High-cholesterol + vitamin D2 regimen: A questionable in-vivo experimental model of aortic valve stenosis

Journal of Heart Valve Disease

Volumn 18, Issue 2, 2009, Pages 152-158

  Hekimian, Guillaume ^a   Passefort, Stephanie ^a   Louedec, Liliane ^a   Houard, Xavier ^a   Jacob, Marie Paule ^a   Vahanian, Alec ^a   Michel, Jean Bapstiste ^a   Messika Zeitoun, David ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERGOCALCIFEROL; VITAMIN;

ANIMAL; ANIMAL MODEL; AORTA; AORTA VALVE STENOSIS; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; CALCINOSIS; CAPILLARY PERMEABILITY; CHOLESTEROL INTAKE; MALE; MICROSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; RABBIT;

ANIMALS; AORTA; AORTIC VALVE STENOSIS; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; CALCINOSIS; CAPILLARY PERMEABILITY; CHOLESTEROL, DIETARY; ERGOCALCIFEROLS; MALE; MICROSCOPY; MODELS, ANIMAL; RABBITS; VITAMINS;

EID: 67449091297     PISSN: 09668519     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J 2003;24:1231-1243 (Pubitemid 36834640)
2. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: A population-based study. Lancet 2006;368:1005-1011 (Pubitemid 44353666)
3. O'Brien KD, Kuusisto J, Reichenbach DD, et al. Osteopontin is expressed in human aortic valvular lesions. Circulation 1995;92:2163-2168
4. Mohler ER, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS. Bone formation and inflammation in cardiac valves. Circulation 2001;103:1522-1528 (Pubitemid 32226259)
5. Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003;107:2181-2184 (Pubitemid 36547209)
6. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Circulation 1994;90:844-853 (Pubitemid 24242754)
7. O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis. Arterioscler Thromb Vase Biol 1996;16:523-532 (Pubitemid 26107723)
8. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Clinical factors associated with calcific aortic valve disease. J Am Coll Cardiol 1997;29:630-634
9. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 1999;341:142-147 (Pubitemid 29325741)
10. Cowell SJ, Newby DE, Prescott RJ, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005;352:2389-2397 (Pubitemid 40958435)
11. Guerraty M, Mohler ER. Models of aortic valve calcification. J Invest Med 2007;55:278-283 (Pubitemid 350205421)
12. Cimini M, Boughner DR, Ronald JA, Aldington L, Rogers KA. Development of aortic valve sclerosis in a rabbit model of atherosclerosis: An immunohistochemical and histological study. J Heart Valve Dis 2005;14:365-375 (Pubitemid 47050751)
13. Drolet MC, Arsenault M, Couet J. Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 2003;41:1211-1217 (Pubitemid 36384911)
14. Rajamannan NM, Subramaniam M, Springett M, et al. Atorvastatin inhibits hypercholesterolemiainduced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 2002;105 2660-2665 (Pubitemid 34596044)
15. Rajamannan NM, Subramaniam M, Stock SR, et al. Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart 2005;91:806-810 (Pubitemid 40769233)
16. Bellamy MF, Pellikka PA, Klarich KW, Tajik AJ, Enriquez-Sarano M. Association of cholesterol levels, hydroxymethylglutaryl coenzyme-A reductase inhibitor treatment, and progression of aortic stenosis in the community. J Am Coll Cardiol 2002;40:1723-1730 (Pubitemid 35341948)
17. Messika-Zeitoun D, Bielak LF, Peyser PA, et al. Aortic valve calcification: Determinants and progression in the population. Arterioscler Thromb Vase Biol 2007;27:642-648
18. Palta S, Pai AM, Gill KS, Pai RG. New insights into the progression of aortic stenosis: Implications for secondary prevention. Circulation 2000;101:2497-2502 (Pubitemid 30366254)
19. Rosenhek R, Rader F, Loho N, et al. Statins but not angiotensin- converting enzyme inhibitors delay progression of aortic stenosis. Circulation 2004;110:1291-1295 (Pubitemid 39202347)
20. Moura LM, Ramos SF, Zamorano JL, et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007;49:554-561 (Pubitemid 46177435)
21. Rapp AH, Hillis LD, Lange RA, Cigarroa JE. Prevalence of coronary artery disease in patients with aortic stenosis with and without angina pectoris. Am J Cardiol 2001;87:1216-1217 (Pubitemid 32453250)
22. O'Brien KD. Pathogenesis of calcific aortic valve disease: A disease process comes of age (and a good deal more). Arterioscler Thromb Vase Biol 2006;26:1721-1728 (Pubitemid 44305324)
23. Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Ryden L, Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J Am Coll Cardiol 1994;23:1162-1170 (Pubitemid 24117151)
24. Olsson M, Rosenqvist M, Nilsson J. Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis. J Am Coll Cardiol 1994;24:1664-1671 (Pubitemid 24369191)
25. Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vase Biol 1999;19:1218-1222 (Pubitemid 29227640)
26. Fondard O, Detaint D, lung B, et al. Extracellular matrix remodelling in human aortic valve disease: The role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J 2005;26:1333-1341 (Pubitemid 41435466)
27. O'Brien KD, Shavelle DM, Caulfield MT, et al. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 2002;106:2224-2230 (Pubitemid 35222217)
28. Helske S, Lindstedt KA, Laine M, et al. Induction of local angiotensin II-producing systems in stenotic aortic valves. J Am Coll Cardiol 2004;44:1859-1866 (Pubitemid 39424087)
29. Mohler ER, Adam LP, McClelland P, Graham L, Hathaway DR. Detection of osteopontin in calcified human aortic valves. Arterioscler Thromb Vase Biol 1997;17:547-552 (Pubitemid 27133146)
30. Mohler ER, Chawla MK, Chang AW, et al. Identification and characterization of calcifying valve cells from human and canine aortic valves. J Heart Valve Dis 1999;8:254-260 (Pubitemid 29274326)
31. Liberman M, Bassi E, Martinatti MK, et al. Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vase Biol 2008;28:463-470
32. Drolet MC, Couet J, Arsenault M. Development of aortic valve sclerosis or stenosis in rabbits: Role of cholesterol and calcium. J Heart Valve Dis 2008;17:381-387
33. Ngo DT, Stafford I, Kelly DJ, et al. Vitamin D (2) supplementation induces the development of aortic stenosis in rabbits: Interactions with endothelial function and thioredoxin-interacting protein. Eur J Pharmacol 2008;590:290-296
34. Maher ER, Young G, Smyth-Walsh B, Pugh S, Curtis JR. Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet 1987;2:875-877 (Pubitemid 17154752)
35. Wongpraparut N, Apiyasawat S, Crespo G, Yazdani K, Jacobs LE, Kotler MN. Determinants of progression of aortic stenosis in patients aged > or =40 years. Am J Cardiol 2002;89:350-352 (Pubitemid 34113802)
36. Kawaguchi A, Miyatake K, Yutani C, et al. Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia. Am Heart J 1999;137:410-418 (Pubitemid 29124105)
37. Allen JM, Thompson GR, Myant NB, Steiner R, Oakley CM. Cardiovascular complications of homozygous familial hypercholesterolemia. Br Heart J 1980;44:361-368 (Pubitemid 11250363)
38. Rallidis L, Naoumova RP, Thompson GR, Nihoyannopoulos P. Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia. Heart 1998;80:583-590 (Pubitemid 28561693)
39. Rossebo AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008;359:1343-1356