β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 3, 2011, Pages 590-597

  Chen, Jan Hung ^a,b   Chen, Wen Li Kelly ^a   Sider, Krista L ^a   Yip, Cindy Ying Yin ^a   Simmons, Craig A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

catenin; extracellular matrix mechanics; heart valves; myofibroblast; transforming growth factor ; Wnt

Indexed keywords

BETA CATENIN; COLLAGEN; POLYACRYLAMIDE GEL; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; WNT3A PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; AORTA VALVE; ARTICLE; ATHEROGENIC DIET; CELL DIFFERENTIATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE SILENCING; GENE TRANSLOCATION; HEART MUSCLE COMPLIANCE; IN VITRO STUDY; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SWINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; AORTIC VALVE; BETA CATENIN; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; ELASTICITY; EXTRACELLULAR MATRIX; HEART VALVE DISEASES; MYOFIBROBLASTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA INTERFERENCE; SCLEROSIS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SWINE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEINS;

EID: 79952134815     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.220061     Document Type: Article

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