-
1
-
-
3142546236
-
The Rheb family of GTP-binding proteins
-
Aspuria PJ, Tamanoi F (2004) The Rheb family of GTP-binding proteins. Cell Signal 16: 1105- 1112
-
(2004)
Cell Signal
, vol.16
, pp. 1105-1112
-
-
Aspuria, P.J.1
Tamanoi, F.2
-
2
-
-
42549118675
-
The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast
-
Aspuria PJ, Tamanoi F (2008) The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Mol Genet Genomics 279: 441- 450
-
(2008)
Mol Genet Genomics
, vol.279
, pp. 441-450
-
-
Aspuria, P.J.1
Tamanoi, F.2
-
3
-
-
0347065349
-
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B
-
Astrinidis A, Senapedis W, Coleman TR, Henske EP (2003) Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem 278: 51372- 51379
-
(2003)
J Biol Chem
, vol.278
, pp. 51372-51379
-
-
Astrinidis, A.1
Senapedis, W.2
Coleman, T.R.3
Henske, E.P.4
-
4
-
-
31144452534
-
Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner
-
Astrinidis A, Senapedis W, Henske EP (2006) Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Hum Mol Genet 15: 287- 297
-
(2006)
Hum Mol Genet
, vol.15
, pp. 287-297
-
-
Astrinidis, A.1
Senapedis, W.2
Henske, E.P.3
-
5
-
-
77957922822
-
Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex
-
Birca A, Mercier C, Major P (2010) Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. J Neurosurg Pediatr 6: 381- 384
-
(2010)
J Neurosurg Pediatr
, vol.6
, pp. 381-384
-
-
Birca, A.1
Mercier, C.2
Major, P.3
-
6
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, et al (2008) Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 358: 140- 151
-
(2008)
N Engl J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, L.R.3
Elwing, J.M.4
Chuck, G.5
Leonard, J.M.6
Schmithorst, V.J.7
Laor, T.8
Brody, A.S.9
Bean, J.10
-
7
-
-
66149098514
-
Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis
-
Bonnet CS, Aldred M, von Ruhland C, Harris R, Sandford R, Cheadle JP (2009) Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis. Hum Mol Genet 18: 2166- 2176
-
(2009)
Hum Mol Genet
, vol.18
, pp. 2166-2176
-
-
Bonnet, C.S.1
Aldred, M.2
von Ruhland, C.3
Harris, R.4
Sandford, R.5
Cheadle, J.P.6
-
8
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG Jr. (2003) TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4: 147- 158
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr, W.G.5
-
9
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM (1998) RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 95: 1432- 1437
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
10
-
-
70350729488
-
Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation
-
Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE (2009) Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation. Blood 114: 3392- 3401
-
(2009)
Blood
, vol.114
, pp. 3392-3401
-
-
Campbell, T.B.1
Basu, S.2
Hangoc, G.3
Tao, W.4
Broxmeyer, H.E.5
-
11
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003) Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 278: 32493- 32496
-
(2003)
J Biol Chem
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
12
-
-
0034936816
-
Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B
-
Catania MG, Mischel PS, Vinters HV (2001) Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J Neuropathol Exp Neurol 60: 711- 723
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 711-723
-
-
Catania, M.G.1
Mischel, P.S.2
Vinters, H.V.3
-
13
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16
-
Consortium ECTS
-
Consortium ECTS (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75: 1305- 1315
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
-
15
-
-
70449900928
-
TOR complex 2: a signaling pathway of its own
-
Cybulski N, Hall MN (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 34: 620- 627
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 620-627
-
-
Cybulski, N.1
Hall, M.N.2
-
16
-
-
0035167932
-
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
-
Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, Chung J, Choy YS, Reeve MP, Thiele E, Egelhoff JC, et al (2001) Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 68: 64- 80
-
(2001)
Am J Hum Genet
, vol.68
, pp. 64-80
-
-
Dabora, S.L.1
Jozwiak, S.2
Franz, D.N.3
Roberts, P.S.4
Nieto, A.5
Chung, J.6
Choy, Y.S.7
Reeve, M.P.8
Thiele, E.9
Egelhoff, J.C.10
-
17
-
-
18544375193
-
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, et al (2002) Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277: 35364- 35370
