-
1
-
-
77951060145
-
Proteases and proteolysis in Alzheimer disease: A multifactorial view on the disease process
-
De Strooper B (2010) Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol Rev 90, 465-494.
-
(2010)
Physiol Rev
, vol.90
, pp. 465-494
-
-
De Strooper, B.1
-
2
-
-
33750731675
-
100 Years and counting: Prospects for defeating Alzheimer's disease
-
DOI 10.1126/science.1132813
-
Roberson ED, Mucke L (2006) 100 years and counting: prospects for defeating Alzheimer's disease. Science 314, 781-784. (Pubitemid 44706637)
-
(2006)
Science
, vol.314
, Issue.5800
, pp. 781-784
-
-
Roberson, E.D.1
Mucke, L.2
-
3
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
DOI 10.1038/nrm2101, PII NRM2101
-
Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8, 101-112. (Pubitemid 46432529)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
4
-
-
24144441879
-
Uncovering gamma-secretase
-
Steiner H (2004) Uncovering gamma-secretase. Curr Alzheimer Res 1, 175-181.
-
(2004)
Curr Alzheimer Res
, vol.1
, pp. 175-181
-
-
Steiner, H.1
-
5
-
-
0035955693
-
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
-
Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276, 40288-40292.
-
(2001)
J Biol Chem
, vol.276
, pp. 40288-40292
-
-
Kimberly, W.T.1
Zheng, J.B.2
Guenette, S.Y.3
Selkoe, D.J.4
-
6
-
-
1442264828
-
Take five - BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
-
DOI 10.1038/sj.emboj.7600061
-
Haass C (2004) Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide genera-tion. EMBO J 23, 483-488. (Pubitemid 38282380)
-
(2004)
EMBO Journal
, vol.23
, Issue.3
, pp. 483-488
-
-
Haass, C.1
-
7
-
-
77950613181
-
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
-
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, de Strooper B, Saftig P (2010) The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neu-rosci 30, 4833-4844.
-
(2010)
J Neu-rosci
, vol.30
, pp. 4833-4844
-
-
Jorissen, E.1
Prox, J.2
Bernreuther, C.3
Weber, S.4
Schwanbeck, R.5
Serneels, L.6
Snellinx, A.7
Craessaerts, K.8
Thathiah, A.9
Tesseur, I.10
Bartsch, U.11
Weskamp, G.12
Blobel, C.P.13
Glatzel, M.14
De Strooper, B.15
Saftig, P.16
-
8
-
-
77956392552
-
ADAM10 is the physiologically relevant, constitutive alpha-secretase ofthe amyloid precursor protein in primary neurons
-
Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ell-wart JW, Kremmer E, Rossner S, Lichtenthaler SF (2010) ADAM10 is the physiologically relevant, constitutive alpha-secretase ofthe amyloid precursor protein in primary neurons. EMBO J 29, 3020-3032.
-
(2010)
EMBO J
, vol.29
, pp. 3020-3032
-
-
Kuhn, P.H.1
Wang, H.2
Dislich, B.3
Colombo, A.4
Zeitschel, U.5
Ell-Wart, J.W.6
Kremmer, E.7
Rossner, S.8
Lichtenthaler, S.F.9
-
9
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amy-loid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran, Burgess T, Louis J C, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer's amy-loid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran Burgess, T.18
Louis, J.C.19
Collins, F.20
Treanor, J.21
Rogers, G.22
Citron, M.23
more..
-
10
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
11
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as β-secretase
-
DOI 10.1006/mcne.1999.0811
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14, 419-427. (Pubitemid 30026585)
-
(1999)
Molecular and Cellular Neurosciences
, vol.14
, Issue.6
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
12
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomen-saari SM, Wang S, Walker D, John V (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomen-Saari, S.M.22
Wang, S.23
Walker, D.24
John, V.25
more..
