Transdermal iontophoresis

Expert Opinion on Drug Delivery

Volumn 3, Issue 1, 2006, Pages 127-138

  Priya, Batheja ^a   Rashmi, Thakur ^a   Bozena, Michniak ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Electro osmosis; Electrorepulsion; Iontophoresis; Skin; Transdermal

Indexed keywords

AMINOLEVULINIC ACID; APOMORPHINE; ATENOLOL; BUPRENORPHINE; BUSPIRONE; CAPSAICIN DERIVATIVE; CINEOLE; FENTANYL; FLUOROURACIL; GONADORELIN DERIVATIVE; HYDROXYPROPYLCELLULOSE; INDOMETACIN; INSULIN; KETOROLAC TROMETAMOL; LAUROCAPRAM; LIDOCAINE; MENTHOL; METHYLCELLULOSE; METHYLPHENIDATE; NAFARELIN; PARATHYROID HORMONE; PEPTIDE DERIVATIVE; POVIDONE; PROTIRELIN DERIVATIVE; PULEGONE; ROTIGOTINE; SALCATONIN; SURFACTANT; TIMOLOL; UNINDEXED DRUG;

DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG PENETRATION; DRUG TRANSPORT; ELECTRIC CURRENT; ELECTROPORATION; GASTROINTESTINAL SYMPTOM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; MACROMOLECULE; NANOTECHNOLOGY; PARKINSON DISEASE; PH; REVIEW; SIDE EFFECT; SKIN INFLAMMATION; SKIN NODULE; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; IONTOPHORESIS; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION;

EID: 30344484816     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.3.1.127     Document Type: Review

References (79)

