-
1
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
2
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
3
-
-
0037837754
-
Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
-
Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG. Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 2003;278:11721-11728.
-
(2003)
J Biol Chem
, vol.278
, pp. 11721-11728
-
-
Liu, C.1
Gaca, M.D.2
Swenson, E.S.3
Vellucci, V.F.4
Reiss, M.5
Wells, R.G.6
-
4
-
-
0034678908
-
Transcriptional control by the TGF-beta/Smad signaling system
-
Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 2000;19:1745-1754.
-
(2000)
EMBO J
, vol.19
, pp. 1745-1754
-
-
Massague, J.1
Wotton, D.2
-
5
-
-
44349125602
-
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
-
Schmierer B, Tournier AL, Bates PA, Hill CS. Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc Natl Acad Sci USA 2008;105:6608-6613.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6608-6613
-
-
Schmierer, B.1
Tournier, A.L.2
Bates, P.A.3
Hill, C.S.4
-
6
-
-
0037373277
-
Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome
-
Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B et al. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 2003;33:407-411.
-
(2003)
Nat Genet
, vol.33
, pp. 407-411
-
-
Neptune, E.R.1
Frischmeyer, P.A.2
Arking, D.E.3
Myers, L.4
Bunton, T.E.5
Gayraud, B.6
-
7
-
-
20144367207
-
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
-
Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 2005;37:275-281.
-
(2005)
Nat Genet
, vol.37
, pp. 275-281
-
-
Loeys, B.L.1
Chen, J.2
Neptune, E.R.3
Judge, D.P.4
Podowski, M.5
Holm, T.6
-
8
-
-
33645381280
-
Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome
-
Coucke PJ, Willaert A, Wessels MW, Callewaert B, Zoppi N, De Backer J et al. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Nat Genet 2006;38:452-457.
-
(2006)
Nat Genet
, vol.38
, pp. 452-457
-
-
Coucke, P.J.1
Willaert, A.2
Wessels, M.W.3
Callewaert, B.4
Zoppi, N.5
De Backer, J.6
-
9
-
-
66849131058
-
Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway
-
Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G et al. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J Pathol 2009;218:131-142.
-
(2009)
J Pathol
, vol.218
, pp. 131-142
-
-
Gomez, D.1
Al Haj Zen, A.2
Borges, L.F.3
Philippe, M.4
Gutierrez, P.S.5
Jondeau, G.6
-
10
-
-
0031039041
-
Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice
-
Bonyadi M, Rusholme SA, Cousins FM, Su HC, Biron CA, Farrall M et al. Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Nat Genet 1997;15:207-211.
-
(1997)
Nat Genet
, vol.15
, pp. 207-211
-
-
Bonyadi, M.1
Rusholme, S.A.2
Cousins, F.M.3
Su, H.C.4
Biron, C.A.5
Farrall, M.6
-
11
-
-
0030918193
-
Regulation of differentiation/maturation in vascular smooth muscle cells by hormones and growth factors
-
Owens GK, Wise G. Regulation of differentiation/maturation in vascular smooth muscle cells by hormones and growth factors. Agents Actions Suppl 1997;48:3-24.
-
(1997)
Agents Actions Suppl
, vol.48
, pp. 3-24
-
-
Owens, G.K.1
Wise, G.2
-
12
-
-
69449090360
-
Circulating transforming growth factor-beta in Marfan syndrome
-
Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D et al. Circulating transforming growth factor-beta in Marfan syndrome. Circulation 2009;120:526-532.
-
(2009)
Circulation
, vol.120
, pp. 526-532
-
-
Matt, P.1
Schoenhoff, F.2
Habashi, J.3
Holm, T.4
Van Erp, C.5
Loch, D.6
-
13
-
-
35448991324
-
Extracellular control of TGFbeta signalling in vascular development and disease
-
ten Dijke P, Arthur HM. Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 2007;8:857-869.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 857-869
-
-
Ten Dijke, P.1
Arthur, H.M.2
-
14
-
-
0025886783
-
Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene
-
Dietz HC, Cutting GR, Pyeritz RE, Maslen CL, Sakai LY, Corson GM et al. Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature 1991;352:337-339.
