X, Shao H, Wei Q, Sun Z, Liu N. Advanced glycation end-products enhance calcification in vascular smooth muscle cells. J Int Med Res. 2009;37:847-854.
    • (2009) J Int Med Res , vol.37 , pp. 847-854
    • Ren, X.1    Shao, H.2    Wei, Q.3    Sun, Z.4    Liu, N.5
  • 144
    • 67649447069 scopus 로고    scopus 로고
    • Advanced glycation end products induce calcification of vascular smooth muscle cells through rage/p38 mapk
    • Tanikawa T, Okada Y, Tanikawa R, Tanaka Y. Advanced glycation end products induce calcification of vascular smooth muscle cells through rage/p38 mapk. J Vasc Res. 2009;46:572-580.
    • (2009) J Vasc Res , vol.46 , pp. 572-580
    • Tanikawa, T.1    Okada, Y.2    Tanikawa, R.3    Tanaka, Y.4
  • 145
    • 79551493017 scopus 로고    scopus 로고
    • Vascular calcification: It's all the rage!
    • Towler DA. Vascular calcification: it's all the rage! Arterioscler Thromb Vasc Biol. 2011;31:237-239.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 237-239
    • Towler, D.A.1
  • 146
    • 79551504491 scopus 로고    scopus 로고
    • S100a12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein e-null mice by activating an osteogenic gene regulatory program
    • Hofmann Bowman MA, Gawdzik J, Bukhari U, Husain AN, Toth PT, Kim G, Earley J, McNally EM. S100a12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein e-null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol. 2011;31:337-344.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 337-344
    • Hofmann Bowman, M.A.1    Gawdzik, J.2    Bukhari, U.3    Husain, A.N.4    Toth, P.T.5    Kim, G.6    Earley, J.7    McNally, E.M.8
  • 147
    • 79952105151 scopus 로고    scopus 로고
    • Vascular remodeling and arterial calcification are directly mediated by s100a12 (en-rage) in chronic kidney disease
    • Gawdzik J, Mathew L, Kim G, Puri TS, Hofmann Bowman MA. Vascular remodeling and arterial calcification are directly mediated by s100a12 (en-rage) in chronic kidney disease. Am J Nephrol. 2011;33: 250-259.
    • (2011) Am J Nephrol , vol.33 , pp. 250-259
    • Gawdzik, J.1    Mathew, L.2    Kim, G.3    Puri, T.S.4    Hofmann Bowman, M.A.5
  • 148
    • 64649096899 scopus 로고    scopus 로고
    • Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: The multi-ethnic study of atherosclerosis (mesa)
    • Katz R, Budoff MJ, Takasu J, Shavelle DM, Bertoni A, Blumenthal RS, Ouyang P, Wong ND, O'Brien KD. Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the multi-ethnic study of atherosclerosis (mesa). Diabetes. 2009;58: 813-819.
    • (2009) Diabetes , vol.58 , pp. 813-819
    • Katz, R.1    Budoff, M.J.2    Takasu, J.3    Shavelle, D.M.4    Bertoni, A.5    Blumenthal, R.S.6    Ouyang, P.7    Wong, N.D.8    O'Brien, K.D.9
  • 149
    • 33745741894 scopus 로고    scopus 로고
    • Soluble receptor for advanced glycation end products: From disease marker to potential therapeutic target
    • Geroldi D, Falcone C, Emanuele E. Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target. Curr Med Chem. 2006;13:1971-1978.
