Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus

Behavioural Brain Research

Volumn 201, Issue 2, 2009, Pages 311-317

  Zhao, Haifeng ^a,b   Li, Qiong ^a   Pei, Xinrong ^a   Zhang, Zhaofeng ^a   Yang, Ruiyue ^a   Wang, Junbo ^a   Li, Yong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Ginsenoside; Hippocampus; Memory; Prevention; Synaptic plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GINSENOSIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PLACEBO; PROTEIN KINASE C BETA;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME REGULATION; FEMALE; HIPPOCAMPUS; LONG TERM EXPOSURE; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIAL MEMORY;

AGING; ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; FEMALE; GINSENOSIDES; HIPPOCAMPUS; MAZE LEARNING; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NOOTROPIC AGENTS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 67349199183     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.03.002     Document Type: Article

References (45)

1. Ahmed T., and Frey J.U. Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro. Neuropharmacology 49 (2005) 477-492
2. Armbrecht H.J., Boltz M.A., Kumar V.B., Flood J.F., and Morley J.E. Effect of age on calcium-dependent proteins in hippocampus of senescence-accelerated mice. Brain Res 842 (1999) 287-293
3. Benice T.S., Rizk A., Kohama S., Pfankuch T., and Raber J. Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137 (2006) 413-423
4. Berry A., Greco A., Giorgio M., Pelicci P.G., et al. Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice. Exp Gerontol 43 (2008) 200-208
5. Bimonte H.A., Nelson M.E., and Granholm A.C. Age-related deficits as working memory load increases: relationships with growth factors. Neurobiol Aging 24 (2003) 37-48
6. Chen F., Eckman E.A., and Eckman C.B. Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides. FASEB J 20 (2006) 1269-1271
7. Chen L.W., Wang Y.Q., Wei L.C., Shi M., and Chan Y.S. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets 6 (2007) 273-281
8. Cuppini R., Bucherelli C., Ambrogini P., Ciuffoli S., et al. Age-related naturally occurring depression of hippocampal neurogenesis does not affect trace fear conditioning. Hippocampus 16 (2006) 141-148
9. Donovan M.H., Yazdani U., Norris R.D., Games D., et al. Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease. J Comp Neurol 495 (2006) 70-83
10. Duffy K.B., Spangler E.L., Devan B.D., Guo Z., et al. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29 (2008) 1680-1689
11. Erickson C.A., and Barnes C.A. The neurobiology of memory changes in normal aging. Exp Gerontol 38 (2003) 61-69
12. Fu Y., and Ji L.L. Chronic ginseng consumption attenuates age-associated oxidative stress in rats. J Nutr 133 (2003) 3603-3609
13. Gomez-Pinilla F., Huie J.R., Ying Z., Ferguson A.R., et al. BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience 148 (2007) 893-906
14. Halbreich U., Lumley L.A., Palter S., Manning C., et al. Possible acceleration of age effects on cognition following menopause. J Psychiatr Res 29 (1995) 153-163
15. Hatanpaa K., Isaacs K.R., Shirao T., Brady D.R., and Rapoport S.I. Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. J Neuropathol Exp Neurol 58 (1999) 637-643
16. Hebda-Bauer E.K., Luo J., Watson S.J., and Akil H. Female CREBalphadelta-deficient mice show earlier age-related cognitive deficits than males. Neuroscience 150 (2007) 260-272
17. Ji Y.C., Kim Y.B., Park S.W., Hwang S.N., et al. Neuroprotective effect of ginseng total saponins in experimental traumatic brain injury. J Kor Med Sci 20 (2005) 291-296
18. Kazdoba T.M., Del Vecchio R.A., and Hyde L.A. Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation. Behav Pharmacol 18 (2007) 89-102
