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Volumn 3, Issue 4, 2011, Pages 189-200

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

Author keywords

Lymphangioleiomyomatosis; MTOR; Non canonical; Rheb; Tuberous sclerosis complex

Indexed keywords

GELATINASE A; GELATINASE B; GUANINE NUCLEOTIDE BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NOTCH RECEPTOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE INHIBITOR; RAPAMYCIN; RHO FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 4; VASCULOTROPIN;

EID: 79953280262     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100131     Document Type: Article
Times cited : (73)

References (106)
  • 1
    • 3142546236 scopus 로고    scopus 로고
    • The Rheb family of GTP-binding proteins
    • Aspuria PJ, Tamanoi F (2004) The Rheb family of GTP-binding proteins. Cell Signal 16: 1105- 1112
    • (2004) Cell Signal , vol.16 , pp. 1105-1112
    • Aspuria, P.J.1    Tamanoi, F.2
  • 2
    • 42549118675 scopus 로고    scopus 로고
    • The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast
    • Aspuria PJ, Tamanoi F (2008) The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Mol Genet Genomics 279: 441- 450
    • (2008) Mol Genet Genomics , vol.279 , pp. 441-450
    • Aspuria, P.J.1    Tamanoi, F.2
  • 3
    • 0347065349 scopus 로고    scopus 로고
    • Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B
    • Astrinidis A, Senapedis W, Coleman TR, Henske EP (2003) Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem 278: 51372- 51379
    • (2003) J Biol Chem , vol.278 , pp. 51372-51379
    • Astrinidis, A.1    Senapedis, W.2    Coleman, T.R.3    Henske, E.P.4
  • 4
    • 31144452534 scopus 로고    scopus 로고
    • Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner
    • Astrinidis A, Senapedis W, Henske EP (2006) Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Hum Mol Genet 15: 287- 297
    • (2006) Hum Mol Genet , vol.15 , pp. 287-297
    • Astrinidis, A.1    Senapedis, W.2    Henske, E.P.3
  • 5
    • 77957922822 scopus 로고    scopus 로고
    • Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex
    • Birca A, Mercier C, Major P (2010) Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. J Neurosurg Pediatr 6: 381- 384
    • (2010) J Neurosurg Pediatr , vol.6 , pp. 381-384
    • Birca, A.1    Mercier, C.2    Major, P.3
  • 10
    • 70350729488 scopus 로고    scopus 로고
    • Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation
    • Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE (2009) Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation. Blood 114: 3392- 3401
    • (2009) Blood , vol.114 , pp. 3392-3401
    • Campbell, T.B.1    Basu, S.2    Hangoc, G.3    Tao, W.4    Broxmeyer, H.E.5
  • 11
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003) Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 278: 32493- 32496
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 12
    • 0034936816 scopus 로고    scopus 로고
    • Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B
    • Catania MG, Mischel PS, Vinters HV (2001) Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J Neuropathol Exp Neurol 60: 711- 723
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 711-723
    • Catania, M.G.1    Mischel, P.S.2    Vinters, H.V.3
  • 13
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • Consortium ECTS
    • Consortium ECTS (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75: 1305- 1315
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 15
    • 70449900928 scopus 로고    scopus 로고
    • TOR complex 2: a signaling pathway of its own
    • Cybulski N, Hall MN (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 34: 620- 627
    • (2009) Trends Biochem Sci , vol.34 , pp. 620-627
    • Cybulski, N.1    Hall, M.N.2
  • 16
    • 0035167932 scopus 로고    scopus 로고
    • Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    • Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, Chung J, Choy YS, Reeve MP, Thiele E, Egelhoff JC, et al (2001) Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 68: 64- 80
    • (2001) Am J Hum Genet , vol.68 , pp. 64-80
    • Dabora, S.L.1    Jozwiak, S.2    Franz, D.N.3    Roberts, P.S.4    Nieto, A.5    Chung, J.6    Choy, Y.S.7    Reeve, M.P.8    Thiele, E.9    Egelhoff, J.C.10
  • 17
  • 19
    • 65949106140 scopus 로고    scopus 로고
    • Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner
    • Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M (2009) Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci 29: 5926- 5937
