Selective erasure of a fear memory

Science

Volumn 323, Issue 5920, 2009, Pages 1492-1496

  Han, Jin Hee ^a,b   Kushner, Steven A ^a,c   Yiu, Adelaide P ^a,b   Hsiang, Hwa Lin ^a,b   Buch, Thorsten ^d   Waisman, Ari ^e   Bontempi, Bruno ^f   Neve, Rachael L ^g   Frankland, Paul W ^a,b   Josselyn, Sheena A ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

^f UMR 5287   (France)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIPHTHERIA TOXIN;

MEMORY; NERVOUS SYSTEM; PROTEIN; SUBPOPULATION; TOXIN;

AMNESIA; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; FEAR; LEARNING; MEMORY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AMNESIA; AMYGDALA; ANIMALS; APOPTOSIS; CONDITIONING (PSYCHOLOGY); CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEAR; MEMORY; MENTAL RECALL; MICE; MICE, TRANSGENIC;

EID: 62449248195     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164139     Document Type: Article

References (28)

1. H. L. Roediger, Y. Dudai, S. M. Fitzpatrick, Science of Memory: Concepts (Oxford Univ. Press, New York, 2007).
2. J. Perez-Orive et al., Science 297, 359 (2002).
3. G. J. Quirk, C. Repa, J. E. LeDoux, Neuron 15, 1029 (1995).
4. T. W. Berger, P. C. Rinaldi, D. J. Weisz, R. F. Thompson, J. Neurophysiol. 50, 1197 (1983).
5. L. G. Reijmers, B. L. Perkins, N. Matsuo, M. Mayford, Science 317, 1230 (2007).
6. J. F. Guzowski et al., Curr. Opin. Neurobiol. 15, 599 (2005).
7. J. Hall, K. L. Thomas, B. J. Everitt, J. Neurosci. 21, 2186 (2001).
8. J. H. Han et al., Science 316, 457 (2007).
9. J. E. LeDoux, Annu. Rev. Neurosci. 23, 155 (2000).
10. M. S. Fanselow, G. D. Gale, Ann. N.Y. Acad. Sci. 985, 125 (2003).
11. M. Davis, Annu. Rev. Neurosci. 15, 353 (1992).
12. S. Maren, G. J. Quirk, Nat. Rev. Neurosci. 5, 844 (2004).
13. Materials and methods are available as supporting material on Science Online.
14. R. B. Dorland, J. L. Middlebrook, S. H. Leppla, J. Biol. Chem. 254, 11337 (1979).
15. T. Buch et al., Nat. Methods 2, 419 (2005).
16. J. G. Naglich, L. Eidels, Proc. Natl. Acad. Sci. U.S.A. 87, 7250 (1990).
17. A. Saraste, K. Pulkki, Cardiovasc. Res. 45, 528 (2000).
18. J. F. Guzowski, B. L. McNaughton, C. A. Barnes, P. F. Worley, Nat. Neurosci. 2, 1120 (1999).
19. A. M. Jasnow, C. Shi, J. E. Israel, M. Davis, K. L. Huhman, Behav. Neurosci. 119, 1125 (2005).
20. S. A. Josselyn et al., J. Neurosci. 21, 2404 (2001).
21. T. L. Wallace, K. E. Stellitano, R. L. Neve, R. S. Duman, Biol. Psychiatry 56, 151 (2004).
22. J. H. Han et al., Learn. Mem. 15, 443 (2008).
23. K. Nader, G. E. Schafe, J. E. Le Doux, Nature 406, 722 (2000).
24. Y. Dudai, M. Eisenberg, Neuron 44, 93 (2004).
25. E. S. Levine, I. B. Black, Ann. N.Y. Acad. Sci. 835, 12 (1997).
26. D. Pare, G. J. Quirk, J. E. Ledoux, J. Neurophysiol. 92, 1 (2004).
27. J. L. McClelland, B. L. McNaughton, R. C. O'Reilly, Psychol. Rev. 102, 419 (1995).
28. We thank T. Pekar, J. Park, and J. Guo for technical assistance. Supported by Canadian Institutes of Health Research (MOP74650, MOP77561) and EJLB Foundation grants to S.A.J. and P.W.F., National Alliance for Research on Schizophrenia and Depression fellowship to J.H.H., travel fellowship (France-Canada Research Foundation), Agence Nationale de la Recherche (France) grant (06-NEURO-027-03) to B.B., and Restracomp Fellowships from the Hospital for Sick Children to A.P.Y. and J.H.H.