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Volumn 108, Issue 8, 2011, Pages 1002-1016

The PPAR-RXR transcriptional complex in the vasculature: Energy in the balance

Author keywords

atherosclerosis; diabetes; gene expression; PPARs; RXRs

Indexed keywords

2 [4 [3 [4,5 DIHYDRO 1 (4 METHYLBENZYL) 5 OXO 1H 1,2,4 TRIAZOL 3 YL]PROPYL]PHENOXY] 2 METHYLPROPIONIC ACID; FATTY ACID; HETERODIMER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIOGLITAZONE; RETINOID; RETINOID X RECEPTOR; ROSIGLITAZONE; TRIACYLGLYCEROL;

EID: 79954618658     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.226860     Document Type: Review
Times cited : (129)

References (171)
  • 2
    • 0027196054 scopus 로고
    • The regulatory, informational, and immunomodulatory roles of fat fuels
    • Newsholme EA, Calder P, Yaqoob P. The regulatory, informational, and immunomodulatory roles of fat fuels. Am J Clin Nutr. 1993;57: 738S-750S.
    • (1993) Am J Clin Nutr , vol.57
    • Newsholme, E.A.1    Calder, P.2    Yaqoob, P.3
  • 3
    • 67149137856 scopus 로고    scopus 로고
    • Expansion and contraction: The mighty, mighty fatty acid
    • Plutzky J. Expansion and contraction: the mighty, mighty fatty acid. Nat Med. 2009;15:618-619.
    • (2009) Nat Med , vol.15 , pp. 618-619
    • Plutzky, J.1
  • 4
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • Desvergne B, Michalik L, Wahli W. Transcriptional regulation of metabolism. Physiol Rev. 2006;86:465-514.
    • (2006) Physiol Rev , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 5
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • DOI 10.1161/CIRCULATIONAHA.104.475673, PII 0000301720070130000015
    • Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007; 115:518-533. (Pubitemid 46184203)
    • (2007) Circulation , vol.115 , Issue.4 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 6
    • 77951457202 scopus 로고    scopus 로고
    • Fibrates, glitazones, and peroxisome proliferatoractivated receptors
    • Lalloyer F, Staels B. Fibrates, glitazones, and peroxisome proliferatoractivated receptors. Arterioscler Thromb Vasc Biol. 2010;30:894-899.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 894-899
    • Lalloyer, F.1    Staels, B.2
  • 8
    • 77952997178 scopus 로고    scopus 로고
    • Control of macrophage activation and function by PPARs
    • Chawla A. Control of macrophage activation and function by PPARs. Circ Res. 2010;106:1559-1569.
    • (2010) Circ Res , vol.106 , pp. 1559-1569
    • Chawla, A.1
  • 11
    • 34248350428 scopus 로고    scopus 로고
    • Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)
    • DOI 10.2174/092986707780598023
    • Musa MA, Khan MO, Cooperwood JS. Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs). Curr Med Chem. 2007;14:1249-1261. (Pubitemid 46739325)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.11 , pp. 1249-1261
    • Musa, M.A.1    Khan, M.O.F.2    Cooperwood, J.S.3
  • 12
    • 47249146946 scopus 로고    scopus 로고
    • PPAR modulators and PPAR pan agonists for metabolic diseases: The next generation of drugs targeting peroxisome proliferator-activated receptors?
    • DOI 10.2174/156802608784535084
    • Feldman PL, Lambert MH, Henke BR. PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors? Curr Top Med Chem. 2008; 8:728-749. (Pubitemid 351982563)
    • (2008) Current Topics in Medicinal Chemistry , vol.8 , Issue.9 , pp. 728-749
    • Feldman, P.L.1    Lambert, M.H.2    Henke, B.R.3
  • 13
    • 78650317248 scopus 로고    scopus 로고
    • Endogenous ligands for nuclear receptors: Digging deeper
    • Schupp M, Lazar MA. Endogenous ligands for nuclear receptors: digging deeper. J Biol Chem. 2010;285:40409-40415.
    • (2010) J Biol Chem , vol.285 , pp. 40409-40415
    • Schupp, M.1    Lazar, M.A.2
  • 17
    • 39449102532 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ-mediated effects in the vasculature
    • DOI 10.1161/CIRCRESAHA.107.164384, PII 0000301220080215000007
    • Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res. 2008; 102:283-294. (Pubitemid 351271648)
    • (2008) Circulation Research , vol.102 , Issue.3 , pp. 283-294
    • Duan, S.Z.1    Usher, M.G.2    Mortensen, R.M.3
  • 18
    • 0034332862 scopus 로고    scopus 로고
    • Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: A serial intravascular ultrasound study
    • Takagi T, Akasaka T, Yamamuro A, Honda Y, Hozumi T, Morioka S, Yoshida K. Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study. J Am Coll Cardiol. 2000;36:1529-1535.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1529-1535
    • Takagi, T.1    Akasaka, T.2    Yamamuro, A.3    Honda, Y.4    Hozumi, T.5    Morioka, S.6    Yoshida, K.7
  • 19
    • 39649100393 scopus 로고    scopus 로고
    • Interference with PPARγ Function in Smooth Muscle Causes Vascular Dysfunction and Hypertension
    • DOI 10.1016/j.cmet.2007.12.008, PII S1550413107003816
    • Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 2008; 7:215-226. (Pubitemid 351285526)
    • (2008) Cell Metabolism , vol.7 , Issue.3 , pp. 215-226
    • Halabi, C.M.1    Beyer, A.M.2    De Lange, W.J.3    Keen, H.L.4    Baumbach, G.L.5    Faraci, F.M.6    Sigmund, C.D.7
  • 20
    • 74949126382 scopus 로고    scopus 로고
    • Endothelial and vascular muscle PPARgamma in arterial pressure regulation: Lessons from genetic interference and deficiency
    • Sigmund CD. Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 2010;55:437-444.
    • (2010) Hypertension , vol.55 , pp. 437-444
    • Sigmund, C.D.1
  • 21
    • 77958476011 scopus 로고    scopus 로고
    • Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}
    • Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A. Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}. Circ Res. 2010; 07:953-958.