    • (2009) J Neurosci , vol.29 , pp. 5926-5937
    • Di Nardo, A.1    Kramvis, I.2    Cho, N.3    Sadowski, A.4    Meikle, L.5    Kwiatkowski, D.J.6    Sahin, M.7
  • 20
    • 71049134915 scopus 로고    scopus 로고
    • Perivascular epithelioid cell neoplasms: pathology and pathogenesis
    • Folpe AL, Kwiatkowski DJ (2010) Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol 41: 1- 15
    • (2010) Hum Pathol , vol.41 , pp. 1-15
    • Folpe, A.L.1    Kwiatkowski, D.J.2
  • 21
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: the core pathway and its posttranslational regulation
    • Fortini ME (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 16: 633- 647
    • (2009) Dev Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 25
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du, H, Wang J, Ding X, Chen S, Jiang X (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297- 12305
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 28
    • 21344470906 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways
    • Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F (2005) Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways. Mol Cancer Ther 4: 918- 926
    • (2005) Mol Cancer Ther , vol.4 , pp. 918-926
    • Gau, C.L.1    Kato-Stankiewicz, J.2    Jiang, C.3    Miyamoto, S.4    Guo, L.5    Tamanoi, F.6
  • 29
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: a signalling centre during vertebrate development
    • Goetz SC, Anderson KV (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11: 331- 344
    • (2010) Nat Rev Genet , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 31
    • 34147187417 scopus 로고    scopus 로고
    • Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    • Hall DJ, Grewal SS, de la Cruz AF, Edgar BA (2007) Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol 5: 10
    • (2007) BMC Biol , vol.5 , pp. 10
    • Hall, D.J.1    Grewal, S.S.2    de la Cruz, A.F.3    Edgar, B.A.4
  • 33
    • 57649243069 scopus 로고    scopus 로고
    • The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
    • Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP (2009) The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Hum Mol Genet 18: 151- 163
    • (2009) Hum Mol Genet , vol.18 , pp. 151-163
    • Hartman, T.R.1    Liu, D.2    Zilfou, J.T.3    Robb, V.4    Morrison, T.5    Watnick, T.6    Henske, E.P.7
  • 34
    • 9744224401 scopus 로고    scopus 로고
    • The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked
    • Henske EP (2004) The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked? Curr Mol Med 4: 825- 831
    • (2004) Curr Mol Med , vol.4 , pp. 825-831
    • Henske, E.P.1
  • 36
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28: 4104- 4115
    • (2008) Mol Cell Biol , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 37
    • 68049126433 scopus 로고    scopus 로고
    • Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
    • Huang J, Wu S, Wu CL, Manning BD (2009) Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res 69: 6107- 6114
    • (2009) Cancer Res , vol.69 , pp. 6107-6114
    • Huang, J.1    Wu, S.2    Wu, C.L.3    Manning, B.D.4
  • 40
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL (2003a) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829- 1834
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 41
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL (2003b) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577- 590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 42
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, et al (2006) TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126: 955- 968
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Ouyang, H.2    Zhu, T.3    Lindvall, C.4    Wang, Y.5    Zhang, X.6    Yang, Q.7    Bennett, C.8    Harada, Y.9    Stankunas, K.10
  • 44
    • 0037191045 scopus 로고    scopus 로고
    • Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
    • Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R (2002) Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 159: 217- 224
    • (2002) J Cell Biol , vol.159 , pp. 217-224
    • Jaeschke, A.1    Hartkamp, J.2    Saitoh, M.3    Roworth, W.4    Nobukuni, T.5    Hodges, A.6    Sampson, J.7    Thomas, G.8    Lamb, R.9
  • 46
    • 78650174233 scopus 로고    scopus 로고
    • The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
    • Kang YJ, Lu MK, Guan KL (2011) The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ 18: 133- 144