-
13
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the β-secretase site of β- amyloid precursor protein
-
DOI 10.1073/pnas.97.4.1456
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci USA 97, 1456-1460. (Pubitemid 30118462)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
14
-
-
0035112647
-
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
-
DOI 10.1038/85064
-
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC (2001) BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4, 233-234. (Pubitemid 32194867)
-
(2001)
Nature Neuroscience
, vol.4
, Issue.3
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
McCarthy, D.3
Wen, H.4
Borchelt, D.R.5
Price, D.L.6
Wong, P.C.7
-
15
-
-
0028924248
-
Generation of amyloid beta protein from its precursor is sequence specific
-
Citron M, Teplow DB, Selkoe DJ (1995) Generation of amyloid beta protein from its precursor is sequence specific. Neuron 14, 661-670.
-
(1995)
Neuron
, vol.14
, pp. 661-670
-
-
Citron, M.1
Teplow, D.B.2
Selkoe, D.J.3
-
16
-
-
0345826094
-
BACE1 Suppression by RNA Interference in Primary Cortical Neurons
-
DOI 10.1074/jbc.M309219200
-
Kao SC, Krichevsky AM, Kosik KS Tsai LH (2004) BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem 279, 1942-1949. (Pubitemid 38084465)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.3
, pp. 1942-1949
-
-
Kao, S.-C.1
Krichevsky, A.M.2
Kosik, K.S.3
Tsai, L.-H.4
-
17
-
-
0037038816
-
β-secretase (BACE) as a drug target for Alzheimer's disease
-
DOI 10.1016/S0169-409X(02)00157-6, PII S0169409X02001576
-
Vassar R (2002) Beta-secretase (BACE) as a drug target for Alzheimer's disease. Adv Drug Deliv Rev 54, 1589-1602. (Pubitemid 35346833)
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.12
, pp. 1589-1602
-
-
Vassar, R.1
-
18
-
-
0033793248
-
Coordinated expression of beta-amyloid precursor protein and the putative betasecretase BACE and alpha-secretase ADAM10 in mouse and human brain
-
Marcinkiewicz M, Seidah NG (2000) Coordinated expression of beta-amyloid precursor protein and the putative betasecretase BACE and alpha-secretase ADAM10 in mouse and human brain, J Neurochem 75, 2133-2143.
-
(2000)
J Neurochem
, vol.75
, pp. 2133-2143
-
-
Marcinkiewicz, M.1
Seidah, N.G.2
-
19
-
-
27744501797
-
Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
-
DOI 10.1074/jbc.M504484200
-
Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, Simons K (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem 280, 36815-36823. (Pubitemid 41587762)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 36815-36823
-
-
Kalvodova, L.1
Kahya, N.2
Schwille, P.3
Ehehalt, R.4
Verkade, P.5
Drechsel, D.6
Simons, K.7
-
20
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
-
DOI 10.1038/85059
-
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R (2001) Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phe-notype and abolished beta-amyloid generation. Nat Neurosci 4, 231-232. (Pubitemid 32194866)
-
(2001)
Nature Neuroscience
, vol.4
, Issue.3
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
Denis, P.6
Fan, W.7
Kha, H.8
Zhang, J.9
Gong, Y.10
Martin, L.11
Louis, J.-C.12
Yan, Q.13
Richards, W.G.14
Citron, M.15
Vassar, R.16
-
21
-
-
34548847452
-
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
-
DOI 10.1074/jbc.M611687200
-
McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S (2007). Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synap-tic pathology in APP Transgenic Mice. J Biol Chem 282, 26326-26334. (Pubitemid 47443774)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.36
, pp. 26326-26334
-
-
McConlogue, L.1
Buttini, M.2
Anderson, J.P.3
Brigham, E.F.4
Chen, K.S.5
Freedman, S.B.6
Games, D.7
Johnson-Wood, K.8
Lee, M.9
Zeller, M.10
Liu, W.11
Motter, R.12
Sinha, S.13
-
22
-
-
0033783140
-
Presenilin-1 differen-tially facilitates endoproteolysis ofthe beta-amyloid precursor protein and Notch
-
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C (2000a) Presenilin-1 differen-tially facilitates endoproteolysis ofthe beta-amyloid precursor protein and Notch. Nat Cell Biol 2, 205-211.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 205-211
-
-
Capell, A.1
Steiner, H.2
Romig, H.3
Keck, S.4
Baader, M.5
Grim, M.G.6
Baumeister, R.7
Haass, C.8
-
23
-
-
0034613345
-
Maturation and pro-peptide cleavage of beta-secretase
-
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Wal-ter J, Lammich S, Multhaup G, Haass C (2000b) Maturation and pro-peptide cleavage of beta-secretase. J Biol Chem 275, 30849-30854.