-
(2002)
J Biol Chem
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
Feldman, R.I.4
Sui, X.M.5
Ou, C.C.6
Nellist, M.7
Yeung, R.S.8
Halley, D.J.9
Nicosia, S.V.10
-
18
-
-
38049177875
-
Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
-
Davies DM, Johnson SR, Tattersfield AE, Kingswood JC, Cox JA, McCartney DL, Doyle T, Elmslie F, Saggar A, de Vries PJ, et al (2008) Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis. N Engl J Med 358: 200- 203
-
(2008)
N Engl J Med
, vol.358
, pp. 200-203
-
-
Davies, D.M.1
Johnson, S.R.2
Tattersfield, A.E.3
Kingswood, J.C.4
Cox, J.A.5
McCartney, D.L.6
Doyle, T.7
Elmslie, F.8
Saggar, A.9
de Vries, P.J.10
-
19
-
-
65949106140
-
Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner
-
Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M (2009) Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci 29: 5926- 5937
-
(2009)
J Neurosci
, vol.29
, pp. 5926-5937
-
-
Di Nardo, A.1
Kramvis, I.2
Cho, N.3
Sadowski, A.4
Meikle, L.5
Kwiatkowski, D.J.6
Sahin, M.7
-
20
-
-
71049134915
-
Perivascular epithelioid cell neoplasms: pathology and pathogenesis
-
Folpe AL, Kwiatkowski DJ (2010) Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol 41: 1- 15
-
(2010)
Hum Pathol
, vol.41
, pp. 1-15
-
-
Folpe, A.L.1
Kwiatkowski, D.J.2
-
21
-
-
65549121943
-
Notch signaling: the core pathway and its posttranslational regulation
-
Fortini ME (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 16: 633- 647
-
(2009)
Dev Cell
, vol.16
, pp. 633-647
-
-
Fortini, M.E.1
-
22
-
-
33750206088
-
Tuberin activates the proapoptotic molecule BAD
-
Freilinger A, Rosner M, Krupitza G, Nishino M, Lubec G, Korsmeyer SJ, Hengstschlager M (2006) Tuberin activates the proapoptotic molecule BAD. Oncogene 25: 6467- 6479
-
(2006)
Oncogene
, vol.25
, pp. 6467-6479
-
-
Freilinger, A.1
Rosner, M.2
Krupitza, G.3
Nishino, M.4
Lubec, G.5
Korsmeyer, S.J.6
Hengstschlager, M.7
-
23
-
-
40849147074
-
Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development
-
Galabova-Kovacs G, Catalanotti F, Matzen D, Reyes GX, Zezula J, Herbst R, Silva A, Walter I, Baccarini M (2008) Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180: 947- 955
-
(2008)
J Cell Biol
, vol.180
, pp. 947-955
-
-
Galabova-Kovacs, G.1
Catalanotti, F.2
Matzen, D.3
Reyes, G.X.4
Zezula, J.5
Herbst, R.6
Silva, A.7
Walter, I.8
Baccarini, M.9
-
24
-
-
58049196780
-
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
-
Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA (2008) mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA 105: 19384- 19389
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19384-19389
-
-
Gan, B.1
Sahin, E.2
Jiang, S.3
Sanchez-Aguilera, A.4
Scott, K.L.5
Chin, L.6
Williams, D.A.7
Kwiatkowski, D.J.8
DePinho, R.A.9
-
25
-
-
66449083078
-
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Ganley IG, Lam du, H, Wang J, Ding X, Chen S, Jiang X (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297- 12305
-
(2009)
J Biol Chem
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
26
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D (2002) Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4: 699- 704
-
(2002)
Nat Cell Biol
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
27
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11: 1457- 1466
-
(2003)
Mol Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
28
-
-
21344470906
-
Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways
-
Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F (2005) Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways. Mol Cancer Ther 4: 918- 926
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 918-926
-
-
Gau, C.L.1
Kato-Stankiewicz, J.2
Jiang, C.3
Miyamoto, S.4
Guo, L.5
Tamanoi, F.6
-
29
-
-
77951101203
-
The primary cilium: a signalling centre during vertebrate development
-
Goetz SC, Anderson KV (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11: 331- 344
-
(2010)
Nat Rev Genet
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
30
-
-
33645695725
-
Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: role for tumor suppressor TSC2
-
Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP (2006) Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: role for tumor suppressor TSC2. Am J Respir Cell Mol Biol 34: 561- 572
-
(2006)
Am J Respir Cell Mol Biol
, vol.34
, pp. 561-572
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Spaits, M.3
