Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides

Journal of Immunology

Volumn 177, Issue 10, 2006, Pages 6584-6587

  Gorden, Keith K B ^a   Qiu, Xiaohong X ^a   Binsfeld, Christine C A ^a   Vasilakos, John P ^a   Alkan, Sefik S ^a  

^a 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYNUCLEOTIDE DERIVATIVE; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOSOME; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

EID: 33750823681     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.10.6584     Document Type: Article

References (19)

1. Takeda, K., T, Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21: 335-376.
2. O'Neill, L. A. 2006. How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18: 3-9.
3. Beutler, B., Z. Jiang, P. Georgel, K. Crozac, B. Croker, S. Rutschmann, X. Du, and K. Hoebe. 2006. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol 24: 353-389.
4. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-K by Toll-like receptor 3. Nature 413: 732-738.
5. Diebold, S. S., T. Kaisho, H. Hemmt, S. Aldra, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529-1531.
6. Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, and S. Bauer. 2004. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303: 1526-1529.
7. Tabeta, K., P. Georgel, E. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, et al. 2004. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cyto megalovirus infection. Proc. Natl. Acad. Sci. USA 101: 3516-3521.
8. McCluskie, M. J., J. L. Cartier, A. J. Patrick, D. Sajic, R. D. Weeratna, K. L. Rosenthal, and H. L. Davis. 2006. Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and cesiquimod (R-848). Antiviral Res. 69: 77-85.
9. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Satijo, M. Macsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
10. Jurk, M., F. Heil, J. Vollmer, C. Schetrer, A. M. Krieg, H. Wagner, G. Lipford, and S. Bauer. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antivital compound R-848. Nat. Immunol. 3: 499.
11. Hemmi, H., T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol 3: 196-200.
12. Gorden, K. B., K. S. Gorski, S. J. Gibson, R. M. Kedl, W. C. Kieper, X. Qiu, M. A. Tomai, S. S. Alkan, and J. P. Vasuakos. 2005. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J. Immunol. 174: 1259-1268.
13. Hemmi, H., T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, and S. Akira. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196-200.
14. Honda, K., H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-777.
15. Ishii, K. J., and S. Akira. 2005. Innate immune recognition of nucleic acids: beyond Toll-like receptors. Int. J. Cancer 117: 517-523.
16. Sioud, M. 2005. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. 348: 1079-1090.
17. Sioud, M. 2006. Innate sensing of self and non-self RNAs by Toll-like receptors. Trends Mol. Med. 12: 167-176.
18. Kanneganti, T. D., N. Ozoren, M. Body-Malapel, A. Amer, J. H. Park, L. Franchi, J. Whitfield, W. Barchet, M. Colonna, P. Vandenabeele, et al. 2006. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440: 233-236.
19. Gorden, K. B., X. Qiu, J. L. Battiste, P. D. Wightman, J. P. Vasuakos, and S. S. Alkan. Oligodeoxynucleotides (ODNs) differentially modulate activation of Toll-like receptors TLR7 and TLR8 by imidazoquinolines. J. Immunol. In press.