Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

Journal of Clinical Investigation

Volumn 121, Issue 5, 2011, Pages 1782-1796

  Kastenmüller, Kathrin ^a   Wille Reece, Ulrike ^a,b   Lindsay, Ross W B ^a,c   Trager, Lauren R ^a   Darrah, Patricia A ^a   Flynn, Barbara J ^a   Becker, Maria R ^d   Udey, Mark C ^d   Clausen, Björn E ^e   Igyarto, Botond Z ^f   Kaplan, Daniel H ^f   Kastenmüller, Wolfgang ^g   Germain, Ronald N ^a,g   Seder, Robert A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b PATH Malaria Vaccine Initiative   (United States)

^c INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g Laboratory of Immunology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; OVALBUMIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST;

ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG CONJUGATION; IMMUNIZATION; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

ANIMALS; ANTIGENS; ANTIGENS, CD; ANTIGENS, CD11C; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DENDRITIC CELLS; INTERFERON TYPE I; LECTINS, C-TYPE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; TH1 CELLS; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 79955505656     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45416     Document Type: Article

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