Noonan, D.J.4
Talovskaya, E.5
Eszterhas, A.6
Krymskaya, V.P.7
-
31
-
-
34147187417
-
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
-
Hall DJ, Grewal SS, de la Cruz AF, Edgar BA (2007) Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol 5: 10
-
(2007)
BMC Biol
, vol.5
, pp. 10
-
-
Hall, D.J.1
Grewal, S.S.2
de la Cruz, A.F.3
Edgar, B.A.4
-
32
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110: 177- 189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
33
-
-
57649243069
-
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
-
Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP (2009) The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Hum Mol Genet 18: 151- 163
-
(2009)
Hum Mol Genet
, vol.18
, pp. 151-163
-
-
Hartman, T.R.1
Liu, D.2
Zilfou, J.T.3
Robb, V.4
Morrison, T.5
Watnick, T.6
Henske, E.P.7
-
34
-
-
9744224401
-
The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked
-
Henske EP (2004) The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked? Curr Mol Med 4: 825- 831
-
(2004)
Curr Mol Med
, vol.4
, pp. 825-831
-
-
Henske, E.P.1
-
35
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, et al (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 20: 1981- 1991
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
-
36
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang J, Dibble CC, Matsuzaki M, Manning BD (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28: 4104- 4115
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
37
-
-
68049126433
-
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
-
Huang J, Wu S, Wu CL, Manning BD (2009) Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res 69: 6107- 6114
-
(2009)
Cancer Res
, vol.69
, pp. 6107-6114
-
-
Huang, J.1
Wu, S.2
Wu, C.L.3
Manning, B.D.4
-
38
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT (2002) Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22: 7004- 7014
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
39
-
-
0037068783
-
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells
-
Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S, Worley PF, Boss GR, Pilz RB (2002) Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene 21: 6356- 6365
-
(2002)
Oncogene
, vol.21
, pp. 6356-6365
-
-
Im, E.1
von Lintig, F.C.2
Chen, J.3
Zhuang, S.4
Qui, W.5
Chowdhury, S.6
Worley, P.F.7
Boss, G.R.8
Pilz, R.B.9
-
40
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL (2003a) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829- 1834
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
41
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL (2003b) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577- 590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
42
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, et al (2006) TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126: 955- 968
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
-
43
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, Hall MN (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122- 1128
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
44
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R (2002) Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 159: 217- 224
-
(2002)
J Cell Biol
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
45
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20: 1992- 2003
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
46
-
-
78650174233
-
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
-
Kang YJ, Lu MK, Guan KL (2011) The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ 18: 133- 144
-
(2011)
Cell Death Differ
, vol.18
, pp. 133-144
-
-
Kang, Y.J.1
Lu, M.K.2
Guan, K.L.3
-
47
-
-
77958529748
-
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling
-
Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, et al (2010) Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem 285: 33979- 33991
-
(2010)
J Biol Chem
, vol.285
, pp. 33979-33991
-
-
Karassek, S.1
Berghaus, C.2
Schwarten, M.3
Goemans, C.G.4
Ohse, N.5
Kock, G.6
Jockers, K.7
Neumann, S.8
Gottfried, S.9
Herrmann, C.10
-
48
-
-
32244447213
-
The role of tuberin in cellular differentiation: are B-Raf and MAPK involved
-
Karbowniczek M, Henske EP (2005) The role of tuberin in cellular differentiation: are B-Raf and MAPK involved? Ann N Y Acad Sci 1059: 168- 173
-
(2005)
Ann N Y Acad Sci
, vol.1059
, pp. 168-173
-
-
Karbowniczek, M.1
