SCOPUS 정보 검색 플랫폼

Volumn 16, Issue 48, 2010, Pages 14412-14423

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and swedish-mutant APP

(9) Schieb, Heinke c Weidlich, Sebastian a Schlechtingen, Georg a,b Linning, Philipp a Jennings, Gary b Gruner, Margit a Wiltfang, Jens c Klafki, Hans Wolfgang c Knölker, Hans Joachim a,b

a DRESDEN UNIVERSITY OF TECHNOLOGY (Germany)

b JADO Technologies GmbH (Germany)

c UNIVERSITY OF DUISBURG ESSEN (Germany)

Author keywords

Alzheimer's disease; beta secretase inhibition; lipid rafts; membranes; peptide synthesis

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; BIOLOGICAL ACTIVITIES; CELLULAR SECRETION; COVALENT COUPLINGS; DIHYDROCHOLESTEROL; IN-CELL; LIPID RAFT; LIPID RAFTS; NEURONAL CELL CULTURE; NEUROTOXICITY; NMR SPECTROSCOPY; PEPTIDE SECRETION; PEPTIDE SYNTHESIS; PHARMACOPHORES; SECRETASES; SOLID PHASE PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; SPACER LENGTHS; TRANSITION-STATE; TRIPARTITE STRUCTURES; WILD TYPES; WILD-TYPE PROTEINS;

CELL CULTURE; CELL MEMBRANES; GLYCOPROTEINS; LIPID BILAYERS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTIMIZATION; PEPTIDES; PHARMACODYNAMICS; STRUCTURAL DESIGN;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CHICKEN; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EGG; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; SECRETION; SEQUENCE HOMOLOGY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; ASPARTIC ACID ENDOPEPTIDASES; CELL MEMBRANE; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; EGGS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 78651278930 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201002878 Document Type: Article

Times cited : (26)

References (68)

1
- 0034568802
- H. Steiner, C. Haass, Nat. Rev. Mol. Cell Biol. 2000, 1, 217-224.
- (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 217-224
- Steiner, H.¹ Haass, C.²

2
- 0033382226
- I. Hussain, D. Powell, D. R. Howlett, D. G. Tew, T. D. Meek, C. Chapman, I. S. Gloger, K. E. Murphy, C. D. Southan, D. M. Ryan, T. S. Smith, D. L. Simmons, F. S. Walsh, C. Dingwall, G. Christie, Mol. Cell. Neurosci. 1999, 14, 419-427
- (1999) Mol. Cell. Neurosci. , vol.14 , pp. 419-427
- Hussain, I.¹ Powell, D.² Howlett, D.R.³ Tew, D.G.⁴ Meek, T.D.⁵ Chapman, C.⁶ Gloger, I.S.⁷ Murphy, K.E.⁸ Southan, C.D.⁹ Ryan, D.M.¹⁰ Smith, T.S.¹¹ Simmons, D.L.¹² Walsh, F.S.¹³ Dingwall, C.¹⁴ Christie, G.¹⁵

3
- 0034652309
- X. Lin, G. Koelsch, S. Wu, D. Downs, A. Dashti, J. Tang, Proc. Natl. Acad. Sci. USA 2000, 97, 1456-1460
- (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1456-1460
- Lin, X.¹ Koelsch, G.² Wu, S.³ Downs, D.⁴ Dashti, A.⁵ Tang, J.⁶

4
- 0033518251
- S. Sinha, J. P. Anderson, R. Barbour, G. S. Basi, R. Caccavello, D. Davis, M. Doan, H. F. Dovey, N. Frigon, J. Hong, K. Jacobson-Croak, N. Jewett, P. Keim, J. Knops, I. Lieberburg, M. Power, H. Tan, G. Tatsuno, J. Tung, D. Schenk, P. Seubert, S. M. Suomensaari, S. Wang, D. Walker, J. Zhao, L. McConlogue, V. John, Nature 1999, 402, 537-540
- (1999) Nature , vol.402 , pp. 537-540
- Sinha, S.¹ Anderson, J.P.² Barbour, R.³ Basi, G.S.⁴ Caccavello, R.⁵ Davis, D.⁶ Doan, M.⁷ Dovey, H.F.⁸ Frigon, N.⁹ Hong, J.¹⁰ Jacobson-Croak, K.¹¹ Jewett, N.¹² Keim, P.¹³ Knops, J.¹⁴ Lieberburg, I.¹⁵ Power, M.¹⁶ Tan, H.¹⁷ Tatsuno, G.¹⁸ Tung, J.¹⁹ Schenk, D.²⁰ more..

