Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Chemical Engineering Research and Design

Volumn 86, Issue 11, 2008, Pages 1196-1206

  Davidson, Adam ^a   Al Qallaf, Barrak ^b   Das, Diganta Bhusan ^c  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Coated microneedles; Effective skin permeability; Effective skin thickness; Transdermal drug delivery

Indexed keywords

CAPILLARITY; DRUG DELIVERY; LIQUIDS; SKIN; SOLIDS; SUPRAMOLECULAR CHEMISTRY;

COATED MICRONEEDLES; EFFECTIVE SKIN PERMEABILITY; EFFECTIVE SKIN THICKNESS; TRANSDERMAL DRUG DELIVERY;

CONTROLLED DRUG DELIVERY;

EID: 53249119663     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2008.06.002     Document Type: Article

References (46)

1. Al-Qallaf B., Das D.B., Mori D., and Cui Z.F. Modelling transdermal delivery of high molecular weight drugs from microneedle systems. J Philos Trans R Soc A 365 (2007) 2951-2967
2. Al-Qallaf, B. and Das, D.B., submitted for publication, Optimizing microneedle arrays to increase skin permeability for transdermal drug delivery, in Proceedings of Interdisciplinary Transport Phenomena V (ITP2007): Fluid, Thermal, Biological, Materials and Space Sciences, October 12-19, Bansko, Bulgaria.
3. Badkar A.V., Smith A.M., Eppstein J.A., and Banga A.K. Transdermal delivery of interferon alpha-2B using microporation and iontophoresis in hairless rats. Pharm Res 24 7 (2007) 1389-1395
4. Choi J.W., Park I.B., Ha Y.M., Jung M.G., Lee S.W., and Lee S.H. Insertion force estimation of various microneedle array-type structures fabricated by a Microstereolithography Apparatus. Proceedings of International Joint Conference. October 18-21, Bexco, Pusan, Korea (2006)
5. ® 3 multiphysics modelling, Documentation, Comsol AB, Stockholm, Sweden.
6. Cormier M., Johnson B., Ameri M., Nyam K., Libiran L., Zhang D.D., and Daddona P. Transdermal delivery of desmopressin using a coated microneedle array patch system. J Control Release 97 (2004) 503-511
7. Davis S.P., Landis B.J., Adams Z.H., Allen M.G., and Prausnitz M.R. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech 37 (2004) 1155-1163
8. Gill H.S., and Prausnitz M.R. Coated microneedles for transdermal delivery. J Control Release 117 (2007) 227-237
9. Haider I., Pettis R.J., Davison N., Clarke R., and Zahn J.D. Biomedical and fluid flow characterization of microneedle-based drug delivery devices. Proceedings of the 25th Annual Meeting of the American Society of Biomechanics. August, San Diego, California, USA (2001) (Abstract)
10. Henry S., McAllister D.V., Allen M.G., and Prausnitz M.R. Microfabrication microneedles: a novel approach to transdermal drug delivery. J. Pharm. Sci. 87 8 (1998) 922-925
11. Hsu C.C., Chen Y.T., Tsai C.H., and Kang S.W. Fabrication of microneedles. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems. January 16-19, Bangkok, Thailand (2007)
12. Ito Y., Hagiwara E., Saeki A., Sugioka N., and Takada K. Feasibility of microneedles for percutaneous absorption of insulin. Eur J Pharm Sci 29 (2006) 82-88
13. Khumpuang, S., Horade, M., Fujioka, K., and Sugiyama, S., 2005, Through-hole Microneedle Fabricated by Alignment X-ray Lithography, No. 7, Memoirs of the SR Center Ritsumeikan University, April, Japan, pp. 25-30.
14. Khumpuang S., Horade M., Fujioka K., Kazuya F., and Sugiyama S. Geometrical strengthening and tip-sharpening of a microneedle array fabricated by X-ray lithography. Microsyst Technol 13 (2007) 209-214
15. Kim K., and Lee J.B. High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector. Microsyst Technol 13 (2007) 231-235
16. Kumar R., and Philip A. Modified transdermal technologies: breaking the barriers of drug permeation via the skin. Trop J Pharm Res 6 1 (2007) 633-644
17. Lv Y.G., Liu J., Gao Y.H., and Xu B. Modelling of transdermal drug delivery with a microneedle array. J Micromech Microeng 16 (2006) 2492-2501
18. Martanto W., Davis S.P., Holiday N.R., Wang J., Gill H.S., and Prausnitz M.R. Transdermal delivery of insulin using microneedles in vivo. Pharm Res 21 (2004) 947-952
