Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 819-823

  Geldenhuys, Werner J ^a   Funk, Max O ^b   Barnes, Kendra F ^a   Carroll, Richard T ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

Author keywords

2Fe 2S; Mitochondria; MitoNEET; Pioglitazone; PPAR gamma; Rosiglitazone

Indexed keywords

FREE RADICAL; GLITAZONE DERIVATIVE; MITOCHONDRIAL PROTEIN; MITONEET PROTEIN; PIOGLITAZONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROSIGLITAZONE; ROTENONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2,4-THIAZOLIDINEDIONE; MITOCHONDRIAL PROTEIN 17 KDA, RAT;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MITOCHONDRIAL RESPIRATION; NERVE CELL NECROSIS; NEUROPROTECTION; PHYSICAL CHEMISTRY; PREDICTION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; LIVER MITOCHONDRION; METABOLISM; PHYSIOLOGY; PROCEDURES; PROTEIN SECONDARY STRUCTURE; RAT; SYNTHESIS;

ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG DESIGN; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; PROTEIN STRUCTURE, SECONDARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 74049164270     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.088     Document Type: Article

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