5
- 0033595706
- R. Vassar, B. D. Bennett, S. Babu-Khan, S. Kahn, E. A. Mendiaz, P. Denis, D. B. Teplow, S. Ross, P. Amarante, R. Loeloff, Y. Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M. A. Jarosinski, A. L. Biere, E. Curran, T. Burgess, J. C. Louis, F. Collins, J. Treanor, G. Rogers, M. Citron, Science 1999, 286, 735-741
- (1999) Science , vol.286 , pp. 735-741
- Vassar, R.¹ Bennett, B.D.² Babu-Khan, S.³ Kahn, S.⁴ Mendiaz, E.A.⁵ Denis, P.⁶ Teplow, D.B.⁷ Ross, S.⁸ Amarante, P.⁹ Loeloff, R.¹⁰ Luo, Y.¹¹ Fisher, S.¹² Fuller, J.¹³ Edenson, S.¹⁴ Lile, J.¹⁵ Jarosinski, M.A.¹⁶ Biere, A.L.¹⁷ Curran, E.¹⁸ Burgess, T.¹⁹ Louis, J.C.²⁰ more..

6
- 0033518264
- R. Yan, M. J. Bienkowski, M. E. Shuck, H. Miao, M. C. Tory, A. M. Pauley, J. R. Brashier, N. C. Stratman, W. R. Mathews, A. E. Buhl, D. B. Carter, A. G. Tomasselli, L. A. Parodi, R. L. Heinrikson, M. E. Gurney, Nature 1999, 402, 533-537.
- (1999) Nature , vol.402 , pp. 533-537
- Yan, R.¹ Bienkowski, M.J.² Shuck, M.E.³ Miao, H.⁴ Tory, M.C.⁵ Pauley, A.M.⁶ Brashier, J.R.⁷ Stratman, N.C.⁸ Mathews, W.R.⁹ Buhl, A.E.¹⁰ Carter, D.B.¹¹ Tomasselli, A.G.¹² Parodi, L.A.¹³ Heinrikson, R.L.¹⁴ Gurney, M.E.¹⁵

7
- 0034049944
- B. DeStrooper, W. Annaert, J. Cell Sci. 2000, 113, 1857-1870
- (2000) J. Cell Sci. , vol.113 , pp. 1857-1870
- Destrooper, B.¹ Annaert, W.²

8
- 0142092495
- V. John, J. P. Beck, M. J. Bienkowski, S. Sinha, R. L. Heinrikson, J. Med. Chem. 2003, 46, 4625-4630.
- (2003) J. Med. Chem. , vol.46 , pp. 4625-4630
- John, V.¹ Beck, J.P.² Bienkowski, M.J.³ Sinha, S.⁴ Heinrikson, R.L.⁵

9
- 0034613345
- A. Capell, H. Steiner, M. Willem, H. Kaiser, C. Meyer, J. Walter, S. Lammich, G. Multhaup, C. Haass, J. Biol. Chem. 2000, 275, 30849-30854
- (2000) J. Biol. Chem. , vol.275 , pp. 30849-30854
- Capell, A.¹ Steiner, H.² Willem, M.³ Kaiser, H.⁴ Meyer, C.⁵ Walter, J.⁶ Lammich, S.⁷ Multhaup, G.⁸ Haass, C.⁹