    • (2010) Circ Res , vol.7 , pp. 953-958
    • Subramanian, V.1    Golledge, J.2    Ijaz, T.3    Bruemmer, D.4    Daugherty, A.5
  • 22
    • 56649095916 scopus 로고    scopus 로고
    • Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: Therapeutic implications for cardiovascular diseases
    • Tousoulis D, Andreou I, Antoniades C, Tentolouris C, Stefanadis C. Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases. Atherosclerosis. 2008;201:236-247.
    • (2008) Atherosclerosis , vol.201 , pp. 236-247
    • Tousoulis, D.1    Andreou, I.2    Antoniades, C.3    Tentolouris, C.4    Stefanadis, C.5
  • 23
    • 44649161147 scopus 로고    scopus 로고
    • Pioglitazone inhibits angiotensin II-induced senescene of endothelial progenitor cell
    • DOI 10.1291/hypres.31.757
    • Imanishi T, Kobayashi K, Kuroi A, Ikejima H, Akasaka T. Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell. Hypertens Res. 2008;31:757-765. (Pubitemid 351772867)
    • (2008) Hypertension Research , vol.31 , Issue.4 , pp. 757-765
    • Imanishi, T.1    Kobayashi, K.2    Kuroi, A.3    Ikejima, H.4    Akasaka, T.5
  • 26
    • 67650869950 scopus 로고    scopus 로고
    • Telmisartan induces proliferation of human endothelial progenitor cells via PPARgamma-dependent PI3K/Akt pathway
    • Honda A, Matsuura K, Fukushima N, Tsurumi Y, Kasanuki H, Hagiwara N. Telmisartan induces proliferation of human endothelial progenitor cells via PPARgamma-dependent PI3K/Akt pathway. Atherosclerosis. 2009;205:376-384.
    • (2009) Atherosclerosis , vol.205 , pp. 376-384
    • Honda, A.1    Matsuura, K.2    Fukushima, N.3    Tsurumi, Y.4    Kasanuki, H.5    Hagiwara, N.6
  • 28
    • 66349124432 scopus 로고    scopus 로고
    • GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
    • Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG. GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res. 2009;50(Suppl):S57-S62.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Beigneux, A.P.1    Davies, B.S.2    Bensadoun, A.3    Fong, L.G.4    Young, S.G.5
  • 30
    • 44849141405 scopus 로고    scopus 로고
    • Regulation of macrophage functions by PPAR-alpha PPAR-gamma and LXRs in mice and men
    • Rigamonti E, Chinetti-Gbaguidi G, Staels B. Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men. Arterioscler Thromb Vasc Biol. 2008;28:1050-1059.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1050-1059
    • Rigamonti, E.1    Chinetti-Gbaguidi, G.2    Staels, B.3
  • 31
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • DOI 10.1038/83336
    • Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 2001;7: 48-52. (Pubitemid 32095641)
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 33
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-246.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 37
    • 52949117651 scopus 로고    scopus 로고
    • Targeting the PIAS1 SUMO ligase pathway to control inflammation
    • Liu B, Shuai K. Targeting the PIAS1 SUMO ligase pathway to control inflammation. Trends Pharmacol Sci. 2008;29:505-509.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 505-509
    • Liu, B.1    Shuai, K.2
  • 39
    • 77949878458 scopus 로고    scopus 로고
    • SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR
    • Pourcet B, Pineda-Torra I, Derudas B, Staels B, Glineur C. SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J Biol Chem. 2010;285:5983-5992.
    • (2010) J Biol Chem , vol.285 , pp. 5983-5992
    • Pourcet, B.1    Pineda-Torra, I.2    Derudas, B.3    Staels, B.4    Glineur, C.5
  • 40
    • 44949181877 scopus 로고    scopus 로고
    • SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ
    • DOI 10.1038/nm1756, PII NM1756
    • Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med. 2008;14:656-666. (Pubitemid 351809542)
    • (2008) Nature Medicine , vol.14 , Issue.6 , pp. 656-666
    • Oishi, Y.1    Manabe, I.2    Tobe, K.3    Ohsugi, M.4    Kubota, T.5    Fujiu, K.6    Maemura, K.7    Kubota, N.8    Kadowaki, T.9    Nagai, R.10
  • 43
    • 58849102970 scopus 로고    scopus 로고
    • Posttranslational modifications of PPAR-gamma: Fine-tuning the metabolic master regulator
    • Van Beekum O, Fleskens V, Kalkhoven E. Posttranslational modifications of PPAR-gamma: fine-tuning the metabolic master regulator. Obesity (Silver Spring). 2009;17:213-219.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 213-219
    • Van Beekum, O.1    Fleskens, V.2    Kalkhoven, E.3
  • 44
    • 77951602823 scopus 로고    scopus 로고
    • Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
    • Glass CK, Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol. 2010;10:365-376.
    • (2010) Nat Rev Immunol , vol.10 , pp. 365-376
    • Glass, C.K.1    Saijo, K.2
  • 47
    • 0033594810 scopus 로고    scopus 로고
    • PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation. 1999;99:3125-3131. (Pubitemid 29289077)
    • (1999) Circulation , vol.99 , Issue.24 , pp. 3125-3131
    • Marx, N.1    Sukhova, G.K.2    Collins, T.3    Libby, P.4    Plutzky, J.5
  • 48
    • 0034698074 scopus 로고    scopus 로고
    • 1 → S transition in vascular smooth muscle cells
    • DOI 10.1074/jbc.M910452199
    • Wakino S, Kintscher U, Kim S, Yin F, Hsueh WA, Law RE. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1-S transition in vascular smooth muscle cells. J Biol Chem. 2000;275:22435-22441. (Pubitemid 30621831)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22435-22441
    • Wakino, S.1    Kintscher, U.2    Kim, S.3    Yin, F.4    Hsueh, W.A.5    Law, R.E.6
  • 52
    • 70349659645 scopus 로고    scopus 로고
    • Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
    • Leuenberger N, Pradervand S, Wahli W. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest. 2009;119:3138-3148.
