Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 33018-33027

  Nakatsu, Yusuke ^a   Sakoda, Hideyuki ^b   Kushiyama, Akifumi ^d   Ono, Hiraku ^b   Fujishiro, Midori ^b   Horike, Nanao ^b   Yoneda, Masayasu ^a   Ohno, Haruya ^a   Tsuchiya, Yoshihiro ^a   Kamata, Hideaki ^a   Tahara, Hidetoshi ^a   Isobe, Toshiaki ^e   Nishimura, Fusanori ^a   Katagiri, Hideki ^f   Oka, Yoshitomo ^f   Fukushima, Toshiaki ^a   Takahashi, Shin Ichiro ^c   Kurihara, Hiroki ^b   Uchida, Takafumi ^g   Asano, Tomoichiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d INSTITUTE FOR ADULT DISEASES   (Japan)

^e TOKYO METROPOLITAN UNIVERSITY   (Japan)

^f TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRAL GENE TRANSFER; BINDING PROTEINS; CYTOSOLS; DIABETIC MICE; FORSKOLIN; GENE KNOCK DOWN; HEPG2 CELLS; MOUSE LIVER; MRNA EXPRESSION LEVEL; NUCLEAR LOCALIZATION; NUCLEAR LOCALIZATION SIGNAL; OVER-EXPRESSION; PHOSPHOENOLPYRUVATE CARBOXYKINASE; TARGET PROTEINS; TRANSCRIPTIONAL ACTIVITY;

FETAL MONITORING; GENE TRANSFER;

GENE EXPRESSION;

ADENOVIRUS VECTOR; BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN REGULATED TRANSCRIPTIONAL COACTIVATOR 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN REGULATED TRANSCRIPTIONAL COACTIVATOR 2; MESSENGER RNA; MYC PROTEIN; PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN CRTC1; PROTEIN CRTC2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; CYTOSOL; DIABETES MELLITUS; GENE OVEREXPRESSION; HYPERGLYCEMIA; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TISSUE DISTRIBUTION; VIRAL GENE DELIVERY SYSTEM;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CREB-BINDING PROTEIN; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOSOL; FORSKOLIN; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HUMANS; LIVER; MICE; NUCLEAR LOCALIZATION SIGNALS; PEPTIDYLPROLYL ISOMERASE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MUS;

EID: 77958485211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.137836     Document Type: Article

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