-
1
-
-
0033599038
-
Dominant negative mutations in human PPARy associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, Soos MA, Maslen GL, Williams TD, Lewis H, Schafer AJ, Chatterjee VK, O'sRahilly S. Dominant negative mutations in human PPARy associated with severe insulin resistance, diabetes mellitus and hypertension. Nature. 1999;402:880-883.
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.11
O'srahilly, S.12
-
2
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007; 356:2457-2471. (Pubitemid 46919772)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.24
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
3
-
-
4043151601
-
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARy
-
Tsai YS, Kim HJ, Takahashi N, Kim HS, Hagaman JR, Kim JK, Maeda N. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARy. J Clin Invest. 2004;114:240-249.
-
(2004)
J Clin Invest
, vol.114
, pp. 240-249
-
-
Tsai, Y.S.1
Kim, H.J.2
Takahashi, N.3
Kim, H.S.4
Hagaman, J.R.5
Kim, J.K.6
Maeda, N.7
-
4
-
-
42049101837
-
Interference with PPARy signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling
-
Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, deLange WJ, Keen HL, Tsai Y-S, Maeda N, Sigmund CD, Faraci FM. Interference with PPARy signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 2008;51:867-871.
-
(2008)
Hypertension
, vol.51
, pp. 867-871
-
-
Beyer, A.M.1
Baumbach, G.L.2
Halabi, C.M.3
Modrick, M.L.4
Lynch, C.M.5
Gerhold, T.D.6
Ghoneim, S.M.7
Delange, W.J.8
Keen, H.L.9
Tsai, Y.-S.10
Maeda, N.11
Sigmund, C.D.12
Faraci, F.M.13
-
5
-
-
39649100393
-
Interference with PPARy function in smooth muscle causes vascular dysfunction and hypertension
-
Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPARy function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 2008;7: 215-226.
-
(2008)
Cell Metab
, vol.7
, pp. 215-226
-
-
Halabi, C.M.1
Beyer, A.M.2
De Lange, W.J.3
Keen, H.L.4
Baumbach, G.L.5
Faraci, F.M.6
Sigmund, C.D.7
-
6
-
-
20444497357
-
Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?
-
Feinstein DL, Spagnolo A, Akar C, Weinberg G, Murphy P, Gavrilyuk V, Dello RC. Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key? Biochem Pharmacol. 2005;70: 177-188.
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 177-188
-
-
Feinstein, D.L.1
Spagnolo, A.2
Akar, C.3
Weinberg, G.4
Murphy, P.5
Gavrilyuk, V.6
Dello, R.C.7
-
7
-
-
17044430286
-
PPARy in endothelial cells influences high fat diet-induced hypertension
-
Nicol CJ, Adachi M, Akiyama TE, Gonzalez FJ. PPARy in endothelial cells influences high fat diet-induced hypertension. Am J Hypertens. 2005;18:549-556.
-
(2005)
Am J Hypertens
, vol.18
, pp. 549-556
-
-
Nicol, C.J.1
Adachi, M.2
Akiyama, T.E.3
Gonzalez, F.J.4
-
8
-
-
36849034568
-
PPARy regulates osteoclastogenesis in mice
-
Wan Y, Chong LW, Evans RM. PPARy regulates osteoclastogenesis in mice. Nat Med. 2007;13:1496-1503.
-
(2007)
Nat Med
, vol.13
, pp. 1496-1503
-
-
Wan, Y.1
Chong, L.W.2
Evans, R.M.3
-
9
-
-
34547618810
-
Maternal PPARy protects nursing neonates by suppressing the production of inflammatory milk
-
Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. Maternal PPARy protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev. 2007;21:1895-1908.
