Receptor activator of nuclear factor κB ligand and osteoprotegerin regulate aortic valve calcification

Journal of Molecular and Cellular Cardiology

Volumn 36, Issue 1, 2004, Pages 57-66

  Kaden, Jens J ^a   Bickelhaupt, Svetlana ^a   Grobholz, Rainer ^a   Haase, Karl K ^a   Sarikoç, Aslihan ^a   Kiliç, Refika ^a   Brueckmann, Martina ^a   Lang, Siegfried ^a   Zahn, Ingrid ^b   Vahl, Christian ^a   Hagl, Siegfried ^a   Dempfle, Carl Erik ^a   Borggrefe, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Laboratory Group   (Germany)

Author keywords

Aortic valve calcification; AS; OPG; RANKL; Receptor activator

Indexed keywords

ALKALINE PHOSPHATASE; DNA; ISOENZYME; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TRANSCRIPTION FACTOR RUNX2;

AORTA STENOSIS; AORTA VALVE; AORTA VALVE CALCIFICATION; AORTA VALVE DISEASE; ARTICLE; BONE TURNOVER; CALCIFIC AORTIC STENOSIS; CALCIFICATION; CONTROLLED STUDY; DNA BINDING; EXTRACELLULAR MATRIX; GENE INDUCTION; HEART CELL CULTURE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE LEVEL;

EID: 0347004546     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2003.09.015     Document Type: Article

References (31)

1. Aronow W.S., Kronzon I. Prevalence and severity of valvular aortic stenosis determined by Doppler echocardiography and its association with echocardiographic and electrocardiographic left ventricular hypertrophy and physical signs of aortic stenosis in elderly patients. Am J Cardiol. 67:1991;776-777.
2. Olsson M., Dalsgaard C.J., Haegerstrand A., Rosenqvist M., Ryden L., Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J Am Coll Cardiol. 23:1994;1162-1170.
3. Otto C.M., Kuusisto J., Reichenbach D.D., Gown A.M., O'Brien K.D. Characterization of the early lesion of "degenerative" valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 90:1994;844-853.
4. Mohler E.R. III, Gannon F., Reynolds C., Zimmerman R., Keane M.G., Kaplan F.S. Bone formation and inflammation in cardiac valves. Circulation. 103:2001;1522-1528.
5. O'Brien K.D., Kuusisto J., Reichenbach D.D., Ferguson M., Giachelli C., Alpers C.E., et al. Osteopontin is expressed in human aortic valvular lesions. Circulation. 92:1995;2163-2168.
6. Srivatsa S.S., Harrity P.J., Maercklein P.B., Kleppe L., Veinot J., Edwards W.D., et al. Increased cellular expression of matrix proteins that regulate mineralisation is associated with calcification of native human and procine xenograft bioprosthetic heart valves. J Clin Invest. 99:1997;996-1009.
7. Lee Y.S., Chou Y.Y. Pathogenetic mechanism of senile calcific aortic stenosis: the role of apoptosis. Chin Med J (Engl). 111:1998;934-939.
8. Nakagawa N., Kinosaki M., Yamaguchi K., Shima N., Yasuda H., Yano K., et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 253:1998;395-400.
9. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:1999;315-323.
10. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 89:1997;309-319.
11. Min H., Morony S., Sarosi I., Dunstan C.R., Capparelli C., Scully S., et al. Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med. 192:2000;463-474.
12. Bucay N., Sarosi I., Dunstan C.R., Morony S., Tarpley J., Capparelli C., et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Gene Dev. 12:1998;1260-1268.
13. Mohler E.R. III, Chawla M.K., Chang A.W., Vyavahare N., Levy R.J., Graham L., et al. Identification and characterization of calcifying valve cells from human and canine aortic valves. J Heart Valve Dis. 8:1999;254-260.
14. Shioi A., Nishizawa Y., Jono S., Koyama H., Hosoi M., Morii H. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 15:1995;2003-2009.
15. Shioi A., Katagi M., Okuno Y., Mori K., Jono S., Koyama H., et al. Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: roles of tumor necrosis factor-alpha and oncostatin M derived from macrophages. Circ Res. 91:2002;9-16.
16. Steitz S.A., Speer M.Y., Curinga G., Yang H.Y., Haynes P., Aebersold R., et al. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res. 89:2001;1147-1154.
17. Tintut Y., Patel J., Parhami F., Demer L.L. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation. 102:2000;2636-2642.
18. Lin D.L., Tarnowski C.P., Zhang J., Dai J., Rohn E., Patel A.H., et al. Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro. Prostate. 47:2001;212-221.
19. Stein G.S., Lian J.B., Stein J.L., van Wijnen A.J., Montecino M. Transcriptional control of osteoblast growth and differentiation. Physiol Rev. 76:1996;593-629.
20. Dhore C.R., Cleutjens J.P., Lutgens E., Cleutjens K.B., Geusens P.P., Kitslaar P.J., et al. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 21:2001;1998-2003.
21. Wada T., Mckee M.D., Steitz S., Giachelli C.M. Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circ Res. 84:1999;166-178.
22. Malyankar U.M., Scatena M., Suchland K.L., Yun T.J., Clark E.A., Giachelli C.M. Osteoprotegerin is an alpha v beta 3-induced, NF-kappa B-dependent survival factor for endothelial cells. J Biol Chem. 275:2000;20959-20962.
23. Price P.A., June H.H., Buckley J.R., Williamson M.K. Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol. 21:2001;1610-1616.
24. Siggelkow H., Rebenstorff K., Kurre W., Niedhart C., Engel I., Schulz H., et al. Development of the osteoblast phenotype in primary human osteoblasts in culture: comparison with rat calvarial cells in osteoblast differentiation. J Cell Biochem. 75:1999;22-35.
25. Watson K.E., Bostrom K., Ravindranath R., Lam T., Norton B., Demer L.L. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 93:1994;2106-2113.
26. Jian B., Narula N., Li Q.Y., Mohler E.R. III, Levy R.J. Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg. 75:2003;457-465. discussion 465-6.
27. Proudfoot D., Davies J.D., Skepper J.N., Weissberg P.L., Shanahan C.M. Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation. 106:2002;3044-3050.
28. Levy R.J., Gundberg C., Scheinman R. The identification of the vitamin K-dependent bone protein osteocalcin as one of the gamma-carboxyglutamic acid containing proteins present in calcified atherosclerotic plaque and mineralized heart valves. Atherosclerosis. 46:1983;49-56.
29. Engelse M.A., Neele J.M., Bronckers A.L., Pannekoek H., de Vries C.J. Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor alpha-1 and the protective factor matrix gla protein in human atherogenesis. Cardiovasc Res. 52:2001;281-289.
30. Rajamannan N.M., Subramaniam M., Springett M., Sebo T.C., Niekrasz M., Mcconnell J.P., et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation. 105:2002;2660-2665.
31. Rajamannan N.M., Subramaniam M., Rickard D., Stock S.R., Donovan J., Springett M., et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 107:2003;2181-2184.