Aortic valve endothelial cells undergo transforming growth factor-β-mediated and non-transforming growth factor-β-mediated transdifferentiation in Vitro

American Journal of Pathology

Volumn 159, Issue 4, 2001, Pages 1335-1343

  Paranya, Gretchen ^a   Vineberg, Sabrina ^a   Dvorin, Sabrina ^a   Kaushal, Sunjay ^a   Roth, Stephen J ^a   Rabkin, Elena ^b   Schoen, Frederick J ^b   Bischoff, Joyce ^a  

^a Children s Hospital   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; BASIC FIBROBLAST GROWTH FACTOR; CD31 ANTIGEN; CELL MARKER; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; AORTA VALVE; ARTICLE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOCARDIAL CUSHION DEFECT; ENDOTHELIUM CELL; FROZEN SECTION; HEART VALVE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOMODULATION; MESENCHYME CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SHEEP; SMOOTH MUSCLE FIBER;

EID: 0034800126     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62520-5     Document Type: Article

References (31)

1. Molecular regulation of atrioventricular valvuloseptal morphogenesis
2. Tissue heart valves: Current challenges and future research perspectives
3. Mechanisms of segmentation, septation, and remodeling of the tubular heart: Endocardial cushion fate and cardiac looping
4. Induction of endocardial cushion tissue in the avian heart is regulated in part by TGF-beta3-mediated autocrine signalling
5. TGF beta 2 and TGF beta 3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart
6. An autocrine function for transforming growth factor (TGF)-beta3 in the transformation of atrioventricular canal endocardium into mesenchyme during chick heart development
7. Antisense oligonucleotide complementary to smooth muscle alpha-actin inhibits endothelial-mesenchymal transformation during chick cardiogenesis
8. Phenotypic diversity and lineage relationships in vascular endothelial cells
9. In vitro cultivation and immunogenicity of human cardiac valve endothelium
10. Cell biology of valvular interstitial cells
11. Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells
12. A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation
13. Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth
14. A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors
15. Human vascular endothelial cells in culture
16. Binding of human endothelium to Ulex europaeus I-coated Dynabeads: Application to the isolation of microvascular endothelium
17. E-selectin is upregulated in proliferating endothelial cells in vitro
18. Motility and invasion are differentially modulated by Rho family GTPases
19. Transforming growth factor beta 1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro
20. What's new in human wound healing myofibroblasts
21. Regulation of differentiation of vascular smooth muscle cells
22. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis
23. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
24. Embryonic endothelial cells transdifferentiate into mesenchymal cells expressing smooth muscle actins in vivo and in vitro
25. Antibodies to the type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart
26. Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
27. A role for Smad6 in development and homeostasis of the cardiovascular system
28. Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart
29. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
30. The transcription factor NF-ATc is essential for cardiac valve formation
31. A murine model of hereditary hemorrhagic telangiectasia