19. Kemp A., and Manahan-Vaughan D. Hippocampal long-term depression: master or minion in declarative memory processes?. Trends Neurosci 30 (2007) 111-118
20. Lamprecht R. CREB: a message to remember. Cell Mol Life Sci 55 (1999) 554-563
21. Langui D., Lachapelle F., and Duyckaerts C. Animal models of neurodegenerative diseases. Med Sci (Paris) 23 (2007) 180-186
22. Lau G.C., Saha S., Faris R., and Russek S.J. Up-regulation of NMDAR1 subunit gene expression in cortical neurons via a PKA-dependent pathway. J Neurochem 88 (2004) 564-575
23. Lesne S., Koh M.T., Kotilinek L., Kayed R., et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440 (2006) 352-357
24. Lim J.H., Wen T.C., Matsuda S., Tanaka J., et al. Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root. Neurosci Res 28 (1997) 191-200
25. Lynch G., Rex C.S., and Gall C.M. Synaptic plasticity in early aging. Aging Res Rev 5 (2006) 255-280
26. Morrison J.H., and Hof P.R. Life and death of neurons in the aging brain. Science 278 (1997) 412-419
27. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1984) 47-60
28. Muller F.L., Lustgarten M.S., Jang Y., Richardson A., and Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 43 (2007) 477-503
29. Neves G., Cooke S.F., and Bliss T.V. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev 9 (2008) 65-75
30. Nielsen D.M., and Crnic L.S. Automated analysis of foot-shock sensitivity and concurrent freezing behavior in mice. J Neurosci Methods 115 (2002) 199-209
31. Pang P.T., and Lu B. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Aging Res Rev 3 (2004) 407-430
32. Porte Y., Buhot M.C., and Mons N. Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice. Neurobiol Aging 29 (2008) 1533-1546
33. Ramaswamy S., McBride J.L., and Kordower J.H. Animal models of Huntington's disease. ILAR J/National Research Council, Institute of Laboratory Animal Resources 48 (2007) 356-373
34. Rueda N., Florez J., and Martinez-Cue C. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav Brain Res 188 (2008) 355-367
35. Shukitt-Hale B., Carey A.N., Jenkins D., Rabin B.M., et al. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 28 (2007) 1187-1194
36. Shukitt-Hale B., Lau F.C., and Joseph J.A. Berry fruit supplementation and the aging brain. J Agric Food Chem 56 (2008) 636-641
37. Scharl T., Leisch F., and Herkner K. Strain-dependent regulation of plasticity-related proteins in the mouse hippocampus. Behav Brain Res 165 (2005) 240-246
38. Tohda C., Matsumoto N., Zou K., Meselhy M.R., and Komatsu K. Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 29 (2004) 860-868
39. Topic B., Hasenohrl R.U., Hacker R., Huston J.P., et al. Enhanced conditioned inhibitory avoidance by a combined extract of Zingiber officinale and Ginkgo biloba. Phytother Res 16 (2002) 312-315
40. Topic B., Huston J.P., Namestkova K., Zhu S.W., et al. Extinction-induced "despair" in aged and adult rats: links to neurotrophins in frontal cortex and hippocampus. Neurobiol Learn Mem 90 (2008) 519-526
41. Topic B., Tani E., Tsiakitzis K., Kourounakis P.N., et al. Enhanced maze performance and reduced oxidative stress by combined extracts of Zingiber officinale and Ginkgo biloba in the aged rat. Neurobiol Aging 23 (2002) 135-143
42. Topic B., Willuhn I., Palomero-Gallagher N., Zilles K., et al. Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus. Hippocampus 17 (2007) 68-77
43. Vaynman S., Ying Z., and Gomez-Pinilla F. The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience 144 (2007) 825-833
44. Yamada K., and Nabeshima T. Animal models of Alzheimer's disease and evaluation of anti-dementia drugs. Pharmacol Therapeut 88 (2000) 93-113
45. Zhao S., Chai X., and Frotscher M. Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin. Dev Neurosci 29 (2007) 84-90