    • (2006) Curr Med Chem , vol.13 , pp. 1971-1978
    • Geroldi, D.1    Falcone, C.2    Emanuele, E.3
  • 150
  • 153
    • 33847406741 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation
    • DOI 10.1038/modpathol.3800747, PII 3800747
    • Kalantari F, Miao D, Emadali A, Tzimas GN, Goltzman D, Vali H, Chevet E, Auguste P. Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation. Mod Pathol. 2007;20:357-366. (Pubitemid 46348335)
    • (2007) Modern Pathology , vol.20 , Issue.3 , pp. 357-366
    • Kalantari, F.1    Miao, D.2    Emadali, A.3    Tzimas, G.N.4    Goltzman, D.5    Vali, H.6    Chevet, E.7    Auguste, P.8
  • 156
    • 9344258587 scopus 로고    scopus 로고
    • Molecular and functional characterization of ovine cardiac valve-derived interstitial cells in primary isolates and cultures
    • DOI 10.1089/ten.2004.10.1368
    • Yperman J, De Visscher G, Holvoet P, Flameng W. Molecular and functional characterization of ovine cardiac valve-derived interstitial cells in primary isolates and cultures. Tissue Eng. 2004;10:1368-1375. (Pubitemid 39557841)
    • (2004) Tissue Engineering , vol.10 , Issue.9-10 , pp. 1368-1375
    • Yperman, J.1    De Visscher, G.2    Holvoet, P.3    Flameng, W.4
  • 158
    • 33846647470 scopus 로고    scopus 로고
    • Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells
    • DOI 10.1089/ten.2006.0091
    • Gupta V, Werdenberg JA, Blevins TL, Grande-Allen KJ. Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells. Tissue Eng. 2007;13:41-49. (Pubitemid 46178380)
    • (2007) Tissue Engineering , vol.13 , Issue.1 , pp. 41-49
    • Gupta, V.1    Werdenberg, J.A.2    Blevins, T.L.3    Grande-Allen, K.J.4
  • 159
    • 33747152561 scopus 로고    scopus 로고
    • Matrix Elasticity Directs Stem Cell Lineage Specification
    • DOI 10.1016/j.cell.2006.06.044, PII S0092867406009615
    • Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006;126:677-689. (Pubitemid 44233625)
    • (2006) Cell , vol.126 , Issue.4 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 160
    • 59449090300 scopus 로고    scopus 로고
    • Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment
    • Monzack EL, Gu X, Masters KS. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. Arterioscler Thromb Vasc Biol. 2009;29:246-253.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 246-253
    • Monzack, E.L.1    Gu, X.2    Masters, K.S.3
  • 161
    • 68249150571 scopus 로고    scopus 로고
    • Regulation of valvular interstitial cell calcification by components of the extracellular matrix
    • Rodriguez KJ, Masters KS. Regulation of valvular interstitial cell calcification by components of the extracellular matrix. J Biomed Mater Res A. 2009;90:1043-1053.
    • (2009) J Biomed Mater Res A , vol.90 , pp. 1043-1053
    • Rodriguez, K.J.1    Masters, K.S.2
  • 163
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis (*)
    • Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol. 2009;27:165-197.
    • (2009) Annu Rev Immunol , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 164
    • 70349756976 scopus 로고    scopus 로고
    • Mechanisms linking osteoporosis with cardiovascular calcification
    • Demer LL, Tintut Y. Mechanisms linking osteoporosis with cardiovascular calcification. Curr Osteoporos Rep. 2009;7:42-46.
    • (2009) Curr Osteoporos Rep , vol.7 , pp. 42-46
    • Demer, L.L.1    Tintut, Y.2
  • 167
    • 7444228752 scopus 로고    scopus 로고
    • Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis and calcific mitral valve
    • Nair K, Ramachandran P, Krishnamoorthy KM, Dora S, Achuthan TJ. Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis and calcific mitral valve. J Heart Valve Dis. 2004;13:866-869.
    • (2004) J Heart Valve Dis , vol.13 , pp. 866-869
    • Nair, K.1    Ramachandran, P.2    Krishnamoorthy, K.M.3    Dora, S.4    Achuthan, T.J.5
  • 168
    • 0000721663 scopus 로고
    • Cardiovascular manifestations in progeria. Report of clinical and pathologic findings in a patient with severe arteriosclerotic heart disease and aortic stenosis
    • Makous N, Friedman S, Yakovac W, Maris EP. Cardiovascular manifestations in progeria. Report of clinical and pathologic findings in a patient with severe arteriosclerotic heart disease and aortic stenosis. Am Heart J. 1962;64:334-346.