    • (2009) J Clin Invest , vol.119 , pp. 3138-3148
    • Leuenberger, N.1    Pradervand, S.2    Wahli, W.3
  • 53
    • 33644645013 scopus 로고    scopus 로고
    • PPARδ: A dagger in the heart of the metabolic syndrome
    • DOI 10.1172/JCI27955
    • Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116:590-597. (Pubitemid 43326863)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 55
    • 76749137586 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions
    • Wagner KD, Wagner N. Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol Ther. 2010;125:423-435.
    • (2010) Pharmacol Ther , vol.125 , pp. 423-435
    • Wagner, K.D.1    Wagner, N.2
  • 56
    • 34249087361 scopus 로고    scopus 로고
    • Opposing Effects of Retinoic Acid on Cell Growth Result from Alternate Activation of Two Different Nuclear Receptors
    • DOI 10.1016/j.cell.2007.02.050, PII S0092867407004497
    • Schug TT, Berry DC, Shaw NS, Travis SN, Noy N. Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell. 2007;129:723-733. (Pubitemid 46802374)
    • (2007) Cell , vol.129 , Issue.4 , pp. 723-733
    • Schug, T.T.1    Berry, D.C.2    Shaw, N.S.3    Travis, S.N.4    Noy, N.5
  • 57
    • 67649211584 scopus 로고    scopus 로고
    • All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor
    • Berry DC, Noy N. All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor. Mol Cell Biol. 2009;29: 3286-3296.
    • (2009) Mol Cell Biol , vol.29 , pp. 3286-3296
    • Berry, D.C.1    Noy, N.2
  • 58
    • 70349664475 scopus 로고    scopus 로고
    • Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta
    • Ehrenborg E, Krook A. Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta. Pharmacol Rev. 2009;61:373-393.
    • (2009) Pharmacol Rev , vol.61 , pp. 373-393
    • Ehrenborg, E.1    Krook, A.2
  • 59
    • 43549085285 scopus 로고    scopus 로고
    • PPARβ/δ ligands as modulators of the inflammatory response
    • Kilgore KS, Billin AN. PPARbeta/delta ligands as modulators of the inflammatory response. Curr Opin Investig Drugs. 2008;9:463-469. (Pubitemid 351677899)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.5 , pp. 463-469
    • Kilgore, K.S.1    Billin, A.N.2
  • 60
    • 70349111436 scopus 로고    scopus 로고
    • Emerging roles of peroxisome proliferatoractivated receptor-beta/delta in inflammation
    • Bishop-Bailey D, Bystrom J. Emerging roles of peroxisome proliferatoractivated receptor-beta/delta in inflammation. Pharmacol Ther. 2009; 124:141-150.
    • (2009) Pharmacol Ther , vol.124 , pp. 141-150
    • Bishop-Bailey, D.1    Bystrom, J.2
  • 62
    • 20444378931 scopus 로고    scopus 로고
    • -/- mice
    • DOI 10.1016/j.atherosclerosis.2004.12.028, PII S0021915005000109
    • Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L. The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice. Atherosclerosis. 2005;181:29-37. (Pubitemid 40804690)
    • (2005) Atherosclerosis , vol.181 , Issue.1 , pp. 29-37
    • Graham, T.L.1    Mookherjee, C.2    Suckling, K.E.3    Palmer, C.N.A.4    Patel, L.5
  • 65
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ
    • DOI 10.1126/science.1087344
    • Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003;302:453-457. (Pubitemid 37296272)
    • (2003) Science , vol.302 , Issue.5644 , pp. 453-457
    • Lee, C.-H.1    Chawla, A.2    Urbiztondo, N.3    Liao, D.4    Boisvert, W.A.5    Evans, R.M.6
  • 67
    • 58149465391 scopus 로고    scopus 로고
    • PPAR-delta in vascular pathophysiology
    • Wang N. PPAR-delta in vascular pathophysiology. PPAR Res. 2008; 2008:164163.
    • (2008) PPAR Res , vol.2008 , pp. 164163
    • Wang, N.1
  • 72
    • 77958524950 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {delta} activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner
    • Meissner M, Hrgovic I, Doll M, Naidenow J, Reichenbach G, Hailemariam-Jahn T, Michailidou D, Gille J, Kaufmann R. Peroxisome proliferator-activated receptor {delta} activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner. J Biol Chem. 2010;285:33797-33804.
    • (2010) J Biol Chem , vol.285 , pp. 33797-33804
    • Meissner, M.1    Hrgovic, I.2    Doll, M.3    Naidenow, J.4    Reichenbach, G.5    Hailemariam-Jahn, T.6    Michailidou, D.7    Gille, J.8    Kaufmann, R.9
  • 73
    • 70149095915 scopus 로고    scopus 로고
    • Shear stress induces syntheticto- contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells
    • Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, Chien S, Chiu JJ. Shear stress induces syntheticto- contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator- activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells. Circ Res. 2009;105: 471-480.
    • (2009) Circ Res , vol.105 , pp. 471-480
    • Tsai, M.C.1    Chen, L.2    Zhou, J.3    Tang, Z.4    Hsu, T.F.5    Wang, Y.6    Shih, Y.T.7    Peng, H.H.8    Wang, N.9    Guan, Y.10    Chien, S.11    Chiu, J.J.12
  • 74
    • 76749083354 scopus 로고    scopus 로고
    • PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    • Ali F, Ali NS, Bauer A, Boyle JJ, Hamdulay SS, Haskard DO, Randi AM, Mason JC. PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress. Cardiovasc Res. 2010;85:701-710.
