The vitamin A spectrum: From deficiency to toxicity

American Journal of Clinical Nutrition

Volumn 71, Issue 4, 2000, Pages 878-884

  Russell, Robert M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Retinoids; Robert H Herman Memorial Award in Clinical Nutrition; Stable isotopes; Vitamin A; Vitamin A deficiency; Vitamin A toxicity; Vitamin metabolism

Indexed keywords

BETA CAROTENE; RETINOIC ACID; RETINOID; RETINOL; STABLE ISOTOPE;

ALCOHOL LIVER DISEASE; DARK ADAPTATION; DIET; HUMAN; HYPERLIPIDEMIA; NUTRITION; RETINOL DEFICIENCY; REVIEW; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

ANIMALIA;

EID: 0034102805     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/71.4.878     Document Type: Review

References (49)

1. Russell RM, Multack R, Smith V, Krill A, Rosenberg IH. The use of dark adaptation as a reversible indicator of subclinical vitamin A deficiency in patients with chronic small intestinal disease. Lancet 1973;2:1161-4.
2. Russell RM, Morrison SA, Smith FR, Oaks EV, Carney EA. Vitamin A reversal of abnormal dark adaptation in cirrhosis. Study of effects on the plasma retirol transport system. Ann Intern Med 1978;88: 622-6.
3. Rogers EL, Douglass W, Russell RM, Bushman L, Hubbard TB, Iber FL. Deficiency of fat soluble vitamins after jejunoileal bypass surgery for morbid obesity. Am J Clin Nutr 1980;33:1208-14.
4. Herlong HF, Russell RM, Garrett M, Maddrey WC. Vitamin A deficiency in primary biliary cirrhosis. Hepatology 1981;1:348-51.
5. Dutta SK, Russell RM, Lakhanpal V. Abnormal dark adaptation associated with low plasma levels of vitamin A transport proteins: correction by protein repletion. Nutr Res 1981;1:461-6.
6. Dutta SK, Bustin MP, Russell RM, Boniface SC. Deficiency of fat soluble vitamins in treated patients with pancreatic insufficiency. Ann Intern Med 1982;97:549-74.
7. Loerch JD, Underwood BA, Lewis KC. Response of plasma levels of vitamin A to a dose of vitamin A as an indicator of hepatic vitamin A reserves in rats. J Nutr 1979;109:778-86.
8. Muto Y, Smith JE, Milch PO, Goodman DS. Regulation of retinol binding protein metabolism by vitamin A status in the rat. J Biol Chem 1972;247:2542-50.
9. Mobarhan S, Russell RM, Underwood BA, Wallingford J, Mathieson RD, Al-Midani H. Evaluation of the relative dose response test for vitamin A nutriture in cirrhotics. Am J Clin Nutr 1981; 34:2264-70.
10. Udomkesmaleee E, Dhanamitta S, Sirisinha S, et al. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand. Am J Clin Nutr 1992;56:50-7.
11. Tanumihardjo SA, Muherdiyantiningsih, Permaesih D, et al. Assessment of the vitamin A status in lactating and nonlactating, nonpregnant Indonesian women by use of the modified-relative-dose-response (MRDR) test. Am J Clin Nutr 1994;60:142-7.
12. Tanumihardjo SA, Muhilal, Yuniar Y, et al. Vitamin A status in preschool-age Indonesian children as assessed by the modified relative-dose-response assay. Am J Clin Nutr 1990;52:1068-72.
13. Campos F, Flores H, Underwood BA. Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR). Am J Clin Nutr 1987;46:91-4.
14. Flores H, Campos F, Araujo C, Underwood BA. Assessment of marginal vitamin A deficiency in Brazilian children using the relative dose response procedure. Am J Clin Nutr 1984;40:1281-9.
15. Parisi AF, Vallee BL. Zinc metalloenzymes: characteristics and significance in biology and medicine. Am J Clin Nutr 1969;22:1222-39.
16. Huber AM, Gershoff SN. Effects of zinc deficiency on the oxidation of retinol and ethanol in rats. J Nutr 1975;105:1486-90.
17. Carney EA, Russell RM. Correlation of dark adaptation test results with serum vitamin A levels in diseased adults. J Nutr 1980;110:552-7.
18. Pilch SM, ed. Assessment of the vitamin A nutritional status of the U.S. population based on data collected in the Health and Nutrition Examination Surveys. Bethesda, MD: Life Sciences Research Office, 1985.
19. Wang XD, Liu C, Chung J, Stickel F, Seitz HK, Russell RM. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 expression in liver. Hepatology 1998;28:744-50.
20. Mobarhan S, Seitz HK, Russell RM, et al. Age related effects of chronic ethanol intake on vitamin A status in Fisher 344 rats. J Nutr 1991;121:510-7.
21. De Pee S, West CE, Muhilal, Karyadi D, Hautvast JGAJ. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet 1995;346:75-81.
22. Bulux J, Quan de Serrano J, Giulian A, et al. Plasma response of children to short-term chronic β-carotene supplementation. Am J Clin Nutr 1994;59:1369-75.