10
- 0034721842
- J. T. Huse, D. S. Pijak, G. J. Leslie, V. M. Lee, R. W. Doms, J. Biol. Chem. 2000, 275, 33729-33737
- (2000) J. Biol. Chem. , vol.275 , pp. 33729-33737
- Huse, J.T.¹ Pijak, D.S.² Leslie, G.J.³ Lee, V.M.⁴ Doms, R.W.⁵

11
- 0035805592
- J. Walter, R. Fluhrer, B. Hartung, M. Willem, C. Kaether, A. Capell, S. Lammich, G. Multhaup, C. Haass, J. Biol. Chem. 2001, 276, 14634-14641.
- (2001) J. Biol. Chem. , vol.276 , pp. 14634-14641
- Walter, J.¹ Fluhrer, R.² Hartung, B.³ Willem, M.⁴ Kaether, C.⁵ Capell, A.⁶ Lammich, S.⁷ Multhaup, G.⁸ Haass, C.⁹

12
- 0141482022
- J. M. Cordy, I. Hussain, C. Dingwall, N. M. Hooper, A. J. Turner, Proc. Natl. Acad. Sci. USA 2003, 100, 11735-11740
- (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11735-11740
- Cordy, J.M.¹ Hussain, I.² Dingwall, C.³ Hooper, N.M.⁴ Turner, A.J.⁵

13
- 0037421206
- R. Ehehalt, P. Keller, C. Haass, C. Thiele, K. Simons, J. Cell Biol. 2003, 160, 113-123
- (2003) J. Cell Biol. , vol.160 , pp. 113-123
- Ehehalt, R.¹ Keller, P.² Haass, C.³ Thiele, C.⁴ Simons, K.⁵

14
- 0035928732
- D. R. Riddell, G. Christie, I. Hussain, C. Dingwall, Curr. Biol. 2001, 11, 1288-1293
- (2001) Curr. Biol. , vol.11 , pp. 1288-1293
- Riddell, D.R.¹ Christie, G.² Hussain, I.³ Dingwall, C.⁴

15
- 0036674082
- H. Tun, L. Marlow, I. Pinnix, R. Kinsey, K. Sambamurti, J. Mol. Neurosci. 2002, 19, 31-35.
- (2002) J. Mol. Neurosci. , vol.19 , pp. 31-35
- Tun, H.¹ Marlow, L.² Pinnix, I.³ Kinsey, R.⁴ Sambamurti, K.⁵

16
- 0030949124
- K. Simons, E. Ikonen, Nature 1997, 387, 569-572
- (1997) Nature , vol.387 , pp. 569-572
- Simons, K.¹ Ikonen, E.²

17
- 0032527642
- D. A. Brown, E. London, J. Membr. Biol. 1998, 164, 103-114
- (1998) J. Membr. Biol. , vol.164 , pp. 103-114
- Brown, D.A.¹ London, E.²

18
- 0034620610
- X. Xu, E. London, Biochemistry 2000, 39, 843-849
- (2000) Biochemistry , vol.39 , pp. 843-849
- Xu, X.¹ London, E.²

19
- 0034625373
- D. A. Brown, E. London, J. Biol. Chem. 2000, 275, 17221-17224
- (2000) J. Biol. Chem. , vol.275 , pp. 17221-17224
- Brown, D.A.¹ London, E.²

20
- 0034304851
- K. Simons, D. Toomre, Nat. Rev. Mol. Cell Biol. 2000, 1, 31-39
- (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 31-39
- Simons, K.¹ Toomre, D.²

21
- 4744365276
- W. H. Binder, V. Barragan, F. M. Menger, Angew. Chem. 2003, 115, 5980-6007
- (2003) Angew. Chem. , vol.115 , pp. 5980-6007
- Binder, W.H.¹ Barragan, V.² Menger, F.M.³

22
- 0346158953
- Angew. Chem. Int. Ed. 2003, 42, 5802-5827
- (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 5802-5827

23
- 1842482773
- K. Simons, W. L. C. Vaz, Annu. Rev. Biophys. Biomol. Struct. 2004, 33, 269-295
- (2004) Annu. Rev. Biophys. Biomol. Struct. , vol.33 , pp. 269-295
- Simons, K.¹ Vaz, W.L.C.²