1. POTTS RO, FRANCOEUR ML: The influence of stratum corneum morphology on water permeability. J. Invest. Dermatol. (1991) 96(4):495-499.
2. KALIA YN, MERINO V, GUY RH: Transdermal drug delivery. Clinical aspects. Dermatol. Clin. (1998) 16(2):289-299.
3. CHOI EH, LEE SH, AHN SK, HWANG SM: The pretreatment effect of chemical skin penetration enhancers in transdermal drug delivery using iontophoresis. Skin Pharmacol. Appl. Skin Physiol. (1999) 12(6):326-335.
4. MARJUKKA SUHONEN T, BOUWSTRA JA, URTTI A: Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J. Control. Release (1999) 59(2):149-161.
5. ZHAO K, SINGH J: Mechanisms of percutaneous absorption of tamoxifen by terpenes: eugenol, D-limonene and menthone. J. Control. Release (1998) 55(2-3):253-260.
6. WILLIAMS AC, BARRY BW: Skin absorption enhancers. Crit. Rev. Ther. Drug Carrier Syst. (1992) 9(3-4):305-53.
7. WILLIAMS AC, BARRY BW: Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement. Pharm. Res. (1991) 8(1):17-24.
8. NUGROHO AK, LI G, GROSSKLAUS A, DANHOF M, BOUWSTRA JA: Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skin in vitro. J. Control. Release (2004) 96(1):159-167.
9. MITRAGOTRI S, FARRELL J, TANG H, TERAHARA T, KOST J, LANGER R: Determination of threshold energy dose for ultrasound-induced transdermal drug transport. J. Control. Release (2000) 63(1-2):41-52.
10. LOMBRY C, DUJARDIN N, PREAT V: Transdermal delivery of macromolecules using skin electroporation. Pharm. Res. (2000) 17(1):32-37.
11. TAO SL, DESAI TA: Microfabricated drug delivery systems: from particles to pores. Adv. Drug Deliv. Rev. (2003) 55(3):315-328.
12. DE GRAAFF AM, LI GL, VAN AELST AC, BOUWSTRA JA: Combined chemical and electrical enhancement modulates stratum corneum structure. J. Control. Release (2003) 90(1):49-58.
13. HIRVONEN J, KALIA YN, GUY RH: Transdermal delivery of peptides by iontophoresis. Nat. Biotechnol. (1996) 14(13):1710-1713.
14. RAIMAN J, KOLJONEN M, HUIKKO K, KOSTLAINEN R, HIRVONEN J: Delivery and stability of LHRH and Nafarelin in human skin: the effect of constant/pulsed iontophoresis. Eur. J. Pharm. Sci. (2004) 21(2-3):371-377.
15. PILLAI O, KUMAR N, DEY CS, BORKUTE S, NAGALINGAM S, PANCHAGNULA R: Transdermal iontophoresis of insulin. Part 1: a study on the issues associated with the use of platinum electrodes on rat skin. J. Pharm. Pharmacol. (2003) 55(11):1505-1513.
16. VISCUSI ER, REYNOLDS L, CHUNG F, ATKINSON LE, KHANNA S: Patient-controlled transdermal fentanyl hydrochloride versus intravenous morphine pump for postoperative pain: a randomized controlled trial. JAMA (2004) 291(11):1333-1341.
17. SINGH J, ROBERTS MS: Transdermal delivery of drugs by iontophoresis: a review. Drug Des. Deliv. (1989) 4(1):1-12.
18. BURNETTE RR, ONGPIPATTANAKUL B: Characterization of the permselective properties of excised human skin during iontophoresis. J. Pharm. Sci. (1987) 76(10):765-773.
19. BURTON H, SAGE JR: Iontophoresis. In: Percutaneous Penetration Enhancers. EW Smith, HI Maibach (Eds), CRC Press, Boca Raton, FL, USA (1995):351-368.
20. LEDGER PW: Skin biological issues in electrically enhanced transdermal delivery. Adv. Drug Deliv. Rev. (1992) 9(2-3):289-307.
21. PHIPPS JB, PADMANABHAN RV, LATTIN GA: Iontophoretic delivery of model inorganic and drug ions. J. Pharm. Sci. (1989) 78(5):365-369.
22. RAYNAULD JP, LAVIOLETTE JR: The silver-silver chloride electrode: a possible generator of offset voltages and currents. J. Neurosci. Methods. (1987) 19(3):249-255.
23. SINGH P, MAIBACH HI: Iontophoresis in drug delivery: basic principles and applications. Crit. Rev. Ther. Drug Carrier Syst. (1994) 11(2-3):161-213.
24. KIM A, GREEN PG, RAO G, GUY RH: Convective solvent flow across the skin during iontophoresis. Pharm. Res. (1993) 10(9):1315-1320.
25. MARRO D, KALIA YN, DELGADO-CHARRO MB, GUY RH: Contributions of electromigration and electroosmosis to iontophoretic drug delivery. Pharm. Res. (2001) 18(12):1701-1708.
26. KALIA YN, NAIK A, GARRISON J, GUY RH: Iontophoretic drug delivery. Adv. Drug Deliv. Rev. (2004) 56(5):619-658.
27. GUY RH, KALIA YN, DELGADO-CHARRO MB, MERINO V, LOPEZ A, MARRO D: Iontophoresis: electrorepulsion and electroosmosis. J. Control. Release (2000) 64(1-3):129-132.