-
(2000)
J Biol Chem
, vol.275
, pp. 30849-30854
-
-
Capell, A.1
Steiner, H.2
Willem, M.3
Kaiser, H.4
Meyer, C.5
Wal-Ter, J.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
24
-
-
77953280950
-
Membrane rafts in Alzheimer's disease beta-amyloid production
-
Vetrivel KS, Thinakaran G (2010) Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Bio-phys Acta 1801, 860-867.
-
(2010)
Biochim Bio-phys Acta
, vol.1801
, pp. 860-867
-
-
Vetrivel, K.S.1
Thinakaran, G.2
-
25
-
-
62149091579
-
Alzheimer disease Abeta production in the absence of S-palmitoylation- dependent targeting of BACE1 to lipid rafts
-
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G (2009) Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. JBiol Chem 284, 3793-3803.
-
(2009)
JBiol Chem
, vol.284
, pp. 3793-3803
-
-
Vetrivel, K.S.1
Meckler, X.2
Chen, Y.3
Nguyen, P.D.4
Seidah, N.G.5
Vassar, R.6
Wong, P.C.7
Fukata, M.8
Kounnas, M.Z.9
Thinakaran, G.10
-
26
-
-
42549148456
-
Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting
-
DOI 10.1126/science.1156609
-
Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, Schwille P, Schulz JB, Schroeder C, Simons M, Jennings G, Knolker HJ, Simons K (2008) Efficient inhi-bition ofthe Alzheimer's disease beta-secretase by membrane targeting. Science 320, 520-523. (Pubitemid 351590663)
-
(2008)
Science
, vol.320
, Issue.5875
, pp. 520-523
-
-
Rajendran, L.1
Schneider, A.2
Schlechtingen, G.3
Weidlich, S.4
Ries, J.5
Braxmeier, T.6
Schwille, P.7
Schulz, J.B.8
Schroeder, C.9
Simons, M.10
Jennings, G.11
Knolker, H.-J.12
Simons, K.13
-
27
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
-
DOI 10.1083/jcb.200207113
-
Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160, 113-123. (Pubitemid 36091721)
-
(2003)
Journal of Cell Biology
, vol.160
, Issue.1
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
28
-
-
0028276801
-
Evidence that production and release of amyloid β-protein involves the endocytic pathway
-
Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic path-way. J Biol Chem 269, 17386-17389. (Pubitemid 24218009)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.26
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
29
-
-
33746593662
-
Alzheimer's disease β-amyloid peptides are released in association with exosomes
-
DOI 10.1073/pnas.0603838103
-
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci USA 103, 11172-11177. (Pubitemid 44156491)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.30
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
-
30
-
-
40849097929
-
Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons
-
Schneider A, Rajendran L, Honsho M, Gralle M, Donnert G, Wouters F, Hell SW, Simons M. Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J Neurosci 28, 2874-2882.
-
J Neurosci
, vol.28
, pp. 2874-2882
-
-
Schneider, A.1
Rajendran, L.2
Honsho, M.3
Gralle, M.4
Donnert, G.5
Wouters, F.6
Hell, S.W.7
Simons, M.8
-
31
-
-
0028866435
-
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
-
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1, 1291-1296.
-
(1995)
Nat Med
, vol.1
, pp. 1291-1296
-
-
Haass, C.1
Lemere, C.A.2
Capell, A.3
Citron, M.4
Seubert, P.5
Schenk, D.6
Lannfelt, L.7
Selkoe, D.J.8
-
32
-
-
0029942495
-
Metabolism of the "swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus
-
Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS (1996) Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. JBiol Chem 271, 9390-9397.