    • (2011) Cell Death Differ , vol.18 , pp. 133-144
    • Kang, Y.J.1    Lu, M.K.2    Guan, K.L.3
  • 48
    • 32244447213 scopus 로고    scopus 로고
    • The role of tuberin in cellular differentiation: are B-Raf and MAPK involved
    • Karbowniczek M, Henske EP (2005) The role of tuberin in cellular differentiation: are B-Raf and MAPK involved? Ann N Y Acad Sci 1059: 168- 173
    • (2005) Ann N Y Acad Sci , vol.1059 , pp. 168-173
    • Karbowniczek, M.1    Henske, E.P.2
  • 49
    • 3142757865 scopus 로고    scopus 로고
    • Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
    • Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP (2004) Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem 279: 29930- 29937
    • (2004) J Biol Chem , vol.279 , pp. 29930-29937
    • Karbowniczek, M.1    Cash, T.2    Cheung, M.3    Robertson, G.P.4    Astrinidis, A.5    Henske, E.P.6
  • 50
    • 33747822482 scopus 로고    scopus 로고
    • Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization
    • Karbowniczek M, Robertson GP, Henske EP (2006) Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization. J Biol Chem 281: 25447- 25456
    • (2006) J Biol Chem , vol.281 , pp. 25447-25456
    • Karbowniczek, M.1    Robertson, G.P.2    Henske, E.P.3
  • 52
    • 0037108682 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    • Kenerson HL, Aicher LD, True LD, Yeung RS (2002) Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 62: 5645- 5650
    • (2002) Cancer Res , vol.62 , pp. 5645-5650
    • Kenerson, H.L.1    Aicher, L.D.2    True, L.D.3    Yeung, R.S.4
  • 53
    • 11144262151 scopus 로고    scopus 로고
    • Effects of rapamycin in the Eker rat model of tuberous sclerosis complex
    • Kenerson H, Dundon TA, Yeung RS (2005) Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. Pediatr Res 57: 67- 75
    • (2005) Pediatr Res , vol.57 , pp. 67-75
    • Kenerson, H.1    Dundon, T.A.2    Yeung, R.S.3
  • 55
    • 0037623417 scopus 로고    scopus 로고
    • GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between Raptor and mTOR
    • Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between Raptor and mTOR. Mol Cell 11: 895- 904
    • (2003) Mol Cell , vol.11 , pp. 895-904
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    Latek, R.R.4    Guntur, K.V.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 57
    • 0034578389 scopus 로고    scopus 로고
    • Aggresomes, inclusion bodies and protein aggregation
    • Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10: 524- 530
    • (2000) Trends Cell Biol , vol.10 , pp. 524-530
    • Kopito, R.R.1
  • 58
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H (2002) A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11: 525- 534
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5    el-Hashemite, N.6    Onda, H.7
  • 60
    • 36549026878 scopus 로고    scopus 로고
    • Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
    • Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL (2007a) Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 26: 4812- 4823
    • (2007) EMBO J , vol.26 , pp. 4812-4823
    • Lee, C.H.1    Inoki, K.2    Karbowniczek, M.3    Petroulakis, E.4    Sonenberg, N.5    Henske, E.P.6    Guan, K.L.7
  • 63
    • 0038190932 scopus 로고    scopus 로고
    • The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
    • Li Y, Inoki K, Vacratsis P, Guan KL (2003) The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem 278: 13663- 13671
    • (2003) J Biol Chem , vol.278 , pp. 13663-13671
    • Li, Y.1    Inoki, K.2    Vacratsis, P.3    Guan, K.L.4
  • 64
    • 77952263737 scopus 로고    scopus 로고
    • The genetic basis of kidney cancer: a metabolic disease
    • Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 7: 277- 285
    • (2010) Nat Rev Urol , vol.7 , pp. 277-285
    • Linehan, W.M.1    Srinivasan, R.2    Schmidt, L.S.3
  • 66
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179- 193
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 67
    • 77950576952 scopus 로고    scopus 로고
    • Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL
    • Ma D, Bai X, Zou H, Lai Y, Jiang Y (2010a) Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. J Biol Chem 285: 8621- 8627
    • (2010) J Biol Chem , vol.285 , pp. 8621-8627
    • Ma, D.1    Bai, X.2    Zou, H.3    Lai, Y.4    Jiang, Y.5
  • 68
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, et al (2010b) Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 120: 103- 114
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3    Chen, X.4    Peng, H.5    Sun, Q.6    Zha, X.7    Wang, F.8    Wang, Y.9    Jing, Y.10