    • (1962) Am Heart J , vol.64 , pp. 334-346
    • Makous, N.1    Friedman, S.2    Yakovac, W.3    Maris, E.P.4
  • 169
    • 0035752936 scopus 로고    scopus 로고
    • Aortic valve replacement for aortic stenosis with a small aortic annulus in a patient having Werner's syndrome and liver cirrhosis
    • Sogawa M, Kasuya S, Yamamoto K, Koshika M, Oguma F, Hayashi J. Aortic valve replacement for aortic stenosis with a small aortic annulus in a patient having Werner's syndrome and liver cirrhosis. Ann Thorac Cardiovasc Surg. 2001;7:378-380.
    • (2001) Ann Thorac Cardiovasc Surg , vol.7 , pp. 378-380
    • Sogawa, M.1    Kasuya, S.2    Yamamoto, K.3    Koshika, M.4    Oguma, F.5    Hayashi, J.6
  • 170
    • 0034594448 scopus 로고    scopus 로고
    • Severe heart valve calcification in a young patient with Werner Syndrome
    • DOI 10.1016/S1054-8807(99)00036-8, PII S1054880799000368
    • Grubitzsch H, Beholz S, Wollert HG, Eckel L. Severe heart valve calcification in a young patient with werner syndrome. Cardiovasc Pathol. 2000;9:53-54. (Pubitemid 30157878)
    • (2000) Cardiovascular Pathology , vol.9 , Issue.1 , pp. 53-54
    • Grubitzsch, H.1    Beholz, S.2    Wollert, H.-G.3    Eckel, L.4
  • 173
    • 27644564931 scopus 로고    scopus 로고
    • Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice
    • DOI 10.1016/j.mad.2005.07.007, PII S0047637405001752
    • Masuda H, Chikuda H, Suga T, Kawaguchi H, Kuro-o M. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev. 2005;126:1274-1283. (Pubitemid 41572244)
    • (2005) Mechanisms of Ageing and Development , vol.126 , Issue.12 , pp. 1274-1283
    • Masuda, H.1    Chikuda, H.2    Suga, T.3    Kawaguchi, H.4    Kuro-o, M.5
  • 175
    • 77649253288 scopus 로고    scopus 로고
    • Micrornas add a new dimension to cardiovascular disease
    • Small EM, Frost RJ, Olson EN. Micrornas add a new dimension to cardiovascular disease. Circulation. 2010;121:1022-1032.
    • (2010) Circulation , vol.121 , pp. 1022-1032
    • Small, E.M.1    Frost, R.J.2    Olson, E.N.3
  • 176
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian micrornas predominantly act to decrease target mrna levels
    • Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian micrornas predominantly act to decrease target mrna levels. Nature. 2010;466: 835-840.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 177
    • 77957934288 scopus 로고    scopus 로고
    • Microrna and aging: A novel modulator in regulating the aging network
    • Chen LH, Chiou GY, Chen YW, Li HY, Chiou SH. Microrna and aging: a novel modulator in regulating the aging network. Ageing Res Rev. 2010;9(Suppl 1):S59-S66.
    • (2010) Ageing Res Rev , vol.9 , Issue.SUPPL. 1
    • Chen, L.H.1    Chiou, G.Y.2    Chen, Y.W.3    Li, H.Y.4    Chiou, S.H.5
  • 180
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • DOI 10.1074/jbc.M403702200
    • Schroeder TM, Kahler RA, Li X, Westendorf JJ. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem. 2004;279:41998-42007. (Pubitemid 39313651)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41998-42007
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 183
    • 77956798056 scopus 로고    scopus 로고
    • Roles for gcn5 in promoting nucleosome assembly and maintaining genome integrity
    • Burgess RJ, Zhang Z. Roles for gcn5 in promoting nucleosome assembly and maintaining genome integrity. Cell Cycle. 2010;9: 2979-2985.