-
(1996)
J Biol Chem
, vol.271
, pp. 9390-9397
-
-
Thinakaran, G.1
Teplow, D.B.2
Siman, R.3
Greenberg, B.4
Sisodia, S.S.5
-
33
-
-
33745038221
-
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-β peptides
-
DOI 10.1111/j.1600-0854.2006.00434.x
-
Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM (2006) Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic 7, 873-888. (Pubitemid 43871776)
-
(2006)
Traffic
, vol.7
, Issue.7
, pp. 873-888
-
-
Goldsbury, C.1
Mocanu, M.-M.2
Thies, E.3
Kaether, C.4
Haass, C.5
Keller, P.6
Biernat, J.7
Mandelkow, E.8
Mandelkow, E.-M.9
-
34
-
-
33644862462
-
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
DOI 10.1111/j.1600-0854.2006.00396.x
-
Kaether C, Schmitt S, Willem M, Haass C (2006) Amyloid precursor protein and notch intracellular domains are gen-erated after transport of their precursors to the cell surface. Traffic 7, 408-415. (Pubitemid 43372750)
-
(2006)
Traffic
, vol.7
, Issue.4
, pp. 408-415
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
35
-
-
25144501662
-
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
-
DOI 10.1016/j.neurobiolaging.2005.05.022, PII S0197458005001624
-
Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26, 1235-1244. (Pubitemid 41338539)
-
(2005)
Neurobiology of Aging
, vol.26
, Issue.9
, pp. 1235-1244
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
36
-
-
34347257068
-
Increased Aβ production leads to intracellular accumulation of Aβ in flotillin-1-positive endosomes
-
DOI 10.1159/000101841
-
Rajendran L, Knobloch M, Geiger KD, Dienel S, Nitsch R, Simons K, Konietzko U (2007) Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes. Neurodegener Dis 4, 164-170. (Pubitemid 47000410)
-
(2007)
Neurodegenerative Diseases
, vol.4
, Issue.2-3
, pp. 164-170
-
-
Rajendran, L.1
Knobloch, M.2
Geiger, K.D.3
Dienel, S.4
Nitsch, R.5
Simons, K.6
Konietzko, U.7
-
37
-
-
11144242097
-
Dimerization of β-site β-amyloid precursor protein-cleaving enzyme
-
DOI 10.1074/jbc.M410378200
-
Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C (2004) Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J Biol Chem 279, 53205-53212. (Pubitemid 40051823)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.51
, pp. 53205-53212
-
-
Westmeyer, G.G.1
Willem, M.2
Lichtenthaler, S.F.3
Lurman, G.4
Multhaup, G.5
Assfalg-Machleidt, I.6
Reiss, K.7
Saftig, P.8
Haass, C.9
-
38
-
-
34249734831
-
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
-
DOI 10.1016/j.neuron.2007.05.012, PII S0896627307003467
-
Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE (2007) Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54, 721-737. (Pubitemid 46843521)
-
(2007)
Neuron
, vol.54
, Issue.5
, pp. 721-737
-
-
Tesco, G.1
Koh, Y.H.2
Kang, E.L.3
Cameron, A.N.4
Das, S.5
Sena-Esteves, M.6
Hiltunen, M.7
Yang, S.-H.8
Zhong, Z.9
Shen, Y.10
Simpkins, J.W.11
Tanzi, R.E.12
-
39
-
-
69249212436
-
Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1
-
Cole SL, Vassar R (2009) Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neu¬robiolAging30, 1535-1544.
-
(2009)
Neu¬robiolAging
, vol.30
, pp. 1535-1544
-
-
Cole, S.L.1
Vassar, R.2
-
40
-
-
77954389124
-
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta-and gamma-secretase via distinct mechanisms
-
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF (2010) Bepridil and amiodarone simultaneously target the Alzheimer's disease beta-and gamma-secretase via distinct mechanisms. JNeurosci 30, 8974-8983.
