Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves

European Heart Journal

Volumn 27, Issue 12, 2006, Pages 1495-1504

  Helske, Satu ^a   Syväranta, Suvi ^a   Kupari, Markku ^b   Lappalainen, Jani ^a   Laine, Mika ^c   Lommi, Jyri ^b   Turto, Heikki ^b   Mäyränpää, Mikko ^a   Werkkala, Kalervo ^b   Kovanen, Petri T ^a   Lindstedt, Ken A ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

Angiotensin; Aortic stenosis; Cathepsin G; Elastin; Fibrosis; Mast cell

Indexed keywords

ANGIOTENSIN II; CATHEPSIN G; CIGARETTE SMOKE; COLLAGEN; ELASTIN; LOSARTAN; NICOTINE;

ADULT; AGED; AORTA VALVE STENOSIS; ARTICLE; CELL CULTURE; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROSIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MAJOR CLINICAL STUDY; MALE; MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING;

ADULT; AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; CATHEPSIN G; CATHEPSINS; COLLAGEN; ELASTIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SMOKE; TOBACCO; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33745725939     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehi706     Document Type: Article

References (32)

1. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994;90:844-853.
2. Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Ryden L, Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J Am Coll Cardiol 1994;23:1162-1170.
3. Helske S, Lindstedt KA, Laine M, Mayranpaa M, Werkkala K, Lommi J, Turto H, Kupari M, Kovanen PT. Induction of local angiotensin II-producing systems in stenotic aortic valves. J Am Coll Cardiol 2004;44:1859-1866.
4. Alpert JS. Aortic stenosis: a new face for an old disease. Arch Intern Med 2003;163:1769-1770.
5. Lindroos M, Kupari M, Valvanne J, Strandberg T, Heikkila J, Tilvis R. Factors associated with calcific aortic valve degeneration in the elderly. Eur Heart J 1994;15:865-870.
6. Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997;29:630-634.
7. Olsson M, Rosenqvist M, Nilsson J. Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis. J Am Coll Cardiol 1994;24:1664-1671.
8. O'Brien KD, Shavelle DM, Caulfield MT, McDonald TO, Olin-Lewis K, Otto CM, Probstfield JL. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 2002;106:2224-2230.
9. Weber KT, Swamynathan SK, Guntaka RV, Sun Y. Angiotensin II and extracellular matrix homeostasis. Int J Biochem Cell Biol 1999;31:395-403.
10. Genest J, Cantin M, Garcia R, Thibault G, Gutkowska J, Schiffrin E, Kuchel O, Hamet P. Extrarenal angiotensin-forming enzymes. Clin Exp Hypertens A 1983;5:1065-1080.
11. Boudier C, Godeau G, Hornebeck W, Robert L, Bieth JG. The elastolytic activity of cathepsin G: an ex vivo study with dermal elastin. Am J Respir Cell Mol Biol 1991;4:497-503.
12. McDonnell J, Lobner JM, Knight WB, Lark MW, Green B, Poe M, Moore VL. Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo. Connect Tissue Res 1993;30:1-9.
13. Legedz L, Randon J, Sessa C, Baguet JP, Feugier P, Cerutti C, McGregor J, Bricca G. Cathepsin G is associated with atheroma formation in human carotid artery. J Hypertens 2004;22:157-166.
14. Kupari M, Turto H, Lommi J. Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur Heart J 2005;26:1790-1796.
15. Shiota N, Fukamizu A, Okunishi H, Takai S, Murakami K, Miyazaki M. Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts. Biochem J 1998;333:417-424.
16. Lipp P, Laine M, Tovey SC, Burrell KM, Berridge MJ, Li W, Bootman MD. Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart. Curr Biol 2000;10:939-942.
17. Dahl C, Saito H, Nielsen HV, Schiotz PO. The establishment of a combined serum-free and serum-supplemented culture method of obtaining functional cord blood-derived human mast cells. J Immunol Methods 2002;262:137-143.
18. Shore PA, Burkhalter A, Cohn VH Jr. A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther 1959;127:182-186.
19. Weber KT. Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circulation 1997;96:4065-4082.
20. Jian B, Narula N, Li QY, Mohler ER III, Levy RJ. Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 2003;75:457-465.
21. Mohler ER III, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS. Bone formation and inflammation in cardiac valves. Circulation 2001;103:1522-1528.
22. Kaden JJ, Bickelhaupt S, Grobholz R, Haase KK, Sarikoc A, Kilic R, Brueckmann M, Lang S, Zahn I, Vahl C, Hagl S, Dempfle CE, Borggrefe M. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification. J Mol Cell Cardiol 2004;36:57-66.
23. Rosenhek R, Klaar U, Schemper M, Scholten C, Heger M, Gabriel H, Binder T, Maurer G, Baumgartner H. Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 2004;25:199-205.
24. Kaden JJ, Dempfle CE, Grobholz R, Fischer CS, Vocke DC, Kilic R, Sarikoc A, Pinol R, Hagl S, Lang S, Brueckmann M, Borggrefe M. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol 2005;14:80-87.
25. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998;102:576-583.
26. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 1999;104:1191-1197.
27. Gacko M, Chyczewski L. Activity and localization of cathepsin B, D and G in aortic aneurysm. Int Surg 1997;82:398-402.
28. Tomek RJ, Rimar S, Eghbali-Webb M. Nicotine regulates collagen gene expression, collagenase activity, and DNA synthesis in cultured cardiac fibroblasts. Mol Cell Biochem 1994;136:97-103.
29. Roman J, Ritzenthaler JD, Gil-Acosta A, Rivera HN, Roser-Page S. Nicotine and fibronectin expression in lung fibroblasts: implications for tobacco-related lung tissue remodeling. FASEB J 2004;18:1436-1438.
30. Levy BI. Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system. Circulation 2004;109:8-13.
31. Verma S, Strauss M. Angiotensin receptor blockers and myocardial infarction. BMJ 2004;329:1248-1249.
32. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Levy S, Linde C, Lopez-Sendon JL, Nieminen MS, Pierard L, Remme WJ. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 2005;26:1115-1140.