-
(1991)
Nature
, vol.352
, pp. 337-339
-
-
Dietz, H.C.1
Cutting, G.R.2
Pyeritz, R.E.3
Maslen, C.L.4
Sakai, L.Y.5
Corson, G.M.6
-
15
-
-
3543013177
-
Heterozygous TGFBR2 mutations in Marfan syndrome
-
Mizuguchi T, Collod-Beroud G, Akiyama T, Abifadel M, Harada N, Morisaki T et al. Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet 2004;36:855-860.
-
(2004)
Nat Genet
, vol.36
, pp. 855-860
-
-
Mizuguchi, T.1
Collod-Beroud, G.2
Akiyama, T.3
Abifadel, M.4
Harada, N.5
Morisaki, T.6
-
16
-
-
33644627494
-
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
-
Zhu L, Vranckx R, Khau Van Kien P, Lalande A, Boisset N, Mathieu F et al. Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet 2006;38:343-349.
-
(2006)
Nat Genet
, vol.38
, pp. 343-349
-
-
Zhu, L.1
Vranckx, R.2
Khau Van Kien, P.3
Lalande, A.4
Boisset, N.5
Mathieu, F.6
-
17
-
-
34848825045
-
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II
-
Pannu H, Tran-Fadulu V, Papke CL, Scherer S, Liu Y, Presley C et al. MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet 2007;16:2453-2462.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 2453-2462
-
-
Pannu, H.1
Tran-Fadulu, V.2
Papke, C.L.3
Scherer, S.4
Liu, Y.5
Presley, C.6
-
18
-
-
36549071997
-
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
-
Guo DC, Pannu H, Tran-Fadulu V, Papke CL, Yu RK, Avidan N et al. Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet 2007;39:1488-1493.
-
(2007)
Nat Genet
, vol.39
, pp. 1488-1493
-
-
Guo, D.C.1
Pannu, H.2
Tran-Fadulu, V.3
Papke, C.L.4
Yu, R.K.5
Avidan, N.6
-
19
-
-
52949141431
-
Genetic basis of thoracic aortic aneurysms and dissections: Focus on smooth muscle cell contractile dysfunction
-
Milewicz DM, Guo DC, Tran-Fadulu V, Lafont AL, Papke CL, Inamoto S et al. Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction. Annu Rev Genomics Hum Genet 2008;9:283-302.
-
(2008)
Annu Rev Genomics Hum Genet
, vol.9
, pp. 283-302
-
-
Milewicz, D.M.1
Guo, D.C.2
Tran-Fadulu, V.3
Lafont, A.L.4
Papke, C.L.5
Inamoto, S.6
-
20
-
-
0041827287
-
Aortic valve and aortic arch pathology after coarctation repair
-
Roos-Hesselink JW, Scholzel BE, Heijdra RJ, Spitaels SE, Meijboom FJ, Boersma E et al. Aortic valve and aortic arch pathology after coarctation repair. Heart 2003;89: 1074-1077.
-
(2003)
Heart
, vol.89
, pp. 1074-1077
-
-
Roos-Hesselink, J.W.1
Scholzel, B.E.2
Heijdra, R.J.3
Spitaels, S.E.4
Meijboom, F.J.5
Boersma, E.6
-
21
-
-
13844275555
-
Thoracic and abdominal aortic aneurysms
-
Isselbacher EM. Thoracic and abdominal aortic aneurysms. Circulation 2005;111: 816-828.
-
(2005)
Circulation
, vol.111
, pp. 816-828
-
-
Isselbacher, E.M.1
-
22
-
-
24944499797
-
Thoracic aortic aneurysms
-
Klein DG. Thoracic aortic aneurysms. J Cardiovasc Nurs 2005;20:245-250.
-
(2005)
J Cardiovasc Nurs
, vol.20
, pp. 245-250
-
-
Klein, D.G.1
-
23
-
-
33645672459
-
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
-
Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006;312:117-121.