Henske, E.P.2
-
49
-
-
3142757865
-
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
-
Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP (2004) Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem 279: 29930- 29937
-
(2004)
J Biol Chem
, vol.279
, pp. 29930-29937
-
-
Karbowniczek, M.1
Cash, T.2
Cheung, M.3
Robertson, G.P.4
Astrinidis, A.5
Henske, E.P.6
-
50
-
-
33747822482
-
Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization
-
Karbowniczek M, Robertson GP, Henske EP (2006) Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization. J Biol Chem 281: 25447- 25456
-
(2006)
J Biol Chem
, vol.281
, pp. 25447-25456
-
-
Karbowniczek, M.1
Robertson, G.P.2
Henske, E.P.3
-
51
-
-
74949090816
-
The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
-
Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, Nicolas E, Squillace R, Roegiers F, Henske EP (2010) The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest 120: 93- 102
-
(2010)
J Clin Invest
, vol.120
, pp. 93-102
-
-
Karbowniczek, M.1
Zitserman, D.2
Khabibullin, D.3
Hartman, T.4
Yu, J.5
Morrison, T.6
Nicolas, E.7
Squillace, R.8
Roegiers, F.9
Henske, E.P.10
-
52
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
Kenerson HL, Aicher LD, True LD, Yeung RS (2002) Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 62: 5645- 5650
-
(2002)
Cancer Res
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
Aicher, L.D.2
True, L.D.3
Yeung, R.S.4
-
53
-
-
11144262151
-
Effects of rapamycin in the Eker rat model of tuberous sclerosis complex
-
Kenerson H, Dundon TA, Yeung RS (2005) Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. Pediatr Res 57: 67- 75
-
(2005)
Pediatr Res
, vol.57
, pp. 67-75
-
-
Kenerson, H.1
Dundon, T.A.2
Yeung, R.S.3
-
54
-
-
0037178786
-
mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2002) mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163- 175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
55
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between Raptor and mTOR
-
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between Raptor and mTOR. Mol Cell 11: 895- 904
-
(2003)
Mol Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
56
-
-
38849182213
-
Mechanisms of TSC-mediated control of synapse assembly and axon guidance
-
Knox S, Ge H, Dimitroff BD, Ren Y, Howe KA, Arsham AM, Easterday MC, Neufeld TP, O'Connor MB, Selleck SB (2007) Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One 2: e375
-
(2007)
PLoS One
, vol.2
-
-
Knox, S.1
Ge, H.2
Dimitroff, B.D.3
Ren, Y.4
Howe, K.A.5
Arsham, A.M.6
Easterday, M.C.7
Neufeld, T.P.8
O'Connor, M.B.9
Selleck, S.B.10
-
57
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10: 524- 530
-
(2000)
Trends Cell Biol
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
58
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H (2002) A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11: 525- 534
-
(2002)
Hum Mol Genet
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
el-Hashemite, N.6
Onda, H.7
-
59
-
-
84891583587
-
-
Weinheim, Germany, Wiley-Blackwell:
-
Kwiatkowski DJ, Whittemore VH, Thiele EA (2010) Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics. Weinheim, Germany, Wiley-Blackwell: p 409
-
(2010)
Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics
, pp. 409
-
-
Kwiatkowski, D.J.1
Whittemore, V.H.2
Thiele, E.A.3
-
60
-
-
36549026878
-
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
-
Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL (2007a) Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 26: 4812- 4823
-
(2007)
EMBO J
, vol.26
, pp. 4812-4823
-
-
Lee, C.H.1
Inoki, K.2
Karbowniczek, M.3
Petroulakis, E.4
Sonenberg, N.5
Henske, E.P.6
Guan, K.L.7
-
61
-
-
34547605613
-
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
-
Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, et al (2007b) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130: 440- 455
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.F.1
Kuo, H.P.2
Chen, C.T.3
Hsu, J.M.4
Chou, C.K.5
Wei, Y.6
Sun, H.L.7
Li, L.Y.8
Ping, B.9
Huang, W.C.10
-
62
-
-
74549139627
-
Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells
-
Lee PS, Tsang SW, Moses MA, Trayes-Gibson Z, Hsiao LL, Jensen R, Squillace R, Kwiatkowski DJ (2010) Rapamycin-insensitive up-regulation of MMP2 and other genes in tuberous sclerosis complex 2-deficient lymphangioleiomyomatosis-like cells. Am J Respir Cell Mol Biol 42: 227- 234