-
(2007)
Genes Dev
, vol.21
, pp. 1895-1908
-
-
Wan, Y.1
Saghatelian, A.2
Chong, L.W.3
Zhang, C.L.4
Cravatt, B.F.5
Evans, R.M.6
-
10
-
-
0034891892
-
Vectors for high level expression of cDNAs controlled by tissue-specific promoters in transgenic mice
-
Stec DE, Morimoto S, Sigmund CD. Vectors for high level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Bio-techniques. 2001;31:256-260.
-
(2001)
Bio-techniques
, vol.31
, pp. 256-260
-
-
Stec, D.E.1
Morimoto, S.2
Sigmund, C.D.3
-
11
-
-
33845954722
-
The human renin kidney enhancer is required to maintain baseline renin expression but is dispensable for tissue-specific, cell-specific and regulated expression
-
Zhou X, Davis DR, Sigmund CD. The human renin kidney enhancer is required to maintain baseline renin expression but is dispensable for tissue-specific, cell-specific and regulated expression. J Biol Chem. 2006; 281:35296-35304.
-
(2006)
J Biol Chem
, vol.281
, pp. 35296-35304
-
-
Zhou, X.1
Davis, D.R.2
Sigmund, C.D.3
-
12
-
-
1442288375
-
PPARy agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
-
Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPARy agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension. 2004;43:661-666.
-
(2004)
Hypertension
, vol.43
, pp. 661-666
-
-
Ryan, M.J.1
Didion, S.P.2
Mathur, S.3
Faraci, F.M.4
Sigmund, C.D.5
-
13
-
-
0037112407
-
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice
-
Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91:938-944.
-
(2002)
Circ Res
, vol.91
, pp. 938-944
-
-
Didion, S.P.1
Ryan, M.J.2
Didion, L.A.3
Fegan, P.E.4
Sigmund, C.D.5
Faraci, F.M.6
-
14
-
-
33744946795
-
Selective cerebral vascular dysfunction in Mn-SOD-deficient mice
-
Faraci FM, Modrick ML, Lynch CM, Didion LA, Fegan PE, Didion SP. Selective cerebral vascular dysfunction in Mn-SOD-deficient mice. J Appl Physiol. 2006;100:2089-2093.
-
(2006)
J Appl Physiol
, vol.100
, pp. 2089-2093
-
-
Faraci, F.M.1
Modrick, M.L.2
Lynch, C.M.3
Didion, L.A.4
Fegan, P.E.5
Didion, S.P.6
-
15
-
-
0034791448
-
Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD
-
Didion SP, Hathaway CA, Faraci FM. Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol Heart Circ Physiol. 2001;281:H1697-H1703.
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.281
-
-
Didion, S.P.1
Hathaway, C.A.2
Faraci, F.M.3
-
16
-
-
0033544875
-
Highly Regulated cell-type restricted expression of human renin in mice containing 140 Kb or 160 Kb P1 phage artificial chromosome transgenes
-
Sinn PL, Davis DR, Sigmund CD. Highly Regulated cell-type restricted expression of human renin in mice containing 140 Kb or 160 Kb P1 phage artificial chromosome transgenes. J Biol Chem. 1999;274:35785-35793.
-
(1999)
J Biol Chem
, vol.274
, pp. 35785-35793
-
-
Sinn, P.L.1
Davis, D.R.2
Sigmund, C.D.3
-
17
-
-
0036205326
-
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1 ABCG1 and apoE in macrophages and reduced cholesterol efflux
-
Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB Jr, Gonzalez FJ. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22: 2607-2619.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2607-2619
-
-
Akiyama, T.E.1
Sakai, S.2
Lambert, G.3
Nicol, C.J.4
Matsusue, K.5
Pimprale, S.6
Lee, Y.H.7
Ricote, M.8
Glass, C.K.9
Brewer Jr., H.B.10
Gonzalez, F.J.11
-
18
-
-
0035180319
-
The ligands/activators for peroxisome proliferator-acti-vated receptor alpha (PPARalpha) and PPARy increase Cu2 +,Zn2 +-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells
-
Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari S, Komoda T, Katayama S. The ligands/activators for peroxisome proliferator-acti-vated receptor alpha (PPARalpha) and PPARy increase Cu2 +,Zn2 +-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001;50:3-11.
