Editorial: Pathways of Proliferation: New Targets to Inhibit the Growth of Vascular Smooth Muscle Cells

Circulation Research

Volumn 103, Issue 10, 2008, Pages 1047-1049

  Marsboom, Glenn ^a   Archer, Stephen L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Coronary artery restenosis; Histone deacetylase; Ppar ; Pulmonary arterial hypertension; Telomerase

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE; HISTONE DEACETYLASE; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; REPETITIVE DNA; RETINOBLASTOMA PROTEIN; ROSIGLITAZONE; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE; E2F1 PROTEIN, MOUSE; E2F1 PROTEIN, RAT; MITOGENIC AGENT; PROTEIN P107; PROTEIN P130; RBL1 PROTEIN, MOUSE; RBL2 PROTEIN, MOUSE; RBL2 PROTEIN, RAT; TELOMERASE; TERT PROTEIN, MOUSE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; EDITORIAL; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; TELOMERE; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; DYSLIPIDEMIA; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; NOTE; PHYSIOLOGY; PROMOTER REGION; RAT;

ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DYSLIPIDEMIAS; E2F1 TRANSCRIPTION FACTOR; ENZYME ACTIVATION; G1 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MITOGENS; MYOCYTES, SMOOTH MUSCLE; PPAR ALPHA; PROMOTER REGIONS, GENETIC; RATS; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130; S PHASE; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 58149158210     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.188003     Document Type: Editorial

References (24)

1. 1. Morice MC, Serrays PW, Sousa JE, Fajadet J, Ban Hayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Moinar F, Falotico R. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med. 2002;346:1773-1780. (Pubitemid 34586912)
2. INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circ Res. 2008;103:1155-1163.
3. 3. Gizard F, Amant C, Barbier O, Bellosta S, Robillard R, Percevault F, Sevestre H, Krimpenfort P, Corsini A, Rochette J, Glineur C, Frachart JC, Torpier G, Staels B. PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimai hyperplasia by inducing the tumor suppressor pl6INK4a. J Clin Invest. 2005;115:3228-3238. (Pubitemid 41567587)
4. 4. Schwartz GK, Shah MA. Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol. 2005;23:9408-9421. (Pubitemid 46260200)
5. Fuster JJ, Andres V. Telomere biology and cardiovascular disease. Circ Res. 2006;99:1167-1180.
6. Minamino T, Komuro I. Role of telomeres in vascular senescence. Front Biosci. 2008;13:2971-2979.
7. Won J, Yim J, Kim TK. Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells. FASEB J. 2002;16:1943-1945.
8. Martin KA, Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv Cancer Res. 2002;86:1-39.
9. Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci USA. 2002;99:4319-4324.
10. 10. Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HJF-lalpha-Kvl.5 02-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol. 2008;294:H570-H578. (Pubitemid 351253263)
11. 11. Martin KA, Rzucidlo EM, Merenick BL, Fingar DC, Brown DJ, Wagner RJ, Powell RJ. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol. 2004;286:C507-C517. (Pubitemid 38292656)
12. 12. Wakino S, Kintscher U, Kim S, Yin F, Hsueh WA, Law RE. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and Gl-> S transition in vascular smooth muscle cells. J Biol Chem. 2000;275:22435-22441. (Pubitemid 30621831)
13. 13. Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator- activated receptor-gamma activation. Circulation. 2007;115: 1275-1284. (Pubitemid 46594772)
14. 14. Simosa HF, Wang G, Sui X, Peterson T, Narra V, Altieri DC, Conte MS. Survivin expression is up-regulated in vascular injury and identifies a distinct cellular phenotype. J Vase Surg. 2005;41:682-690. (Pubitemid 40637669)
15. McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Puttagunta L, Michelakis ED. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest. 2005;115:1479-1491.
16. 16. Suzuki A, Hayashida M, Ito T, Kawano H, Nakano T, Miura M, Akahane K, Shiraki K. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/pl6(INK4a) and Cdk2/cyclin E complex activation. Oncogene. 2000;19:3225-3234. (Pubitemid 30487409)
17. 17. van der Veer E, Nong Z, O'Neil C, Urquhart B, Freeman D, Pickering JG. Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ Res. 2005;97:25-34. (Pubitemid 40982319)
18. Richon VM, Sandhoff TW, Rifkind RA, Marks PA. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA. 2000;97:10014-10019.
19. Okamoto H, Fujioka Y, Takahashi A, Takahashi T, Taniguchi T, Ishikawa Y, Yokoyama M. Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAFl). JAtheroscler Thromb. 2006;13:183-191.
20. 20. Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC. Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation. 2001; 104:790-795. (Pubitemid 32762677)
21. 21. Tada Y, Majka S, Can M, Harral J, Crona D, Kuriyama T, West J. Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1556-L1563. (Pubitemid 47077371)
22. 22. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol. 2001;21:3336-3342. (Pubitemid 32381769)
23. Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007;11:37-51.
24. 24. Lacerte A, Korah J, Roy M, Yang XJ, Lemay S, Lebrun JJ. Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factors. Cell Signal. 2008;20:50-59. (Pubitemid 350138369)