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, pp. 227-234
-
-
Lee, P.S.1
Tsang, S.W.2
Moses, M.A.3
Trayes-Gibson, Z.4
Hsiao, L.L.5
Jensen, R.6
Squillace, R.7
Kwiatkowski, D.J.8
-
63
-
-
0038190932
-
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
-
Li Y, Inoki K, Vacratsis P, Guan KL (2003) The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem 278: 13663- 13671
-
(2003)
J Biol Chem
, vol.278
, pp. 13663-13671
-
-
Li, Y.1
Inoki, K.2
Vacratsis, P.3
Guan, K.L.4
-
64
-
-
77952263737
-
The genetic basis of kidney cancer: a metabolic disease
-
Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 7: 277- 285
-
(2010)
Nat Rev Urol
, vol.7
, pp. 277-285
-
-
Linehan, W.M.1
Srinivasan, R.2
Schmidt, L.S.3
-
65
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457- 468
-
(2002)
Mol Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
66
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179- 193
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
67
-
-
77950576952
-
Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL
-
Ma D, Bai X, Zou H, Lai Y, Jiang Y (2010a) Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. J Biol Chem 285: 8621- 8627
-
(2010)
J Biol Chem
, vol.285
, pp. 8621-8627
-
-
Ma, D.1
Bai, X.2
Zou, H.3
Lai, Y.4
Jiang, Y.5
-
68
-
-
74949092824
-
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
-
Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, et al (2010b) Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 120: 103- 114
-
(2010)
J Clin Invest
, vol.120
, pp. 103-114
-
-
Ma, J.1
Meng, Y.2
Kwiatkowski, D.J.3
Chen, X.4
Peng, H.5
Sun, Q.6
Zha, X.7
Wang, F.8
Wang, Y.9
Jing, Y.10
-
69
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151- 162
-
(2002)
Mol Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
70
-
-
0036021402
-
Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe
-
Matsumoto S, Bandyopadhyay A, Kwiatkowski DJ, Maitra U, Matsumoto T (2002) Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics 161: 1053- 1063
-
(2002)
Genetics
, vol.161
, pp. 1053-1063
-
-
Matsumoto, S.1
Bandyopadhyay, A.2
Kwiatkowski, D.J.3
Maitra, U.4
Matsumoto, T.5
-
71
-
-
0036159634
-
Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation
-
Miloloza A, Kubista M, Rosner M, Hengstschlager M (2002) Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation. J Neuropathol Exp Neurol 61: 154- 163
-
(2002)
J Neuropathol Exp Neurol
, vol.61
, pp. 154-163
-
-
Miloloza, A.1
Kubista, M.2
Rosner, M.3
Hengstschlager, M.4
-
72
-
-
77149141403
-
Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
-
Nakashima A, Sato T, Tamanoi F (2010) Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. J Cell Sci 123: 777- 786
-
(2010)
J Cell Sci
, vol.123
, pp. 777-786
-
-
Nakashima, A.1
Sato, T.2
Tamanoi, F.3
-
73
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29: 541- 551
-
(2008)
Mol Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
Ozcan, L.2
Yilmaz, E.3
Duvel, K.4
Sahin, M.5
Manning, B.D.6
Hotamisligil, G.S.7
-
74
-
-
0037406694
-
Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis
-
Panepinto JC, Oliver BG, Fortwendel JR, Smith DL, Askew DS, Rhodes JC (2003) Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis. Infect Immun 71: 2819- 2826
-
(2003)
Infect Immun
, vol.71
, pp. 2819-2826
-
-
Panepinto, J.C.1
Oliver, B.G.2
Fortwendel, J.R.3
Smith, D.L.4
Askew, D.S.5
Rhodes, J.C.6
-
75
-
-
70449558169
-
A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila
-
Patch K, Stewart SR, Welch A, Ward RE (2009) A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila. PLoS One 4: e7574
-
(2009)
PLoS One
, vol.4
-
-
Patch, K.1
Stewart, S.R.2
Welch, A.3
Ward, R.E.4
-
76
-
-
74949110559
-
New roles for Notch in tuberous sclerosis
-
Pear WS (2010) New roles for Notch in tuberous sclerosis. J Clin Invest 120: 84- 87
-
(2010)
J Clin Invest
, vol.120
, pp. 84-87
-
-
Pear, W.S.1
-
77
-
-
0032213545
-
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
-
Plank TL, Yeung RS, Henske EP (1998) Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 58: 4766- 4770
-
(1998)
Cancer Res
, vol.58
, pp. 4766-4770
-
-
Plank, T.L.1
Yeung, R.S.2
Henske, E.P.3
-
78
-
-
52949137425
-
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2. components rictor and sin1
-
Rosner M, Hengstschlager M (2008) Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2. components rictor and sin1. Hum Mol Genet 17: 2934- 2948
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2934-2948