-
(2010)
JNeurosci
, vol.30
, pp. 8974-8983
-
-
Mitterreiter, S.1
Page, R.M.2
Kamp, F.3
Hopson, J.4
Winkler, E.5
Ha, H.R.6
Hamid, R.7
Herms, J.8
Mayer, T.U.9
Nelson, D.J.10
Steiner, H.11
Stahl, T.12
Zeitschel, U.13
Rossner, S.14
Haass, C.15
Lichtenthaler, S.F.16
-
41
-
-
0035974650
-
Structure-based design: Potent inhibitors of human brain memapsin 2 (β-secretase)
-
DOI 10.1021/jm0101803
-
Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J (2001) Structure-based design: potent inhibitors ofhuman brain memapsin 2 (beta-secretase). JMed Chem 44, 2865-2868. (Pubitemid 32879115)
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, Issue.18
, pp. 2865-2868
-
-
Ghosh, A.K.1
Bilcer, G.2
Harwood, C.3
Kawahama, R.4
Shin, D.5
Hussain, K.A.6
Hong, L.7
Loy, J.A.8
Nguyen, C.9
Koelsch, G.10
Ermolieff, J.11
Tang, J.12
-
42
-
-
0034613320
-
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
-
Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J (2000) Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Sci-ence 290, 150-153.
-
(2000)
Sci-ence
, vol.290
, pp. 150-153
-
-
Hong, L.1
Koelsch, G.2
Lin, X.3
Wu, S.4
Terzyan, S.5
Ghosh, A.K.6
Zhang, X.C.7
Tang, J.8
-
43
-
-
63949088562
-
Function, regulation and therapeutic properties of beta-secretase (BACE1)
-
Willem M, Lammich S, Haass C (2009) Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin Cell Dev Biol 20, 175-182.
-
(2009)
Semin Cell Dev Biol
, vol.20
, pp. 175-182
-
-
Willem, M.1
Lammich, S.2
Haass, C.3
-
44
-
-
47949095541
-
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice
-
Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF (2008) P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. J Pharmacol Exp Ther 326, 502-513.
-
(2008)
J Pharmacol Exp Ther
, vol.326
, pp. 502-513
-
-
Meredith Jr., J.E.1
Thompson, L.A.2
Toyn, J.H.3
Marcin, L.4
Barten, D.M.5
Marcinkeviciene, J.6
Kopcho, L.7
Kim, Y.8
Lin, A.9
Guss, V.10
Burton, C.11
Iben, L.12
Polson, C.13
Cantone, J.14
Ford, M.15
Drexler, D.16
Fiedler, T.17
Lentz, K.A.18
Grace, J.E.J.R.19
Kolb, J.20
Corsa, J.21
Pierdomenico, M.22
Jones, K.23
Olson, R.E.24
MacOr, J.E.25
Albright, C.F.26
more..
-
45
-
-
0034617199
-
Expression analysis of BACE2 in brain and peripheral tissues
-
DOI 10.1074/jbc.M002688200
-
Bennett BD, Babu-Khan S, Loeloff R, Louis JC, Curran E, Citron M, Vassar R (2000) Expression analysis of BACE2 in brain andperipheraltissues. J Biol Chem275, 20647-20651. (Pubitemid 30457651)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.27
, pp. 20647-20651
-
-
Bennett, B.D.1
Babu-Khan, S.2
Loeloff, R.3
Louis, J.-C.4
Curran, E.5
Citron, M.6
Vassar, R.7
-
46
-
-
0030949124
-
Functional rafts in cell mem-branes
-
Simons K, Ikonen E (1997) Functional rafts in cell mem-branes. Nature 387, 569-572.
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
47
-
-
74849118341
-
Lipid rafts as a membrane-organizing principle
-
Lingwood D, Simons K (2010) Lipid rafts as a membrane-organizing principle. Science 327, 46-50.