28. GUY RH, DELGADO-CHARRO MB, KALIA YN: Iontophoretic transport across the skin. Skin Pharmacol. Appl. Skin. Physiol. (2001) 14 (Suppl. 1):35-40.
29. LAI PM, ROBERTS MS: An analysis of solute structure-human epidermal transport relationships in epidermal iontophoresis using the ionic mobility: pore model. J. Control. Release (1999) 58(3):323-333.
30. ROBERTS MS, LAI PM, ANISSIMOV YG: Epidermal iontophoresis: I. Development of the ionic mobility-pore model. Pharm. Res. (1998) 15(10):1569-1578.
31. LI SK, HIGUCHI WI, KOCHAMBILLI RP, ZHU H: Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane. Int. J. Pharm. (2004) 273(1-2):9-22.
32. ROBERTS MS, LAI PM, CROSS SE: Solute structure as a determinant of iontophoretic transport. In: Mechanisms of Transdermal Drug Delivery. RO Potts, RH Guy (Eds), Marcel Dekker, NY, USA (1997) 83:291-349.
33. BURNETTE RR: Iontophoresis. In: Transdermal Drug Delivery. J Hadgraft, RH Guy (Eds), Marcel Dekker, NY, USA (1988) 35:247-288.
34. CULLANDER C, GUY RH: Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J. Invest. Dermatol. (1991) 97(1):55-64.
35. MONTEIRO-RIVIERE NA, INMAN AO, RIVIERE JE: Identification of the pathway of iontophoretic drug delivery: light and ultrastructural studies using mercuric chloride in pigs. Pharm. Res. (1994) 11(2):251-256.
36. JUNG G, KATZ H, SCHMITT H, VOGES KP, MENESTRINA G, BOHEIM G: Conformational requirements for the potential dependant pore formation of the peptide antibiotics alamethicin, suzukacillin and trichotoxin. In: Physical Chemistry of Transmembrane Ion Motion. G Spach (Ed.), Elseveir, NY, USA (1983).
37. SIDDIQUI O, ROBERTS MS, POLACK AE: The effect of iontophoresis and vehicle PH on the in-vitro permeation of lignocaine through human stratum corneum. J. Pharm. Pharmacol. (1985) 37(10):732-735.
38. DEL TERZO S, BEHL CR, NASH RA: Iontophoretic transport of a homologous series of ionized and nonionized model compounds: influence of hydrophobicity and mechanistic interpretation. Pharm. Res. (1989) 6(1):85-90.
39. YOSHIDA NH, ROBERTS MS: Solute molecular size and transdermal iontophoresis across excised human skin. J. Control. Release (1993) 25(3):177-195.
40. PIKAL MJ: The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. (2001) 46(1-3):281-305.
41. SINGH P, BONIELLO S, LIU P, DINH S: Transdermal iontophoretic delivery of methylphenidate HCl in vitro. Int. J. Pharm. (1999) 178(1):121-128.
42. BURNETTE RR, MARRERO D: Comparison between the iontophoretic and passive transport of thyrotropin releasing hormone across excised nude mouse skin. J. Pharm. Sci. (1986) 75(8):738-743.
43. KASTING GB, KEISTER JC: Application of electrodiffusion theory for a homogeneous membrane to iontophoretic transport through skin. J. Control. Release (1989) 8(3):195-210.
44. LAWLER JC, DAVIS MJ, GRIFFITH EC: Electrical characteristics of the skin. The impedance of the surface sheath and deep tissues. J. Invest. Dermatol. (1960) 34:301-308.
45. BAGNIEFSKI T, BURNETTE RR: A comparison of pulsed and continuous current iontophoresis. J. Control. Release (1990) 11(1-3):113-122.
46. CHIEN YW, SIDDIQUI O, SHI WM, LELAWONGS P, LIU JC: Direct current iontophoretic transdermal delivery of peptide and protein drugs. J. Pharm. Sci. (1989) 78(5):376-383.
47. VAN DER GEEST R, VAN LAAR T, GUBBENS-STIBBE JM, BODDE HE, DANHOF M: Iontophoretic delivery of apomorphine. II: an in vivo study in patients with Parkinson's disease. Pharm. Res. (1997) 14(12):1804-1810.
48. VAN DER GEEST R, DANHOF M, BODDE HE: Iontophoretic delivery of apomorphine. I: in vitro optimization and validation. Pharm. Res. (1997) 14(12):1798-1803.
49. NUGROHO AK, LI GL, DANHOF M, BOUWSTRA JA.: Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration. Pharm. Res. (2004) 21(5):580-844.
50. FANG JY, HUNG CF, FANG YP, CHAN TF: Transdermal iontophoresis of 5-fluorouracil combined with electroporation and laser treatment. Int. J. Pharm. (2004) 270(1-2):241-249.
51. MEIDAN VM, AL-KHALILI M, MICHNIAK BB: Enhanced iontophoretic delivery of buspirone hydrochloride across human skin using chemical enhancers. Int. J. Pharm. (2003) 264(1-2):73-83.
52. LI GL, GROSSKLAUS A, DANHOF M, BOUWSTRA JA: Iontophoretic R-apomorphine delivery in combination with surfactant pretreatment: in vitro validation studies. Int. J. Pharm. (2003) 266(1-2):61-68.