    • (2010) Cardiovasc Res , vol.85 , pp. 701-710
    • Ali, F.1    Ali, N.S.2    Bauer, A.3    Boyle, J.J.4    Hamdulay, S.S.5    Haskard, D.O.6    Randi, A.M.7    Mason, J.C.8
  • 75
    • 33947715721 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-δ upregulates 14-3-3ε in human endothelial cells via CCAAT/enhancer binding protein-β
    • DOI 10.1161/01.RES.0000260805.99076.22
    • Brunelli L, Cieslik KA, Alcorn JL, Vatta M, Baldini A. Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta. Circ Res. 2007;100:e59-e71. (Pubitemid 46594890)
    • (2007) Circulation Research , vol.100 , Issue.5
    • Brunelli, L.1    Cieslik, K.A.2    Alcorn, J.L.3    Vatta, M.4    Baldini, A.5
  • 76
    • 79951711259 scopus 로고    scopus 로고
    • PPARdelta agonists suppress angiogenesis in a VEGFR2-dependent manner
    • Meissner M, Hrgovic I, Doll M, Kaufmann R. PPARdelta agonists suppress angiogenesis in a VEGFR2-dependent manner. Arch Dermatol Res. 2011;303:41-47.
    • (2011) Arch Dermatol Res , vol.303 , pp. 41-47
    • Meissner, M.1    Hrgovic, I.2    Doll, M.3    Kaufmann, R.4
  • 77
    • 48049084162 scopus 로고    scopus 로고
    • Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells
    • He T, Lu T, d'Uscio LV, Lam CF, Lee HC, Katusic ZS. Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res. 2008;103:80-88.
    • (2008) Circ Res , vol.103 , pp. 80-88
    • He, T.1    Lu, T.2    D'Uscio, L.V.3    Lam, C.F.4    Lee, H.C.5    Katusic, Z.S.6
  • 81
    • 58549107793 scopus 로고    scopus 로고
    • PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle
    • Lim HJ, Lee S, Park JH, Lee KS, Choi HE, Chung KS, Lee HH, Park HY. PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Atherosclerosis. 2009;202:446-454.
    • (2009) Atherosclerosis , vol.202 , pp. 446-454
    • Lim, H.J.1    Lee, S.2    Park, J.H.3    Lee, K.S.4    Choi, H.E.5    Chung, K.S.6    Lee, H.H.7    Park, H.Y.8
  • 82
    • 68849103137 scopus 로고    scopus 로고
    • PPARdelta-mediated p21/p27 induction via increased CREBbinding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells
    • Sue YM, Chung CP, Lin H, Chou Y, Jen CY, Li HF, Chang CC, Juan SH. PPARdelta-mediated p21/p27 induction via increased CREBbinding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells. Am J Physiol Cell Physiol. 2009;297:C321-C329.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Sue, Y.M.1    Chung, C.P.2    Lin, H.3    Chou, Y.4    Jen, C.Y.5    Li, H.F.6    Chang, C.C.7    Juan, S.H.8
  • 83
    • 77953024399 scopus 로고    scopus 로고
    • PPARdelta inhibits IL-1beta-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra
    • Kim HJ, Kim MY, Hwang JS, Lee JH, Chang KC, Kim JH, Han CW, Seo HG. PPARdelta inhibits IL-1beta-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra. Cell Mol Life Sci. 2010;67:2119-2130.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2119-2130
    • Kim, H.J.1    Kim, M.Y.2    Hwang, J.S.3    Lee, J.H.4    Chang, K.C.5    Kim, J.H.6    Han, C.W.7    Seo, H.G.8
  • 84
    • 67949095966 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3
    • Kim HJ, Kim MY, Jin H, Kang SS, Lee JH, Chang KC, Hwang JY, Yabe-Nishimura C, Kim JH, Seo HG. Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3. Circ Res. 2009;105:16-24.
    • (2009) Circ Res , vol.105 , pp. 16-24
    • Kim, H.J.1    Kim, M.Y.2    Jin, H.3    Kang, S.S.4    Lee, J.H.5    Chang, K.C.6    Hwang, J.Y.7    Yabe-Nishimura, C.8    Kim, J.H.9    Seo, H.G.10
  • 85
    • 77449141973 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) beta/delta: A new potential therapeutic target for the treatment of metabolic syndrome
    • Coll T, Rodriguez-Calvo R, Barroso E, Serrano L, Eyre E, Palomer X, Vazquez-Carrera M. Peroxisome proliferator-activated receptor (PPAR) beta/delta: a new potential therapeutic target for the treatment of metabolic syndrome. Curr Mol Pharmacol. 2009;2:46-55.
    • (2009) Curr Mol Pharmacol , vol.2 , pp. 46-55
    • Coll, T.1    Rodriguez-Calvo, R.2    Barroso, E.3    Serrano, L.4    Eyre, E.5    Palomer, X.6    Vazquez-Carrera, M.7
  • 86
    • 37549038650 scopus 로고    scopus 로고
    • Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex
    • DOI 10.1016/j.febslet.2007.11.081, PII S0014579307012355
    • Ziouzenkova O, Plutzky J. Retinoid metabolism and nuclear receptor responses: new insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett. 2008;582:32-38. (Pubitemid 50019948)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 32-38
    • Ziouzenkova, O.1    Plutzky, J.2
  • 87
    • 73249126548 scopus 로고    scopus 로고
    • Retinoid X receptor heterodimer variants and cardiovascular risk factors
    • Nohara A, Kobayashi J, Mabuchi H. Retinoid X receptor heterodimer variants and cardiovascular risk factors. J Atheroscler Thromb. 2009; 16:303-318.
    • (2009) J Atheroscler Thromb , vol.16 , pp. 303-318
    • Nohara, A.1    Kobayashi, J.2    Mabuchi, H.3
  • 88
    • 78049278719 scopus 로고    scopus 로고
    • Retinoid X receptors: Common heterodimerization partners with distinct functions
    • Lefebvre P, Benomar Y, Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab. 2010;21:676-683.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 676-683
    • Lefebvre, P.1    Benomar, Y.2    Staels, B.3
  • 90
    • 77952358850 scopus 로고    scopus 로고
    • Ligand regulation of retinoic acid receptor-related orphan receptors: Implications for development of novel therapeutics
    • Solt LA, Griffin PR, Burris TP. Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr Opin Lipidol. 2010;21:204-211.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 204-211
    • Solt, L.A.1    Griffin, P.R.2    Burris, T.P.3
  • 92
    • 0033855471 scopus 로고    scopus 로고
    • Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
    • Gampe RT Jr, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix. Genes Dev. 2000;14:2229-2241.