23. Tang G, Gu X-F, Hu S-M, et al. Green and yellow vegetables can maintain body stores of vitamin A in Chinese children. Am J Clin Nutr 1999;70:1069-76.
24. Russell RM, Boyer JL, Bagheri S, Hruban Z. Hepatic toxicity from chronic hyper-vitaminosis. A unique morphologic lesion resulting in portal hypertension and ascites. N Engl J Med 1974; 291:435-40.
25. Ellis JK, Russell RM, Makrauer FL, Schaefer EJ. Increased risk of vitamin A toxicity in severe hypertriglyceridemia. Ann Intern Med 1986;105:877-9.
26. Carpenter TO, Pettifor JM, Russell RM, et al. Severe hypervitaminosis A in siblings: evidence of variable tolerance to retinol intake. J Pediatr 1987;111:507-12.
27. Krasinski SD, Cohn JS, Schaefer EJ, Russell RM. Postprandial plasma retinyl ester response is greater in older subjects compared with younger subjects. J Clin Invest 1990;85:883-92.
28. Hollander D, Morgan D. Aging: its influence on vitamin A intestinal absorption in vivo by the rat. Exp Gerontol 1979;14:301-5.
29. Krasinski SD, Russell RM, Otradovec CL, et al. Relationship of vitamin A and E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, α-tocopherol, and cholesterol among elderly people and young adults increased plasma retinyl esters among vitamin A-supplemented users. Am J Clin Nutr 1989;49:112-20.
30. Leo MA, Aleynik SI, Aleynik MK, Lieber CS. β-Carotene beadlets potentiate hepatotoxicity of alcohol. Am J Clin Nutr 1997;66: 1461-9.
31. Wang XD, Tang GW, Fox JG, Krinsky NI, Russell RM. Enzymatic conversion of β-carotene into β-apo-carotenals and retinoids by human, monkey, ferret and rat tissue. Arch Biochem Biophys 1991;121:510-7.
32. Wang XD, Russell RM, Marini RP, et al. Intestinal perfusion of β-carotene in the ferret raises retinoic acid level in portal blood. Biochim Biophys Acta 1993;1167:159-64.
33. Wang XD, Krinsky NI, Benott PN, Russell RM. Biosynthesis of 9-cis-retinoic acid from β-carotene in human intestinal mucosa. Arch Biochem Biophys 1994;313:150-5.
34. Hebuterne X, Wang XD, Smith DE, Tang GW, Russell RM. In vivo biosynthesis of retinoic acid from β-carotene involves an excentric cleavage pathway in ferret intestine. J Lipid Res 1996;37:482-92.
35. Wang XD, Krinsky NI, Tang GW, Russell RM. Retinoic acid can be produced from excentric cleavage of β-carotene in human intestinal mucosa. Arch Biochem Biophys 1992;293:298-304.
36. Yeum KJ, Lee YC, Yoon S, et al. Similar metabolites formed from β-carotene by either lipoxygenase or human gastric mucosal homogenate. Arch Biochem Biophys 1995;321:167-74.
37. Wang XD, Russell RM, Liu C, Stickel F, Smith DE, Krinsky NI. A type of β-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from β-apocarotenoic acids. J Biol Chem 1996;271:26490-8.
38. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in males smokers. N Engl J Med 1994;330:1029-35.
39. Omenn GS, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996;88:1550-9.
40. Wang XD, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell RM. Alteration of retinoid signaling and AP1 expression by β-carotene supplements in smoke exposed ferrets. J Natl Cancer Inst 1999;91:60-6.
41. Geberg JF, Moghal N, Frangioni JV, Sugar-Baker DJ, Neel BG. High frequency of retinoic acid receptor βabnormalities in human lung cancer. Oncogene 1991;6:1859-68 (published erratum appears in Oncogene 1992;7:821).
42. Dolle P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P. Retinoic acid receptors and cellular retinoid binding proteins. 1. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 1990;11:1133-51.
43. Nervi C, Vollberg TM, George MD, Zelent A, Chambon P, Jetten AM. Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells. Exp Cell Res 1991:195:163-70.
44. Lotan R. Retinoids in cancer chemoprevention. FASEB J 1996: 10:1031-9.
45. Zhang XK, Liu Y, Lee MO. Retinoid receptors in human lung cancer and breast cancer. Mutat Res 1996;350:267-77.
46. Xu XC, Sozzi G, Lee JS, et al. Suppression of retinoic acid receptor β in non-small-cell lung cancer in vivo: implications for lung cancer development. J Natl Cancer Inst 1997:89:624-9.
47. Houle B, Rochette-Egly C, Bradley WE. Tumor-suppressive effect of the retinoic acid receptor βin human epidermoid lung cancer cells. Proc Natl Acad Sci U S A 1993:90:985-9.
48. Lee HY, Dawson MI, Claret FX, et al. Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells. Cell Growth Differ 1997;8:283-91.
49. Salgo MG, Cueto R, Winston GW, Pryor WA. Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA. Free Radic Biol Med 1996;26:162-73.