Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression

EMBO Journal

Volumn 26, Issue 12, 2007, Pages 2880-2889

  Ravnskjaer, Kim ^a   Kester, Henri ^a   Liu, Yi ^a   Zhang, Xinmin ^a   Lee, Dong ^a   Yates III, John R ^b   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cAMP; CBP; CREB; p300; TORC2

Indexed keywords

CELL PROTEIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; PROTEIN TORC2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRESS; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION; HUMANS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 34250814515     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601715     Document Type: Article

References (42)

1. Asahara H, Santoso B, Du K, Cole P, Montminy M (2001) Chromatin dependent cooperativity between constitutive and inducible activation domains in CREB. Mol Cell Biol 21: 7892-7900
2. Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M (2004) Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr Biol 14: 2156-2161
3. Bonni A, Ginty D, Dudek H, Greenberg M (1995) Serine 133 phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol Cell Neurosci 6: 168-183
4. Brindle P, Linke S, Montminy M (1993) Analysis of a PK-A dependent activator in CREB reveals a new role for the CREM Family of repressors. Nature 364: 821-824
5. Brindle P, Nakajima T, Montminy M (1995) Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. Proc Natl Acad Sci USA 92: 10521-10525
6. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (2003) TORCs: transducers of regulated CREB activity. Mol Cell 12: 413-423
7. De Cesare D, Sassone-Corsi P (2000) Transcriptional regulation by cyclic AMP-responsive factors. Prog Nucleic Acid Res Mol Biol 64: 343-369
8. Dentin R, Pegorier JP, Benhamed F, Foufelle F, Ferre P, Fauveau V, Magnuson MA, Girard J, Postic C (2004) Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279: 20314-20326
9. Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (2001) MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol 21: 2249-2258
10. Fimia GM, De Cesare D, Sassone-Corsi P (2000) A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Mol Cell Biol 20: 8613-8622
11. Fisch TM, Prywes R, Roeder RG (1987) c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore. Mol Cell Biol 7: 3490-3502
12. Gardner KH, Montminy M (2005) Can you hear me now? Regulating transcriptional activators by phosphorylation. Sci STKE 2005: pe44
13. Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (2002) Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J Biol Chem 277: 43168-43174
14. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR (1993) Coupling of hormonal stimulation and transcription via cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol 13: 4852-4859
15. Holmberg CI, Tran SE, Eriksson JE, Sistonen L (2002) Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends Biochem Sci 27: 619-627
16. Impey S, Goodman RH (2001) CREB signaling - timing is everything. Sci STKE 2001: PE1
17. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (2003) Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci USA 100: 12147-12152
18. Johannessen M, Delghandi MP, Moens U (2004a) What turns CREB on? Cell Signal 16: 1211-1227
19. Johannessen M, Delghandi MP, Seternes OM, Johansen B, Moens U (2004b) Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain. Cell Signal 16: 1187-1199
20. Kachi K, French SW (1994) The connection between the nuclei of binucleated hepatocytes: an ultrastructural study. J Submicrosc Cytol Pathol 26: 163-172
21. Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK (2002) A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419: 738-743
22. Katoh Y, Takemori H, Lin X, Tamura M, MMuraoka Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters L, Nakamura H, Okamoto M (2006) Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. FEBS J 273: 2730-2748
23. Kitabayashi I, Kawakami Z, Matsuoka T, Chiu R, Gachelin G, Yokoyama K (1993) Two cis-regulatory elements that mediate different signaling pathways for serum-dependent activation of the junB gene. J Biol Chem 268: 14482-14489
24. Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437: 1109-1111
25. Leung TH, Hoffmann A, Baltimore D (2004) One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 118: 453-464
26. Lonze B, Ginty D (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35: 605
27. Mayr B, Montminy M (2001) Tanscriptional regulation by the phosphorylation dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609
28. Mayr B, Canetierri L, Montminy M (2001) Distinct effects of cAMP and mitogenic signals on CBP recruitment impart specificity to target gene activation via CREB. Proc Natl Acad Sci USA 98: 10936-10941
29. Mengus G, Fadloun A, Kobi D, Thibault C, Perletti L, Michel I, Davidson I (2005) TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. EMBO J 24: 2753-2767
30. Perez-Albuerne ED, Schatteman G, Sanders LK, Nathans D (1993) Transcriptional regulatory elements downstream of the JunB gene. Proc Natl Acad Sci USA 90: 11960-11964
31. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M (2006) TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312: 1763-1766
32. Radhakrishnan I, Perez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (1997) Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell 91: 741-752
33. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schutz G, Linden DJ, Ginty DD (2005) SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 8: 759-767
34. Saluja D, Vassallo M, Tanese N (1998) Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators. Mol Cell Biol 18: 5734-5743
35. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates III JR, Takemori H, Okamoto M, Montminy M (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119: 61-74
36. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of. Science 310: 1642-1646
37. Shaywitz AJ, Greenberg ME (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68: 821-861
38. Takemori H, Kanematsu M, Kajimura J, Hatano O, Katoh Y, Lin XZ, Min L, Yamazaki T, Doi J, Okamoto M (2007) Dephosphorylation of TORC initiates expression of the StAR gene. Mol Cell Endocrinol 265-266: 196-204
39. Tiscornia G, Singer O, Ikawa M, Verma IM (2003) A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci USA 100: 1844-1848
40. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN (2004) Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428: 185-189
41. Xu W, Kasper L, Lerach S, Jeevan T, Brindle P (2006) CREB-target genes dictate usage of at least three distinct cAMP-responsive coactivation mechanisms. Submitted
42. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M (2005) Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 102: 4459-4464