-
-
Rosner, M.1
Hengstschlager, M.2
-
79
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA 101: 13489- 13494
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
80
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098- 1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
81
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5: 566- 571
-
(2003)
Nat Cell Biol
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
82
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 5: 559- 565
-
(2003)
Nat Cell Biol
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
83
-
-
28044456974
-
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
-
Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8: 1727- 1734
-
(2005)
Nat Neurosci
, vol.8
, pp. 1727-1734
-
-
Tavazoie, S.F.1
Alvarez, V.A.2
Ridenour, D.A.3
Kwiatkowski, D.J.4
Sabatini, B.L.5
-
84
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J (2002) Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99: 13571- 13576
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
85
-
-
24044442298
-
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
-
Tee AR, Blenis J, Proud CG (2005) Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 579: 4763- 4768
-
(2005)
FEBS Lett
, vol.579
, pp. 4763-4768
-
-
Tee, A.R.1
Blenis, J.2
Proud, C.G.3
-
86
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023- 8032
-
(2009)
J Biol Chem
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
Reichling, L.J.7
Sim, T.8
Sabatini, D.M.9
Gray, N.S.10
-
87
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277: 27975- 27981
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
88
-
-
58749112340
-
A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans
-
Tsao CC, Chen YT, Lan CY (2009) A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans. Fungal Genet Biol 46: 126- 136
-
(2009)
Fungal Genet Biol
, vol.46
, pp. 126-136
-
-
Tsao, C.C.1
Chen, Y.T.2
Lan, C.Y.3
-
89
-
-
0034646618
-
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
-
Urano J, Tabancay AP, Yang W, Tamanoi F (2000) The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. J Biol Chem 275: 11198- 11206
-
(2000)
J Biol Chem
, vol.275
, pp. 11198-11206
-
-
Urano, J.1
Tabancay, A.P.2
Yang, W.3
Tamanoi, F.4
-
90
-
-
27944452168
-
Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
-
Urano J, Comiso MJ, Guo L, Aspuria PJ, Deniskin R, Tabancay AP, Jr., Kato-Stankiewicz J, Tamanoi F (2005) Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Mol Microbiol 58: 1074- 1086
-
(2005)
Mol Microbiol
, vol.58
, pp. 1074-1086
-
-
Urano, J.1
Comiso, M.J.2
Guo, L.3
Aspuria, P.J.4
Deniskin, R.5
Tabancay Jr, A.P.6
Kato-Stankiewicz, J.7
Tamanoi, F.8
-
91
-
-
33847651745
-
Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
-
Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F (2007) Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci USA 104: 3514- 3519
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3514-3519
-
-
Urano, J.1
Sato, T.2
Matsuo, T.3
Otsubo, Y.4
Yamamoto, M.5
Tamanoi, F.6
-
92
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, et al (1997) Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277: 805- 808
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
van Slegtenhorst, M.1
de Hoogt, R.2
Hermans, C.3
Nellist, M.4
Janssen, B.5
Verhoef, S.6
Lindhout, D.7
van den Ouweland, A.8
Halley, D.9
Young, J.10
-
93
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P (1998) Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 7: 1053- 1057
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1053-1057
-
-
van Slegtenhorst, M.1
Nellist, M.2
Nagelkerken, B.3
Cheadle, J.4
Snell, R.5
van den Ouweland, A.6
Reuser, A.7
Sampson, J.8
Halley, D.9
van der Sluijs, P.10
-
94
-
-
1842424927
-
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe
-
van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP (2004) Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J Biol Chem 279: 12706- 12713
-
(2004)
J Biol Chem
, vol.279
, pp. 12706-12713
-
-
van Slegtenhorst, M.1
Carr, E.2
Stoyanova, R.3
Kruger, W.D.4
Henske, E.P.5
-
95
-
-
34249054108
-
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast
-
Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175: 1153- 1162
-
(2007)
Genetics
, vol.175
, pp. 1153-1162
-
-
Weisman, R.1
Roitburg, I.2
Schonbrun, M.3
Harari, R.4
Kupiec, M.5
-
96
-
-
84886117516
-
The history of tuberous sclerosis complex.