-
(2010)
Science
, vol.327
, pp. 46-50
-
-
Lingwood, D.1
Simons, K.2
-
48
-
-
1842482773
-
Model systems, lipid rafts, and cell membranes
-
DOI 10.1146/annurev.biophys.32.110601.141803
-
Simons K, Vaz WL (2004) Model systems, lipid rafts, and cell membranes. Annu Rev Biophys Biomol Struct 33, 269-295. (Pubitemid 38829961)
-
(2004)
Annual Review of Biophysics and Biomolecular Structure
, vol.33
, pp. 269-295
-
-
Simons, K.1
Vaz, W.L.C.2
-
49
-
-
17244380947
-
Lipid rafts and membrane dynamics
-
DOI 10.1242/jcs.01681
-
Rajendran L, Simons K (2005) Lipid rafts and membrane dynamics. J Cell Sci 118, 1099-1102. (Pubitemid 40528680)
-
(2005)
Journal of Cell Science
, vol.118
, Issue.6
, pp. 1099-1102
-
-
Rajendran, L.1
Simons, K.2
-
50
-
-
33747591249
-
Dynamics in the plasma membrane: How to combine fluidity and order
-
DOI 10.1038/sj.emboj.7601204, PII 7601204
-
Marguet D, Lenne PF, Rigneault H, He HT (2006) Dynamics in the plasma membrane: how to combine fluidity and order. EMBO J 25, 3446-3457. (Pubitemid 44264856)
-
(2006)
EMBO Journal
, vol.25
, Issue.15
, pp. 3446-3457
-
-
Marguet, D.1
Lenne, P.-F.2
Rigneault, H.3
He, H.-T.4
-
51
-
-
34447273123
-
Mechanisms of disease: New therapeutic strategies for Alzheimer's disease - Targeting APP processing in lipid rafts
-
DOI 10.1038/ncpneuro0549, PII NCPNEURO0549
-
Cheng H, Vetrivel KS, Gong P, Meckler X, Parent A, Thi-nakaran G (2007) Mechanisms of disease: new therapeutic strategies for Alzheimer's disease-targeting APP processing in lipid rafts. Nat Clin Pract Neurol 3, 374-382. (Pubitemid 47040327)
-
(2007)
Nature Clinical Practice Neurology
, vol.3
, Issue.7
, pp. 374-382
-
-
Cheng, H.1
Vetrivel, K.S.2
Gong, P.3
Meckler, X.4
Parent, A.5
Thinakaran, G.6
-
52
-
-
0141482022
-
Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein
-
DOI 10.1073/pnas.1635130100
-
Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ (2003) Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci USA 100, 11735-11740. (Pubitemid 37206004)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.20
, pp. 11735-11740
-
-
Cordy, J.M.1
Hussain, I.2
Dingwall, C.3
Hooper, N.M.4
Turner, A.J.5
-
53
-
-
33645299023
-
The involvement of lipid rafts in Alzheimer's disease
-
Cordy JM, Hooper NM, Turner AJ (2006) The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 23, 111-122.
-
(2006)
Mol Membr Biol
, vol.23
, pp. 111-122
-
-
Cordy, J.M.1
Hooper, N.M.2
Turner, A.J.3
-
54
-
-
10344263931
-
Neuronal membrane cholesterol loss enhances amyloid peptide generation
-
DOI 10.1083/jcb.200404149
-
Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, de Strooper B, Dotti CG (2004) Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol 167, 953-960. (Pubitemid 39628117)
-
(2004)
Journal of Cell Biology
, vol.167
, Issue.5
, pp. 953-960
-
-
Abad-Rodriguez, J.1
Ledesma, M.D.2
Craessaerts, K.3
Perga, S.4
Medina, M.5
Delacourte, A.6
Dingwall, C.7
De Strooper, B.8
Dotti, C.G.9
-
55
-
-
2442664072
-
A seed for Alzheimer amyloid in the brain
-
DOI 10.1523/JNEUROSCI.0861-04.2004
-
Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K (2004) A seed for Alzheimer amyloid in the brain. J Neurosci 24, 4894-4902. (Pubitemid 38668215)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.20
, pp. 4894-4902
-
-
Hayashi, H.1
Kimura, N.2
Yamaguchi, H.3
Hasegawa, K.4
Yokoseki, T.5
Shibata, M.6
Yamamoto, N.7
Michikawa, M.8
Yoshikawa, Y.9
Terao, K.10
Matsuzaki, K.11
Lemere, C.A.12
Selkoe, D.J.13
Naiki, H.14
Yanagisawa, K.15
-
56
-
-
79953138568
-
Inhibi-tion of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1
-
Zhou L, Chavez-Gutierrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, de Strooper B (2011) Inhibi-tion of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. JBiol Chem 286, 8677-8687.
