Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus

Neuropsychopharmacology

Volumn 29, Issue 8, 2004, Pages 1432-1439

  Zhang, Han Ting ^a   Zhao, Yu ^a   Huang, Ying ^a   Dorairaj, Nandakumar R ^b   Chandler, L Judson ^c   O'Donnell, James M ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Hippocampus; Memory; Mitogen activated protein kinase (ERK); Phosphodiesterase 4 (PDE4); Rolipram; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARM; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN CORTEX; BRAIN REGION; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HIPPOCAMPUS; INFUSION; LONG TERM MEMORY; MALE; MAZE TEST; NERVE CELL; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; AVOIDANCE LEARNING; BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICROINJECTIONS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NITRILES; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; SIGNAL TRANSDUCTION;

EID: 3242758203     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300440     Document Type: Article

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