Dysregulation of protein kinase A signaling in the aged prefrontal cortex: New strategy for treating age-related cognitive decline

Neuron

Volumn 40, Issue 4, 2003, Pages 835-845

  Ramos, Brian P ^a   Birnbaum, Shari G ^a   Lindenmayer, Isabelle ^a   Newton, Samuel S ^a   Duman, Ronald S ^a   Arnsten, Amy F T ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

AGE DISTRIBUTION; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MONKEY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0242460552     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(03)00694-9     Document Type: Article

References (62)

1. Abel T., Nguyen P.V., Barad M., Deuel T.A., Kandel E.R., Bourtchouladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 88:1997;615-626.
2. Albert M.S. The ageing brain. normal and abnormal memory Philos. Trans. R. Soc. Lond. B Biol. Sci. 352:1997;1703-1709.
3. Ando S., Ohashi Y. Longitudinal study on age-related changes of working and reference memory in the rat. Neurosci. Lett. 128:1991;17-20.
4. Araki T., Kato H., Fujiwara T., Itoyama Y. Age-related changes in bindings of second messengers in the rat brain. Brain Res. 704:1995;227-232.
5. Araki T., Kato H., Shuto K., Fujiwara T., Itoyama Y. Effect of nitric oxide synthase inhibitor on age-related changes in second messenger systems and calcium channels in rats. Metab. Brain Dis. 12:1997;83-92.
6. Arnsten A.F.T. The biology of feeling frazzled. Science. 280:1998;1711-1712.
7. Arnsten A.F.T. Stress impairs PFC function in rats and monkeys. role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms Prog. Brain Res. 126:2000;183-192.
8. Arnsten A.F.T., Goldman-Rakic P.S. Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science. 230:1985;1273-1276.
9. Arnsten A.F., Cai J.X., Goldman-Rakic P.S. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects. evidence for alpha-2 receptor subtypes J. Neurosci. 8:1988;4287-4298.
10. Baker L.P., Nielsen M.D., Impey S., Hacker B.M., Poser S.W., Chan M.Y.M., Storm D.R. Regulation and immunohistochemical localization of βγ-stimulated adenylyl cyclases in mouse hippocampus. J. Neuroscience. 19:1999;180-192.
11. Barad M., Bourtchouladze R., Winder D.G., Golan H., Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc. Natl. Acad. Sci. USA. 95:1998;15020-15025.
12. Barros D.M., Izquierdo L.A., Mello e Souza T., Ardenghi P.G., Pereira P., Medina J.H., Izquierdo I. Molecular signaling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats. Behav. Brain Res. 114:2000;183-192.
13. Bartus R.T., Fleming D., Johnson H.R. Aging in the rhesus monkey. debilitating effects on short-term memory J. Gerontol. 33:1978;858-871.
14. Bernabeu R., Bevilaqua L., Ardenghi P., Bromberg E., Schmitz P., Bianchin M., Izquierdo I., Medina J.H. Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. Proc. Natl. Acad. Sci. USA. 94:1997;7041-7046.
15. Bimonte H.A., Nelson M.E., Granholm A.C. Age-related deficits as working memory load increases. relationships with growth factors Neurobiol. Aging. 24:2003;37-48.
16. Birnbaum S.G., Gobeske K.T., Auerbach J., Taylor J.R., Arnsten A.F.T. A role for norepinephrine in stress-induced cognitive deficits. alpha-1-adrenoceptor mediation in prefrontal cortex Biol. Psychiatry. 46:1999;1266-1274.
17. Bourtchouladze R., Abel T., Berman N., Gordon R., Lapidus K., Kandel E. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn. Mem. 5:1998;365-374.
18. Bunge S.A., Ochsner K.N., Desmond J.E., Glover G.H., Gabrieli J.D. Prefrontal regions involved in keeping information in and out of mind. Brain. 124:2001;2074-2086.
19. Carlson S., Tanila H., Rama P., Mecke E., Pertovaara A. Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats. Behav. Neural Biol. 58:1992;113-119.
20. Chao L.L., Knight R.T. Prefrontal deficits in attention and inhibitory control with aging. Cereb. Cortex. 7:1997;63-69.
21. Colombo P.J., Wetsel W.C., Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc. Natl. Acad. Sci. USA. 94:1997;14195-14199.
22. Coven E., Ni Y., Widnell K.L., Chen J., Walker W.H., Habener J.F., Nestler E.J. Cell type-specific regulation of CREB gene expression. mutational analysis of CREB promoter activity J. Neurochem. 71:1998;1865-1874.
23. de Toledo-Morrell L., Morrell F., Fleming S., Cohen M.M. Pentoxifylline reverses age-related deficits in spatial memory. Behav. Neural Biol. 42:1984;1-8.
24. Divac I. Frontal lobe system and spatial reversal in the rat. Neuropsychologia. 9:1971;175-183.
25. Feldman M.L., Dowd C. Loss of dendritic spines in aged cerebral cortex. Anat. Embryol. 148:1975;279-301.
26. Franowicz J.C.S., Arnsten A.F.T. The alpha-2A noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys. Psychopharmacology. 136:1998;8-14.
27. Frey U., Huang Y.-Y., Kandel E.R. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science. 260:1993;1661-1664.
28. Gallagher M., Rapp P.R. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 48:1997;339-370.