-
(2006)
Science
, vol.312
, pp. 117-121
-
-
Habashi, J.P.1
Judge, D.P.2
Holm, T.M.3
Cohn, R.D.4
Loeys, B.L.5
Cooper, T.K.6
-
24
-
-
33747812887
-
Aneurysm syndromes caused by mutations in the TGF-beta receptor
-
Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 2006;355: 788-798.
-
(2006)
N Engl J Med
, vol.355
, pp. 788-798
-
-
Loeys, B.L.1
Schwarze, U.2
Holm, T.3
Callewaert, B.L.4
Thomas, G.H.5
Pannu, H.6
-
25
-
-
33745737894
-
The molecular genetics of Marfan syndrome and related disorders
-
Robinson PN, Arteaga-Solis E, Baldock C, Collod-Beroud G, Booms P, De Paepe A et al. The molecular genetics of Marfan syndrome and related disorders. J Med Genet 2006;43:769-787.
-
(2006)
J Med Genet
, vol.43
, pp. 769-787
-
-
Robinson, P.N.1
Arteaga-Solis, E.2
Baldock, C.3
Collod-Beroud, G.4
Booms, P.5
De Paepe, A.6
-
26
-
-
50549084575
-
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: A paradox in pathogenesis
-
Jones JA, Spinale FG, Ikonomidis JS. Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res 2009;46: 119-137.
-
(2009)
J Vasc Res
, vol.46
, pp. 119-137
-
-
Jones, J.A.1
Spinale, F.G.2
Ikonomidis, J.S.3
-
27
-
-
0030850459
-
Recommendations guiding physicians in biomedical research involving human subjects
-
World Medical Association Declaration of Helsinki
-
World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 1997;35:2-3.
-
(1997)
Cardiovasc Res
, vol.35
, pp. 2-3
-
-
-
28
-
-
42149145311
-
Dilation-dependent activation of platelets and prothrombin in human thoracic ascending aortic aneurysm
-
Touat Z, Lepage L, Ollivier V, Nataf P, Hvass U, Labreuche J et al. Dilation-dependent activation of platelets and prothrombin in human thoracic ascending aortic aneurysm. Arterioscler Thromb Vasc Biol 2008;28:940-946.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 940-946
-
-
Touat, Z.1
Lepage, L.2
Ollivier, V.3
Nataf, P.4
Hvass, U.5
Labreuche, J.6
-
29
-
-
0028606206
-
Hyperproliferation of aortic smooth muscle cells and fibroblasts from young SHR rats is not shared by endothelial cells
-
Battle T, Arnal JF, Michel JB. Hyperproliferation of aortic smooth muscle cells and fibroblasts from young SHR rats is not shared by endothelial cells. Clin Exp Pharmacol Physiol 1994;21:981-989.
-
(1994)
Clin Exp Pharmacol Physiol
, vol.21
, pp. 981-989
-
-
Battle, T.1
Arnal, J.F.2
Michel, J.B.3
-
30
-
-
68949101788
-
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes-but without modulating bone morphogenetic protein 7 signaling
-
Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes-but without modulating bone morphogenetic protein 7 signaling. Hepatology 2009;49:2021-2030.
-
(2009)
Hepatology
, vol.49
, pp. 2021-2030
-
-
Gressner, O.A.1
Lahme, B.2
Siluschek, M.3
Rehbein, K.4
Weiskirchen, R.5
Gressner, A.M.6
-
31
-
-
48249127225
-
Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
-
Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci USA 2008;105: 9047-9052.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9047-9052
-
-
Villeneuve, L.M.1
Reddy, M.A.2
Lanting, L.L.3
Wang, M.4
Meng, L.5
Natarajan, R.6
-
32
-
-
0031889595
-
Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway
-
Takenoshita S, Mogi A, Nagashima M, Yang K, Yagi K, Hanyu A et al. Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway. Genomics 1998;48:1-11.