24
- 74849118341
- D. Lingwood, K. Simons, Science 2010, 327, 46-50.
- (2010) Science , vol.327 , pp. 46-50
- Lingwood, D.¹ Simons, K.²

25
- 78651270560
- International Patent, WO 2005/097199
- T. Braxmeier, T. Friedrichson, W. Fröhner, G. Jennings, M. Munick, G. Schlechtingen, C. Schroeder, H.-J. Knölker, K. Simons, M. Zerial, T. Kurzchalia, International Patent, WO 2005/097199, 2005
- (2005)
- Braxmeier, T.¹ Friedrichson, T.² Fröhner, W.³ Jennings, G.⁴ Munick, M.⁵ Schlechtingen, G.⁶ Schroeder, C.⁷ Knölker, H.-J.⁸ Simons, K.⁹ Zerial, M.¹⁰ Kurzchalia, T.¹¹

26
- 78651314177
- PCT/EP2005/003740, 2004
- PCT/EP2005/003740, 2004.

27
- 42549148456
- L. Rajendran, A. Schneider, G. Schlechtingen, S. Weidlich, J. Ries, T. Braxmeier, P. Schwille, J. B. Schulz, C. Schroeder, M. Simons, G. Jennings, H.-J. Knölker, K. Simons, Science 2008, 320, 520-523
- (2008) Science , vol.320 , pp. 520-523
- Rajendran, L.¹ Schneider, A.² Schlechtingen, G.³ Weidlich, S.⁴ Ries, J.⁵ Braxmeier, T.⁶ Schwille, P.⁷ Schulz, J.B.⁸ Schroeder, C.⁹ Simons, M.¹⁰ Jennings, G.¹¹ Knölker, H.-J.¹² Simons, K.¹³

28
- 81855198522
- SS 26
- R. Martin, J. Kirst, S. Weidlich, H. Schieb, G. Schlechtingen, A. Jäger, L. Rajendran, M. Böhl, S. Richter, R. Fedorov, D. J. Manstein, H. O. Gutzeit, H. Klafki, J. Wiltfang, K. Simons, H.-J. Knölker, Med. Chem. Res. 2010, 20, S 23 -S 26
- (2010) Med. Chem. Res. , vol.20 , pp. 23
- Martin, R.¹ Kirst, J.² Weidlich, S.³ Schieb, H.⁴ Schlechtingen, G.⁵ Jäger, A.⁶ Rajendran, L.⁷ Böhl, M.⁸ Richter, S.⁹ Fedorov, R.¹⁰ Manstein, D.J.¹¹ Gutzeit, H.O.¹² Klafki, H.¹³ Wiltfang, J.¹⁴ Simons, K.¹⁵ Knölker, H.-J.¹⁶

29
- 74049133619
- L. Rajendran, H.-J. Knölker, K. Simons, Nat. Rev. Drug Discovery 2010, 9, 29-42.
- (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 29-42
- Rajendran, L.¹ Knölker, H.-J.² Simons, K.³

30
- 0026745610
- M. Citron, T. Oltersdorf, C. Haass, L. McConlogue, A. Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, D. J. Selkoe, Nature 1992, 360, 672-674
- (1992) Nature , vol.360 , pp. 672-674
- Citron, M.¹ Oltersdorf, T.² Haass, C.³ McConlogue, L.⁴ Hung, A.Y.⁵ Seubert, P.⁶ Vigo-Pelfrey, C.⁷ Lieberburg, I.⁸ Selkoe, D.J.⁹

31
- 0027526419
- X. D. Cai, T. E. Golde, S. G. Younkin, Science 1993, 259, 514-516.
- (1993) Science , vol.259 , pp. 514-516
- Cai, X.D.¹ Golde, T.E.² Younkin, S.G.³