  • 69
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151- 162
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 70
    • 0036021402 scopus 로고    scopus 로고
    • Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe
    • Matsumoto S, Bandyopadhyay A, Kwiatkowski DJ, Maitra U, Matsumoto T (2002) Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics 161: 1053- 1063
    • (2002) Genetics , vol.161 , pp. 1053-1063
    • Matsumoto, S.1    Bandyopadhyay, A.2    Kwiatkowski, D.J.3    Maitra, U.4    Matsumoto, T.5
  • 71
    • 0036159634 scopus 로고    scopus 로고
    • Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation
    • Miloloza A, Kubista M, Rosner M, Hengstschlager M (2002) Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation. J Neuropathol Exp Neurol 61: 154- 163
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 154-163
    • Miloloza, A.1    Kubista, M.2    Rosner, M.3    Hengstschlager, M.4
  • 72
    • 77149141403 scopus 로고    scopus 로고
    • Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
    • Nakashima A, Sato T, Tamanoi F (2010) Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. J Cell Sci 123: 777- 786
    • (2010) J Cell Sci , vol.123 , pp. 777-786
    • Nakashima, A.1    Sato, T.2    Tamanoi, F.3
  • 73
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29: 541- 551
    • (2008) Mol Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 74
    • 0037406694 scopus 로고    scopus 로고
    • Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis
    • Panepinto JC, Oliver BG, Fortwendel JR, Smith DL, Askew DS, Rhodes JC (2003) Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis. Infect Immun 71: 2819- 2826
    • (2003) Infect Immun , vol.71 , pp. 2819-2826
    • Panepinto, J.C.1    Oliver, B.G.2    Fortwendel, J.R.3    Smith, D.L.4    Askew, D.S.5    Rhodes, J.C.6
  • 75
    • 70449558169 scopus 로고    scopus 로고
    • A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila
    • Patch K, Stewart SR, Welch A, Ward RE (2009) A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila. PLoS One 4: e7574
    • (2009) PLoS One , vol.4
    • Patch, K.1    Stewart, S.R.2    Welch, A.3    Ward, R.E.4
  • 76
    • 74949110559 scopus 로고    scopus 로고
    • New roles for Notch in tuberous sclerosis
    • Pear WS (2010) New roles for Notch in tuberous sclerosis. J Clin Invest 120: 84- 87
    • (2010) J Clin Invest , vol.120 , pp. 84-87
    • Pear, W.S.1
  • 77
    • 0032213545 scopus 로고    scopus 로고
    • Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    • Plank TL, Yeung RS, Henske EP (1998) Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 58: 4766- 4770
    • (1998) Cancer Res , vol.58 , pp. 4766-4770
    • Plank, T.L.1    Yeung, R.S.2    Henske, E.P.3
  • 78
    • 52949137425 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2. components rictor and sin1
    • Rosner M, Hengstschlager M (2008) Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2. components rictor and sin1. Hum Mol Genet 17: 2934- 2948
    • (2008) Hum Mol Genet , vol.17 , pp. 2934-2948
    • Rosner, M.1    Hengstschlager, M.2
  • 79
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    • Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA 101: 13489- 13494
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13489-13494
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5
  • 80
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098- 1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 81
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5: 566- 571
    • (2003) Nat Cell Biol , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 84
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J (2002) Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99: 13571- 13576
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 85
    • 24044442298 scopus 로고    scopus 로고
    • Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
    • Tee AR, Blenis J, Proud CG (2005) Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 579: 4763- 4768
    • (2005) FEBS Lett , vol.579 , pp. 4763-4768
    • Tee, A.R.1    Blenis, J.2    Proud, C.G.3
  • 87
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277: 27975- 27981
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 88
    • 58749112340 scopus 로고    scopus 로고
    • A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans
    • Tsao CC, Chen YT, Lan CY (2009) A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans. Fungal Genet Biol 46: 126- 136