-
(1998)
Genomics
, vol.48
, pp. 1-11
-
-
Takenoshita, S.1
Mogi, A.2
Nagashima, M.3
Yang, K.4
Yagi, K.5
Hanyu, A.6
-
33
-
-
27644589675
-
The diverse functions of histone lysine methylation
-
Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 2005;6:838-849.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 838-849
-
-
Martin, C.1
Zhang, Y.2
-
34
-
-
27144527031
-
Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer
-
Ogishima T, Shiina H, Breault JE, Terashima M, Honda S, Enokida H et al. Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer. Oncogene 2005;24:6765-6772.
-
(2005)
Oncogene
, vol.24
, pp. 6765-6772
-
-
Ogishima, T.1
Shiina, H.2
Breault, J.E.3
Terashima, M.4
Honda, S.5
Enokida, H.6
-
35
-
-
0036051343
-
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
-
Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002;4:599-604.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 599-604
-
-
Abreu, J.G.1
Ketpura, N.I.2
Reversade, B.3
De Robertis, E.M.4
-
36
-
-
43049172112
-
Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone
-
Mochizuki K, Takabe S, Goda T. Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. Biochem Biophys Res Commun 2008;371:324-327.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 324-327
-
-
Mochizuki, K.1
Takabe, S.2
Goda, T.3
-
37
-
-
33644943043
-
Histone H3 acetylated at lysine 9 in promoter is associated with low nucleosome density in the vicinity of transcription start site in human cell
-
Nishida H, Suzuki T, Kondo S, Miura H, Fujimura Y, Hayashizaki Y. Histone H3 acetylated at lysine 9 in promoter is associated with low nucleosome density in the vicinity of transcription start site in human cell. Chromosome Res 2006;14:203-211.
-
(2006)
Chromosome Res
, vol.14
, pp. 203-211
-
-
Nishida, H.1
Suzuki, T.2
Kondo, S.3
Miura, H.4
Fujimura, Y.5
Hayashizaki, Y.6
-
38
-
-
55449107515
-
Regulation of TGF-beta family signaling by E3 ubiquitin ligases
-
Inoue Y, Imamura T. Regulation of TGF-beta family signaling by E3 ubiquitin ligases. Cancer Sci 2008;99:2107-2112.
-
(2008)
Cancer Sci
, vol.99
, pp. 2107-2112
-
-
Inoue, Y.1
Imamura, T.2
-
39
-
-
1942534004
-
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation
-
Izzi L, Attisano L. Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation. Oncogene 2004;23:2071-2078.
-
(2004)
Oncogene
, vol.23
, pp. 2071-2078
-
-
Izzi, L.1
Attisano, L.2
-
40
-
-
34249736457
-
Programming smooth muscle plasticity with chromatin dynamics
-
McDonald OG, Owens GK. Programming smooth muscle plasticity with chromatin dynamics. Circ Res 2007;100:1428-1441.
-
(2007)
Circ Res
, vol.100
, pp. 1428-1441
-
-
McDonald, O.G.1
Owens, G.K.2
-
41
-
-
3042588831
-
Molecular regulation of vascular smooth muscle cell differentiation in development and disease
-
Owens GK, Kumar MS,Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004;84:767-801.
-
(2004)
Physiol Rev
, vol.84
, pp. 767-801
-
-
Owens, G.K.1
Kumar, M.S.2
Wamhoff, B.R.3
-
42
-
-
31044442783
-
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo
-
McDonald OG, Wamhoff BR, Hoofnagle MH, Owens GK. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J Clin Invest 2006;116:36-48.
-
(2006)
J Clin Invest
, vol.116
, pp. 36-48
-
-
McDonald, O.G.1
Wamhoff, B.R.2
Hoofnagle, M.H.3
Owens, G.K.4
-
44
-
-
70350461683
-
Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells
-
Lee S, Park JR, Seo MS, Roh KH, Park SB, Hwang JW et al. Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells. Cell Prolif 2009;42:711-720.
-
(2009)
Cell Prolif
, vol.42
, pp. 711-720
-
-
Lee, S.1
Park, J.R.2
Seo, M.S.3
Roh, K.H.4
Park, S.B.5
Hwang, J.W.6
|