32
- 0037122704
- J. S. Tung, D. L. Davis, J. P. Anderson, D. E. Walker, S. Mamo, N. Jewett, R. K. Hom, S. Sinha, E. D. Thorsett, V. John, J. Med. Chem. 2002, 45, 259-262.
- (2002) J. Med. Chem. , vol.45 , pp. 259-262
- Tung, J.S.¹ Davis, D.L.² Anderson, J.P.³ Walker, D.E.⁴ Mamo, S.⁵ Jewett, N.⁶ Hom, R.K.⁷ Sinha, S.⁸ Thorsett, E.D.⁹ John, V.¹⁰

33
- 0037085453
- A. Capell, L. Meyn, R. Fluhrer, D. B. Teplow, J. Walter, C. Haass, J. Biol. Chem. 2002, 277, 5637-5643.
- (2002) J. Biol. Chem. , vol.277 , pp. 5637-5643
- Capell, A.¹ Meyn, L.² Fluhrer, R.³ Teplow, D.B.⁴ Walter, J.⁵ Haass, C.⁶

34
- 78651289965
- International Patent, WO 03/045378
- V. John, International Patent, WO 03/045378, 2003
- (2003)
- John, V.¹

35
- 78651279680
- PCT/US02/37360, 2002
- PCT/US02/37360, 2002

36
- 4644229581
- J. N. Cumming, U. Iserloh, M. E. Kennedy, Curr. Opin. Drug Discov. Devel. 2004, 7, 536-556.
- (2004) Curr. Opin. Drug Discov. Devel. , vol.7 , pp. 536-556
- Cumming, J.N.¹ Iserloh, U.² Kennedy, M.E.³

37
- 0025265014
- B. Blankemeyer-Menge, M. Nimtz, R. Frank, Tetrahedron Lett. 1990, 31, 1701-1704.
- (1990) Tetrahedron Lett. , vol.31 , pp. 1701-1704
- Blankemeyer-Menge, B.¹ Nimtz, M.² Frank, R.³

38
- 0141521583
- T. Nguyen, M. B. Francis, Org. Lett. 2003, 5, 3245-3248.
- (2003) Org. Lett. , vol.5 , pp. 3245-3248
- Nguyen, T.¹ Francis, M.B.²

39
- 2242467850
- L. A. Carpino, H. Imazumi, A. El-Faham, F. J. Ferrer, C. Zhang, Y. Lee, B. M. Foxman, P. Henklein, C. Hanay, C. Mügge, H. Wenschuh, J. Klose, M. Beyermann, M. Bienert, Angew. Chem. 2002, 114, 457-461
- (2002) Angew. Chem. , vol.114 , pp. 457-461
- Carpino, L.A.¹ Imazumi, H.² El-Faham, A.³ Ferrer, F.J.⁴ Zhang, C.⁵ Lee, Y.⁶ Foxman, B.M.⁷ Henklein, P.⁸ Hanay, C.⁹ Mügge, C.¹⁰ Wenschuh, H.¹¹ Klose, J.¹² Beyermann, M.¹³ Bienert, M.¹⁴

40
- 0036462499
- Angew. Chem. Int. Ed. 2002, 41, 441-445.
- (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 441-445

41
- 0026045172
- R. Wang, J. F. Meschia, R. J. Cotter, S. S. Sisodia, J. Biol. Chem. 1991, 266, 16960-16964.
- (1991) J. Biol. Chem. , vol.266 , pp. 16960-16964
- Wang, R.¹ Meschia, J.F.² Cotter, R.J.³ Sisodia, S.S.⁴

42
- 0034613320
- L. Hong, G. Koelsch, X. Lin, S. Wu, S. Terzyan, A. K. Ghosh, X. C. Zhang, J. Tang, Science 2000, 290, 150-153.
- (2000) Science , vol.290 , pp. 150-153
- Hong, L.¹ Koelsch, G.² Lin, X.³ Wu, S.⁴ Terzyan, S.⁵ Ghosh, A.K.⁶ Zhang, X.C.⁷ Tang, J.⁸

43
- 78651278034
- unpublished results
- D.C. Carrer, S. Weidlich, P. Schwille, H.-J. Knölker, unpublished results.
- Carrer, D.C.¹ Weidlich, S.² Schwille, P.³ Knölker, H.-J.⁴