    • (2000) Genes Dev , vol.14 , pp. 2229-2241
    • Gampe Jr., R.T.1    Montana, V.G.2    Lambert, M.H.3    Wisely, G.B.4    Milburn, M.V.5    Xu, H.E.6
  • 93
    • 0031470903 scopus 로고    scopus 로고
    • Vitamin A deficiency and mutations of RXRα, RXRβ and RARα lead to early differentiation of embryonic ventricular cardiomyocytes
    • Kastner P, Messaddeq N, Mark M, Wendling O, Grondona JM, Ward S, Ghyselinck N, Chambon P. Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development. 1997;124: 4749-4758. (Pubitemid 28014378)
    • (1997) Development , vol.124 , Issue.23 , pp. 4749-4758
    • Kastner, P.1    Messaddeq, N.2    Mark, M.3    Wendling, O.4    Grondons, J.M.5    Ward, S.6    Ghyselinck, N.7    Chambon, P.8
  • 94
    • 0029832219 scopus 로고    scopus 로고
    • RXR gamma null mice are apparently normal and compound RXR alpha/-/RXR beta-/-/RXR gamma-/- mutant mice are viable
    • Krezel W, Dupe V, Mark M, Dierich A, Kastner P, Chambon P. RXR gamma null mice are apparently normal and compound RXR alpha/-/RXR beta-/-/RXR gamma-/- mutant mice are viable. Proc Natl Acad Sci USA. 1996;93:9010-9014.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9010-9014
    • Krezel, W.1    Dupe, V.2    Mark, M.3    Dierich, A.4    Kastner, P.5    Chambon, P.6
  • 95
    • 0029884057 scopus 로고    scopus 로고
    • Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells
    • Miano JM, Topouzis S, Majesky MW, Olson EN. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation. 1996;93:1886-1895.
    • (1996) Circulation , vol.93 , pp. 1886-1895
    • Miano, J.M.1    Topouzis, S.2    Majesky, M.W.3    Olson, E.N.4
  • 96
    • 0034102805 scopus 로고    scopus 로고
    • The vitamin A spectrum: From deficiency to toxicity
    • Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr. 2000;71:878-884. (Pubitemid 30176568)
    • (2000) American Journal of Clinical Nutrition , vol.71 , Issue.4 , pp. 878-884
    • Russell, R.M.1
  • 97
    • 0032616999 scopus 로고    scopus 로고
    • Retinoic acid: Its biosynthesis and metabolism
    • Napoli JL. Retinoic acid: its biosynthesis and metabolism. Prog Nucleic Acid Res Mol Biol. 1999;63:139-188.
    • (1999) Prog Nucleic Acid Res Mol Biol , vol.63 , pp. 139-188
    • Napoli, J.L.1
  • 99
    • 33144488245 scopus 로고    scopus 로고
    • Function of retinoid nuclear receptors: Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    • DOI 10.1146/annurev.pharmtox.46.120604.141156
    • Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol. 2006;46:451-480. (Pubitemid 43271197)
    • (2006) Annual Review of Pharmacology and Toxicology , vol.46 , pp. 451-480
    • Mark, M.1    Ghyselinck, N.B.2    Chambon, P.3
  • 100
    • 34047160095 scopus 로고    scopus 로고
    • Carotenoids and human health
    • DOI 10.1016/j.phrs.2007.01.012, PII S1043661807000357, Nutritional Pharmacology
    • Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res. 2007;55:207-216. (Pubitemid 46518154)
    • (2007) Pharmacological Research , vol.55 , Issue.3 , pp. 207-216
    • Rao, A.V.1    Rao, L.G.2
  • 102
    • 34548364227 scopus 로고    scopus 로고
    • Identification of pathways for atherosclerosis in mice: Integration of quantitative trait locus analysis and global gene expression data
    • DOI 10.1161/CIRCRESAHA.107.152975, PII 0000301220070803000017
    • Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res. 2007;101:e11-e30. (Pubitemid 47344081)
    • (2007) Circulation Research , vol.101 , Issue.3
    • Wang, S.S.1    Schadt, E.E.2    Wang, H.3    Wang, X.4    Ingram-Drake, L.5    Shi, W.6    Drake, T.A.7    Lusis, A.J.8
  • 103
    • 33845996557 scopus 로고    scopus 로고
    • Asymmetric cleavage of β-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses
    • DOI 10.1210/me.2006-0225
    • Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky J. Asymmetric cleavage of betacarotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Mol Endocrinol. 2007;21:77-88. (Pubitemid 46041692)
    • (2007) Molecular Endocrinology , vol.21 , Issue.1 , pp. 77-88
    • Ziouzenkova, O.1    Orasanu, G.2    Sukhova, G.3    Lau, E.4    Berger, J.P.5    Tang, G.6    Krinsky, N.I.7    Dolnikowski, G.G.8    Plutzky, J.9
  • 104
    • 77956259307 scopus 로고    scopus 로고
    • Beta, beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta, beta-carotene oxygenase 1-dependent manner
    • Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta, beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta, beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010;285:27891-27899.
    • (2010) J Biol Chem , vol.285 , pp. 27891-27899
    • Lobo, G.P.1    Amengual, J.2    Li, H.N.3    Golczak, M.4    Bonet, M.L.5    Palczewski, K.6    Von Lintig, J.7
  • 108
    • 34548506744 scopus 로고    scopus 로고
    • Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse
    • DOI 10.1096/fj.06-7964com
    • Zhang M, Hu P, Krois CR, Kane MA, Napoli JL. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007;21:2886-2896. (Pubitemid 47372755)
    • (2007) FASEB Journal , vol.21 , Issue.11 , pp. 2886-2896
    • Zhang, M.1    Hu, P.2    Krois, C.R.3    Kane, M.A.4    Napoli, J.L.5
  • 109
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • DOI 10.1038/nature03711
    • Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-362. (Pubitemid 41065039)
    • (2005) Nature , vol.436 , Issue.7049 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3    Preitner, F.4    Peroni, O.D.5    Zabolotny, J.M.6    Kotani, K.7    Quadro, L.8    Kahn, B.B.9
  • 111
    • 69249097456 scopus 로고    scopus 로고
    • Retinol-binding protein 4 (RBP4): A biomarker for subclinical atherosclerosis?