29. Goldman-Rakic P.S. Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory. Plum F. Handbook of Physiology, The Nervous System, Higher Functions of the Brain. 1987;American Physiological Society, Bethesda. 373-417.pp.
30. Gonzalez G.A., Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:1989;675-680.
31. Herndon J.G., Moss M.B., Rosene D.L., Killiany R.J. Patterns of cognitive decline in aged rhesus monkeys. Behav. Brain Res. 87:1997;25-34.
32. Huang Y.-Y., Kandel E.R. Post-synaptic induction of PKA-dependent expression of LTP in the lateral amygdala. Neuron. 21:1998;169-178.
33. Huang Y.Y., Martin K.C., Kandel E.R. Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J. Neurosci. 20:2000;6317-6325.
34. Imanishi T., Sawa A., Ichimaru Y., Miyashiro M., Kato S., Yamamoto T., Ueki S. Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. Eur. J. Pharmacol. 321:1997;273-278.
35. Iyengar R. Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J. 7:1993;768-775.
36. Kapur S., Craik F.I., Jones C., Brown G.M., Houle S., Tulving E. Functional role of the prefrontal cortex in retrieval of memories. a PET study Neuroreport. 6:1995;1880-1884.
37. Lane-Ladd S.B., Pineda J., Boundy V.A., Pfeuffer T., Krupinski J., Aghajanian G.K., Nestler E.J. CREB (cAMP Response Element-Binding Protein) in the locus coeruleus. biochemical, physiological and behavioral evidence for a role in opiate dependence J. Neurosci. 17:1997;7890-7901.
38. Langreth, R. (2002). Viagra for the brain. Forbes February 4.
39. Lepage M., Ghaffar O., Nyberg L., Tulving E. Prefrontal cortex and episodic memory retrieval mode. Proc. Natl. Acad. Sci. USA. 97:2000;506-511.
40. Lopez-Salon M., Alonso M., Vianna M.R., Viola H., Mello e Souza T., Izquierdo I., Pasquini J.M., Medina J.H. The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Eur. J. Neurosci. 14:2001;1820-1826.
41. Mons N., Harry A., Dubourg P., Premont R.T., Iyengar R., Cooper D.M. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proc. Natl. Acad. Sci. USA. 92:1995;8473-8477.
42. Nibuya M., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases the expression of CREB and BDNF in rat hippocampus. J. Neuroscience. 16:1996;2365-2372.
43. Nielsen-Bohlman L., Knight R.T. Prefrontal alterations during memory processing in aging. Cereb. Cortex. 5:1995;541-549.
44. Page T.L., Einstein M., Duan H., He Y., Flores T., Rolshud D., Erwin J.M., Wearne S.L., Morrison J.H., Hof P.R. Morphological alterations in neurons forming corticocortical projections in the neocortex of aged Patas monkeys. Neurosci. Lett. 317:2002;37-41.
45. Punch L.J., Self D.W., Nestler E.J., Taylor J.R. Opposite modulation of opiate withdrawal behaviors on microinfusion of protein kinase A inhibitor vs. activator into the locus coeruleus or periaqueductal gray. J. Neurosci. 17:1997;8520-8527.
46. Rama P., Linnankoski I., Tanila H., Pertovaara A., Carlson S. Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys. Pharmacol. Biochem. Behav. 54:1996;1-7.
47. Randt C.T., Judge M.E., Bonnet K.A., Quartermain D. Brain cyclic AMP and memory in mice. Pharmacol. Biochem. Behav. 17:1982;677-680.
48. Rapp P.R., Amaral D.G. Evidence for task-dependent memory dysfunction in the aged monkey. J. Neurosci. 9:1989;3568-3576.
49. Rotenberg A., Abel T., Hawkins R.D., Kandel E.R., Muller R.U. Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity. J. Neurosci. 20:2000;8096-8102.
50. Sakai N., Thome J., Newton S.S., Chen J., Kelz M.B., Steffen C., Nestler E.J., Duman R.S. Inducible and brain region specific CREB transgenic mice. Mol. Pharmacol. 61:2002;1453-1464.
51. Schacter D.L., Savage C.R., Alpert N.M., Rauch S.L., Albert M.S. The role of hippocampus and frontal cortex in age-related memory changes. a PET study Neuroreport. 7:1996;1165-1169.
52. Schafe G.E., LeDoux J.E. Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J. Neurosci. 20:2000;RC96.
53. Stuss D.T., Knight R.T. Principles of Frontal Lobe Function. 2002;Oxford University Press, New York.
54. Tanila H. Noradrenergic regulation of hippocampal place cells. Hippocampus. 11:2001;793-808.
55. Tanila H., Rama P., Carlson S. The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res. Bull. 40:1996;117-119.
56. Taussig R., Tang W.J., Hepler J.R., Gilman A.G. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J. Biol. Chem. 269:1994;6093-6100.
57. Taylor J.R., Birnbaum S.G., Ubriani R., Arnsten A.F.T. Activation of protein kinase A in prefrontal cortex impairs working memory performance. J. Neurosci. 19:1999;RC23.
58. Wellman C.L. Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J. Neurobiol. 49:2001;245-253.
59. West R.L. An application of prefrontal cortex function theory to cognitive aging. Psychol. Bull. 120:1996;272-292.
60. Zhang H.T., O'Donnell J.M. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl.). 150:2000;311-316.
61. Zhang H.T., Crissman A.M., Dorairaj N.R., Chandler L.J., O'Donnell J.M. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology. 23:2000;198-204.
62. Zhu J., Mix E., Winblad B. The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev. 7:2001;387-398.