44
- 23944510149
- J. A. Carrodeguas, A. Rodolosse, M. V. Garza, A. Sanz-Clemente, R. Perez-Pe, A. M. Lacosta, L. Dominguez, I. Monleon, R. Sanchez-Diaz, V. Sorribas, M. Sarasa, Neuroscience 2005, 134, 1285-1300.
- (2005) Neuroscience , vol.134 , pp. 1285-1300
- Carrodeguas, J.A.¹ Rodolosse, A.² Garza, M.V.³ Sanz-Clemente, A.⁴ Perez-Pe, R.⁵ Lacosta, A.M.⁶ Dominguez, L.⁷ Monleon, I.⁸ Sanchez-Diaz, R.⁹ Sorribas, V.¹⁰ Sarasa, M.¹¹

45
- 0028924248
- M. Citron, D. B. Teplow, D. J. Selkoe, Neuron 1995, 14, 661-670.
- (1995) Neuron , vol.14 , pp. 661-670
- Citron, M.¹ Teplow, D.B.² Selkoe, D.J.³

46
- 76249125728
- H. Yamakawa, S. Yagishita, E. Futai, S. Ishiura, J. Biol. Chem. 2010, 285, 1634-1642
- (2010) J. Biol. Chem. , vol.285 , pp. 1634-1642
- Yamakawa, H.¹ Yagishita, S.² Futai, E.³ Ishiura, S.⁴

47
- 33846261909
- I. Hussain, J. Hawkins, D. Harrison, C. Hille, G. Wayne, L. Cutler, T. Buck, D. Walter, E. Demont, C. Howes, A. Naylor, P. Jeffrey, M. I. Gonzalez, C. Dingwall, A. Michel, S. Redshaw, J. B. Davis, J. Neurochem. 2007, 100, 802-809.
- (2007) J. Neurochem. , vol.100 , pp. 802-809
- Hussain, I.¹ Hawkins, J.² Harrison, D.³ Hille, C.⁴ Wayne, G.⁵ Cutler, L.⁶ Buck, T.⁷ Walter, D.⁸ Demont, E.⁹ Howes, C.¹⁰ Naylor, A.¹¹ Jeffrey, P.¹² Gonzalez, M.I.¹³ Dingwall, C.¹⁴ Michel, A.¹⁵ Redshaw, S.¹⁶ Davis, J.B.¹⁷

48
- 0037085353
- F. Gruninger-Leitch, D. Schlatter, E. Kung, P. Nelbock, H. Dobeli, J. Biol. Chem. 2002, 277, 4687-4693.
- (2002) J. Biol. Chem. , vol.277 , pp. 4687-4693
- Gruninger-Leitch, F.¹ Schlatter, D.² Kung, E.³ Nelbock, P.⁴ Dobeli, H.⁵

49
- 24144443470
- H. Vanderstichele, M. G. De, N. Andreasen, V. Kostanjevecki, A. Wallin, A. Olsson, K. Blennow, E. Vanmechelen, Clin. Chem. 2005, 51, 1650-1660.
- (2005) Clin. Chem. , vol.51 , pp. 1650-1660
- Vanderstichele, H.¹ De, M.G.² Andreasen, N.³ Kostanjevecki, V.⁴ Wallin, A.⁵ Olsson, A.⁶ Blennow, K.⁷ Vanmechelen, E.⁸

50
- 18444393054
- J. Wiltfang, H. Esselmann, M. Bibl, A. Smirnov, M. Otto, S. Paul, B. Schmidt, H. W. Klafki, M. Maler, T. Dyrks, M. Bienert, M. Beyermann, E. Ruther, J. Kornhuber, J. Neurochem. 2002, 81, 481-496.
- (2002) J. Neurochem. , vol.81 , pp. 481-496
- Wiltfang, J.¹ Esselmann, H.² Bibl, M.³ Smirnov, A.⁴ Otto, M.⁵ Paul, S.⁶ Schmidt, B.⁷ Klafki, H.W.⁸ Maler, M.⁹ Dyrks, T.¹⁰ Bienert, M.¹¹ Beyermann, M.¹² Ruther, E.¹³ Kornhuber, J.¹⁴