-
(2011)
JBiol Chem
, vol.286
, pp. 8677-8687
-
-
Zhou, L.1
Chavez-Gutierrez, L.2
Bockstael, K.3
Sannerud, R.4
Annaert, W.5
May, P.C.6
Karran, E.7
De Strooper, B.8
-
57
-
-
0037122704
-
Design of substrate-based inhibitors of human β-secretase
-
DOI 10.1021/jm0155695
-
Tung JS, Davis DL, Anderson JP, Walker DE, Mamo S, Jewett N, Hom RK, Sinha S, Thorsett ED, John V (2002) Design of substrate-based inhibitors ofhuman beta-secretase. J Med Chem 45, 259-262. (Pubitemid 34073445)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.2
, pp. 259-262
-
-
Tung, J.S.1
Davis, D.L.2
Anderson, J.P.3
Walker, D.E.4
Mamo, S.5
Jewett, N.6
Hom, R.K.7
Sinha, S.8
Thorsett, E.D.9
John, V.10
-
58
-
-
0037085453
-
Apical sorting of β-secretase limits amyloid β-peptide production
-
DOI 10.1074/jbc.M109119200
-
Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C (2002) Apical sorting of beta-secretase limits amyloid beta-peptide production. J Biol Chem 277, 5637-5643. (Pubitemid 34968618)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.7
, pp. 5637-5643
-
-
Capell, A.1
Meyn, L.2
Fluhrer, R.3
Teplow, D.B.4
Walter, J.5
Haass, C.6
-
59
-
-
33646121776
-
Inhibitors and modulators of beta-and gamma-secretase
-
Schmidt B, Baumann S, Braun HA, Larbig G (2006) Inhibitors and modulators of beta-and gamma-secretase. Curr Top Med Chem 6, 377-392.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 377-392
-
-
Schmidt, B.1
Baumann, S.2
Braun, H.A.3
Larbig, G.4
-
61
-
-
65249085618
-
Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency
-
Ingallinella P, Bianchi E, Ladwa NA, Wang YJ, Hrin R, Veneziano M, Bonelli F, Ketas TJ, Moore JP, Miller MD, Pessi A (2009) Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency. Proc Natl Acad Sci USA 106, 5801-5806.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5801-5806
-
-
Ingallinella, P.1
Bianchi, E.2
Ladwa, N.A.3
Wang, Y.J.4
Hrin, R.5
Veneziano, M.6
Bonelli, F.7
Ketas, T.J.8
Moore, J.P.9
Miller, M.D.10
Pessi, A.11
-
62
-
-
78651278930
-
Structural design, solid-phase synthesis and activity of membrane-anchored beta-secretase inhibitors on Abeta gen-eration from wild-type and Swedish-mutant APP
-
Schieb H, Weidlich S, Schlechtingen G, Linning P, Jennings G, Gruner M, Wiltfang J, Klafki HW, Knolker HJ (2010) Structural design, solid-phase synthesis and activity of membrane-anchored beta-secretase inhibitors on Abeta gen-eration from wild-type and Swedish-mutant APP Chemistry 16, 14412-14423.
-
(2010)
Chemistry
, vol.16
, pp. 14412-14423
-
-
Schieb, H.1
Weidlich, S.2
Schlechtingen, G.3
Linning, P.4
Jennings, G.5
Gruner, M.6
Wiltfang, J.7
Klafki, H.W.8
Knolker, H.J.9
-
64
-
-
0344791683
-
Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails
-
DOI 10.1083/jcb.144.6.1271
-
Mukherjee S, Soe TT, Maxfield FR (1999) Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails, J Cell Biol 144, 1271-1284. (Pubitemid 29157304)
-
(1999)
Journal of Cell Biology
, vol.144
, Issue.6
, pp. 1271-1284
-
-
Mukherjee, S.1
Soe, T.T.2
Maxfield, F.R.3
-
65
-
-
74049133619
-
Subcellular tar-geting strategies for drug design and delivery
-
Rajendran L, Knolker HJ, Simons K (2010) Subcellular tar-geting strategies for drug design and delivery. Nat Rev Drug Discov 9, 29-42.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 29-42
-
-
Rajendran, L.1
Knolker, H.J.2
Simons, K.3
|