    • Stuck BJ, Kahn BB. Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis? Am J Hypertens. 2009;22:948-949.
    • (2009) Am J Hypertens , vol.22 , pp. 948-949
    • Stuck, B.J.1    Kahn, B.B.2
  • 112
    • 68949218847 scopus 로고    scopus 로고
    • Retinol-binding protein 4 & atherosclerosis: Risk factor or innocent bystander?
    • von Eynatten M, Humpert PM. Retinol-binding protein 4 & atherosclerosis: risk factor or innocent bystander? Atherosclerosis. 2009;206: 38-39.
    • (2009) Atherosclerosis , vol.206 , pp. 38-39
    • Von Eynatten, M.1    Humpert, P.M.2
  • 113
    • 0036048693 scopus 로고    scopus 로고
    • Retinoids and cardiovascular developmental defects
    • DOI 10.1385/CT:2:1:25
    • Colbert MC. Retinoids and cardiovascular developmental defects. Cardiovasc Toxicol. 2002;2:25-39. (Pubitemid 37070570)
    • (2002) Cardiovascular Toxicology , vol.2 , Issue.1 , pp. 25-39
    • Colbert, M.C.1
  • 114
    • 33947176562 scopus 로고    scopus 로고
    • Retinoic acid and the heart
    • Pan J, Baker KM. Retinoic acid and the heart. Vitam Horm. 2007;75: 257-283.
    • (2007) Vitam Horm , vol.75 , pp. 257-283
    • Pan, J.1    Baker, K.M.2
  • 115
    • 77951215303 scopus 로고    scopus 로고
    • MiR-10a contributes to retinoid acid-induced smooth muscle cell differentiation
    • Huang H, Xie C, Sun X, Ritchie RP, Zhang J, Chen YE. miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation. J Biol Chem. 2010;285:9383-9389.
    • (2010) J Biol Chem , vol.285 , pp. 9383-9389
    • Huang, H.1    Xie, C.2    Sun, X.3    Ritchie, R.P.4    Zhang, J.5    Chen, Y.E.6
  • 116
    • 13844266343 scopus 로고    scopus 로고
    • Retinoids and pulmonary hypertension
    • DOI 10.1161/01.CIR.0000155254.86840.47
    • Preston IR, Tang G, Tilan JU, Hill NS, Suzuki YJ. Retinoids and pulmonary hypertension. Circulation. 2005;111:782-790. (Pubitemid 40250639)
    • (2005) Circulation , vol.111 , Issue.6 , pp. 782-790
    • Preston, I.R.1    Tang, G.2    Tilan, J.U.3    Hill, N.S.4    Suzuki, Y.J.5
  • 117
    • 0034283415 scopus 로고    scopus 로고
    • Retinoids: Versatile biological response modifiers of vascular smooth muscle phenotype
    • Miano JM, Berk BC. Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype. Circ Res. 2000;87:355-362.
    • (2000) Circ Res , vol.87 , pp. 355-362
    • Miano, J.M.1    Berk, B.C.2
  • 119
    • 40949122872 scopus 로고    scopus 로고
    • RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells
    • Chai D, Wang B, Shen L, Pu J, Zhang XK, He B. RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells. Free Radic Biol Med. 2008;44:1334-1347.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1334-1347
    • Chai, D.1    Wang, B.2    Shen, L.3    Pu, J.4    Zhang, X.K.5    He, B.6
  • 123
    • 67649427433 scopus 로고    scopus 로고
    • Vitamins and cardiovascular disease
    • Honarbakhsh S, Schachter M. Vitamins and cardiovascular disease. Br J Nutr. 2009;101:1113-1131.
    • (2009) Br J Nutr , vol.101 , pp. 1113-1131
    • Honarbakhsh, S.1    Schachter, M.2
  • 125
    • 70349737880 scopus 로고    scopus 로고
    • Is the evidence from clinical trials for cardiovascular risk or harm for glitazones convincing?
    • Mannucci E, Monami M. Is the evidence from clinical trials for cardiovascular risk or harm for glitazones convincing? Curr Diab Rep. 2009; 9:342-347.