51
- 35648929821
- J. M. Maler, H. W. Klafki, S. Paul, S. P. Spitzer, T. W. Groemer, A. W. Henkel, H. Esselmann, P. Lewczuk, J. Kornhuber, J. Wiltfang, Proteomics 2007, 7, 3815-3820.
- (2007) Proteomics , vol.7 , pp. 3815-3820
- Maler, J.M.¹ Klafki, H.W.² Paul, S.³ Spitzer, S.P.⁴ Groemer, T.W.⁵ Henkel, A.W.⁶ Esselmann, H.⁷ Lewczuk, P.⁸ Kornhuber, J.⁹ Wiltfang, J.¹⁰

52
- 0028922667
- C. Haass, A. Capell, M. Citron, D. B. Teplow, D. J. Selkoe, J. Biol. Chem. 1995, 270, 6186-6192
- (1995) J. Biol. Chem. , vol.270 , pp. 6186-6192
- Haass, C.¹ Capell, A.² Citron, M.³ Teplow, D.B.⁴ Selkoe, D.J.⁵

53
- 0033953961
- R. Cescato, E. Dummermuth, M. Spiess, P. A. Paganetti, J. Neurochem. 2003, 74, 1131-1139.
- (2003) J. Neurochem. , vol.74 , pp. 1131-1139
- Cescato, R.¹ Dummermuth, E.² Spiess, M.³ Paganetti, P.A.⁴

54
- 0012510759
- C. L. Masters, G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald, K. Beyreuther, Proc. Natl. Acad. Sci. USA 1985, 82, 4245-4249
- (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 4245-4249
- Masters, C.L.¹ Simms, G.² Weinman, N.A.³ Multhaup, G.⁴ McDonald, B.L.⁵ Beyreuther, K.⁶

55
- 0027184611
- D. L. Miller, I. A. Papayannopoulos, J. Styles, S. A. Bobin, Y. Y. Lin, K. Biemann, K. Iqbal, Arch. Biochem. Biophys. 1993, 301-307, 41-52
- (1993) Arch. Biochem. Biophys. , vol.301-307 , pp. 41-52
- Miller, D.L.¹ Papayannopoulos, I.A.² Styles, J.³ Bobin, S.A.⁴ Lin, Y.Y.⁵ Biemann, K.⁶ Iqbal, K.⁷

56
- 0027477463
- A. E. Roher, J. D. Lowenson, S. Clarke, C. Wolkow, R. Wang, R. J. Cotter, I. M. Reardon, H. A. Zürcher-Neely, R. L. Heinrikson, M. J. Ball, B. D. Greenberg, J. Biol. Chem. 1993, 268, 3072-3083.
- (1993) J. Biol. Chem. , vol.268 , pp. 3072-3083
- Roher, A.E.¹ Lowenson, J.D.² Clarke, S.³ Wolkow, C.⁴ Wang, R.⁵ Cotter, R.J.⁶ Reardon, I.M.⁷ Zürcher-Neely, H.A.⁸ Heinrikson, R.L.⁹ Ball, M.J.¹⁰ Greenberg, B.D.¹¹

57
- 0035918312
- Y. M. Kuo, T. A. Kokjohn, T. G. Beach, L. I. Sue, D. Brune, J. C. Lopez, W. M. Kalback, D. Abramowski, C. Sturchler-Pierrat, M. Staufenbiel, A. E. Roher, J. Biol. Chem. 2001, 276, 12991-12998.
- (2001) J. Biol. Chem. , vol.276 , pp. 12991-12998
- Kuo, Y.M.¹ Kokjohn, T.A.² Beach, T.G.³ Sue, L.I.⁴ Brune, D.⁵ Lopez, J.C.⁶ Kalback, W.M.⁷ Abramowski, D.⁸ Sturchler-Pierrat, C.⁹ Staufenbiel, M.¹⁰ Roher, A.E.¹¹

