Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling

Journal of Biological Chemistry

Volumn 283, Issue 22, 2008, Pages 15319-15327

  Chang, Hyun Byon ^a   Javed, Amjad ^d,e   Dai, Qun ^b   Kappes, John C ^b,c,f   Clemens, Thomas L ^c,e   Darley Usmar, Victor M ^c,d   McDonald, Jay M ^c,e,f   Chen, Yabing ^c,d,e,g  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f BIRMINGHAM VA MEDICAL CENTER   (United States)

^g NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMINERALIZATION; BONE; CELL DEATH; HYDROGEN; HYDROGEN PEROXIDE; MODULATION; NUCLEIC ACIDS; OXIDATIVE STRESS; PROTEINS; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS;

APOPTOSIS; ATHEROSCLEROTIC LESIONS; OSTEOGENIC DIFFERENTIATIONS; OSTEOGENIC PHENOTYPES; OVEREXPRESSION; PHENOTYPIC SWITCHES; VASCULAR CALCIFICATIONS; VASCULAR CELLS; VASCULAR SMOOTH MUSCLE CELLS;

BLOOD VESSEL PROSTHESES;

HYDROGEN PEROXIDE; PROTEIN KINASE B; RNA; TRANSCRIPTION FACTOR RUNX2; RUNX2 PROTEIN, MOUSE;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD VESSEL CALCIFICATION; CONTROLLED STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; ATHEROSCLEROSIS; CALCINOSIS; CELL CULTURE; DRUG ANTAGONISM; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ADENOVIRIDAE;

ADENOVIRIDAE; ANIMALS; ATHEROSCLEROSIS; CALCINOSIS; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HYDROGEN PEROXIDE; MICE; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 47249157776     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800021200     Document Type: Article

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