    • (2009) Curr Diab Rep , vol.9 , pp. 342-347
    • Mannucci, E.1    Monami, M.2
  • 127
    • 78751619380 scopus 로고    scopus 로고
    • Role of fibrates in cardiovascular disease prevention, the ACCORD-Lipid perspective
    • Elam M, Lovato LC, Ginsberg H. Role of fibrates in cardiovascular disease prevention, the ACCORD-Lipid perspective. Curr Opin Lipidol. 2011;22:55-61.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 55-61
    • Elam, M.1    Lovato, L.C.2    Ginsberg, H.3
  • 129
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A consensus statement from the American Heart Association and American Diabetes Association
    • DOI 10.2337/diacare.27.1.256
    • Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care. 2004;27:256-263. (Pubitemid 38196741)
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3    Fonseca, V.4    Grundy, S.M.5    Horton, E.S.6    Le Winter, M.7    Porte, D.8    Semenkovich, C.F.9    Smith, S.10    Young, L.H.11    Kahn, R.12
  • 132
    • 42449088235 scopus 로고    scopus 로고
    • Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus
    • DOI 10.1161/CIRCULATIONAHA.107.746610
    • Davidson M, Meyer PM, Haffner S, Feinstein S, D'Agostino R Sr, Kondos GT, Perez A, Chen Z, Mazzone T. Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus. Circulation. 2008;117:2123-2130. (Pubitemid 351572171)
    • (2008) Circulation , vol.117 , Issue.16 , pp. 2123-2130
    • Davidson, M.1    Meyer, P.M.2    Haffner, S.3    Feinstein, S.4    D'Agostino Sr., R.5    Kondos, G.T.6    Perez, A.7    Chen, Z.8    Mazzone, T.9
  • 133
    • 78650904244 scopus 로고    scopus 로고
    • Lowering the triglyceride/highdensity lipoprotein cholesterol ratio is associated with the beneficial impact of pioglitazone on progression of coronary atherosclerosis in diabetic patients: Insights from the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study
    • Nicholls SJ, Tuzcu EM, Wolski K, Bayturan O, Lavoie A, Uno K, Kupfer S, Perez A, Nesto R, Nissen SE. Lowering the triglyceride/highdensity lipoprotein cholesterol ratio is associated with the beneficial impact of pioglitazone on progression of coronary atherosclerosis in diabetic patients: insights from the PERISCOPE (Pioglitazone Effect on Regression of Intravascular Sonographic Coronary Obstruction Prospective Evaluation) study. J Am Coll Cardiol. 2011;57:153-159.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 153-159
    • Nicholls, S.J.1    Tuzcu, E.M.2    Wolski, K.3    Bayturan, O.4    Lavoie, A.5    Uno, K.6    Kupfer, S.7    Perez, A.8    Nesto, R.9    Nissen, S.E.10
  • 134
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007; 356:2457-2471. (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 135
    • 77954667427 scopus 로고    scopus 로고
    • Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: Pioglitazone versus rosiglitazone
    • Simo R, Rodriguez A, Caveda E. Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone. Curr Drug Saf. 2010;5:234-244.
    • (2010) Curr Drug Saf , vol.5 , pp. 234-244
    • Simo, R.1    Rodriguez, A.2    Caveda, E.3
  • 136
    • 55449094392 scopus 로고    scopus 로고
    • Rosiglitazone and cardiovascular risk
    • Kaul S, Diamond GA. Rosiglitazone and cardiovascular risk. Curr Atheroscler Rep. 2008;10:398-404.
    • (2008) Curr Atheroscler Rep , vol.10 , pp. 398-404
    • Kaul, S.1    Diamond, G.A.2
  • 137
    • 67649298019 scopus 로고    scopus 로고
    • Risk of fractures with glitazones: A critical review of the evidence to date
    • Bodmer M, Meier C, Kraenzlin ME, Meier CR. Risk of fractures with glitazones: a critical review of the evidence to date. Drug Saf. 2009;32: 539-547.
    • (2009) Drug Saf , vol.32 , pp. 539-547
    • Bodmer, M.1    Meier, C.2    Kraenzlin, M.E.3    Meier, C.R.4
  • 138
  • 139
    • 0030459837 scopus 로고    scopus 로고
    • Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone
    • DOI 10.1021/jm9605694
    • Tanis SP, Parker TT, Colca JR, Fisher RM, Kletzein RF. Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. J Med Chem. 1996;39:5053-5063. (Pubitemid 27008952)
    • (1996) Journal of Medicinal Chemistry , vol.39 , Issue.26 , pp. 5053-5063
    • Tanis, S.P.1    Parker, T.T.2    Colca, J.R.3    Fisher, R.M.4    Kletzein, R.F.5
  • 140
    • 49849086021 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice
    • Orasanu G, Ziouzenkova O, Devchand PR, Nehra V, Hamdy O, Horton ES, Plutzky J. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol. 2008;52:869-881.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 869-881
    • Orasanu, G.1    Ziouzenkova, O.2    Devchand, P.R.3    Nehra, V.4    Hamdy, O.5    Horton, E.S.6    Plutzky, J.7
  • 141
    • 0030451897 scopus 로고    scopus 로고
    • Discovery of ligands for the nuclear peroxisome proliferator-activated receptors
    • DOI 10.1111/j.1749-6632.1996.tb18622.x
    • Willson TM, Lehmann JM, Kliewer SA. Discovery of ligands for the nuclear peroxisome proliferator- activated receptors. Ann N Y Acad Sci. 1996;804:276-283. (Pubitemid 27056616)
    • (1996) Annals of the New York Academy of Sciences , vol.804 , pp. 276-283
    • Willson, T.M.1    Lehmann, J.M.2    Kliewer, S.A.3
  • 143
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin, and cardiovascular disease: Subgroup analysis from the Department of Veterans Affairs High-density Lipoprotein Intervention Trial (VA-HIT)
    • DOI 10.1001/archinte.162.22.2597
    • Rubins HB, Robins SJ, Collins D, Nelson DB, Elam MB, Schaefer EJ, Faas FH, Anderson JW. Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch Intern Med. 2002;162:2597-2604. (Pubitemid 35453499)
    • (2002) Archives of Internal Medicine , vol.162 , Issue.22 , pp. 2597-2604
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3    Nelson, D.B.4    Elam, M.B.5    Schaefer, E.J.6    Faas, F.H.7    Anderson, J.W.8
  • 146
    • 67649598394 scopus 로고    scopus 로고
    • MBX- 102/JNJ39659100, a novel peroxisome proliferator-activated receptorligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema
    • Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE. MBX- 102/JNJ39659100, a novel peroxisome proliferator-activated receptorligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009;23: 975-988.
    • (2009) Mol Endocrinol , vol.23 , pp. 975-988
    • Gregoire, F.M.1    Zhang, F.2    Clarke, H.J.3    Gustafson, T.A.4    Sears, D.D.5    Favelyukis, S.6    Lenhard, J.7    Rentzeperis, D.8    Clemens, L.E.9    Mu, Y.10    Lavan, B.E.11
  • 148
    • 74049164270 scopus 로고    scopus 로고
    • Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET
    • Geldenhuys WJ, Funk MO, Barnes KF, Carroll RT. Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2010;20:819-823.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 819-823
    • Geldenhuys, W.J.1    Funk, M.O.2    Barnes, K.F.3    Carroll, R.T.4
  • 149
    • 79954593739 scopus 로고    scopus 로고
    • Treatment of obesityrelated complications with novel classes of naturally occurring PPAR agonists
    • Bassaganya-Riera J, Guri AJ, Hontecillas R. Treatment of obesityrelated complications with novel classes of naturally occurring PPAR agonists. J Obes. 2011;2011:897894.