    • (2010) Cell Cycle , vol.9 , pp. 2979-2985
    • Burgess, R.J.1    Zhang, Z.2
  • 189
    • 74949091630 scopus 로고    scopus 로고
    • Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: Results of the aortic stenosis progression observation: Measuring effects of rosuvastatin (astronomer) trial
    • Chan KL, Teo K, Dumesnil JG, Ni A, Tam J. Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (astronomer) trial. Circulation. 2010;121:306-314.
    • (2010) Circulation , vol.121 , pp. 306-314
    • Chan, K.L.1    Teo, K.2    Dumesnil, J.G.3    Ni, A.4    Tam, J.5
  • 190
    • 33644694919 scopus 로고    scopus 로고
    • Rho gtpases, statins, and nitric oxide
    • Rikitake Y, Liao JK. Rho gtpases, statins, and nitric oxide. Circ Res. 2005;97:1232-1235.
    • (2005) Circ Res , vol.97 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 191
    • 77951709095 scopus 로고    scopus 로고
    • Pleiotropic effects of statins- basic research and clinical perspectives
    • Zhou Q, Liao JK. Pleiotropic effects of statins- basic research and clinical perspectives. Circ J. 2010;74:818-826.
    • (2010) Circ J , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2
  • 192
    • 77956525807 scopus 로고    scopus 로고
    • The effect of statins on carotid plaque morphology: A ldl-associated action or one more pleiotropic effect of statins?
    • Makris GC, Lavida A, Nicolaides AN, Geroulakos G. The effect of statins on carotid plaque morphology: a ldl-associated action or one more pleiotropic effect of statins? Atherosclerosis. 2010;213:8-20.
    • (2010) Atherosclerosis , vol.213 , pp. 8-20
    • Makris, G.C.1    Lavida, A.2    Nicolaides, A.N.3    Geroulakos, G.4
  • 193
    • 0035913111 scopus 로고    scopus 로고
    • The development of calcium deposits in atherosclerotic lesions and their persistence after lipid regression
    • PII S0002914901017131
    • Stary HC. The development of calcium deposits in atherosclerotic lesions and their persistence after lipid regression. Am J Cardiol. 2001; 88:16E-19E. (Pubitemid 32721978)
    • (2001) American Journal of Cardiology , vol.88 , Issue.SUPPL. 1
    • Stary, H.C.1
  • 194
    • 0034099161 scopus 로고    scopus 로고
    • Natural history of calcium deposits in atherosclerosis progression and regression
    • Stary HC. Natural history of calcium deposits in atherosclerosis progression and regression. Z Kardiol. 2000;89(Suppl 2):28-35.
    • (2000) Z Kardiol , vol.89 , Issue.SUPPL. 2 , pp. 28-35
    • Stary, H.C.1
  • 196
    • 76349101869 scopus 로고    scopus 로고
    • Beta glycosphingolipids suppress rank expression and inhibit natural killer t cell and cd8- accumulation in alleviating aortic valve calcification
    • Shuvy M, Ben Ya'acov A, Zolotarov L, Lotan C, Ilan Y. Beta glycosphingolipids suppress rank expression and inhibit natural killer t cell and cd8- accumulation in alleviating aortic valve calcification. Int J Immunopathol Pharmacol. 2009;22:911-918.
    • (2009) Int J Immunopathol Pharmacol , vol.22 , pp. 911-918
    • Shuvy, M.1    Ben Ya'Acov, A.2    Zolotarov, L.3    Lotan, C.4    Ilan, Y.5
  • 199
    • 0037341318 scopus 로고    scopus 로고
    • Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification
    • DOI 10.1161/01.ATV.0000059406.92165.31
    • Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol. 2003;23:489-494. (Pubitemid 36337227)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.3 , pp. 489-494
    • Tyson, K.L.1    Reynolds, J.L.2    McNair, R.3    Zhang, Q.4    Weissberg, P.L.5    Shanahan, C.M.6
  • 202
    • 66149119371 scopus 로고    scopus 로고
    • Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype
    • Webber J, Meran S, Steadman R, Phillips A. Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype. J Biol Chem. 2009;284:9083-9092.
