Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation

Science

Volumn 316, Issue 5824, 2007, Pages 612-616

  Burgdorf, Sven ^a   Kautz, Andreas ^a   Böhnert, Volker ^a   Knolle, Percy A ^a   Kurts, Christian ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MANNOSE RECEPTOR;

ANTIGEN; IMMUNE RESPONSE; IMMUNE SYSTEM; PROTEIN; SUGAR;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; EFFECTOR CELL; ENDOCYTOSIS; ENDOSOME; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; ENDOCYTOSIS; ENDOSOMES; HISTOCOMPATIBILITY ANTIGENS CLASS II; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; LYSOSOMES; MACROPHAGES; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; OVALBUMIN; PINOCYTOSIS; RECEPTORS, CELL SURFACE; RECEPTORS, SCAVENGER;

EID: 34247627809     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1137971     Document Type: Article

References (34)

1. I. Mellman, R. M. Steinman, Cell 106, 255 (2001).
2. E. S. Trombetta, M. Ebersold, W. Garrett, M. Pypaert, I. Mellman, Science 299, 1400 (2003).
3. M. J. Bevan, J. Exp. Med. 143, 1283 (1976).
4. C. C. Norbury et al., Science 304, 1318 (2004).
5. C. Kurts et al., J. Exp. Med. 184, 923 (1996).
6. A. Y. Huang et al., Science 264, 961 (1994).
7. W. R. Heath, F. R. Carbone, Nat. Rev. Immunol. 1, 126 (2001).
8. A. L. Ackerman, A. Giodini, P. Cresswell, Immunity 25, 607 (2006).
9. J. M. den Haan, S. M. Lehar, M. J. Bevan, J. Exp. Med. 192, 1685 (2000).
10. J. W. Yewdell, S. M. Haeryfar, Annu. Rev. Immunol. 23, 651 (2005).
11. M. Houde et al., Nature 425, 402 (2003).
12. P. Guermonprez et al., Nature 425, 397 (2003).
13. C. Reis e Sousa, R. N. Germain, J. Exp. Med. 182, 841 (1995).
14. R. M. Zinkernagel, Eur. J. Immunol. 32, 2385 (2002).
15. T. A. Groothuis, J. Neefjes, J. Exp. Med. 202, 1313 (2005).
16. N. Touret et al., Cell 123, 157 (2005).
17. S. Burgdorf, V. Lukacs-Kornek, C. Kurts, J. Immunol. 176, 6770 (2006).
18. S. J. Lee et al., Science 295, 1898 (2002).
19. Materials and methods are available as supporting material on Science Online.
20. F. Sallusto, M. Cella, C. Danieli, A. Lanzavecchia, J. Exp. Med. 182, 389 (1995).
21. D. Dudziak et al., Science 315, 107 (2007).
22. L. A. Pozzi, J. W. Maciaszek, K. L. Rock, J. Immunol. 175, 2071 (2005).
23. A. Palecanda, L. Kobzik, Curr. Mol. Med. 1, 589 (2001).
24. K. Mahnke et al., J. Cell Biol. 151, 673 (2000).
25. A. Porgador, J. W. Yewdell, Y. Deng, J. R. Bennink, R. N. Germain, Immunity 6, 715 (1997).
26. F. Castellino et al., J. Exp. Med. 191, 1957 (2000).
27. L. Delamarre, M. Pack, H. Chang, I. Mellman, E. S. Trombetta, Science 307, 1630 (2005).
28. J. L. Pooley, W. R. Heath, K. Shortman, J. Immunol. 166, 5327 (2001).
29. P. Schnorrer et al., Proc. Natl. Acad. Sci. U.S.A. 103, 10729 (2006).
30. S. R. Bennett, F. R. Carbone, F. Karamalis, J. F. Miller, W. R. Heath, J. Exp. Med. 186, 65 (1997).
31. E. M. Janssen et al., Nature 421, 852 (2003).
32. A. Savina et al., Cell 126, 205 (2006).
33. M. Lakadamyali, M. J. Rust, X. Zhuang, Cell 124, 997 (2006).
34. -/- mice, W. R. Heath for OT-I and OT-II mice, R. Germain and J. Yewdell for 25-D1.16 antibody, A. F. Kiderlen for L-929 cells, and J. F. A. P. Miller, M. C. Nussenzweig, and N. Eter for critically reading the manuscript. We acknowledge technical support by the flow-cytometry core facility and the House for Experimental Therapy (HET) of the Medical Faculty of Bonn University. This work was supported by an institutional BONFOR grant, by a grant from the Sonderforschungsbereich (SFB) 704 of the Deutsche Forschungsgemeinschaft, and by a career development grant from the German state of Nordrhein-Westfalen to C.K.