    • (2011) J Obes , vol.2011 , pp. 897894
    • Bassaganya-Riera, J.1    Guri, A.J.2    Hontecillas, R.3
  • 152
    • 67649839953 scopus 로고    scopus 로고
    • Effect of the dual peroxisome proliferator-activated receptoralpha/ gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): A phase II, randomised, dose-ranging study
    • Henry RR, Lincoff AM, Mudaliar S, Rabbia M, Chognot C, Herz M. Effect of the dual peroxisome proliferator-activated receptoralpha/ gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study. Lancet. 2009;374:126-135.
    • (2009) Lancet , vol.374 , pp. 126-135
    • Henry, R.R.1    Lincoff, A.M.2    Mudaliar, S.3    Rabbia, M.4    Chognot, C.5    Herz, M.6
  • 154
    • 75149162437 scopus 로고    scopus 로고
    • Phospholipase A2-modified low-density lipoprotein activates macrophage peroxisome proliferator-activated receptors
    • Namgaladze D, Morbitzer D, von Knethen A, Brune B. Phospholipase A2-modified low-density lipoprotein activates macrophage peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010; 30:313-320.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 313-320
    • Namgaladze, D.1    Morbitzer, D.2    Von Knethen, A.3    Brune, B.4
  • 158
    • 77957859675 scopus 로고    scopus 로고
    • PPARalpha is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis
    • Benameur T, Tual-Chalot S, Andriantsitohaina R, Martinez MC. PPARalpha is essential for microparticle-induced differentiation of mouse bone marrow-derived endothelial progenitor cells and angiogenesis. PLoS One. 2010;5:e12392.
    • (2010) PLoS One , vol.5
    • Benameur, T.1    Tual-Chalot, S.2    Andriantsitohaina, R.3    Martinez, M.C.4
  • 160
    • 34948859481 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance
    • DOI 10.2337/db07-0069
    • Werner C, Kamani CH, Gensch C, Bohm M, Laufs U. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes. 2007; 56:2609-2615. (Pubitemid 47523269)
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2609-2615
    • Werner, C.1    Kamani, C.H.2    Gensch, C.3    Bohm, M.4    Laufs, U.5
  • 162
    • 53249111805 scopus 로고    scopus 로고
    • Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet
    • Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res. 2008;103:654-661.
    • (2008) Circ Res , vol.103 , pp. 654-661
    • Beyer, A.M.1    De Lange, W.J.2    Halabi, C.M.3    Modrick, M.L.4    Keen, H.L.5    Faraci, F.M.6    Sigmund, C.D.7
  • 165
    • 46749157907 scopus 로고    scopus 로고
    • Beyond the classic angiotensin-receptor-blocker profile
    • DOI 10.1038/ncpcardio0805, PII NCPCARDIO0805
    • Kurtz TW. Beyond the classic angiotensin-receptor-blocker profile. Nat Clin Pract Cardiovasc Med. 2008;5(Suppl 1):S19-S26. (Pubitemid 351940520)
    • (2008) Nature Clinical Practice Cardiovascular Medicine , vol.5 , Issue.SUPPL. 1
    • Kurtz, T.W.1
  • 166
    • 77951197658 scopus 로고    scopus 로고
    • The natural protective mechanism against hyperglycemia in vascular endothelial cells: Roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta
    • Riahi Y, Sin-Malia Y, Cohen G, Alpert E, Gruzman A, Eckel J, Staels B, Guichardant M, Sasson S. The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta. Diabetes. 2010;59:808-818.
    • (2010) Diabetes , vol.59 , pp. 808-818
    • Riahi, Y.1    Sin-Malia, Y.2    Cohen, G.3    Alpert, E.4    Gruzman, A.5    Eckel, J.6    Staels, B.7    Guichardant, M.8    Sasson, S.9
  • 167
    • 0038078864 scopus 로고    scopus 로고
    • Activation of peroximase proliferator-activated receptors α and γ1 inhibits human smooth muscle cell proliferation
    • DOI 10.1023/A:1023424500160
    • Zahradka P, Yurkova N, Litchie B, Moon MC, Del Rizzo DF, Taylor CG. Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation. Mol Cell Biochem. 2003;246:105-110. (Pubitemid 36798729)
    • (2003) Molecular and Cellular Biochemistry , vol.246 , Issue.1-2 , pp. 105-110
    • Zahradka, P.1    Yurkova, N.2    Litchie, B.3    Moon, M.C.4    Del Rizzo, D.F.5    Taylor, C.G.6
  • 168
    • 63849146427 scopus 로고    scopus 로고
    • The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation
    • Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D. The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circ Res. 2008;103:1155-1163.
    • (2008) Circ Res , vol.103 , pp. 1155-1163
    • Gizard, F.1    Nomiyama, T.2    Zhao, Y.3    Findeisen, H.M.4    Heywood, E.B.5    Jones, K.L.6    Staels, B.7    Bruemmer, D.8
  • 169
    • 58149158210 scopus 로고    scopus 로고
    • Pathways of proliferation: New targets to inhibit the growth of vascular smooth muscle cells
    • Marsboom G, Archer SL. Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells. Circ Res. 2008;103: 1047-1049.
    • (2008) Circ Res , vol.103 , pp. 1047-1049
    • Marsboom, G.1    Archer, S.L.2
  • 170
    • 33750214897 scopus 로고    scopus 로고
    • Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor α-dependent repression of cyclin D1
    • DOI 10.1161/01.ATV.0000242013.29441.81, PII 0004360520061100000008
    • Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol. 2006;26:2462-2468. (Pubitemid 44607466)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.11 , pp. 2462-2468
    • Ng, V.Y.1    Morisseau, C.2    Falck, J.R.3    Hammock, B.D.4    Kroetz, D.L.5


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