19. Matriano J.A., Cormier M., Johnson J., Young W.A., Buttery M., Nyam K., and Daddona P.E. Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm Res 19 1 (2002) 63-70
20. McAllister D.V., Wang P.M., Davis S.P., Park J.H., Canatella P.J., Allen M.G., and Prausnitz M.R. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. PNAS 100 (2003) 13755-13760
21. Merino G., Kalia Y.N., and Guy R.H. Ultrasound enhanced transdermal transport. J Pharm Sci 92 (2003) 1125-1137
22. Mitragotri S., Blankschtein D., and Langer R. Ultrasound-mediated transdermal protein delivery. Science 269 (1995) 850-853
23. Mukerjee E.V., Collins S.D., Isseroff R.R., and Smith R.L. Microneedle array for transdermal biological fluid extraction and in situ analysis. Sens Actuators A 114 (2004) 267-275
24. Ovsianikov A., and Chichkov B. Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery. Int J Appl Ceram Technol 4 1 (2007) 22-29
25. Park J.H., Allen M.G., and Prausnitz M.R. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release 104 (2005) 51-66
26. Park J.H., Yoon Y.K., Choi S.O., Prausnitz M.R., and Allen M.G. Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery. IEEE Trans Biomed Eng 54 5 (2007) 903-913
27. Parker E.R., Rao M.P., Turner K.L., Meinhart C.D., and MacDonald N.C. Bulk micromachined titanium microneedles. J Microelectromech Syst 16 2 (2007) 289-295
28. Prausnitz M.R. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev 56 (2004) 581-587
29. Rajaraman S., and Henderson H.T. A unique fabrication approach for microneedles using coherent porous silicon technology. Sens Actuators B 105 (2005) 443-448
30. Rodriquez A., Molinero D., Valera E., Trifonov T., Marsal L.F., Pallares J., and Alcubilla R. Fabrication of silicon oxide microneedles from macroporous silicon. Sens Actuators B 109 (2005) 135-140
31. Sen A., Daly M.E., and Hui S.W. Transdermal insulin delivery using lipid enhanced electroporation. Biochim Biophys Acta 1564 (2002) 5-8
32. Sintov A.C., and Wormser U. Topical iodine facilitates transdermal delivery of insulin. J f Control Release 118 (2007) 185-188
33. Stoeber B., and Liepmann D. Arrays of hollow out-of-plane microneedles for drug delivery. J Microelectromech Syst 14 3 (2005) 472-479
34. Tao S.L., and Desai T.A. Microfabricated drug delivery systems: from particles to pores. Adv Drug Deliv Rev 55 (2003) 315-328
35. Teo M.A.L., Shearwood C., Ng K.C., Lu J., and Moochhala S. In vitro and in vivo characterization of MEMS microneedles. Biomed Microdevices 7 1 (2005) 47-52
36. Teo M.A.L., Shearwood C., Ng K.C., Lu J., and Moochhala S. Transdermal microneedles for drug delivery applications. Mater Sci Eng 132 (2006) 151-154
37. Tojo K. Mathematical modelling of transdermal drug delivery. J Chem Eng Jpn 20 (1987) 300-308
38. Tojo K. Mathematical Models of Transdermal and Topical Drug Delivery. 2nd ed. (2005), Biocom Systems Inc., Japan
39. Wang P.M., Cornwell M., Hill J., and Prausnitz M.R. Precise microinjection into skin using hollow microneedles. J Invest Dermatol 126 (2006) 1080-1087
40. Wilke N., Reed M.L., and Morrissey A. The evolution from convex corner undercut towards microneedle formation: theory and experimental verification. J Micromech Microeng 16 (2006) 808-814
41. Wilke N., and Morrissey A. Silicon microneedle formation using modified mask designs based on convex corner undercut. J Micromech Microeng 17 (2007) 238-244
42. Williams A.C., and Barry B.W. Penetration enhancers. Adv Drug Deliv Rev 56 (2004) 603-618
43. Widera G., Johnson J., Kim L., Libiran L., Nyam K., Daddona P., and Cormier M. Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system. Vaccine 24 (2006) 1653-1664
44. Wu X.M., Todo H., and Sugibayashi K. Effects of pretreatment of needle puncture and sandpaper abrasion on the in vitro skin permeation of fluorescein isothiocyanate (FITC)-dextran. Int J Pharm 316 (2006) 102-108
45. Wu X.M., Todo H., and Sugibayashi K. Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. J Control Release 118 (2007) 189-195
46. Xie Y., Xu B., and Gao Y. Controlled transdermal delivery of model drug compounds by MEMS microneedle array. Nanomed Nanotechnol Biol Med 1 (2005) 184-190