-
(2001)
Metabolism
, vol.50
, pp. 3-11
-
-
Inoue, I.1
Goto, S.2
Matsunaga, T.3
Nakajima, T.4
Awata, T.5
Hokari, S.6
Komoda, T.7
Katayama, S.8
-
19
-
-
1542652475
-
Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: Evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways
-
Cho DH, Choi YJ, Jo SA, Jo I. Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways. J Biol Chem. 2004;279:2499-2506.
-
(2004)
J Biol Chem
, vol.279
, pp. 2499-2506
-
-
Cho, D.H.1
Choi, Y.J.2
Jo, S.A.3
Jo, I.4
-
20
-
-
0033608242
-
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: A new possible role of PPARγ on vascular endothelial function
-
DOI 10.1006/bbrc.1998.0126
-
Satoh H, Tsukamoto K, Hashimoto Y, Hashimoto N, Togo M, Hara M, Maekawa H, Isoo N, Kimura S, Watanabe T. Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARy on vascular endothelial function. Biochem Biophys Res Commun. 1999;254:757-763. (Pubitemid 29290541)
-
(1999)
Biochemical and Biophysical Research Communications
, vol.254
, Issue.3
, pp. 757-763
-
-
Satoh, H.1
Tsukamoto, K.2
Hashimoto, Y.3
Hashimoto, N.4
Togo, M.5
Hara, M.6
Maekawa, H.7
Isoo, N.8
Kimura, S.9
Watanabe, T.10
-
21
-
-
0033520304
-
Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
-
Delerive P, Martin-Nizard F, Chinetti G, Trottein F, Fruchart JC, Najib J, Duriez P, Staels B. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res. 1999;85:394-402.
-
(1999)
Circ Res
, vol.85
, pp. 394-402
-
-
Delerive, P.1
Martin-Nizard, F.2
Chinetti, G.3
Trottein, F.4
Fruchart, J.C.5
Najib, J.6
Duriez, P.7
Staels, B.8
-
22
-
-
41549155180
-
Regional heterogeneity of functional changes in conduit arteries after high-fat diet
-
Bhattacharya I, Mundy AL, Widmer CC, Kretz M, Barton M. Regional heterogeneity of functional changes in conduit arteries after high-fat diet. Obesity (Silver Spring). 2008;16:743-748.
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 743-748
-
-
Bhattacharya, I.1
Mundy, A.L.2
Widmer, C.C.3
Kretz, M.4
Barton, M.5
-
23
-
-
33745138155
-
Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome
-
Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism. 2006;55: 928-934.
-
(2006)
Metabolism
, vol.55
, pp. 928-934
-
-
Roberts, C.K.1
Barnard, R.J.2
Sindhu, R.K.3
Jurczak, M.4
Ehdaie, A.5
Vaziri, N.D.6
-
24
-
-
0030985318
-
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
-
Krey G, Braissant O, L'sHorset F, Kalkhoven E, Perroud M, Parker MG, Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol. 1997;11:779-791.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 779-791
-
-
Krey, G.1
Braissant, O.2
L'shorset, F.3
Kalkhoven, E.4
Perroud, M.5
Parker, M.G.6
Wahli, W.7
-
25
-
-
33748937223
-
Non-DNA binding, dominant-negative, human PPARy mutations cause lipodys-trophic insulin resistance
-
Agostini M, Schoenmakers E, Mitchell C, Szatmari I, Savage D, Smith A, Rajanayagam O, Semple R, Luan J, Bath L, Zalin A, Labib M, Kumar S, Simpson H, Blom D, Marais D, Schwabe J, Barroso I, Trembath R, Wareham N, Nagy L, Gurnell M, O'sRahilly S, Chatterjee K. Non-DNA binding, dominant-negative, human PPARy mutations cause lipodys-trophic insulin resistance. Cell Metab. 2006;4:303-311.
