Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor α/δ activations by prostacyclin released by sheared endothelial cells

Circulation Research

Volumn 105, Issue 5, 2009, Pages 471-480

  Tsai, Min Chien ^a,b   Chen, Lihong ^c   Zhou, Jing ^a   Tang, Zhihui ^d   Hsu, Tzu Fang ^a   Wang, Ying ^d   Shih, Yu Tsung ^a,b   Peng, Hsin Hsin ^a   Wang, Nanping ^d   Guan, Youfei ^c   Chien, Shu ^e   Chiu, Jeng Jiann ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c Department of Physiology and Pathophysiology ^*  (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelial cell; Peroxisome proliferator activated receptor; Prostacyclin; Shear stress; Smooth muscle cell

Indexed keywords

ANGIOTENSIN II; BIOLOGICAL MARKER; CONTRACTILE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTACYCLIN; SMALL INTERFERING RNA; ACTIN BINDING PROTEIN; AUTACOID; LIGAND; MUSCLE PROTEIN; SERUM RESPONSE FACTOR; TRANSGELIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; ATHEROPROTECTION; BINDING AFFINITY; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGAND BINDING; MALE; MODULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; SHEAR STRESS; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; UPREGULATION; ANIMAL; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; CULTURE MEDIUM; GENETIC TRANSCRIPTION; GENETICS; HOMEOSTASIS; MECHANICAL STRESS; METABOLISM; MOUSE MUTANT; PARACRINE SIGNALING; PROMOTER REGION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANGIOTENSIN II; ANIMALS; BINDING SITES; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; EPOPROSTENOL; HOMEOSTASIS; HUMANS; INFLAMMATION MEDIATORS; LIGANDS; MALE; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PARACRINE COMMUNICATION; PHENOTYPE; PPAR ALPHA; PPAR DELTA; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; SERUM RESPONSE FACTOR; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION, GENETIC; TRANSFECTION; VASOCONSTRICTION;

EID: 70149095915     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.193656     Document Type: Article

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