-
In:, Kwiatkowski DJ, Whittemore VH, Thiele EA (eds), Weinheim, Germany, Wiley-Blackwell:
-
Whittemore VH (2010) The history of tuberous sclerosis complex. In: Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics, Kwiatkowski DJ, Whittemore VH, Thiele EA (eds), Weinheim, Germany, Wiley-Blackwell: pp 3- 8
-
(2010)
Tuberous Sclerosis Complex: Genes, Clinical Features, and Therapeutics
, pp. 3-8
-
-
Whittemore, V.H.1
-
97
-
-
33748060509
-
+/- mice
-
+/- mice. Cancer Res 66: 7934- 7938
-
(2006)
Cancer Res
, vol.66
, pp. 7934-7938
-
-
Wilson, C.1
Bonnet, C.2
Guy, C.3
Idziaszczyk, S.4
Colley, J.5
Humphreys, V.6
Maynard, J.7
Sampson, J.R.8
Cheadle, J.P.9
-
98
-
-
0032143608
-
Craf-1 protein kinase is essential for mouse development
-
Wojnowski L, Stancato LF, Zimmer AM, Hahn H, Beck TW, Larner AC, Rapp UR, Zimmer A (1998) Craf-1 protein kinase is essential for mouse development. Mech Dev 76: 141- 149
-
(1998)
Mech Dev
, vol.76
, pp. 141-149
-
-
Wojnowski, L.1
Stancato, L.F.2
Zimmer, A.M.3
Hahn, H.4
Beck, T.W.5
Larner, A.C.6
Rapp, U.R.7
Zimmer, A.8
-
99
-
-
78951473590
-
Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex
-
Yalon M, Ben-Sira L, Constantini S, Toren A (2011) Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex. Childs Nerv Syst 27: 179- 181
-
(2011)
Childs Nerv Syst
, vol.27
, pp. 179-181
-
-
Yalon, M.1
Ben-Sira, L.2
Constantini, S.3
Toren, A.4
-
100
-
-
0031039427
-
Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals
-
Yee WM, Worley PF (1997) Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol Cell Biol 17: 921- 933
-
(1997)
Mol Cell Biol
, vol.17
, pp. 921-933
-
-
Yee, W.M.1
Worley, P.F.2
-
101
-
-
77949846455
-
mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis
-
Yu J, Henske EP (2010) mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphat Res Biol 8: 43- 49
-
(2010)
Lymphat Res Biol
, vol.8
, pp. 43-49
-
-
Yu, J.1
Henske, E.P.2
-
102
-
-
1642290141
-
Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
-
Yu J, Astrinidis A, Howard S, Henske EP (2004) Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. Am J Physiol Lung Cell Mol Physiol 286: L694- L700
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
-
-
Yu, J.1
Astrinidis, A.2
Howard, S.3
Henske, E.P.4
-
103
-
-
27944503577
-
Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B
-
Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L (2005) Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep 32: 205- 214
-
(2005)
Mol Biol Rep
, vol.32
, pp. 205-214
-
-
Yuan, J.1
Shan, Y.2
Chen, X.3
Tang, W.4
Luo, K.5
Ni, J.6
Wan, B.7
Yu, L.8
-
104
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5: 578- 581
-
(2003)
Nat Cell Biol
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
105
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541- 1545
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
106
-
-
67049158203
-
Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy
-
Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL (2009) Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci USA 106: 8923- 8928
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8923-8928
-
-
Zhou, X.1
Ikenoue, T.2
Chen, X.3
Li, L.4
Inoki, K.5
Guan, K.L.6
|