-
(2006)
Cell Metab
, vol.4
, pp. 303-311
-
-
Agostini, M.1
Schoenmakers, E.2
Mitchell, C.3
Szatmari, I.4
Savage, D.5
Smith, A.6
Rajanayagam, O.7
Semple, R.8
Luan, J.9
Bath, L.10
Zalin, A.11
Labib, M.12
Kumar, S.13
Simpson, H.14
Blom, D.15
Marais, D.16
Schwabe, J.17
Barroso, I.18
Trembath, R.19
Wareham, N.20
Nagy, L.21
Gurnell, M.22
O'srahilly, S.23
Chatterjee, K.24
more..
-
26
-
-
0036908619
-
Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter
-
Girnun GD, Domann FE, Moore SA, Robbins ME. Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol Endocrinol. 2002;16:2793-2801.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2793-2801
-
-
Girnun, G.D.1
Domann, F.E.2
Moore, S.A.3
Robbins, M.E.4
-
27
-
-
0033008702
-
Induction of the rat Cu/Zn superoxide dismutase gene through the peroxisome proliferator-responsive element by arachidonic acid
-
Yoo HY, Chang MS, Rho HM. Induction of the rat Cu/Zn superoxide dismutase gene through the peroxisome proliferator-responsive element by arachidonic acid. Gene. 1999;234:87-91.
-
(1999)
Gene
, vol.234
, pp. 87-91
-
-
Yoo, H.Y.1
Chang, M.S.2
Rho, H.M.3
-
28
-
-
24144444526
-
Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects
-
Calkin AC, Forbes JM, Smith CM, Lassila M, Cooper ME, Jandeleit-Dahm KA, Allen TJ. Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects. Arterioscler Thromb Vasc Biol. 2005;25:1903-1909.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1903-1909
-
-
Calkin, A.C.1
Forbes, J.M.2
Smith, C.M.3
Lassila, M.4
Cooper, M.E.5
Jandeleit-Dahm, K.A.6
Allen, T.J.7
-
29
-
-
11144297987
-
Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle
-
Weber DS, Rocic P, Mellis AM, Laude K, Lyle AN, Harrison DG, Griendling KK. Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2005;288:H37-H42.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Weber, D.S.1
Rocic, P.2
Mellis, A.M.3
Laude, K.4
Lyle, A.N.5
Harrison, D.G.6
Griendling, K.K.7
-
30
-
-
19944403875
-
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice
-
Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol. 2005;288:H7-12.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Laude, K.1
Cai, H.2
Fink, B.3
Hoch, N.4
Weber, D.S.5
McCann, L.6
Kojda, G.7
Fukai, T.8
Schmidt, H.H.9
Dikalov, S.10
Ramasamy, S.11
Gamez, G.12
Griendling, K.K.13
Harrison, D.G.14
-
31
-
-
0037076294
-
Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferator- activated receptor-gamma
-
Diep QN, El Mabrouk M, Cohn JS, Endemann D, Amiri F, Virdis A, Neves MF, Schiffrin EL. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation. 2002; 105:2296-2302.
-
(2002)
Circulation
, vol.105
, pp. 2296-2302
-
-
Diep, Q.N.1
El Mabrouk, M.2
Cohn, J.S.3
Endemann, D.4
Amiri, F.5
Virdis, A.6
Neves, M.F.7
Schiffrin, E.L.8
-
32
-
-
0033213637
-
PPARy is required for placental, cardiac, and adipose tissue development
-
Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM. PPARy is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999;4:585-595.
-
(1999)
Mol Cell
, vol.4
, pp. 585-595
-
-
Barak, Y.1
Nelson, M.C.2
Ong, E.S.3
Jones, Y.Z.4
Ruiz-Lozano, P.5
Chien, K.R.6
Koder, A.7
Evans, R.M.8
|