    • (2009) Fungal Genet Biol , vol.46 , pp. 126-136
    • Tsao, C.C.1    Chen, Y.T.2    Lan, C.Y.3
  • 89
    • 0034646618 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
    • Urano J, Tabancay AP, Yang W, Tamanoi F (2000) The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J Biol Chem 275: 11198- 11206
    • (2000) J Biol Chem , vol.275 , pp. 11198-11206
    • Urano, J.1    Tabancay, A.P.2    Yang, W.3    Tamanoi, F.4
  • 91
    • 33847651745 scopus 로고    scopus 로고
    • Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
    • Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F (2007) Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci USA 104: 3514- 3519
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3514-3519
    • Urano, J.1    Sato, T.2    Matsuo, T.3    Otsubo, Y.4    Yamamoto, M.5    Tamanoi, F.6
  • 94
    • 1842424927 scopus 로고    scopus 로고
    • Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe
    • van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP (2004) Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem 279: 12706- 12713
    • (2004) J Biol Chem , vol.279 , pp. 12706-12713
    • van Slegtenhorst, M.1    Carr, E.2    Stoyanova, R.3    Kruger, W.D.4    Henske, E.P.5
  • 95
    • 34249054108 scopus 로고    scopus 로고
    • Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast
    • Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175: 1153- 1162
    • (2007) Genetics , vol.175 , pp. 1153-1162
    • Weisman, R.1    Roitburg, I.2    Schonbrun, M.3    Harari, R.4    Kupiec, M.5
  • 96
    • 84886117516 scopus 로고    scopus 로고
    • The history of tuberous sclerosis complex.
    • In:, Kwiatkowski DJ, Whittemore VH, Thiele EA (eds), Weinheim, Germany, Wiley-Blackwell:
    • Whittemore VH (2010) The history of tuberous sclerosis complex. In: Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics, Kwiatkowski DJ, Whittemore VH, Thiele EA (eds), Weinheim, Germany, Wiley-Blackwell: pp 3- 8
    • (2010) Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics , pp. 3-8
    • Whittemore, V.H.1
  • 99
    • 78951473590 scopus 로고    scopus 로고
    • Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex
    • Yalon M, Ben-Sira L, Constantini S, Toren A (2011) Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex. Childs Nerv Syst 27: 179- 181
    • (2011) Childs Nerv Syst , vol.27 , pp. 179-181
    • Yalon, M.1    Ben-Sira, L.2    Constantini, S.3    Toren, A.4
  • 100
    • 0031039427 scopus 로고    scopus 로고
    • Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
    • Yee WM, Worley PF (1997) Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol Cell Biol 17: 921- 933
    • (1997) Mol Cell Biol , vol.17 , pp. 921-933
    • Yee, W.M.1    Worley, P.F.2
  • 101
    • 77949846455 scopus 로고    scopus 로고
    • mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis
    • Yu J, Henske EP (2010) mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphat Res Biol 8: 43- 49
    • (2010) Lymphat Res Biol , vol.8 , pp. 43-49
    • Yu, J.1    Henske, E.P.2
  • 102
    • 1642290141 scopus 로고    scopus 로고
    • Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
    • Yu J, Astrinidis A, Howard S, Henske EP (2004) Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. Am J Physiol Lung Cell Mol Physiol 286: L694- L700
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Yu, J.1    Astrinidis, A.2    Howard, S.3    Henske, E.P.4
  • 103
    • 27944503577 scopus 로고    scopus 로고
    • Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B
    • Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L (2005) Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep 32: 205- 214
    • (2005) Mol Biol Rep , vol.32 , pp. 205-214
    • Yuan, J.1    Shan, Y.2    Chen, X.3    Tang, W.4    Luo, K.5    Ni, J.6    Wan, B.7    Yu, L.8
  • 104
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5: 578- 581
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 105
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541- 1545
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 106
    • 67049158203 scopus 로고    scopus 로고
    • Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy
    • Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL (2009) Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci USA 106: 8923- 8928
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8923-8928
    • Zhou, X.1    Ikenoue, T.2    Chen, X.3    Li, L.4    Inoki, K.5    Guan, K.L.6


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