58
- 0026794746
- H. Mori, K. Takio, M. Ogawara, D. J. Selkoe, J. Biol. Chem. 1992, 267, 17082-17086
- (1992) J. Biol. Chem. , vol.267 , pp. 17082-17086
- Mori, H.¹ Takio, K.² Ogawara, M.³ Selkoe, D.J.⁴

59
- 0028855851
- T. C. Saido, T. Iwatsubo, D. M. Mann, H. Shimada, Y. Ihara, S. Kawashima, Neuron 1995, 14, 457-466.
- (1995) Neuron , vol.14 , pp. 457-466
- Saido, T.C.¹ Iwatsubo, T.² Mann, D.M.³ Shimada, H.⁴ Ihara, Y.⁵ Kawashima, S.⁶

60
- 0033578402
- W. He, C. J. Barrow, Biochemistry 1999, 38, 10871-10877.
- (1999) Biochemistry , vol.38 , pp. 10871-10877
- He, W.¹ Barrow, C.J.²

61
- 0018669616
- B. Pettmann, J. C. Louis, M. Sensenbrenner, Nature 1979, 281, 378-380.
- (1979) Nature , vol.281 , pp. 378-380
- Pettmann, B.¹ Louis, J.C.² Sensenbrenner, M.³

62
- 77954359268
- L. M. Munter, A. Botev, L. Richter, P. W. Hildebrand, V. Althoff, C. Weise, D. Kaden, G. Multhaup, J. Biol. Chem. 2010, 285, 21636-21643.
- (2010) J. Biol. Chem. , vol.285 , pp. 21636-21643
- Munter, L.M.¹ Botev, A.² Richter, L.³ Hildebrand, P.W.⁴ Althoff, V.⁵ Weise, C.⁶ Kaden, D.⁷ Multhaup, G.⁸

63
- 0021061819
- T. Mosmann, J. Immunol. Methods 1983, 65, 55-63.
- (1983) J. Immunol. Methods , vol.65 , pp. 55-63
- Mosmann, T.¹

64
- 0029665851
- H. W. Klafki, J. Wiltfang, M. Staufenbiel, Anal. Biochem. 1996, 237, 24-29
- (1996) Anal. Biochem. , vol.237 , pp. 24-29
- Klafki, H.W.¹ Wiltfang, J.² Staufenbiel, M.³

65
- 0030951595
- J. Wiltfang, A. Smirnov, B. Schnierstein, G. Kelemen, U. Matthies, H. W. Klafki, M. Staufenbiel, G. Huther, E. Ruther, J. Kornhuber, Electrophoresis 1997, 18, 527-532.
- (1997) Electrophoresis , vol.18 , pp. 527-532
- Wiltfang, J.¹ Smirnov, A.² Schnierstein, B.³ Kelemen, G.⁴ Matthies, U.⁵ Klafki, H.W.⁶ Staufenbiel, M.⁷ Huther, G.⁸ Ruther, E.⁹ Kornhuber, J.¹⁰

66
- 0029661424
- N. Ida, T. Hartmann, J. Pantel, J. Schroder, R. Zerfass, H. Forstl, R. Sandbrink, C. L. Masters, K. Beyreuther, J. Biol. Chem. 1996, 271, 22908-22914.
- (1996) J. Biol. Chem. , vol.271 , pp. 22908-22914
- Ida, N.¹ Hartmann, T.² Pantel, J.³ Schroder, J.⁴ Zerfass, R.⁵ Forstl, H.⁶ Sandbrink, R.⁷ Masters, C.L.⁸ Beyreuther, K.⁹

67
- 0014949207
- U. K. Laemmli, Nature 1970, 227, 680-685.
- (1970) Nature , vol.227 , pp. 680-685
- Laemmli, U.K.¹

68
- 0009482260
- H. Towbin, T. Staehelin, J. Gordon, Proc. Natl. Acad. Sci. USA 1979, 76, 4350-4354.
- (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
- Towbin, H.¹ Staehelin, T.² Gordon, J.³

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