53. CHO YA, GWAK HS: Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. Drug Dev. Ind. Pharm. (2004) 30(6):557-564.
54. KIM BY, DOH HJ, LE TN et al.: Ketorolac amide prodrugs for transdermal delivery: stability and in vitro rat skin permeation studies. Int. J. Pharm. (2005) 293(1-2):193-202.
55. ROY SD, MANOUKIAN E, COMBS D: Absorption of transdermally delivered ketorolac acid in humans. J. Pharm. Sci. (1995) 84(1):49-52.
56. TIWARI SB, UDUPA N: Investigation into the potential of iontophoresis facilitated delivery of ketorolac. Int. J. Pharm. (2003) 260(1):93-103.
57. PILLAI O, BORKUTE SD, SIVAPRASAD N, PANCHAGNULA R: Transdermal iontophoresis of insulin. II. Physicochemical considerations. Int. J. Pharm. (2003) 254(2):271-280.
58. PILLAI O, PANCHAGNULA R: Transdermal delivery of insulin from poloxamer gel: ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers. J. Control. Release (2003) 89(1):127-140.
59. PILLAI O, PANCHAGNULA R: Transdermal iontophoresis of insulin. V. Effect of terpenes. J. Control. Release (2003) 88(2):287-296.
60. PILLAI O, NAIR V, PANCHAGNULA R: Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers. Int. Pharm. (2004) 269(1):109-120.
61. HUANG YY, WU S-M: Stability of peptides during iontophoretic transdermal delivery Int. J. Pharm. (1996) 131:19-23.
62. BOMMANNAN DB, TAMADA J, LEUNG L, POTTS RO: Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharm. Res. (1994) 11(12):1809-1814.
63. CHANG SL, HOFMANN GA, ZHANG L, DEFTOS LJ, BANGA AK: The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones. J. Control. Release (2000) 66(2-3):127-133.
64. DENET AR, UCAKAR B, PREAT V: Transdermal delivery of timolol and atenolol using electroporation and iontophoresis in combination: a mechanistic approach. Pharm. Res. (2003) 20(12):1946-1951.
65. FANG JY, SUNG KC, WANG JJ, CHU CC, CHEN KT: The effects of iontophoresis and electroporation on transdermal delivery of buprenorphine from solutions and hydrogels. J. Pharm. Pharmacol. (2002) 54(10):1329-1337.
66. PAN Y, ZHAO HY, ZHENG JM: [The enhancing effect of electroporation and iontophoresis on the permeation of insulin through human skin]. Yao Xue Xue Bao (2002) 37(8):649-652.
67. MEDI BM, SINGH J: Electronically facilitated transdermal delivery of human parathyroid hormone (1-34). Int. J. Pharm. (2003) 263(1-2):25-33.
68. FANG JY, HWANG TL, HUANG YB, TSAI YH: Transdermal iontophoresis of sodium nonivamide acetate. V. Combined effect of physical enhancement methods. Int. J. Pharm. (2002) 235(1-2):95-105.
69. FANG JY, HUANG Y-B, LIN H-H, TSAI YH: Transdermal iontophoresis of sodium nonivamide acetate. IV. Effect of polymer formulations. Int. J. Pharm. (1998) 173:127-140.
70. FANG JY, SUNG KC, LIN HH, FANG CL: Transdermal iontophoretic delivery of diclofenac sodium from various polymer formulations: in vitro and in vivo studies. Int. J. Pharm. (1999) 178(1):83-92.
71. NICOLI S, SANTI P, COUVREUR P, COUARRAZE G, COLOMBO P, FATTAL E: Design of triptorelin loaded nanospheres for transdermal iontophoretic administration. Int. J. Pharm. (2001) 214(1-2):31-35.
72. VUTLA NB, BETAGERI GV, BANGA AK: Transdermal iontophoretic delivery of enkephalin formulated in liposomes. J. Pharm. Sci. (1996) 85(1):5-8.
73. WANG Y, THAKUR R, FAN Q, MICHNIAK B: Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur. J. Pharm. Biopharm. (2005) 60(2):179-191.
74. KULKARNI SB, BETAGERI GV: Transdermal iontophoretic delivery of colchicine encapsulated in liposomes. J. Drug Del. (1996) 3:245-250.
75. ESSA EA, BONNER MC, BARRY BW: Iontophoretic estradiol skin delivery and tritium exchange in ultradeformable liposomes. Int. J. Pharm. (2002) 240(1-2):55-66.
76. PANCHAGNULA R, PILLAI O, NAIR VB, RAMARAO P: Transdermal iontophoresis revisited. Curr. Opin. Chem. Biol. (2000) 4(4):468-473.
77. POTTS RO, TAMADA JA, TIERNEY MJ: Glucose monitoring by reverse iontophoresis. Diabetes Metab. Res. Rev. (2002) 18 (Suppl. 1):S49-S53.
78. HAMMOND KB, TURCIOS NL, GIBSON LE: Clinical evaluation of the macroduct sweat collection system and conductivity analyzer in the diagnosis of cystic fibrosis. J. Pediatr. (1994) 124(2):255-260.
79. AKINS DL, MEISENHEIMER JL, DOBSON RL: Efficacy of the Drionic unit in the treatment of hyperhidrosis. J. Am. Acad. Dermatol. (1987) 16(4):828-832.