    • (2009) J Biol Chem , vol.284 , pp. 9083-9092
    • Webber, J.1    Meran, S.2    Steadman, R.3    Phillips, A.4
  • 204
    • 43049180323 scopus 로고    scopus 로고
    • Why have antioxidants failed in clinical trials?
    • Steinhubl SR. Why have antioxidants failed in clinical trials? Am J Cardiol. 2008;101:14D-19D.
    • (2008) Am J Cardiol , vol.101
    • Steinhubl, S.R.1
  • 206
    • 18244407290 scopus 로고    scopus 로고
    • 2 receptor comes of age
    • DOI 10.1161/01.HYP.0000159192.93968.8f
    • Carey RM. Cardiovascular and renal regulation by the angiotensin type 2 receptor: the at2 receptor comes of age. Hypertension. 2005;45: 840-844. (Pubitemid 40628923)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 840-844
    • Carey, R.M.1
  • 207
    • 74949092226 scopus 로고    scopus 로고
    • New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin i metabolism
    • Ferrario CM. New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin i metabolism. Hypertension. 2010;55:445-452.
    • (2010) Hypertension , vol.55 , pp. 445-452
    • Ferrario, C.M.1
  • 208
    • 47649128227 scopus 로고    scopus 로고
    • Over-expression of angiotensin ii type 2 receptor (agtr2) reduces atherogenesis and modulates lox-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression
    • Hu C, Dandapat A, Chen J, Liu Y, Hermonat PL, Carey RM, Mehta JL. Over-expression of angiotensin ii type 2 receptor (agtr2) reduces atherogenesis and modulates lox-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression. Atherosclerosis. 2008;199:288-294.
    • (2008) Atherosclerosis , vol.199 , pp. 288-294
    • Hu, C.1    Dandapat, A.2    Chen, J.3    Liu, Y.4    Hermonat, P.L.5    Carey, R.M.6    Mehta, J.L.7
  • 209
    • 70349095254 scopus 로고    scopus 로고
    • Chronic angiotensin-(1-7) administration improves vascular remodeling after angioplasty through the regulation of the tgf-beta/smad signaling pathway in rabbits
    • Zeng W, Chen W, Leng X, He JG, Ma H. Chronic angiotensin-(1-7) administration improves vascular remodeling after angioplasty through the regulation of the tgf-beta/smad signaling pathway in rabbits. Biochem Biophys Res Commun. 2009;389:138-144.
    • (2009) Biochem Biophys Res Commun. , vol.389 , pp. 138-144
    • Zeng, W.1    Chen, W.2    Leng, X.3    He, J.G.4    Ma, H.5
  • 211
    • 35848933241 scopus 로고    scopus 로고
    • Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice
    • DOI 10.1161/CIRCULATIONAHA.107.698852
    • Thorp E, Kuriakose G, Shah YM, Gonzalez FJ, Tabas I. Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice. Circulation. 2007;116:2182-2190. (Pubitemid 350060356)
    • (2007) Circulation , vol.116 , Issue.19 , pp. 2182-2190
    • Thorp, E.1    Kuriakose, G.2    Shah, Y.M.3    Gonzalez, F.J.4    Tabas, I.5
  • 212
    • 79251581020 scopus 로고    scopus 로고
    • The art of microrna research
    • van Rooij E. The art of microrna research. Circ Res. 2011;108:219-234.
    • (2011) Circ Res , vol.108 , pp. 219-234
    • Van Rooij, E.1
  • 219
    • 75149165994 scopus 로고    scopus 로고
    • Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?
    • Salmon AB, Richardson A, Perez VI. Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med. 2010;48:642-655.
    • (2010) Free Radic Biol Med , vol.48 , pp. 642-655
    • Salmon, A.B.1    Richardson, A.2    Perez, V.I.3
  • 221
    • 77953728107 scopus 로고    scopus 로고
    • Rank(l) as a key target for controlling bone loss
    • Leibbrandt A, Penninger JM. Rank(l) as a key target for controlling bone loss. Adv Exp Med Biol. 2009;647:130-145.
    • (2009) Adv Exp Med Biol , vol.647 , pp. 130-145
    • Leibbrandt, A.1    Penninger, J.M.2
  • 223
    • 0347379905 scopus 로고    scopus 로고
    • Teriparatide (Human Parathyroid Hormone (1-34)) Inhibits Osteogenic Vascular Calcification in Diabetic Low Density Lipoprotein Receptor-deficient Mice
    • DOI 10.1074/jbc.M308825200
    • Shao JS, Cheng SL, Charlton-Kachigian N, Loewy AP, Towler DA. Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptordeficient mice. J Biol Chem. 2003;278:50195-50202. (Pubitemid 37548859)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50195-50202
    • Shao, J.-S.1    Cheng, S.-L.2    Charlton-Kachigian, N.3    Loewy, A.P.4    Towler, D.A.5
  • 224
    • 0034704998 scopus 로고    scopus 로고
    • Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase
    • Lee TC, Zhao YD, Courtman DW, Stewart DJ. Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation. 2000;101:2345-2348. (Pubitemid 30329122)
    • (2000) Circulation , vol.101 , Issue.20 , pp. 2345-2348
    • Lee, T.C.1    Zhao, Y.D.2    Courtman, D.W.3    Stewart, D.J.4
  • 228
    • 24344434589 scopus 로고    scopus 로고
    • Development of aortic valve sclerosis in a rabbit model of atherosclerosis: An immunohistochemical and histological study
    • Cimini M, Boughner DR, Ronald JA, Aldington L, Rogers KA. Development of aortic valve sclerosis in a rabbit model of atherosclerosis: an immunohistochemical and histological study. J Heart Valve Dis. 2005; 14:365-375. (Pubitemid 47050751)
    • (2005) Journal of Heart Valve Disease , vol.14 , Issue.3 , pp. 365-375
    • Cimini, M.1    Boughner, D.R.2    Ronald, J.A.3    Aldington, L.4    Rogers, K.A.5
  • 230
    • 50249161499 scopus 로고    scopus 로고
    • Development of aortic valve sclerosis or stenosis in rabbits: Role of cholesterol and calcium
    • Drolet MC, Couet J, Arsenault M. Development of aortic valve sclerosis or stenosis in rabbits: role of cholesterol and calcium. J Heart Valve Dis. 2008;17:381-387.
    • (2008) J Heart Valve Dis , vol.17 , pp. 381-387
    • Drolet, M.C.1    Couet, J.2    Arsenault, M.3
  • 238
    • 77955960185 scopus 로고    scopus 로고
    • Recombinant apolipoprotein a-i milano rapidly reverses aortic valve stenosis and decreases leaflet inflammation in an experimental rabbit model
    • Speidl WS, Cimmino G, Ibanez B, Elmariah S, Hutter R, Garcia MJ, Fuster V, Goldman ME, Badimon JJ. Recombinant apolipoprotein a-i milano rapidly reverses aortic valve stenosis and decreases leaflet inflammation in an experimental rabbit model. Eur Heart J. 2010;31: 2049-2057.
    • (2010) Eur Heart J , vol.31 , pp. 2049-2057
    • Speidl, W.S.1    Cimmino, G.2    Ibanez, B.3    Elmariah, S.4    Hutter, R.5    Garcia, M.J.6    Fuster, V.7    Goldman, M.E.8    Badimon, J.J.9
  • 239
    • 17644380642 scopus 로고    scopus 로고
    • Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    • DOI 10.1161/01.RES.0000161998.92009.64
    • Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ Res. 2005;96:792-799. (Pubitemid 40559519)
    • (2005) Circulation Research , vol.96 , Issue.7 , pp. 792-799
    • Simmons, C.A.1    Grant, G.R.2    Manduchi, E.3    Davies, P.F.4


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